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Volumn 11, Issue 4, 2013, Pages 381-392

Effects of simultaneous knockdown of HER2 and PTK6 on malignancy and tumor progression in human breast cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P27; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE 6; UNCLASSIFIED DRUG;

EID: 84876514602     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-12-0378     Document Type: Article
Times cited : (22)

References (48)
  • 1
    • 34547922452 scopus 로고    scopus 로고
    • Targeting the function of the HER2 oncogene in human cancer therapeutics
    • DOI 10.1038/sj.onc.1210478, PII 1210478
    • Moasser MM. Targeting the function oftheHER2 oncogene in human cancer therapeutics. Oncogene 2007;26:6577-92. (Pubitemid 47573679)
    • (2007) Oncogene , vol.26 , Issue.46 , pp. 6577-6592
    • Moasser, M.M.1
  • 2
    • 36249003805 scopus 로고    scopus 로고
    • The HER family and cancer: emerging molecular mechanisms and therapeutic targets
    • DOI 10.1016/j.molmed.2007.10.002, PII S1471491407001864
    • Sergina NV, Moasser MM. The HER family and cancer: emerging molecular mechanisms and therapeutic targets. Trends Mol Med 2007;13:527-34. (Pubitemid 350130347)
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.12 , pp. 527-534
    • Sergina, N.V.1    Moasser, M.M.2
  • 4
    • 0242624620 scopus 로고    scopus 로고
    • Biologic and therapeutic role of HER2 in cancer
    • Menard S, Pupa SM, Campiglio M, Tagliabue E. Biologic and therapeutic role of HER2 in cancer. Oncogene 2003;22:6570-8. (Pubitemid 37372337)
    • (2003) Oncogene , vol.22 , Issue.43 , pp. 6570-6578
    • Menard, S.1    Pupa, S.M.2    Campiglio, M.3    Tagliabue, E.4
  • 5
    • 84861166159 scopus 로고    scopus 로고
    • New therapies in HER2-positive breast cancer: A major step towards a cure of the disease?
    • Awada A, Bozovic-Spasojevic I, Chow L. New therapies in HER2-positive breast cancer: a major step towards a cure of the disease? Cancer Treat Rev 2012;38:494-504
    • (2012) Cancer Treat Rev , vol.38 , pp. 494-504
    • Awada, A.1    Bozovic-Spasojevic, I.2    Chow, L.3
  • 6
    • 0035259989 scopus 로고    scopus 로고
    • Cardiac toxicity of trastuzumab (Herceptin): Implications for the design of adjuvant trials
    • Sparano JA. Cardiac toxicity of trastuzumab (Herceptin): implications for the design of adjuvant trials. Semin Oncol 2001;28:20-7.
    • (2001) Semin Oncol , vol.28 , pp. 20-27
    • Sparano, J.A.1
  • 7
    • 41949125812 scopus 로고    scopus 로고
    • Lapatinib: A sword with two edges
    • Kopper L. Lapatinib: a sword with two edges. Pathol Oncol Res 2008;14:1-8.
    • (2008) Pathol Oncol Res , vol.14 , pp. 1-8
    • Kopper, L.1
  • 8
    • 12544250996 scopus 로고    scopus 로고
    • Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line
    • Nagy P, Friedlander E, Tanner M, Kapanen AI, Carraway KL, Isola J, et al. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res 2005;65:473-82.
    • (2005) Cancer Res , vol.65 , pp. 473-482
    • Nagy, P.1    Friedlander, E.2    Tanner, M.3    Kapanen, A.I.4    Carraway, K.L.5    Isola, J.6
  • 9
    • 11144348206 scopus 로고    scopus 로고
    • Silencing of the HER2/neu gene by siRNA inhibits proliferation and induces apoptosis in HER2/neu-overexpressing breast cancer cells
    • DOI 10.1593/neo.04313
