Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep

Pediatrics

Volumn 102, Issue 5, 1998, Pages 1098-1106

  Gunn, Alistair J ^a   Gunn, Tania R ^a   Gunning, Mark I ^a   Williams, Christopher E ^a   Gluckman, Peter D ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Cerebral ischemia therapy; Fetal lamb; Fetal monitoring; Hypothermia induced; Hypoxic ischemic encephalopathy

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPHYXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FETUS; FETUS GROWTH; GLUCOSE BLOOD LEVEL; HYPOTHERMIA; LACTATE BLOOD LEVEL; NEUROPROTECTION; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROGNOSIS; SHEEP;

EID: 0031789208     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.102.5.1098     Document Type: Article

References (45)

1. Gunn AJ, Gunn TR, de Haan HH, Williams CE, Gluckman PD. Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal sheep. J Clin Invest. 1997;99:248-256
2. Sirimanne ES, Blumberg RM, Bossano D, et al. The effect of prolonged modification of cerebral temperature on outcome following hypoxic ischemic injury in the infant rat. Pediatr Res. 1996;39:591-598
3. Edwards AD, Yue X, Squier MV, et al. Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. Biochem Biophys Res Commun. 1995;217:1193-1199
4. Colbourne F, Corbett D. Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection. J Neurosci. 1995;15:7250-7260
5. Coimbra C, Wieloch T. Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia. Acta Neuropathol Berl. 1994;87:325-331
6. Ekert P, Perlman M, Steinlin M, Hao Y. Predicting the outcome of postasphyxial hypoxic-ischemic encephalopathy within 4 hours of birth. J Pediatr. 1997;131:613-617
7. Vanlieshout HBM, Jacobs JWFM, Rotteveel JJ, Geven W, Hof MV. The prognostic value of the EEG in asphyxiated newborns. Acta Neurol Scand. 1995;91:203-207
8. Thoresen M, Penrice J, Lorek A, et al. Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res. 1995;37:667-670
9. Roth SC, Baudin J, Cady E, et al. Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years. Dev Med Child Neurol. 1997;39:718-725
10. Williams CE, Gunn AJ, Gluckman PD, Synek B. Delayed seizures occurring with hypoxic-ischemic encephalopathy in the fetal sheep. Pediatr Res. 1990;27:561-565
11. Williams CE, Gunn AJ, Gluckman PD. The time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep. Stroke. 1991;22:516-521
12. Tan WKM, Williams CE, During MJ, et al. Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep. Pediatr Res. 1996;39:791-797
13. Marks KA, Mallard EC, Roberts I, et al. Delayed vasodilation and altered oxygenation following cerebral ischemia in fetal sheep. Pediatr Res. 1996;39:48-54
14. Thoresen M, Bagenholm R, Loberg EM, Apricena F, Kjellmer I. Posthypoxic cooling of neonatal rats provides protection against brain injury. Arch Dis Child Fetal Neonate Ed. 1996;74:F1-F7
15. Yager JY, Asselin J. Effect of mild hypothermia on cerebral energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat. Stroke. 1996;27:919-925
16. Haaland K, Loberg EM, Steen PA, Thoresen M. Posthypoxic hypothermia in newborn piglets. Pediatr Res. 1997;41:505-512
17. Laptook AR, Corbett RJT, Sterett R, Burns DK, Garcia D, Tollefsbol G. Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia. Pediatr Res. 1997;42:17-23
18. Trescher WH, Ishiwa S, Johnston MV. Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury. Brain Dev. 1997;19: 326-338
19. Coimbra C, Drake M, Boris-Moller F, Wieloch T. Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug. Evidence for chronic encephalopathic processes following ischemia. Stroke. 1996;27:1578-1585
20. Schubert A. Side effects of mild hypothermia. J Neurosurg Anesthesiol. 1995;7:139-147
21. Gunn TR, Butler JH, Gluckman PD. Metabolic and hormonal responses to cooling the fetal lamb in utero. J Dev Physiol. 1986;8:55-66
