Role of phospholipids in protection of the GI mucosa

Digestive Diseases and Sciences

Volumn 58, Issue 4, 2013, Pages 891-893

  Lichtenberger, Lenard M ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; BICARBONATE; CYCLOOXYGENASE 1; GASTRIN; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; HISTAMINE; HISTAMINE H2 RECEPTOR ANTAGONIST; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHOLIPID; PROSTAGLANDIN; PROTON PUMP INHIBITOR;

BLOATING; CELL PROTECTION; DIARRHEA; GASTROINTESTINAL MUCOSA; HELICOBACTER PYLORI; HUMAN; HYDROPHOBICITY; IMMUNOHISTOCHEMISTRY; INTESTINAL SECRETION; INTESTINE BLOOD FLOW; INTESTINE MUSCLE; NONHUMAN; PATHOGENESIS; PEPTIC ULCER; PRIORITY JOURNAL; REVIEW; SMOOTH MUSCLE CONTRACTION; SPONTANEOUS ABORTION; STOMACH ACID SECRETION; STOMACH CANCER; STOMACH EROSION; STOMACH PROTECTION; STOMACH ULCER; TRADITIONAL MEDICINE; ULCER HEALING; UTERUS CONTRACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; GASTRIC MUCOSA; HUMANS; INTESTINAL MUCOSA; PHOSPHOLIPIDS; STOMACH ULCER;

EID: 84876672676     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2530-8     Document Type: Review

References (41)

