Obestatin does not modify weight and nutritional behaviour but is associated with metabolic syndrome in old women

Clinical Endocrinology

Volumn 78, Issue 6, 2013, Pages 882-890

  Mora, Mireia ^a   Granada, Maria L ^b   Roca, Maria ^b   Palomera, Elisabet ^c   Puig, Rocio ^b   Serra Prat, Mateu ^c   Puig Domingo, Manel ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^c HOSPITAL DE MATARÓ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCOSE; INSULIN; LIPID; OBESTATIN;

ADULT; AGE DISTRIBUTION; AGED; AGING; ANTHROPOMETRY; ARTICLE; BASAL METABOLIC RATE; BLOOD PRESSURE; BLOOD SAMPLING; BODY MASS; BODY WEIGHT; CLINICAL EVALUATION; CONTROLLED STUDY; DIETARY INTAKE; DISEASE ASSOCIATION; FEEDING BEHAVIOR; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HEALTH BEHAVIOR; HORMONE DETERMINATION; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALNUTRITION; METABOLIC SYNDROME X; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; TREND STUDY; WAIST CIRCUMFERENCE;

AGED; AGED, 80 AND OVER; ANOREXIA NERVOSA; COHORT STUDIES; FEMALE; GHRELIN; HUMANS; METABOLIC SYNDROME X; NUTRITIONAL STATUS; OBESITY; PROSPECTIVE STUDIES; SPAIN; WAIST CIRCUMFERENCE; WEIGHT LOSS;

EID: 84876522013     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2012.04489.x     Document Type: Article

References (31)

1. Kojima, M., Hosoda, H., Date, Y., et al,. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402, 656-660.
2. Zhang, J.V., Ren, P.G., vsian-Kretchmer, O., et al,. (2005) Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science, 310, 996-999.
3. Gualillo, O., Lago, F., Casanueva, F.F., et al,. (2006) One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effects. Molecular and Cellular Endocrinology, 256, 1-8.
4. Epelbaum, J., Bedjaoui, N., Dardennes, R., et al,. (2010) Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis. Molecular and Cellular Endocrinology, 314, 244-247.
5. Hassouna, R., Zizzari, P., &, Tolle, V., (2010) The ghrelin/obestatin balance in the physiological and pathological control of growth hormone secretion, body composition and food intake. Journal of Neuroendocrinology, 22, 793-804.
6. Nakazato, M., Murakami, N., Date, Y., et al,. (2001) A role for ghrelin in the central regulation of feeding. Nature, 409, 194-198.
7. Nogueiras, R., Pfluger, P., Tovar, S., et al,. (2007) Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology, 148, 21-26.
8. Vicennati, V., Genghini, S., De, I.R., et al,. (2007) Circulating obestatin levels and the ghrelin/obestatin ratio in obese women. European Journal of Endocrinology, 157, 295-301.
9. Guo, Z.F., Zheng, X., Qin, Y.W., et al,. (2007) Circulating preprandial ghrelin to obestatin ratio is increased in human obesity. Journal of Clinical Endocrinology and Metabolism, 92, 1875-1880.
10. Nakahara, T., Harada, T., Yasuhara, D., et al,. (2008) Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa. Biological Psychiatry, 64, 252-255.
11. Monteleone, P., Serritella, C., Martiadis, V., et al,. (2008) Plasma obestatin, ghrelin, and ghrelin/obestatin ratio are increased in underweight patients with anorexia nervosa but not in symptomatic patients with bulimia nervosa. Journal of Clinical Endocrinology and Metabolism, 93, 4418-4421.
12. Zizzari, P., Longchamps, R., Epelbaum, J., et al,. (2007) Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents. Endocrinology, 148, 1648-1653.
13. Rigamonti, A.E., Pincelli, A.I., Corra, B., et al,. (2002) Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients. Journal of Endocrinology, 175, R1-R5.
14. Serra-Prat, M., Fernandez, X., Burdoy, E., et al,. (2007) The role of ghrelin in the energy homeostasis of elderly people: a population-based study. Journal of Endocrinological Investigation, 30, 484-490.
15. Serra-Prat, M., Alfaro, S.R., Palomera, E., et al,. (2009) Relationship between ghrelin and the metabolic syndrome in the elderly: a longitudinal population-based study. Clinical Endocrinology, 70, 227-232.
16. Serra-Prat, M., Palomera, E., Roca, M., et al,. (2010) Long-term effect of ghrelin on nutritional status and functional capacity in the elderly: a population-based cohort study. Clinical Endocrinology, 73, 41-47.
17. Puig-Domingo, M., Serra-Prat, M., Merino, M.J., et al,. (2008) Muscle strength in the Mataro aging study participants and its relationship to successful aging. Aging Clinical and Experimental Research, 20, 439-446.
18. Rubenstein, L.Z., Harker, J.O., Salva, A., et al,. (2001) Screening for undernutrition in geriatric practice: developing the short-form mini-nutritional assessment (MNA-SF). The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 56, M366-M372.
19. Mahoney, F.I., &, Barthel, D.W., (1965) Functional evaluation: the Barthel index. Mayland State Medical Journal, 14, 61-65.
20. Folstein, M.F., Folstein, S.E., &, McHugh, P.R., (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198.
21. Hoyl, M.T., Alessi, C.A., Harker, J.O., et al,. (1999) Development and testing of a five-item version of the Geriatric Depression Scale. Journal of the American Geriatric Society, 47, 873-878.
22. Anonymous,. (2001) Executive summary of the Third Report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA, 285, 2486-2497.
23. Bresciani, E., Rapetti, D., Dona, F., et al,. (2006) Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat. Journal of Endocrinoogical Investigation, 29, RC16-RC18.
24. Seoane, L.M., Al-Massadi, O., Pazos, Y., et al,. (2006) Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats. Journal of Endocrinological Investigation, 29, RC13-RC15.
25. Huda, M.S., Durham, B.H., Wong, S.P., et al,. (2008) Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal. International Journal of Obesity, 32, 129-135.
26. Gurriaran-Rodriguez, U., Al-Massadi, O., Roca-Rivada, A., et al,. (2011) Obestatin as a regulator of adipocyte metabolism and adipogenesis. Journal of Cellular and Molecular Medicine, 15, 1927-1940.
27. Pan, W., Tu, H., &, Kastin, A.J., (2006) Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides, 27, 911-916.
28. Lagaud, G.J., Young, A., Acena, A., et al,. (2007) Obestatin reduces food intake and suppresses body weight gain in rodents. Biochemical and Biophysical Research Communications, 357, 264-269.
29. Nagaraj, S., Peddha, M.S., &, Manjappara, U.V., (2008) Fragments of obestatin as modulators of feed intake, circulating lipids, and stored fat. Biochemical and Biophysical Research Communications, 366, 731-737.
30. De, S.B., Vergote, V., Pezeshki, A., et al,. (2008) Impurity profiling quality control testing of synthetic peptides using liquid chromatography- photodiode array-fluorescence and liquid chromatography-electrospray ionization-mass spectrometry: the obestatin case. Analytical Biochemistry, 376, 229-234.
31. Chanoine, J.P., Wong, A.C., &, Barrios, V., (2006) Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas. Hormone Research, 66, 81-88.