TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats

Journal of Virology

Volumn 80, Issue 14, 2006, Pages 7052-7059

  Siu, Yeung Tung ^a   Chin, King Tung ^a   Siu, Kam Leung ^a   Choy, Elizabeth Yee Wai ^a   Jeang, Kuan Teh ^b   Jin, Dong Yan ^a,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HISTONE ACETYLTRANSFERASE PCAF; PROTEIN BZIP; TAX PROTEIN; TRANSCRIPTION FACTOR; TRANSDUCER OF REGULATED CREB ACTIVITY 1; TRANSDUCER OF REGULATED CREB ACTIVITY 2; TRANSDUCER OF REGULATED CREB ACTIVITY 3; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; GENE CONTROL; HELA CELL; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMIA CELL LINE; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; VIRUS TRANSCRIPTION;

ACTIVATING TRANSCRIPTION FACTOR 4; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAX; HELA CELLS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; P300-CBP TRANSCRIPTION FACTORS; PHOSPHOPROTEINS; PROTEIN BINDING; TERMINAL REPEAT SEQUENCES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VIRUS ACTIVATION;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 33745854207     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00103-06     Document Type: Article

References (42)

1. Ahn, S., M. Olive, S. Aggarwal, D. Krylov, D. Ginty, and C. Vinson. 1998. A dominate-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. Mol. Cell. Biol. 18:967-977.
2. Bittinger, M. Á., E. McWhinnie, J. Meltzer, V. Iourgenko, B. Latario, X. Liu, C. H. Chen, C. Song, D. Garza, and M. Labow. 2004. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr. Biol. 14:2156-2161.
3. Caron, C., R. Rousset, C. Béraud, V. Moncollin, J. M. Egly, and P. Jalinot. 1993. Functional and biochemical interaction of the HTLV-1 Tax1 transactivator with TBP. EMBO J. 12:4269-4278.
4. 1128 interacts with the human T cell leukemia virus type I Tax transactivator and promotes its transcriptional activity. Proc. Natl. Acad. Sci. USA 94:3662-3667.
5. Chin, K. T., H. J. Zhou, C. M. Wong, J. M. F. Lee, C. P. Chan, B. Q. Qiang, J. G. Yuan, I. O. L. Ng, and D. Y. Jin. 2005. The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma. Nucleic Acids Res. 33:1859-1873.
6. Ching, Y. P., A. C. S. Chun, K. T. Chin, Z. Q. Zhang, K. T. Jeang, and D. Y. Jin. 2004. Specific TATAA and bZIP requirements suggest that HTLV-1 Tax has transcriptional activity subsequent to the assembly of an initiation complex. Retrovirology 1:18.
7. Chun, A. C. S., Y. Zhou, C. M. Wong, H. Kung, K. T. Jeang, and D. Y. Jin. 2000. Coiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors. AIDS Res. Hum. Retrovir. 16:1689-1694.
8. Conkright, M. D., G. Canettieri, R. Screaton, E. Guzman, L. Miraglia, J. B. Hogenesch, and M. Montminy. 2003. TORCs: transducers of regulated CREB activity. Mol. Cell 12:413-423.
9. Gachon, F., S. Thebault, A. Peleraux, C. Devaux, and J. M. Mesnard. 2000. Molecular interactions involved in the transactivation of the human T-Cell leukemia virus type 1 promoter mediated by Tax and CREB-2 (ATF-4). Mol. Cell. Biol. 20:3470-3481.
10. Gatza, M. L., J. C. Watt, and S. J. Marriott. 2003. Cellular transformation by the HTLV-1 Tax protein, a jack-of-all-trades. Oncogene 22:5141-5149.
11. Harrod, R., Y. Tang, C. Nicot, H. S. Lu, A. Vassilev, Y. Nakatani, and C. Z. Giam. 1998. An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300. Mol. Cell. Biol. 18:5052-5061.
12. Harrod, R., Y. L. Kuo, Y. Tang, Y. Yao, A. Vassilev, Y. Nakatani, and C. Z. Giam. 2000. p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex. J. Biol. Chem. 275:11852-11857.
13. Huang, G. J., Z. Q. Zhang, and D. Y. Jin. 2002. Stimulation of IKK-oligomerization by the T-cell leukemia virus oncoprotein Tax. FEBS Lett. 531:494-498.
14. Iourgenko, V., W. Zhang, C. Mickanin, I. Daly, C. Jiang, J. M. Hexham, A. P. Orth, L. Miraglia, J. Meltzer, D. Garza, G. W. Chirn, E. McWhinnie, D. Cohen, J. Skelton, R. Terry, Y. Yu, D. Bodian, F. P. Buxton, J. Zhu, C. Song, and M. A. Labow. 2003. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Natl. Acad. Sci. USA 100:12147-12152.
15. Ito, A., C. H. Lai, X. Zhao, S. Saito, M. H. Hamilton, E. Appella, and T. P. Yao. 2001. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J. 20:1331-1340.
16. Jeang, K. T., C. Z. Giam, F. Majone, and M. Aboud. 2004. Life, death, and Tax: role of HTLV-1 oncoprotein in genetic instability and cellular transformation. J. Biol. Chem. 279:31991-31994.
17. Jiang, H., H. Lu, R. L. Schiltz, C. A. Pise-Masison, V. V. Ogryzko, Y. Nakatani, and J. N. Brady. 1999. PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner. Mol. Cell. Biol. 19:8136-8145.
