A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats

American Journal of Respiratory and Critical Care Medicine

Volumn 166, Issue 4, 2002, Pages 496-500

  Kuraki, Takashige ^a   Ishibashi, Masayoshi ^a   Takayama, Masanori ^a   Shiraishi, Motokimi ^a   Yoshida, Minoru ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

Acute lung injury; Human neutrophil elastase; Neutrophil elastase inhibitor; Pulmonary emphysema

Indexed keywords

HEMOGLOBIN; LEUKOCYTE ELASTASE INHIBITOR; MYELOPEROXIDASE; ONO 6818;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; EMPHYSEMA; ENZYME ACTIVITY; FUNCTIONAL RESIDUAL CAPACITY; HEMOGLOBIN DETERMINATION; LEUKOCYTE COUNT; LUNG COMPLIANCE; LUNG HEMORRHAGE; LUNG INJURY; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TOTAL LUNG CAPACITY;

ADMINISTRATION, ORAL; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; EMPHYSEMA; FUNCTIONAL RESIDUAL CAPACITY; HUMANS; LEUKOCYTE COUNT; LEUKOCYTE ELASTASE; LUNG COMPLIANCE; LUNG VOLUME MEASUREMENTS; MALE; NEUTROPHILS; OXADIAZOLES; PYRIMIDINONES; RATS; RATS, WISTAR; RESPIRATORY MECHANICS; SPUTUM;

EID: 0037102183     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.2103118     Document Type: Article

References (30)

1. The definition of emphysema
2. Chronic obstructive pulmonary disease
3. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
4. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema
5. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema
6. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line
7. Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by α1-antitrypsin
8. Excessive neutrophil elastase in bronchoalveolar lavage fluid in subclinical emphysema
9. Synthetic elastase inhibitors: Prospects for use in the treatment of emphysema
10. PMN Elastase: A comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors
11. Development of orally active nonpeptidic inhibitors of human neutrophil elastase
12. Bronchopulmonary lavage of small laboratory animals
13. Effect of neutrophil elastase inhibitor (ONO-5046) on lung injury after intestinal ischemia-reperfusion
14. A method for occult blood in faeces using non-carcinogenic regents
15. Lung myeloperoxidase as a measure of pulmonary leukocytosis in rabbits
16. Respiratory mechanics in normal hamsters
17. Respiratory mechanics and lung volume in normal rats
18. Elastin and collagen remodeling in emphysema: A scanning electron microscopy study
19. Internal surface area and other measurements in emphysema
20. Inhibition of elastase-induced acute inflammation and pulmonary emphysema in hamsters by a novel neutrophil elastase inhibitor FR901277
21. Biologic characterization of ICI 200,880 and ICI 200,355, novel inhibitors of human neutrophil elastase
22. Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep
23. MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: A double-blind, randomized, placebo-controlled clinical trial
24. ONO-5046, a novel inhibitor of human neutrophil elastase
25. Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor
26. Animal model of emphysema
27. An 18-month study of the effects on hamster lungs of intratracheally administered human neutrophil elastase
28. Chronic obstructive pulmonary disease
29. High cathepsin B activity in alveolar macrophages occurs with elastase-induced emphysema but not with bleomycin-induced pulmonary fibrosis in hamsters
30. Protease/antiproteases: Pathogenesis and role in therapy