Immunomodulatory activity of amphiphilic antimicrobials on mouse macrophages

International Journal of Immunopharmacology

Volumn 18, Issue 6-7, 1996, Pages 423-426

  Bukovsky M ^a   Mlynarcik D ^a   Ondrackova V ^a  

^a Physics and Informatics   (Slovakia)

Author keywords

amial oxides; Amphiphiles; Immunomodulatory activity; Macrophage; QAS

Indexed keywords

AMINE OXIDE; AMPHOPHILE; ANTIINFECTIVE AGENT; LYSOZYME; QUATERNARY AMMONIUM DERIVATIVE; TRIMETHYLAMINE OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; IMMUNOMODULATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CANDIDA; CANDIDA ALBICANS; CHEMISTRY, PHYSICAL; ESCHERICHIA COLI; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MURAMIDASE; PEROXIDASES; PHAGOCYTOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030159273     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(96)00040-9     Document Type: Article

References (13)

1. Ashman, R. B., Blanden, R. V., Ninham, B. W. & Evans, D. F. (1986) Interaction of amphiphilic aggregates with cells of the immune system. Immun. Today, 7, 278-283.
2. Ashman, R. B. & Ninham, B. W. (1985) Immunosupressive effects of cationic vesicles. Molec. Immun., 22, 612-685.
3. Auger, M.J. & Ross, J.A. (1992). The biology of the macrophage. In The macrophage (eds Lewis, C.E. and McGee, J.O.D.), pp. 3-56. Oxford University Press, New York.
4. Ferenčik, M., Lacko, I. & Devinsky, F. (1990) Immunomodulatory activity of some amphiphilic compounds. Pharmazie, 45, 965-966.
5. Finch, R. (1980) Immunomodulating effect of antimicrobial agents. J. Antimicrob. Chemother., 6, 691-693.
6. Hugo, W.B. (1976). Survival of microbes exposed to chemical stress. In The survival of vegetative microbes (eds Gray, T.G.R. and Postgate, J.R.), pp. 383-413. Cambridge University Press, Cambridge.
7. Knoller, S., Shpungin, S. & Pick, E. (1991) The membrane-associated component of the amphiphile-activated, cytosol-dependent superoxide-forming NADPH oxidase of macrrophages is identical cytochrome b559. J. biol. Chem, 266, 2795-2804.
8. Kopecká-Leitmanová, A., Devinsky, F., Mlynarčík, D. & Lacko, I. (1989) Interaction of amine oxides and quaternary ammonium salts with membrane and membrane-associated processes in E. coli cells: mode of action. Drug Metabol. Drug Interact., 7, 29-50.
9. Krivoshein, Yu. S. & Shatrov, V. A. (1990) Immunoadjuvant action of synthetic surface-active substances. Immunologia Moscow, 2, 38-40.
10. Lehrer, R. I. (1975) The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms. J. clin. Invest., 55, 338-346.
11. Lehrer, R. I. & Cline, M. J. (1969) Leukocyte myeloperoxidase deficiency and disseminated candidiasis: The role of myeloperoxidase in resistance to Candida infection. J. clin. Invest., 48, 1478-1488.
12. Mandell, L. A. (1982) Effect of antimicrobial and antineoplastic drugs on phagocytic and microbicidal function of the polymorphonuclear leukocyte. Rev. Infect. Dis., 4, 683-697.
13. Mlynarčík, D., Denyer, S. P. & Hugo, W. B. (1981) A study of the action of a bisquatenary ammonium salt, an amine oxide and an alkoxyphenylcarbamic acid ester on some metabolic function in Staphylococcus aureus. Microbios, 30, 27-35.