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Volumn 10, Issue 1, 2013, Pages

Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats

Author keywords

CREB; CREB regulating transcriptional activators; HTLV 1; P21 activated kinases; Tax

Indexed keywords

CREB REGULATING TRANSCRIPTIONAL COACTIVATOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; E1A ASSOCIATED P300 PROTEIN; P21 ACTIVATED KINASE 1; P21 ACTIVATED KINASE 3; SMALL INTERFERING RNA; TAX PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84876668064     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-10-47     Document Type: Article
Times cited : (12)

References (56)
  • 3
    • 0029861653 scopus 로고    scopus 로고
    • Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat
    • 190925, 8970957
    • Tie F, Adya N, Greene WC, Giam CZ. Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat. J Virol 1996, 70:8368-8374. 190925, 8970957.
    • (1996) J Virol , vol.70 , pp. 8368-8374
    • Tie, F.1    Adya, N.2    Greene, W.C.3    Giam, C.Z.4
  • 4
    • 17744377229 scopus 로고    scopus 로고
    • Specific TATAA and bZIP requirements suggest that HTLV-1 Tax has transcriptional activity subsequent to the assembly of an initiation complex
    • 10.1186/1742-4690-1-18, 509288, 15285791
    • Ching YP, Chun ACS, Chin KT, Zhang ZQ, Jeang KT, Jin DY. Specific TATAA and bZIP requirements suggest that HTLV-1 Tax has transcriptional activity subsequent to the assembly of an initiation complex. Retrovirology 2004, 1:18. 10.1186/1742-4690-1-18, 509288, 15285791.
    • (2004) Retrovirology , vol.1 , pp. 18
    • Ching, Y.P.1    Chun, A.C.S.2    Chin, K.T.3    Zhang, Z.Q.4    Jeang, K.T.5    Jin, D.Y.6
  • 5
    • 25444462807 scopus 로고    scopus 로고
    • Transcriptional and post-transcriptional gene regulation of HTLV-1
    • 10.1038/sj.onc.1208973, 16155601
    • Kashanchi F, Brady JN. Transcriptional and post-transcriptional gene regulation of HTLV-1. Oncogene 2005, 24:5938-5951. 10.1038/sj.onc.1208973, 16155601.
    • (2005) Oncogene , vol.24 , pp. 5938-5951
    • Kashanchi, F.1    Brady, J.N.2
  • 6
    • 0029875008 scopus 로고    scopus 로고
    • Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP
    • 10.1038/380642a0, 8602268
    • Kwok RP, Laurance ME, Lundblad JR, Goldman PS, Shih HM, Connor LM, Marriott SJ, Goodman RH. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature 1996, 380:642-646. 10.1038/380642a0, 8602268.
    • (1996) Nature , vol.380 , pp. 642-646
    • Kwok, R.P.1    Laurance, M.E.2    Lundblad, J.R.3    Goldman, P.S.4    Shih, H.M.5    Connor, L.M.6    Marriott, S.J.7    Goodman, R.H.8
  • 7
    • 11244303595 scopus 로고    scopus 로고
    • Enhanced activation of Tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3
    • 10.1074/jbc.M409021200, 15466468
    • Koga H, Ohshima T, Shimotohno K. Enhanced activation of Tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. J Biol Chem 2004, 279:52978-52983. 10.1074/jbc.M409021200, 15466468.
    • (2004) J Biol Chem , vol.279 , pp. 52978-52983
    • Koga, H.1    Ohshima, T.2    Shimotohno, K.3
  • 8
    • 33745854207 scopus 로고    scopus 로고
    • TORC1 and TORC2 coactivators are required for Tax activation of the human T-cell leukemia virus type 1 long terminal repeats
    • 10.1128/JVI.00103-06, 1489057, 16809310
    • Siu YT, Chin KT, Siu KL, Choy EYW, Jeang KT, Jin DY. TORC1 and TORC2 coactivators are required for Tax activation of the human T-cell leukemia virus type 1 long terminal repeats. J Virol 2006, 80:7052-7059. 10.1128/JVI.00103-06, 1489057, 16809310.
