Gut microbiota, the genome, and diet in atherogenesis

New England Journal of Medicine

Volumn 368, Issue 17, 2013, Pages 1647-1649

  Loscalzo, Joseph ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; DIMETHYLAMINE; METHYLAMINE; TRIMETHYLAMINE OXIDE;

ATHEROGENESIS; ATHEROGENIC DIET; BACTERIAL GENOME; BIOSYNTHESIS; CARDIOVASCULAR RISK; EDITORIAL; EPIGENETICS; GENE FUNCTION; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INTESTINE FLORA; MICROBIAL COMMUNITY; NONHUMAN; ORGANISMAL INTERACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING;

EID: 84876518172     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe1302154     Document Type: Editorial

References (20)

1. Pflughoeft KJ, Versalovic J. Human microbiome in health and disease. Annu Rev Pathol 2012;7:99-122.
2. Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature 2012;489:242-9.
3. Cotter DG, Schugar RC, Crawford PA. Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol 2013 February 8 (Epub ahead of print).
4. Peterson DA, Frank DN, Pacew NR, Gordon JI. Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe 2008;3:417-27. (Pubitemid 351773097)
5. Montoliu I, Genick U, Ledda M, et al. Current status on genome-metabolome-wide associations: an opportunity in nutrition research. Genes Nutr 2013;8:19-27.
6. Tang WHW, Wang Z, Levison BS, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013;368:1575-84.
7. Wang Z, Klipfell E, Bennett BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011;472:57-63.
8. Lewis GD, Wei R, Liu E, et al. Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest 2008;118:3503-12.
9. Martin JC, Canlet C, Delplanque B, et al. 1H NMR metabonomics can differentiate the early atherogenic effect of dairy products in hyperlipidemic hamsters. Atherosclerosis 2009;206:127-33.
10. Bennett BJ, de Aguiar Vallim TQ, Wang Z, et al. Trimethyl-amine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab 2013;17:49-60.
11. Yancy PH. Organic osmolytes as compatible, metabolic, and counteracting cytoprotectants in high osmolality and other stresses. J Exp Biol 2005;208:2819-30.
12. Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem 2010;43:732-44.
13. Brzezinski B, Zundel G. Formation of disulphide bonds in the reaction of SH group-containing amino acids with trimethylamine N-oxide: a regulatory mechanism in proteins. FEBS Lett 1993;333:331-3. (Pubitemid 23324010)
14. Bukovský M, Mlynarcik D, Ondrácková V. Immunomodulatory activity of amphiphilic antimicrobials on mouse macrophages. Int J Immunopharmacol 1996;18:423-6. (Pubitemid 27033241)
15. Rebouche CJ, Chenard CA. Metabolic fate of dietary carnitine in human adults: identification and quantification of urinary and fecal metabolites. J Nutr 1991;121:539-46.
16. Mitchell SC, Zhang AQ, Noblet JMD, Gillespie S, Jones N, Smith RL. Metabolic disposition of [14C]-trimethylamine N-oxide in rat: variation with dose and route of administration. Xenobiotica 1997;27:1187-97. (Pubitemid 27497242)
17. Tsikas D, Thum T, Becker T, et al. Accurate quantification of dimethylamine (DMA) in human urine by gas chromatographymass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease. J Chromatogr B Analyt Technol Biomed Life Sci 2007;851:229-39. (Pubitemid 46720136)
18. Park CS, Baek HM, Chung WG, Lee KH, Ryu SD, Cha YN. Suppression of flavin-containing monooxygenase by overproduced nitric oxide in rat liver. Mol Pharmacol 1999;56:507-14.
19. Ryu SD, Yi HG, Cha YN, et al. Flavin-containing monooxygenase activity can be inhibited by nitric oxide-mediated S-nitrosylation. Life Sci 2004;75:2559-72.
20. Karlsson FH, Fak F, Nookaew I, et al. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun 2012;3:1245.