Genetic predisposition to left ventricular hypertrophy and the potential involvement of cystatin-C in untreated hypertension

American Journal of Hypertension

Volumn 26, Issue 5, 2013, Pages 683-690

  Tousoulis, Dimitris ^a   Androulakis, Emmanuel ^a   Papageorgiou, Nikolaos ^a   Miliou, Antigoni ^a   Chatzistamatiou, Evaggelos ^a   Oikonomou, Evaggelos ^a   Moustakas, George ^a   Kallikazaros, Ioannis ^a   Stefanadis, Christodoulos ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

aldosterone synthase; angiotensinogen; blood pressure; cystatin C; hypertension; hypertrophy; polymorphism

Indexed keywords

ALDOSTERONE SYNTHASE; C REACTIVE PROTEIN; CHOLESTEROL; CREATININE; CYSTATIN C; FIBRINOGEN; GLUCOSE; INTERCELLULAR ADHESION MOLECULE 1; URIC ACID; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGE; ALLELE; ARTICLE; BODY MASS; CARDIOVASCULAR PARAMETERS; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATIONAL STUDY; CREATININE BLOOD LEVEL; DIASTOLE; DIASTOLIC ARTERIAL PRESSURE; DIASTOLIC DYSFUNCTION; DNA POLYMORPHISM; DYSLIPIDEMIA; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBRINOGEN BLOOD LEVEL; GENDER; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; GEOMETRY; GLUCOSE BLOOD LEVEL; HEART INDEX; HEART LEFT ATRIUM; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HOMOZYGOSITY; HUMAN; HYPERTENSION; INTERVENTRICULAR SEPTAL WALL THICKNESS; LEFT ATRIAL VOLUME INDEX; LONG AXIS LEFT ATRIAL DIAMETER; MAJOR CLINICAL STUDY; MALE; MOLECULAR MECHANICS; NEPHELOMETRY; PEAK EARLY MYOCARDIAL TISSUE VELOCITY; PEAK LATE MYOCARDIAL TISSUE VELOCITY; POLYMERASE CHAIN REACTION; POSTERIOR WALL THICKNESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RELATIVE WALL THICKNESS; SMOKING; SYSTOLIC ARTERIAL PRESSURE; URIC ACID BLOOD LEVEL; VASCULITIS;

ADULT; AGED; ALDOSTERONE SYNTHASE; ALLELES; ANGIOTENSINOGEN; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CYSTATIN C; ECHOCARDIOGRAPHY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; INTERCELLULAR ADHESION MOLECULE-1; MALE; MIDDLE AGED; PREVALENCE; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84876536280     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hps089     Document Type: Article

References (30)