    • (2006) J Virol , vol.80 , pp. 7052-7059
    • Siu, Y.T.1    Chin, K.T.2    Siu, K.L.3    Choy, E.Y.W.4    Jeang, K.T.5    Jin, D.Y.6
  • 9
    • 69849093236 scopus 로고    scopus 로고
    • Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-1
    • 10.1186/1742-4690-6-73, 2734550, 19664292
    • Jiang S, Inada T, Tanaka M, Furuta RA, Shingu K, Fujisawa J. Involvement of TORC2, a CREB co-activator, in the in vivo-specific transcriptional control of HTLV-1. Retrovirology 2009, 6:73. 10.1186/1742-4690-6-73, 2734550, 19664292.
    • (2009) Retrovirology , vol.6 , pp. 73
    • Jiang, S.1    Inada, T.2    Tanaka, M.3    Furuta, R.A.4    Shingu, K.5    Fujisawa, J.6
  • 10
    • 77950807932 scopus 로고    scopus 로고
    • The HTLV-1 Tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription
    • 10.1038/onc.2009.498, 2851846, 20101207
    • Kim YM, Geiger TR, Egan DI, Sharma N, Nyborg JK. The HTLV-1 Tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription. Oncogene 2010, 29:2142-2152. 10.1038/onc.2009.498, 2851846, 20101207.
    • (2010) Oncogene , vol.29 , pp. 2142-2152
    • Kim, Y.M.1    Geiger, T.R.2    Egan, D.I.3    Sharma, N.4    Nyborg, J.K.5
  • 11
    • 0032888951 scopus 로고    scopus 로고
    • Phosphorylation of the human T-cell leukemia virus type 1 transactivator Tax on adjacent serine residues is critical for Tax activation
    • 103881, 9847380
    • Bex F, Murphy K, Wattiez R, Burny A, Gaynor RB. Phosphorylation of the human T-cell leukemia virus type 1 transactivator Tax on adjacent serine residues is critical for Tax activation. J Virol 1999, 73:738-745. 103881, 9847380.
    • (1999) J Virol , vol.73 , pp. 738-745
    • Bex, F.1    Murphy, K.2    Wattiez, R.3    Burny, A.4    Gaynor, R.B.5
  • 12
    • 33846024067 scopus 로고    scopus 로고
    • Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein
    • 10.1074/jbc.M607011200, 16923801
    • Durkin SS, Ward MD, Fryrear KA, Semmes OJ. Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein. J Biol Chem 2006, 281:31705-31712. 10.1074/jbc.M607011200, 16923801.
    • (2006) J Biol Chem , vol.281 , pp. 31705-31712
    • Durkin, S.S.1    Ward, M.D.2    Fryrear, K.A.3    Semmes, O.J.4
  • 13
    • 38949166315 scopus 로고    scopus 로고
    • The human T-cell leukemia virus type 1 Tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB
    • 10.1128/MCB.01657-07, 2258755, 18070920
    • Geiger TR, Sharma N, Kim YM, Nyborg JK. The human T-cell leukemia virus type 1 Tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB. Mol Cell Biol 2008, 28:1383-1392. 10.1128/MCB.01657-07, 2258755, 18070920.
    • (2008) Mol Cell Biol , vol.28 , pp. 1383-1392
    • Geiger, T.R.1    Sharma, N.2    Kim, Y.M.3    Nyborg, J.K.4
  • 14
    • 79951962147 scopus 로고    scopus 로고
    • CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
    • 10.1038/nrm3072, 21346730
    • Altarejos JY, Montminy M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 2011, 12:141-151. 10.1038/nrm3072, 21346730.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 141-151
    • Altarejos, J.Y.1    Montminy, M.2
  • 15
    • 79953033524 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy
    • 10.1038/onc.2010.537, 3413891, 21119600
    • Matsuoka M, Jeang KT. Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy. Oncogene 2011, 30:1379-1389. 10.1038/onc.2010.537, 3413891, 21119600.
    • (2011) Oncogene , vol.30 , pp. 1379-1389
    • Matsuoka, M.1    Jeang, K.T.2
  • 19
    • 38949197214 scopus 로고    scopus 로고
    • A tale of two Paks
    • 10.1042/BC20070109, 18199048
    • Arias-Romero LE, Chernoff J. A tale of two Paks. Biol Cell 2008, 100:97-108. 10.1042/BC20070109, 18199048.
