Impurity profiling quality control testing of synthetic peptides using liquid chromatography-photodiode array-fluorescence and liquid chromatography-electrospray ionization-mass spectrometry: The obestatin case

Analytical Biochemistry

Volumn 376, Issue 2, 2008, Pages 229-234

  De Spiegeleer, Bart ^a   Vergote, Valentijn ^a   Pezeshki, Adel ^a   Peremans, Kathelijne ^a   Burvenich, Christian ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

ESI ion trap MS MS; Fluorescence; HPLC PDA; Impurity profile; Obestatin GPR39 binding; Peptide quality; Synthesis impurities

Indexed keywords

ELECTROSPRAY IONIZATION; FLUORESCENCE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDES;

BIOMEDICAL RESEARCH; HPLC- PDA; IMPURITY PROFILE; IMPURITY PROFILING; ION TRAPS; LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-MASS SPECTROMETRIES; OBESTATIN; QUALITY-CONTROL TESTING;

QUALITY CONTROL;

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 39; OBESTATIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MEDICAL RESEARCH; PRIORITY JOURNAL; QUALITY CONTROL; RECEPTOR UPREGULATION; SPECTROFLUOROMETRY; ULTRAVIOLET SPECTROSCOPY;

EID: 41849122633     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2008.02.014     Document Type: Article

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