22. Van Bel F, Roman C, Klautz RJM, Teitel DF, Rudolph AM. Relationship between brain blood flow and carotid arterial flow in the sheep fetus. Pediatr Res. 1994;35:329-333
23. Gluckman PD, Parsons Y. Stereotaxic method and atlas for the ovine fetal forebrain. J Dev Physiol. 1983;5:101-128
24. Smith DC. Effects of skin blood flow and temperature on skin-electrode impedance and offset potential: measurements at low alternating current density. J Med Eng Tcchnol. 1992;16:112-116
25. Covert RF, Schreiber MD, Torgerson LJ, Torgerson RW, Miletich DJ. Prediction of cerebral blood flow in fetal lambs by carotid artery ultrasonic flow transducer. Reprod Fertil Dev. 1996;8:157-162
26. Kuboyama K, Safar P, Radovsky A, Tisherman SA, Stezoski SW, Alexander H. Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: a prospective, randomized study. Crit Care Med. 1993;21:1348-1358
27. Shuaib A, Trulove D, Ijaz MS, Kanthan R, Kalra J. The effect of post-ischemic hypothermia following repetitive cerebral ischemia in gerbils. Neurosci Lett. 1995;186:165-168
28. Busto R, Dietrich WD, Globus MY, Ginsberg MD. Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosei Lett. 1989;101:299-304
29. Carroll M, Beek O. Protection against hippocampal CA1 cell loss by post-ischemic hypothermia is dependent on delay of initiation and duration. Metab Brain Dis. 1992;7:45-50
30. Colbourne F, Corbett D. Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil. Brain Res. 1994;654:265-272
31. Dietrich WD, Busto R, Alonso O, Globus MY, Ginsberg MD. Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab. 1993;13:541-549
32. Nurse S, Corbett D. Neuroprotection after several days of mild, drug-induced hypothermia. J Cereb Blood Flow Metab. 1996;16:474-480
33. de Haan HH, Gunn AJ, Williams CE, Gluckman PD. Brief repeated umbilical cord occlusions cause sustained cytotoxic cerebral edema and focal infarcts in near-term fetal lambs. Pediatr Res. 1997;41:96-104
34. Marion DW, Penrod LE, Kelsey SF, et al. Treatment of traumatic brain injury with moderate hypothermia. N Engl J Med. 1997;336:540-546
35. 1H magnetic resonance spectroscopy. Pediatr Res. 1995;38:919-925
36. Nakashima K, Todd MM. Effects of hypothermia, pentobarbital, and isoflurane on postdepolarization amino acid release during complete global cerebral ischemia. Anesthesiology. 1996:85:161-168
37. Thoresen M, Satas S, Pukasundvall M, et al. Post-hypoxic hypothermia reduces cerebrocortical release of NO and excitotoxins. Neitro Rep. 1997; 8:3359-3362
38. Goss JR, Styren SD, Miller PD, et al. Hypothermia attenuates the normal increase in interleukin 1 beta RNA and nerve growth factor following traumatic brain injury in the rat. J Neurotrauina. 1995;12:159-167
39. Bruno VMG, Goldberg MP, Dugan LL, Giffard RG, Choi DW. Neuroprotective effect of hypothermia in cortical cultures exposed to oxygenglucose deprivation or excitatory amino acids. J Neitrocheni. 1994;63: 1398-1406
40. Gottron FJ, Ying HS, Choi DW. Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death. Mol Cell Neurosci. 1997;9:159-169
41. Zeevalk GD, Nicklas WJ. Hypothermia and metabolic stress -narrowing the cellular site of early neuroprotection. J Pharmacol Exp Ther. 1996;279:332-339
42. Schwab S, Spranger M, Aschoff A, Steiner T, Hacke W. Brain temperature monitoring and modulation in patients with severe MCA infarction. Neurology. 1997;48:762-767
43. Tan WKM, Williams CE, Gunn AJ, Mallard EC, Gluckman PD. Suppression of postischemic epileptiform activity with MK-801 improves neural outcome in fetal sheep. Ann Neural. 1992;32:677-682
44. Van Bel F, Dorrepaal CA, Benders MJ, Zeeuwe PE, van de Bor M, Berger HM. Changes in cerebral hemodynamics and oxygenation in the first 24 hours after birth asphyxia. Pediatrics. 1993;92:365-372
45. Nevander G, Ingvar M, Auer RN, Siesjö BK. Status epilepticus in well-oxygenated rats causes neuronal necrosis. Ann Neural. 1985;18: 281-290