Predictors of neurological outcome in cooled neonates

Pediatrics International

Volumn 55, Issue 2, 2013, Pages 169-176

  Li, Jingang ^a,b   Funato, Masahisa ^a   Tamai, Hiroshi ^a   Wada, Hiroshi ^a   Nishihara, Masato ^a   Iwamoto, Hirotaka ^a   Okazaki, Yoko ^a   Shintaku, Haruo ^b  

^a YODOGAWA CHRISTIAN HOSPITAL   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

birth asphyxia; electroencephalogram; hypothermia therapy; hypoxic ischemic encephalopathy; magnetic resonance imaging; neurological outcome predictor

Indexed keywords

DOBUTAMINE; LACTIC ACID; THIAMYLAL;

ARTICLE; BRAIN BLOOD FLOW; BRAIN DAMAGE; CENTRAL NERVOUS SYSTEM FUNCTION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; COOLING; DIAGNOSTIC ACCURACY; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; LACTATE BLOOD LEVEL; MALE; MOTOR PERFORMANCE; NEUROIMAGING; NEUROLOGIC DISEASE; NEWBORN; NEWBORN CARE; NEWBORN MORTALITY; NEWBORN PERIOD; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RESUSCITATION; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SUBDURAL HEMATOMA; VASCULAR RESISTANCE;

BRAIN; CHILD, PRESCHOOL; ELECTROENCEPHALOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HEAD; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT; INFANT, NEWBORN; MAGNETIC RESONANCE IMAGING; MALE; PROGNOSIS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 84876547326     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/ped.12008     Document Type: Article

References (40)

1. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005; 365: 663-670.
2. Shankaran S, Pappas A, Laptook AR, et al. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics 2008; 122: e791-798.
3. Azzopardi D, Brocklehurst P, Edwards D, et al.; TOBY Study Group. The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial. BMC Pediatr. 2008; 8: 17.
4. Cheung PY, Robertson CMT,. Predicting the outcome of term neonates with intrapartum asphyxia. Acta Paediatr. 2000; 89: 262-271.
5. Sarnat HB, Sarnat MS,. Neonatal encephalopathy following foetal distress. A clinical and electroencephalographic study. Arch. Neurol. 1976; 33: 696-705.
6. Watanabe K, Miyazaki S, Hara K, Hakamada S,. Behavioral state cycles, background EEGs and prognosis of newborns with perinatal hypoxia. Electroencephalogr. Clin. Neurophysiol. 1980; 49: 618-625.
7. Murray DM, Boylan GB, Ryan CA, Connolly S,. Early EEG findings in hypoxicischemic encephalopathy predict outcomes at 2 years. Pediatrics 2009; 124: E459-467.
8. Murray DM, Boylan GB, Fitzgerald AP, Ryan CA, Murphy BP, Connolly S,. Persistent lactic acidosis in neonatal hypoxic-ischaemic encephalopathy correlates with EEG grade and electrographic seizure burden. Arch. Dis. Child. Fetal Neonatal Ed. 2008; 93: F183-186.
9. da Silva S, Hennebert N, Denis R, Wayenberg JL,. Clinical value of a single postnatal lactate measurement after intrapartum asphyxia. Acta Paediatr. 2000; 89: 320-323.
10. Shah S, Tracy M, Smyth J,. Postnatal lactate as an early predictor of short-term outcome after intrapartum asphyxia. J. Perinatol. 2004; 24: 16-20.
11. Ilves P, Lintrop M, Metsvaht T, Vaher U, Talvik T,. Cerebral blood-flow velocities in predicting outcome of asphyxiated newborn infants. Acta Paediatr. 2004; 93: 523-528.
12. Archer LN, Levene MI, Evans DH,. Cerebral artery Doppler ultrasonography for prediction of outcome after perinatal asphyxia. Lancet 1986; 15: 1116-1117.
13. Rutherford MA, Azzopardi D, Whitelaw A, et al. Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy. Pediatrics 2005; 116: 1001-1006.
14. Rutherford M, Ramenghi LA, Edwards AD, et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol. 2010; 9: 39-45.
15. Wintermark P, Hansen A, Soul J, Labrecque M, Robertson RL, Warfield SK,. Early versus late MRI in asphyxiated newborns treated with hypothermia. Arch. Dis. Child. Fetal Neonatal Ed. 2011; 96: F36-44.
16. Cowan F, Rutherford M, Groenendaal F, et al. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet 2003; 361: 736-742.
17. Twomey E, Twomey A, Ryan S, Murphy J, Donoghue VB,. MR imaging of term infants with hypoxic-ischaemic encephalopathy as a predictor of neurodevelopmental outcome and late MRI appearances. Pediatr. Radiol. 2010; 40: 1526-1535.
18. Gunn AJ, Wyatt JS, Whitelaw A, et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J. Pediatr. 2008; 152: 55-58.
19. Mires GJ, Patel NB, Forsyth JS, Howie PW,. Neonatal cerebral Doppler flow velocity waveforms in the uncomplicated pre-term infant: reference values. Early Hum. Dev. 1994; 36: 205-212.
20. Pourcelot L,. Diagnostic ultrasound for vascular disease. In:, Donald I, Levi S, (eds). Present and Future in Diagnostic Ultrasound. Kooker, Rotterdam, 1976; 141.
21. Ichiba H, Yokoi T, Tamai H, Ueda T, Kim TJ, Yamano T,. Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulphate. Pediatr. Int. 2006; 48: 70-75.
22. Ikeda T, Murata Y, Quilligan EJ, et al. Foetal heart rate patterns in postasphyxiated fetal lambs with brain damage. Am. J. Obstet. Gynecol. 1998; 179: 1330-1337.
23. Pryds O, Greisen G, Lou H, Friis-Hansen B,. Vasoparalysis associated with brain damage in asphyxiated term infants. J. Pediatr. 1990; 117: 119-125.
24. Elstad M, Whitelaw A, Thoresen M,. Cerebral Resistance Index is less predictive in hypothermic encephalopathic newborns. Acta Pædiatrica 2011; 100: 1344-1349.
25. Jacobs SE, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG,. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst. Rev. 2007; (4) CD003311.
26. Hunt R, Osborn D,. Dopamine for prevention of morbidity and mortality in term newborn infants with suspected perinatal asphyxia. Cochrane Database Syst. Rev. 2002; (3) CD003484.
27. Thoresen M, Hellström-Westas L, Liu X, de, Vries LS,. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics 2010; 126: e131-139.
28. Horan M, Azzopardi D, Edwards AD, Firmin RK, Field D,. Lack of influence of mild hypothermia on amplitude integrated electroencephalography in neonates receiving extracorporeal membrane oxygenation. Early Hum. Dev. 2007; 83: 69-75.
29. Toet MC, Hellström-Westas L, Groenendaal F, de, Vries LS,. Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch. Dis. Child. Fetal Neonatal Ed. 1999; 81: F19-23.
30. Ekert P, Perlman M, Steinlin M, Hao Y,. Predicting the outcome of postasphyxial hypoxic-ischemic encephalopathy within 4 hours of birth. J. Pediatr. 1997; 131: 613-617.
31. Shellhaas RA, Gallagher PR, Clancy RR,. Assessment of neonatal electroencephalography (EEG) background by conventional and two amplitude-integrated EEG classification systems. J. Pediatr. 2008; 153: 369-374.
32. Lynch NE, Stevenson NJ, Livingstone V, Murphy BP, Rennie JM, Boylan GB,. The temporal evolution of electrographic seizure burden in neonatal hypoxic ischemic encephalopathy. Epilepsia 2012; 53: 549-557.
33. Glass HC, Nash KB, Bonifacio SL, et al. Seizures and magnetic resonance imaging: detected brain injury in newborns cooled for hypoxic-ischemic encephalopathy. J. Pediatr. 2011; 159: 731-735.
34. Booth D, Evans DJ,. Anticonvulsants for neonates with seizures. Cochrane Database Syst. Rev. 2004; (3) CD004218.
35. Gunn AJ, Gunn TR, Gunning MI, Williams CE, Gluckman PD,. Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep. Pediatrics 1998; 102: 1098-1106.
36. Shah DK, Boylan GB, Rennie JM,. Monitoring of seizures in the newborn. Arch. Dis. Child. Fetal Neonatal Ed. 2012; 97: F65-F69.
37. Martinez-Biarge M, Bregant T, Wusthoff CJ, et al. White matter and cortical injury in hypoxic-ischemic encephalopathy: antecedent factors and 2-year outcome. J Pediatr. 2012; 161: 799-807.
38. Martinez-Biarge M, Diez-Sebastian J, Kapellou O, et al. Predicting motor outcome and death in term hypoxic-ischemic encephalopathy. Neurology 2011; 76: 2055-2061.
39. Walsh BH, Boylan GB, Murray DM,. Nucleated Red Blood Cells and early EEG: Predicting Sarnat stage and two year outcome. Early Hum. Dev. 2011; 87: 335-339.
40. Perlman JM, Risser R,. Can asphyxiated infants at risk for neonatal seizures be rapidly identified by current high-risk markers? Pediatrics 1996; 97: 456-462.