    • (2008) Biol Cell , vol.100 , pp. 97-108
    • Arias-Romero, L.E.1    Chernoff, J.2
  • 20
    • 67651097663 scopus 로고    scopus 로고
    • PAK signaling in oncogenesis
    • 10.1038/onc.2009.119, 2731678, 19465939
    • Molli PR, Li DQ, Murray BW, Rayala SK, Kumar R. PAK signaling in oncogenesis. Oncogene 2009, 28:2545-2555. 10.1038/onc.2009.119, 2731678, 19465939.
    • (2009) Oncogene , vol.28 , pp. 2545-2555
    • Molli, P.R.1    Li, D.Q.2    Murray, B.W.3    Rayala, S.K.4    Kumar, R.5
  • 21
    • 34248531653 scopus 로고    scopus 로고
    • P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation
    • 10.1158/0008-5472.CAN-06-3994, 17440071
    • Ching YP, Leong VYL, Lee MF, Xu HT, Jin DY, Ng IOL. p21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. Cancer Res 2007, 67:3601-3608. 10.1158/0008-5472.CAN-06-3994, 17440071.
    • (2007) Cancer Res , vol.67 , pp. 3601-3608
    • Ching, Y.P.1    Leong, V.Y.L.2    Lee, M.F.3    Xu, H.T.4    Jin, D.Y.5    Ng, I.O.L.6
  • 22
    • 79954581842 scopus 로고    scopus 로고
    • Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis
    • 10.1158/0008-5472.CAN-10-4046, 21385901
    • Mak GWY, Chan MML, Leong VYL, Lee JMF, Yau TO, Ng IOL, Ching YP. Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis. Cancer Res 2011, 71:2949-2958. 10.1158/0008-5472.CAN-10-4046, 21385901.
    • (2011) Cancer Res , vol.71 , pp. 2949-2958
    • Mak, G.W.Y.1    Chan, M.M.L.2    Leong, V.Y.L.3    Lee, J.M.F.4    Yau, T.O.5    Ng, I.O.L.6    Ching, Y.P.7
  • 23
    • 77249150989 scopus 로고    scopus 로고
    • An emerging role for p21-activated kinases (Paks) in viral infections
    • 10.1016/j.tcb.2009.12.005, 20071173
    • Van den Broeke C, Radu M, Chernoff J, Favoreel HW. An emerging role for p21-activated kinases (Paks) in viral infections. Trends Cell Biol 2010, 20:160-169. 10.1016/j.tcb.2009.12.005, 20071173.
    • (2010) Trends Cell Biol , vol.20 , pp. 160-169
    • Van den Broeke, C.1    Radu, M.2    Chernoff, J.3    Favoreel, H.W.4
  • 24
    • 0032561355 scopus 로고    scopus 로고
    • Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation
    • 10.1074/jbc.273.43.28191, 9774440
    • Frost JA, Khokhlatchev A, Stippec S, White MA, Cobb MH. Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation. J Biol Chem 1998, 273:28191-28198. 10.1074/jbc.273.43.28191, 9774440.
    • (1998) J Biol Chem , vol.273 , pp. 28191-28198
    • Frost, J.A.1    Khokhlatchev, A.2    Stippec, S.3    White, M.A.4    Cobb, M.H.5
  • 25
    • 0036711657 scopus 로고    scopus 로고
    • Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
    • 10.1038/ncb838, 12198493
    • Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, Kumar R. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 2002, 4:681-690. 10.1038/ncb838, 12198493.
    • (2002) Nat Cell Biol , vol.4 , pp. 681-690
    • Vadlamudi, R.K.1    Li, F.2    Adam, L.3    Nguyen, D.4    Ohta, Y.5    Stossel, T.P.6    Kumar, R.7
  • 26
    • 33947212877 scopus 로고    scopus 로고
    • The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity
    • 10.1038/sj.onc.1209983, 17001318
    • Thullberg M, Gad A, Beeser A, Chernoff J, Strömblad S. The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity. Oncogene 2007, 26:1820-1828. 10.1038/sj.onc.1209983, 17001318.