1. Bralow SP. Current concepts of peptic ulceration. Am J Dig Dis. 1969;14:655-677.
2. Grossman MI, Guth PH, Isenberg JI, et al. A new look at peptic ulcer. Ann Intern Med. 1976;84:57-67.
3. Black JW, Duncan WA, Durant CJ, Ganellin CR, Parsons EM. Definition and antagonism of histamine H2-receptors. Nature. 1972;236:385-390.
4. Isenberg JI. H2-receptor antagonists in the treatment of peptic ulcer. Ann Intern Med. 1976;84:212-214.
5. Olbe L, Carlsson E, Lindberg P. A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole. Nat Rev Drug Discov. 2003;2:132-139.
6. Wolfe MM, Sachs G. Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal reflux disease, and stress-related erosive syndrome. Gastroenterology. 2000;118:S9-S31.
7. Scarpignato C, Pelosini I, Di Mario F. Acid suppression therapy: where do we go from here? Dig Dis. 2006;24:11-46.
8. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology. 1979;77:433-443.
9. Nishizaki Y, Guth PH, Quintero E, Bover J, Del Rivero M, Kaunitz JD. Prostaglandin E2 enhances gastric defense mechanisms against acid injury in uremic rats. Gastroenterology. 1994;107:1382-1389.
10. Lichtenberger LM. The hydrophobic barrier properties of gastrointestinal mucus. Annu Rev Physiol. 1995;57:565-583.
11. Cryer B. Mucosal defense and repair. Role of prostaglandins in the stomach and duodenum. Gastroenterol Clin N Am. 2001;30:877-894, v-vi.
12. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1:1311-1315.
13. Forman D, Graham DY. Review article: impact of Helicobacter pylori on society-role for a strategy of "search and eradicate". Aliment Pharmacol Ther. 2004;19:17-21.
14. Huang JQ, Hunt RH. Review article: Helicobacter pylori and gastric cancer - the clinicians' point of view. Aliment Pharmacol Ther. 2000;14:48-54.
15. Buret AG, Fedwick JP, Flynn AN. Host epithelial interactions with Helicobacter pylori: a role for disrupted gastric barrier function in the clinical outcome of infection? Can J Gastroenterol. 2005;19:543-552.
16. Ham M, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol. 2008;24:665-673.
17. Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med. 1999;340:1888-1899.
18. Maiden L, Thjodleifsson B, Theodors A, Gonzalez J, Bjarnason I. A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. Gastroenterology. 2005;128:1172-1178.
19. Vane J. Towards a better aspirin. Nature. 1994;367:215-216.
20. Lichtenberger LM. Where is the evidence that cyclooxygenase inhibition is the primary cause of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal injury? Topical injury revisited. Biochem Pharmacol. 2001;61:631-637.
21. Bresalier RS, Sandler RS, Quan H, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med. 2005;352:1092-1102.
22. Sandweiss DJ. The Sippy treatment for peptic ulcer-fifty years later. Am J Dig Dis. 1961;6:929-937.
23. Ippoliti AF, Maxwell V, Isenberg JI. The effect of various forms of milk on gastric-acid secretion. Studies in patients with duodenal ulcer and normal subjects. Ann Intern Med. 1976;84:286-289.
24. Hollander D, Tarnawski A. Is there a role for dietary essential fatty acids in gastroduodenal mucosal protection? J Clin Gastroenterol. 1991;13:S72-S74.
25. Spychal RT, Goggin PM, Marrero JM, et al. Surface hydrophobicity of gastric mucosa in peptic ulcer disease. Relationship to gastritis and Campylobacter pylori infection. Gastroenterology. 1990;98:1250-1254.
26. Eliakim R, DeSchryver-Kecskemeti K, Nogee L, Stenson WF, Alpers DH. Isolation and characterization of a small intestinal surfactant-like particle containing alkaline phosphatase and other digestive enzymes. J Biol Chem. 1989;264:20614-20619.
27. Ehehalt R, Wagenblast J, Erben G, et al. Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoElectrospray-tandem mass spectrometry. Scand J Gastroenterol. 2004;39:737-742.
28. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol. 2010;44:e101-e107.
29. Dial EJ, Lichtenberger LM. A role for milk phospholipids in protection against gastric acid. Studies in adult and suckling rats. Gastroenterology. 1984;87:379-385.
30. Lichtenberger LM, Wang ZM, Romero JJ, et al. Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: insight into the mechanism and reversal of NSAID-induced gastrointestinal injury. Nat Med. 1995;1:154-158.
31. Lichtenberger LM, Zhou Y, Jayaraman V, et al. Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: characterization of interaction of NSAIDs with phosphatidylcholine. Biochim Biophys Acta. 2012;1821:994-1002.
32. Cryer B, Bhatt DL, Lanza FL, Dong JF, Lichtenberger LM, Marathi UK. Low-dose aspirin-induced ulceration is attenuated by aspirin- phosphatidylcholine: a randomized clinical trial. Am J Gastroenterol. 2011;106:272-277.
33. Lanza FL, Marathi UK, Anand BS, Lichtenberger LM. Clinical trial: comparison of ibuprofen-PC and ibuprofen on the GI safety and analgesic efficacy in osteoarthritic patients. Aliment Pharmacol Ther. 2008;28:431-442.
34. Tanaka T, Morito K, Kinoshita M. Orally administered phosphatidic acids and lysophosphatidic acids ameliorate aspirin-induced mucosal injury in mice. Dig Dis Sci. 2012. (Epub ahead of print). doi: 10.1007/s10620-012-2475-y.
35. Deng W, Shuyu E, Tsukahara R, et al. The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology. 2007;132:1834-1851.
36. Kang YC, Kim KM, Lee KS, et al. Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3 K/Akt-dependent cFLIP expression and Bad phosphorylation. Cell Death Differ. 2004;11:1287-1298.
37. Tanaka T, Horiuchi G, Matsuoka M, et al. Formation of lysophosphatidic acid, a wound-healing lipid, during digestion of cabbage leaves. Biosci Biotechnol Biochem. 2009;73:1293-1300.
38. Dial EJ, Romero JJ, Villa X, Mercer DW, Lichtenberger LM. Lipopolysaccharide-induced gastrointestinal injury in rats: role of surface hydrophobicity and bile salts. Shock. 2002;17:77-80.
39. Zayat M, Lichtenberger LM, Dial EJ. Pathophysiology of LPS-induced gastrointestinal injury in the rat: role of secretory phospholipase A2. Shock. 2008;30:206-211.
40. Cheney G. Rapid healing of peptic ulcers in patients receiving fresh cabbage juice. Calif Med. 1949;70:10-15.
41. Moschetta A, Xu F, Hagey LR, et al. A phylogenetic survey of biliary lipids in vertebrates. J Lipid Res. 2005;46:2221-2232.