1. Konoshita T; Genomic Disease Outcome Consortium (G-DOC) Study Investigators. Do genetic variants of the renin-angiotensin system predict blood pressure response to renin-angiotensin systemblocking drugs: a systematic review of pharmacogenomics in the renin-angiotensin system. Curr Hypertens Rep 2011; 13:356-361.
2. Corvol P, Soubrier F, Jeunemaitre X. Molecular genetics of the reninangiotensin-aldosterone system in human hypertension. Pathol Biol (Paris) 1997; 45:229-239. (Pubitemid 27207336)
3. Ramachandran V, Ismail P, Stanslas J, Shamsudin N. Analysis of reninangiotensin aldosterone system gene polymorphisms in Malaysian essential hypertensive and type 2 diabetic subjects. Cardiovasc Diabetol 2009; 8:11.
4. Devereux RB, Alderman MH. Role of preclinical cardiovascular disease in the evolution from risk factor exposure to development of morbid events. Circulation 1993; 88:1444-1455. (Pubitemid 23296890)
5. Verdecchia P, Angeli F, Borgioni C, Gattobigio R, de Simone G, Devereux RB, Porcellati C. Changes in cardiovascular risk by reduction of left ventricular mass in hypertension: a meta-analysis. Am J Hypertens 2003; 16:895-899. (Pubitemid 37315486)
6. Demenais F. Detection of putative functional angiotensinogen (AGT) gene variants controlling plasma AGT levels by combined segregationlinkage analysis. Eur J Hum Genet 2002; 10:715-723. (Pubitemid 35460580)
7. Sethi AA, Nordestgaard BG, Agerholm-Larsen B, Frandsen E, Jensen G, Tybjaerg-Hansen A. Angiotensinogen polymorphisms and elevated blood pressure in the general population: the Copenhagen City Heart Study. Hypertension 2001; 37:875-881. (Pubitemid 32221607)
8. Lynch AI, Tang W, Shi G, Devereux RB, Eckfeldt JH, Arnett DK. Epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients: the HyperGEN study. J Hum Hypertens 2012; 26:133-140.
9. Stella P, Bigatti G, Tizzoni L, Barlassina C, Lanzani C, Bianchi G, Cusi D. Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension. J Am Coll Cardiol 2004; 43:265-270. (Pubitemid 38201154)
10. Schunkert H, Hengstenberg C, Holmer SR, Broeckel U, Luchner A, Muscholl MW, Kzinger S, Ding A, Hense HW, Riegger GA. Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure. Circulation 1999; 99:2255-2260. (Pubitemid 29201131)
11. Masiha S, Sundstr J, Lind L. Inflammatory markers are associated with left ventricular hypertrophy and diastolic dysfunction in a population-based sample of elderly men and women. J Hum Hypertens 2013; 27(1):13-7.
12. Prats M, Font R, BardajA, Gutierrez C, Lalana M, Vilanova A, Martinez-Vea A. Cystatin C and cardiac hypertrophy in primary hypertension. Blood Press 2010; 19:20-25.
13. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Boudier HA, Zanchetti A, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Erdine S, Kiowski W, Agabiti-Rosei E, Ambrosioni E, Lindholm LH, Viigimaa M, Adamopoulos S, Agabiti-Rosei E, Ambrosioni E, Bertomeu V, Clement D, Erdine S, Farsang C, Gaita D, Lip G, Mallion JM, Manolis AJ, Nilsson PM, O'Brien E, Ponikowski P, Redon J, Ruschitzka F, Tamargo J, van Zwieten P, Waeber B, Williams B; Management of Arterial Hypertension of the European Society of Hypertension; European Society of Cardiology. 2007 guidelines for the management of arterial hypertension. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007; 25:1105-1187. (Pubitemid 46924065)
14. Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man: anatomic validation of the method. Circulation 1997; 55:613-619.
15. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ; Chamber Quantification Writing Group; American Society of Echocardiography's Guidelines and Standards Committee; European Association of Echocardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18:1440-1463. (Pubitemid 41821197)
16. Tousoulis D, Androulakis E, Papageorgiou N, Chatzistamatiou E, Miliou A, Moustakas G, Latsios G, Kampoli AM, Toutouzas K, Oikonomou E, Zaromytidou M, Kallikazaros I, Stefanadis C. Genetic polymorphism M235T of angiotensinogen: Effects on endothelial function and arterial stiffness in hypertensives. Int J Cardiol 2012; 155:501-503.
17. Ji LD, Zhang LN, Shen P, Wang P, Zhang YM, Xing WH, Xu J. Association of angiotensinogen gene M235T and angiotensin-converting enzyme gene I/D polymorphisms with essential hypertension in Han Chinese population: a meta-analysis. J Hypertens 2010; 28:419-428.
18. Bloem LJ, Foroud TM, Ambrosius WT, Hanna MP, Tewksbury DA, Pratt JH. Association of the angiotensinogen gene to serum angiotensinogen in blacks and whites. Hypertension 1997; 29: 1078-1082. (Pubitemid 27198213)
19. Kauma H, Ikeimo M, Savolainen MJ, Kiema TR, Rantala AO, Lilja M, Reunanen A, Kesiemi YA. Variants of reninangiotensin system genes and echocardiographic left ventricular mass. Eur Heart J 1998; 19:1109-1117. (Pubitemid 28321392)
20. Ferndez-Llama P, Poch E, Oriola J, Botey A, Rivera F, Revert L. Angiotensinogen gene M235T and T174M polymorphisms in essential hypertension: relation with target organ damage. Am J Hypertens 1998; 11:439-444. (Pubitemid 28231456)
21. Jeng JR. Left ventricular mass, carotid wall thickness, and angiotensinogen gene polymorphism in patients with hypertension. Am J Hypertens 1999; 12:443-450.
22. Stella P, Bigatti G, Tizzoni L, Barlassina C, Lanzani C, Bianchi G, Cusi D. Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension. J Am Coll Cardiol 2004;43: 265-270. (Pubitemid 38201154)
23. Sookoian S, Gianotti TF, Pirola CJ. Role of the C-344T aldosterone synthase gene variant in left ventricular mass and left ventricular structurerelated phenotypes. Heart 2008; 94:903-910. (Pubitemid 351914703)
24. Hengstenberg C, Holmer SR, Mayer B, Lel H, Engel S, Hense HW, Riegger GA, Schunkert H. Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction. Hypertension 2000; 35:704-709. (Pubitemid 30165313)
25. Davies E, Holloway CD, Ingram MC, Inglis GC, Friel EC, Morrison C, Anderson NH, Fraser R, Connell JM. Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. Hypertension 1999; 33:703-707. (Pubitemid 29091652)
26. Cheng XW, Obata K, Kuzuya M, Izawa H, Nakamura K, Asai E, Nagasaka T, Saka M, Kimata T, Noda A, Nagata K, Jin H, Shi GP, Iguchi A, Murohara T, Yokota M. Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure. Hypertension 2006; 48:979-987. (Pubitemid 44611013)
27. Sam F, Siwik DA. Digesting the remodeled heart: role of lysosomal cysteine proteases in heart failure. Hypertension 2006; 48:830-831. (Pubitemid 44610992)
28. Kupari M, Hautanen A, Lankinen L, Koskinen P, Virolainen J, Nikkila H, White PC. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. Circulation 1998; 97:569-575. (Pubitemid 28090686)
29. Androulakis ES, Tousoulis D, Papageorgiou N, Tsioufis C, Kallikazaros I, Stefanadis C. Essential hypertension: is there a role for inflammatory mechanisms Cardiol Rev 2009; 17:216-221.
30. Edelmann F, Tomaschitz A, Wachter R, Gelbrich G, Knoke M, Dgen HD, Pilz S, Binder L, Stahrenberg R, Schmidt A, Mz W, Pieske B. Serum aldosterone and its relationship to left ventricular structure and geometry in patients with preserved left ventricular ejection fraction. Eur Heart J 2012; 33:203-212.