Identification of gender-specific candidate genes that influence bone microarchitecture in chromosome 1

Calcified Tissue International

Volumn 92, Issue 4, 2013, Pages 362-371

  Mohan, Subburaman ^a,b   Hu, Yan ^a   Edderkaoui, Bouchra ^a,b  

^a Jerry L Pettis Memorial VA Medical Center   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone mineral density; Chromosome 1; Congenic mouse; Gender candidate gene; Trabecular bone thickness

Indexed keywords

CALCIUM BINDING PROTEIN; PRESENILIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; BONE MICROSTRUCTURE; BONE STRUCTURE; CHROMOSOME 1; CNST GENE; CONGENIC STRAIN; CONSORTIN GENE; CONTROLLED STUDY; CORTICAL BONE; EFCAB2 GENE; FEMALE; GENDER; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENETIC POLYMORPHISM; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PHENOTYPE; PRIORITY JOURNAL; PSEN2 GENE; REGULATORY MECHANISM; SEX DIFFERENCE; THICKNESS; TRABECULAR BONE;

ANIMALS; BONE AND BONES; BONE DENSITY; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CHROMOSOMES; FEMALE; GENES, REGULATOR; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PRESENILIN-2; SEX CHARACTERISTICS;

EID: 84876665301     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-012-9687-1     Document Type: Article

References (38)

1. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 22(3):465-475
2. Huddleston JM, Whitford KJ (2001) Medical care of elderly patients with hip fractures. Mayo Clin Proc 76(3):295-298
3. Ferretti JL, Capozza RF, Mondelo N, Zanchetta JR (1993) Interrelationships between densitometric, geometric, and mechanical properties of rat femora: inferences concerning mechanical regulation of bone modeling. J Bone Miner Res 8(11):1389-1396
4. Gilsanz V, Loro ML, Roe TF, Sayre J, Gilsanz R, Schulz EE (1995) Vertebral size in elderly women with osteoporosis. Mechanical implications and relationship to fractures. J Clin Invest 95(5):2332-2337
5. Vega E, Ghiringhelli G, Mautalen C, Rey Valzacchi G, Scaglia H, Zylberstein C (1998) Bone mineral density and bone size in men with primary osteoporosis and vertebral fractures. Calcif Tissue Int 62(5):465-469
6. Dalle Carbonare L, Giannini S (2004) Bone microarchitecture as an important determinant of bone strength. J Endocrinol Invest 27(1):99-105
7. Earnshaw SA, Cawte SA, Worley A, Hosking DJ (1998) Colles' fracture of the wrist as an indicator of underlying osteoporosis in postmenopausal women: a prospective study of bone mineral density and bone turnover rate. Osteoporos Int 8(1):53-60
8. Kanterewicz E, Yanez A, Perez-Pons A, Codony I, Del Rio L, Diez-Perez A (2002) Association between Colles' fracture and low bone mass: age-based differences in postmenopausal women. Osteoporos Int 13(10):824-828
9. Riggs BL, Melton LJ 3rd (1986) Involutional osteoporosis. N Engl J Med 314(26):1676-1686
10. Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ (2001) Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6 J and C3H/HeJ inbred strains of mice. J Bone Miner Res 16:1195-1206
11. Beamer WG, Shultz KL, Churchill GA, Frankel WN, Baylink DJ, Rosen CJ, Donahue LR (1999) Quantitative trait loci for bone density in C57BL/6 J and CAST/EiJ inbred mice. Mamm Genome 10:1043-1049
12. Eisman JA (1999) Genetics of osteoporosis. Endocr Rev 20(6):788-804
13. Krall EA, Dawson-Hughes B (1993) Heritable and life-style determinants of bone mineral density. J Bone Miner Res 8(1):1-9
14. Lu PW, Cowell CT, LLoyd-Jones SA, Briody JN, Howman-Giles R (1996) Volumetric bone mineral density in normal subjects, aged 5-27 years. J Clin Endocrinol Metab 81(4):1586-1590
15. Ruff CB, Hayes WC (1988) Sex differences in age-related remodeling of the femur and tibia. J Orthop Res 6(6):886-896
16. Sode M, Burghardt AJ, Kazakia GJ, Link TM, Majumdar S (2010) Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia. Bone 46(6):1652-1660
17. Duncan EL, Cardon LR, Sinsheimer JS, Wass JA, Brown MA (2003) Site and gender specificity of inheritance of bone mineral density. J Bone Miner Res 18(8):1531-1538
18. Ng MY, Sham PC, Paterson AD, Chan V, Kung AW (2006) Effect of environmental factors and gender on the heritability of bone mineral density and bone size. Ann Hum Genet 70(Pt 4):428-438
19. Ioannidis JP, Ng MY, Sham PC, Zintzaras E, Lewis CM, Deng HW, Econs MJ, Karasik D, Devoto M, Kammerer CM, Spector T, Andrew T, Cupples LA, Duncan EL, Foroud T, Kiel DP, Koller D, Langdahl B, Mitchell BD, Peacock M, Recker R, Shen H, Sol-Church K, Spotila LD, Uitterlinden AG, Wilson SG, Kung AW, Ralston SH (2007) Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass. J Bone Miner Res 22(2):173-183
20. Peacock M, Koller DL, Fishburn T, Krishnan S, Lai D, Hui S, Johnston CC, Foroud T, Econs MJ (2005) Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in men. J Clin Endocrinol Metab 90(5):3060-3066
21. Orwoll ES, Belknap JK, Klein RF (2001) Gender specificity in the genetic determinants of peak bone mass. J Bone Miner Res 16:1962-1971
22. Turner CH, Sun Q, Schriefer J, Pitner N, Price R, Bouxsein ML, Rosen CJ, Donahue LR, Shultz KL, Beamer WG (2003) Congenic mice reveal sex-specific genetic regulation of femoral structure and strength. Calcif Tissue Int 73:297-303
23. Beamer WG, Shultz KL, Ackert-Bicknell CL, Horton LG, Delahunty KM, Coombs HF, Donahue LR, Canalis E, Rosen CJ (2007) Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTL with sex dependent regulation of bone phenotypes. J Bone Miner Res 22(8):1187-1196
24. Edderkaoui B, Baylink DJ, Beamer WG, Shultz KL, Wergedal JE, Mohan S (2007) Genetic regulation of femoral bone mineral density: complexity of sex effect in chromosome 1 revealed by congenic sublines of mice. Bone 41(3):340-345
25. Edderkaoui B, Baylink DJ, Beamer WG, Wergedal JE, Dunn NR, Shultz KL, Mohan S (2006) Multiple genetic loci from CAST/EiJ chromosome 1 affect vBMD either positively or negatively in a C57BL/6 J background. J Bone Miner Res 21(1):97-104
26. Dietrich WF, Miller J, Steen R, Merchant MA, Damron-Boles D, Husain Z, Dredge R, Daly MJ, Ingalls KA, O'Connor TJ (1996) A comprehensive genetic map of the mouse genome. Nature 380:149-152
27. Lutz J, Tesar R (1990) Mother-daughter pairs: spinal and femoral bone densities and dietary intakes. Am J Clin Nutr 52(5):872-877
28. Van Pottelbergh I, Goemaere S, Zmierczak H, De Bacquer D, Kaufman JM (2003) Deficient acquisition of bone during maturation underlies idiopathic osteoporosis in men: evidence from a three-generation family study. J Bone Miner Res 18(2):303-311
29. Devoto M, Specchia C, Li HH, Caminis J, Tenenhouse A, Rodriguez H, Spotila LD (2001) Variance component linkage analysis indicates a QTL for femoral neck bone mineral density on chromosome 1p36. Hum Mol Genet 10(21):2447-2452
30. Daci E, Verstuyf A, Moermans K, Bouillon R, Carmeliet G (2000) Mice lacking the plasminogen activator inhibitor 1 are protected from trabecular bone loss induced by estrogen deficiency. J Bone Miner Res 15:1510-1516
31. Turner RT (1999) Mice, estrogen, and postmenopausal osteoporosis. J Bone Miner Res 14:187-191
32. -/- mice. J Clin Invest 104:895-901
33. Alberich-Bayarri A, Marti-Bonmati L, Sanz-Requena R, Belloch E, Moratal D (2008) In vivo trabecular bone morphologic and mechanical relationship using high-resolution 3-T MRI. AJR Am J Roentgenol 191(3):721-726
34. Pardo SJ, Patel MJ, Sykes MC, Platt MO, Boyd NL, Sorescu GP, Xu M, van Loon JJ, Wang MD, Jo H (2005) Simulated microgravity using the random positioning machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts. Am J Physiol Cell Physiol 288(6):C1211-C1221
35. Kitching R, Qi S, Li V, Raouf A, Vary CP, Seth A (2002) Coordinate gene expression patterns during osteoblast maturation and retinoic acid treatment of MC3T3-E1 cells. J Bone Miner Metab 20(5):269-280
36. Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B (2008) Dimorphic effects of Notch signaling in bone homeostasis. Nat Med 14(3):299-305
37. Schroeder TM, Nair AK, Staggs R, Lamblin AF, Westendorf JJ (2007) Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors. BMC Genomics 9(8):362
38. Dufour CR, Wilson BJ, Huss JM, Kelly DP, Alaynick WA, Downes M, Evans RM, Blanchette M, Giguère V (2007) Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab 5(5):345-356