18. Jin, D. Y., and K. T. Jeang. 1997. HTLV-1 Tax self-association in optimal trans-activation function. Nucleic Acids Res. 25:379-388.
19. Jin, D. Y., F. Spencer, and K. T. Jeang. 1998. Human T-cell leukemia virus type I oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93:81-91.
20. Jin, D. Y., V. Giordano, K. V. Kibler, H. Nakano, and K. T. Jeang. 1999. Role of adaptor function in oncoprotein-mediated activation of NF-κB: HTLV-1 Tax interacts directly with IκB kinase γ. J. Biol. Chem. 274:17402-17405.
21. Jin, D. Y., H. L. Wang, Y. Zhou, A. C. S. Chun, K. V. Kibler, Y. D. Hou, H. Kung, and K. T. Jeang. 2000. Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation. EMBO J. 19:729-740.
22. Kashanchi, F., J. F. Duvall, R. P. S. Kwok, J. R. Lundblad, R. H. Goodman, and J. N. Brady. 1998. The coactivator CBP stimulates human T-cell lymphotropic virus type 1 Tax transactivation in vitro. J. Biol. Chem. 273:34646-34652.
23. Kashanchi, F., and J. N. Brady. 2005. Transcriptional and post-transcriptional gene regulation of HTLV-1. Oncogene 24:5938-5951.
24. Kimzey, A. L., and W. S. Dynan. 1998. Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking. J. Biol. Chem. 273:13768-13775.
25. Koga, H., T. Ohshima, and K. Shimotohno. 2004. Enhanced activation of Tax-dependent transcription of human T-cell leukemia virus type I (HTLV-1) long terminal repeat by TORC3. J. Biol. Chem. 279:52978-52983.
26. Koo, S. H., L. Flechner, L. Qi, X. Zhang, R. A. Screaton, S. Jeffries, S. Hedrick, W. Xu, F. Boussouar, P. Brindle, H. Takemori, and M. Montminy. 2005. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437:1109-1111.
27. Kwok, R. P., M. E. Laurance, J. R. Lundblad, P. S. Goldman, H. M. Shih, L. M. Connor, S. J. Marriott, and R. H. Goodman. 1996. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature 380:642-646.
28. Lemasson, I., N. J. Polakowski, P. J. Laybourn, and J. K. Nyborg. 2004. Transcription regulatory complexes bind the human T-cell leukemia virus 5′ and 3′ long terminal repeats to control gene expression. Mol. Cell. Biol. 24:6117-6126.
29. Lundblad, J. R., R. P. Kwok, M. E. Laurance, M. S. Huang, J. P. Richards, R. G. Brennan, and R. H. Goodman. 1998. The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove. J. Biol. Chem. 273:19251-19259.
30. Ma, K., J. K. Chan, G. Zhu, and Z. Wu. 2005. Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Mol. Cell. Biol. 25:3575-3582.
31. Madison, D. L., P. Yaciuk, R. P. Kwok, and J. R. Lundblad. 2002. Acetylation of the adenovirus-transforming protein ElA determines nuclear localization by disrupting association with importin-α. J. Biol. Chem. 277:38755-38763.
32. Matsuoka, M., and K. T. Jeang. 2005. Human T-cell leukemia virus type I at age 25: a progress report. Cancer Res. 65:4467-4470.
33. Miyazato, A., S. Sheleg, H. Iha, Y. Li, and K. T. Jeang. 2005. Evidence for NF-κB- and CBP-independent repression of p53's transcriptional activity by human T-cell leukemia virus type 1 Tax in mouse embryo and primary human fibroblasts. J. Virol. 79:9346-9350.
34. Paddison, P. J., A. A. Caudy, and G. J. Hannon. 2002. Stable suppression of gene expression by RNAi in mammalian cells. Proc. Natl. Acad. Sci. USA 99:1443-1448.
35. Reddy, T. R., H. Tang, X. Li, and F. Wong-Staal. 1997. Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4). Oncogene 14:2785-2792.
36. Roeder, R. G. 2005. Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett. 579:909-915.
37. Screaton, R. A., M. D. Conkright, Y. Katoh, J. L. Best, G. Canettieri, S. Jeffries, E. Guzman, S. Niessen, J. R. Yates III, H. Takemori, M. Okamoto, and M. Montminy. 2004. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119:61-74.
38. Shaw, R. J., K. A. Lamia, D. Vasquez, S. H. Koo, N. Bardeesy, R. A. DePinho, M. Montminy, and L. C. Cantley. 2005. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310:1642-1646.
39. Tie, F., N. Adya, W. C. Greene, and C. Z. Giam. 1996. Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat. J. Virol. 70:8368-8374.
40. Yang, X. J., V. V. Ogryzko, J. Nishikawa, B. H. Howard, and Y. Nakatani. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382:319-324.
41. Zhao, L. J., and C. Z. Giam. 1991. Interaction of the human T-cell lymphotrophic virus (HTLV) type I transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-1 enhancer. Proc. Natl. Acad. Sci. USA 88:11445-11449.
42. Zhou, H. J., C. M. Wong, J. H. Chen, B. Q. Qiang, J. G. Yuan, and D. Y. Jin. 2001. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. J. Biol. Chem. 276:28933-28938.