    • (2007) Oncogene , vol.26 , pp. 1820-1828
    • Thullberg, M.1    Gad, A.2    Beeser, A.3    Chernoff, J.4    Strömblad, S.5
  • 27
    • 55549119209 scopus 로고    scopus 로고
    • Scaffolding function of PAK in the PDK1-Akt pathway
    • 10.1038/ncb1795, 18931661
    • Higuchi M, Onishi K, Kikuchi C, Gotoh Y. Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol 2008, 10:1356-1364. 10.1038/ncb1795, 18931661.
    • (2008) Nat Cell Biol , vol.10 , pp. 1356-1364
    • Higuchi, M.1    Onishi, K.2    Kikuchi, C.3    Gotoh, Y.4
  • 28
    • 84858714200 scopus 로고    scopus 로고
    • Dynamic roles for NF-κB in HTLV-I and HIV-1 retroviral pathogenesis
    • 10.1111/j.1600-065X.2012.01094.x, 22435562
    • Chan JK, Greene WC. Dynamic roles for NF-κB in HTLV-I and HIV-1 retroviral pathogenesis. Immunol Rev 2012, 246:286-310. 10.1111/j.1600-065X.2012.01094.x, 22435562.
    • (2012) Immunol Rev , vol.246 , pp. 286-310
    • Chan, J.K.1    Greene, W.C.2
  • 29
    • 33744474809 scopus 로고    scopus 로고
    • Requirement of the human T-cell leukemia virus (HTLV-1) Tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes
    • 10.1182/blood-2005-08-3138, 16467195
    • Wäldele K, Silbermann K, Schneider G, Ruckes T, Cullen BR, Grassmann R. Requirement of the human T-cell leukemia virus (HTLV-1) Tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes. Blood 2006, 107:4491-4499. 10.1182/blood-2005-08-3138, 16467195.
    • (2006) Blood , vol.107 , pp. 4491-4499
    • Wäldele, K.1    Silbermann, K.2    Schneider, G.3    Ruckes, T.4    Cullen, B.R.5    Grassmann, R.6
  • 30
    • 0034733041 scopus 로고    scopus 로고
    • Stimulation of NFκB activity by multiple signaling pathways requires PAK1
    • 10.1074/jbc.M909860199, 10779525
    • Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, Cobb MH. Stimulation of NFκB activity by multiple signaling pathways requires PAK1. J Biol Chem 2000, 275:19693-19699. 10.1074/jbc.M909860199, 10779525.
    • (2000) J Biol Chem , vol.275 , pp. 19693-19699
    • Frost, J.A.1    Swantek, J.L.2    Stippec, S.3    Yin, M.J.4    Gaynor, R.5    Cobb, M.H.6
  • 32
    • 81155154278 scopus 로고    scopus 로고
    • P21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor
    • 10.1074/jbc.M111.262246, 3220523, 21949127
    • Thévenot E, Moreau AW, Rousseau V, Combeau G, Domenichini F, Jacquet C, Goupille O, Amar M, Kreis P, Fossier P, Barnier JV. p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor. J Biol Chem 2011, 286:40044-40059. 10.1074/jbc.M111.262246, 3220523, 21949127.
    • (2011) J Biol Chem , vol.286 , pp. 40044-40059
    • Thévenot, E.1    Moreau, A.W.2    Rousseau, V.3    Combeau, G.4    Domenichini, F.5    Jacquet, C.6    Goupille, O.7    Amar, M.8    Kreis, P.9    Fossier, P.10    Barnier, J.V.11
  • 33
    • 0026458338 scopus 로고
    • Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins
    • 240413, 1433511
    • Semmes OJ, Jeang KT. Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins. J Virol 1992, 66:7183-7192. 240413, 1433511.
    • (1992) J Virol , vol.66 , pp. 7183-7192
    • Semmes, O.J.1    Jeang, K.T.2
  • 34
    • 0028798333 scopus 로고
    • Definition of a minimal activation domain in human T-cell leukemia virus type I Tax
    • 188792, 7853523
    • Semmes OJ, Jeang KT. Definition of a minimal activation domain in human T-cell leukemia virus type I Tax. J Virol 1995, 69:1827-1833. 188792, 7853523.
    • (1995) J Virol , vol.69 , pp. 1827-1833
    • Semmes, O.J.1    Jeang, K.T.2
  • 35
    • 0034332197 scopus 로고    scopus 로고
    • Coiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors
    • Chun ACS, Zhou Y, Wong CM, Kung HF, Jeang KT, Jin DY. Coiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors. AIDS Res Hum Retrov 2000, 16:1689-1694.
    • (2000) AIDS Res Hum Retrov , vol.16 , pp. 1689-1694
    • Chun, A.C.S.1    Zhou, Y.2    Wong, C.M.3    Kung, H.F.4    Jeang, K.T.5    Jin, D.Y.6
  • 36
    • 0031883280 scopus 로고    scopus 로고
    • A dominate-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos
    • 108809, 9447994
    • Ahn S, Olive M, Aggarwal S, Krylov D, Ginty D, Vinson C. A dominate-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol Cell Biol 1998, 18:967-977. 108809, 9447994.
    • (1998) Mol Cell Biol , vol.18 , pp. 967-977
    • Ahn, S.1    Olive, M.2    Aggarwal, S.3    Krylov, D.4    Ginty, D.5    Vinson, C.6
  • 37
    • 58149286561 scopus 로고    scopus 로고
    • Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation
    • 10.1091/mbc.E08-04-0369, 2575155, 18784253
    • Siu YT, Ching YP, Jin DY. Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation. Mol Biol Cell 2008, 19:4750-4761. 10.1091/mbc.E08-04-0369, 2575155, 18784253.
    • (2008) Mol Biol Cell , vol.19 , pp. 4750-4761
    • Siu, Y.T.1    Ching, Y.P.2    Jin, D.Y.3
  • 38
    • 0037064068 scopus 로고    scopus 로고
    • Acetylation of the adenovirus-transforming protein E1A determines nuclear localization by disrupting association with importin-α
    • 10.1074/jbc.M207512200, 12161448
    • Madison DL, Yaciuk P, Kwok RP, Lundblad JR. Acetylation of the adenovirus-transforming protein E1A determines nuclear localization by disrupting association with importin-α. J Biol Chem 2002, 277:38755-38763. 10.1074/jbc.M207512200, 12161448.
    • (2002) J Biol Chem , vol.277 , pp. 38755-38763
    • Madison, D.L.1    Yaciuk, P.2    Kwok, R.P.3    Lundblad, J.R.4
  • 39
    • 33847010696 scopus 로고    scopus 로고
    • Human T-cell leukemia virus oncoprotein Tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1
    • 10.1158/0008-5472.CAN-06-3053, 17283140
    • Chin KT, Chun ACS, Ching YP, Jeang KT, Jin DY. Human T-cell leukemia virus oncoprotein Tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1. Cancer Res 2007, 67:1072-1081. 10.1158/0008-5472.CAN-06-3053, 17283140.
    • (2007) Cancer Res , vol.67 , pp. 1072-1081
    • Chin, K.T.1    Chun, A.C.S.2    Ching, Y.P.3    Jeang, K.T.4    Jin, D.Y.5
  • 40
    • 24044525271 scopus 로고    scopus 로고
    • Nuclear localization and chromatin targets of p21-activated kinase 1
    • Singh RR, Song C, Yang Z, Kumar R. Nuclear localization and chromatin targets of p21-activated kinase 1. J Biol Chem 2005, 280:18130-18137.
    • (2005) J Biol Chem , vol.280 , pp. 18130-18137
    • Singh, R.R.1    Song, C.2    Yang, Z.3    Kumar, R.4
  • 41
    • 0030693113 scopus 로고    scopus 로고
    • X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro
    • 10.1006/viro.1997.8781, 9344914
    • Derse D, Mikovits J, Ruscetti F. X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro. Virology 1997, 237:123-128. 10.1006/viro.1997.8781, 9344914.
    • (1997) Virology , vol.237 , pp. 123-128
    • Derse, D.1    Mikovits, J.2    Ruscetti, F.3
  • 42
    • 0043125507 scopus 로고    scopus 로고
    • Functional inactivation of a transcriptional corepressor by a signalling kinase
    • 10.1038/nsb957, 12872159
    • Barnes CJ, Vadlamudi RK, Mishra SK, Jacobson RH, Li F, Kumar R. Functional inactivation of a transcriptional corepressor by a signalling kinase. Nat Struct Biol 2003, 10:622-628. 10.1038/nsb957, 12872159.
    • (2003) Nat Struct Biol , vol.10 , pp. 622-628
    • Barnes, C.J.1    Vadlamudi, R.K.2    Mishra, S.K.3    Jacobson, R.H.4    Li, F.5    Kumar, R.6
  • 43
    • 27644562675 scopus 로고    scopus 로고
    • A mechanism of COOH-terminal binding protein-mediated repression
    • 10.1158/1541-7786.MCR-05-0088, 16254191
    • Meloni AR, Lai CH, Yao TP, Nevins JR. A mechanism of COOH-terminal binding protein-mediated repression. Mol Cancer Res 2005, 3:575-583. 10.1158/1541-7786.MCR-05-0088, 16254191.
    • (2005) Mol Cancer Res , vol.3 , pp. 575-583
    • Meloni, A.R.1    Lai, C.H.2    Yao, T.P.3    Nevins, J.R.4
  • 44
    • 0036668638 scopus 로고    scopus 로고
    • P21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells
    • 10.1093/embo-reports/kvf157, 1084211, 12151336
    • Li F, Adam L, Vadlamudi RK, Zhou H, Sen S, Chernoff J, Mandal M, Kumar R. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep 2002, 3:767-73. 10.1093/embo-reports/kvf157, 1084211, 12151336.
    • (2002) EMBO Rep , vol.3 , pp. 767-773
    • Li, F.1    Adam, L.2    Vadlamudi, R.K.3    Zhou, H.4    Sen, S.5    Chernoff, J.6    Mandal, M.7    Kumar, R.8
  • 45
    • 0030292953 scopus 로고    scopus 로고
    • Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques
    • 10.1016/S0960-9822(96)00757-9, 8939608
    • Sawai ET, Khan IH, Montbriand PM, Peterlin BM, Cheng-Mayer C, Luciw PA. Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques. Curr Biol 1996, 6:1519-1527. 10.1016/S0960-9822(96)00757-9, 8939608.
    • (1996) Curr Biol , vol.6 , pp. 1519-1527
    • Sawai, E.T.1    Khan, I.H.2    Montbriand, P.M.3    Peterlin, B.M.4    Cheng-Mayer, C.5    Luciw, P.A.6
  • 46
    • 33645960667 scopus 로고    scopus 로고
    • "UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection
    • 10.1128/JVI.80.1.130-137.2006, 1317519, 16352537
    • Nguyen DG, Wolff KC, Yin H, Caldwell JS, Kuhen KL. "UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection. J Virol 2006, 80:130-137. 10.1128/JVI.80.1.130-137.2006, 1317519, 16352537.
    • (2006) J Virol , vol.80 , pp. 130-137
    • Nguyen, D.G.1    Wolff, K.C.2    Yin, H.3    Caldwell, J.S.4    Kuhen, K.L.5
  • 47
    • 84862742319 scopus 로고    scopus 로고
    • Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1
    • 10.1053/j.gastro.2012.03.053, 22484303
    • Xu J, Liu H, Chen L, Wang S, Zhou L, Yun X, Sun L, Wen Y, Gu J. Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1. Gastroenterology 2012, 143:199-212. 10.1053/j.gastro.2012.03.053, 22484303.
    • (2012) Gastroenterology , vol.143 , pp. 199-212
    • Xu, J.1    Liu, H.2    Chen, L.3    Wang, S.4    Zhou, L.5    Yun, X.6    Sun, L.7    Wen, Y.8    Gu, J.9
  • 48
    • 84863968373 scopus 로고    scopus 로고
    • Molecular pathways: targeting p21-activated kinase 1 signaling in cancer - opportunities, challenges, and limitations
    • 10.1158/1078-0432.CCR-11-1952, 22595609
    • Eswaran J, Li DQ, Shah A, Kumar R. Molecular pathways: targeting p21-activated kinase 1 signaling in cancer - opportunities, challenges, and limitations. Clin Cancer Res 2012, 18:3743-3749. 10.1158/1078-0432.CCR-11-1952, 22595609.
    • (2012) Clin Cancer Res , vol.18 , pp. 3743-3749
    • Eswaran, J.1    Li, D.Q.2    Shah, A.3    Kumar, R.4
  • 49
    • 25444478908 scopus 로고    scopus 로고
    • Molecular mechanisms of cellular transformation by HTLV-1 Tax
    • 10.1038/sj.onc.1208978, 16155604
    • Grassmann R, Aboud M, Jeang KT. Molecular mechanisms of cellular transformation by HTLV-1 Tax. Oncogene 2005, 24:5976-5985. 10.1038/sj.onc.1208978, 16155604.
    • (2005) Oncogene , vol.24 , pp. 5976-5985
    • Grassmann, R.1    Aboud, M.2    Jeang, K.T.3
  • 50
    • 34347391261 scopus 로고    scopus 로고
    • CREB-a real culprit in oncogenesis
    • 10.1111/j.1742-4658.2007.05884.x, 17565603
    • Siu YT, Jin DY. CREB-a real culprit in oncogenesis. FEBS J 2007, 274:3224-3232. 10.1111/j.1742-4658.2007.05884.x, 17565603.
    • (2007) FEBS J , vol.274 , pp. 3224-3232
    • Siu, Y.T.1    Jin, D.Y.2
  • 51
    • 79955075657 scopus 로고    scopus 로고
    • The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response
    • 10.1016/j.chom.2011.03.007, 21501829
    • Kok KH, Lui PY, Ng MHJ, Siu KL, Au SWN, Jin DY. The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response. Cell Host Microbe 2011, 9:299-309. 10.1016/j.chom.2011.03.007, 21501829.
    • (2011) Cell Host Microbe , vol.9 , pp. 299-309
    • Kok, K.H.1    Lui, P.Y.2    Ng, M.H.J.3    Siu, K.L.4    Au, S.W.N.5    Jin, D.Y.6
  • 52
    • 83755195759 scopus 로고    scopus 로고
    • MIP-T3 is a negative regulator of innate type I IFN response
    • 10.4049/jimmunol.1100719, 22079989
    • Ng MHJ, Ho TH, Kok KH, Siu KL, Li J, Jin DY. MIP-T3 is a negative regulator of innate type I IFN response. J Immunol 2011, 187:6473-6482. 10.4049/jimmunol.1100719, 22079989.
    • (2011) J Immunol , vol.187 , pp. 6473-6482
    • Ng, M.H.J.1    Ho, T.H.2    Kok, K.H.3    Siu, K.L.4    Li, J.5    Jin, D.Y.6
  • 54
    • 84873619237 scopus 로고    scopus 로고
    • REV7 is required for anaphase promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1
    • 10.4161/cc.23214, 23287467
    • Chun ACS, Kok KH, Jin DY. REV7 is required for anaphase promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1. Cell Cycle 2013, 12:365-378. 10.4161/cc.23214, 23287467.
    • (2013) Cell Cycle , vol.12 , pp. 365-378
    • Chun, A.C.S.1    Kok, K.H.2    Jin, D.Y.3
  • 55
    • 17844395201 scopus 로고    scopus 로고
    • The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
    • 10.1093/nar/gki332, 1072803, 15800215
    • Chin KT, Zhou HJ, Wong CM, Lee JMF, Chan CP, Qiang BQ, Yuan JG, Ng IOL, Jin DY. The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma. Nucleic Acids Res 2005, 33:1859-1873. 10.1093/nar/gki332, 1072803, 15800215.
    • (2005) Nucleic Acids Res , vol.33 , pp. 1859-1873
    • Chin, K.T.1    Zhou, H.J.2    Wong, C.M.3    Lee, J.M.F.4    Chan, C.P.5    Qiang, B.Q.6    Yuan, J.G.7    Ng, I.O.L.8    Jin, D.Y.9
  • 56
    • 84875965249 scopus 로고    scopus 로고
    • LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription
    • 10.1186/1742-4690-10-40, 3640950, 23577667
    • Tang HMV, Gao WW, Chan CP, Siu YT, Wong CM, Kok KH, Ching YP, Takemori H, Jin DY. LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. Retrovirology 2013, 10:40. 10.1186/1742-4690-10-40, 3640950, 23577667.
    • (2013) Retrovirology , vol.10 , pp. 40
    • Tang, H.M.V.1    Gao, W.W.2    Chan, C.P.3    Siu, Y.T.4    Wong, C.M.5    Kok, K.H.6    Ching, Y.P.7    Takemori, H.8    Jin, D.Y.9


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