    • Faltus T, Yuan J, Zimmer B, Kramer A, Loibl S, Kaufmann M, et al. Silencing of the HER2/neu gene by siRNA inhibits proliferation and nduces apoptosis in HER2/neu-overexpressing breast cancer cells. Neoplasia 2004;6:786-95. (Pubitemid 40041497)
    • (2004) Neoplasia , vol.6 , Issue.6 , pp. 786-795
    • Faltus, T.1    Yuan, J.2    Zimmer, B.3    Kramer, A.4    Loibl, S.5    Kaufmann, M.6    Strebhardt, K.7
  • 10
    • 77956594900 scopus 로고    scopus 로고
    • RNAi-mediated down-regulation of uPAR synergizes with targeting of HER2 through the ERK pathway in breast cancer cells
    • Li C, Cao S, Liu Z, Ye X, Chen L, Meng S. RNAi-mediated down-regulation of uPAR synergizes with targeting of HER2 through the ERK pathway in breast cancer cells. Int J Cancer 2010;127: 1507-16.
    • (2010) Int J Cancer , vol.127 , pp. 1507-1516
    • Li, C.1    Cao, S.2    Liu, Z.3    Ye, X.4    Chen, L.5    Meng, S.6
  • 12
    • 0038713797 scopus 로고    scopus 로고
    • Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells
    • DOI 10.1038/sj.onc.1206465
    • Derry JJ, Rins GS, Ray V, Tyner AL. Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumour cells. Oncogene 2003;22:4212-20. (Pubitemid 36876242)
    • (2003) Oncogene , vol.22 , Issue.27 , pp. 4212-4220
    • Derry, J.J.1    Prins, G.S.2    Ray, V.3    Tyner, A.L.4
  • 15
    • 34249339776 scopus 로고    scopus 로고
    • Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells
    • DOI 10.1158/0008-5472.CAN-06-3409
    • Ostrander JH, Daniel AR, Lofgren K, Kleer CG, Lange CA. Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells. Cancer Res 2007;67:4199-209. (Pubitemid 46815066)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4199-4209
    • Ostrander, J.H.1    Daniel, A.R.2    Lofgren, K.3    Kleer, C.G.4    Lange, C.A.5
  • 16
    • 10044284340 scopus 로고    scopus 로고
    • Brkactivates rac1 and promotes cell migration and invasion by phosphorylating paxillin
    • Chen HY, Shen CH, Tsai YT, Lin FC, Huang YP, Chen RH. Brkactivates rac1 and promotes cell migration and invasion by phosphorylating paxillin. Mol Cell Biol 2004;24:10558-72.
    • (2004) Mol Cell Biol , vol.24 , pp. 10558-10572
    • Chen, H.Y.1    Shen, C.H.2    Tsai, Y.T.3    Lin, F.C.4    Huang, Y.P.5    Chen, R.H.6
  • 17
    • 53049087852 scopus 로고    scopus 로고
    • Prognostic value of protein tyrosine kinase 6 (PTK6) for longterm survival of breast cancer patients
    • Aubele M, Walch AK, Ludyga N, Braselmann H, Atkinson MJ, Luber B, et al. Prognostic value of protein tyrosine kinase 6 (PTK6) for longterm survival of breast cancer patients. Br J Cancer 2008;99: 1089-95.
    • (2008) Br J Cancer , vol.99 , pp. 1089-1095
    • Aubele, M.1    Walch, A.K.2    Ludyga, N.3    Braselmann, H.4    Atkinson, M.J.5    Luber, B.6
  • 18
    • 78049516402 scopus 로고    scopus 로고
    • Deregulation of the cell cycle by breast tumor kinase (Brk)
    • Chan E, Nimnual AS. Deregulation of the cell cycle by breast tumor kinase (Brk). Int J Cancer 2010;127:2723-31.
    • (2010) Int J Cancer , vol.127 , pp. 2723-2731
    • Chan, E.1    Nimnual, A.S.2
  • 19
    • 79954459766 scopus 로고    scopus 로고
    • Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer
    • Ludyga N, Anastasov N, Gonzalez-Vasconcellos I, Ram M, Höfler H, Aubele M. Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer. Mol Biosyst 2011;7:1603-12.
    • (2011) Mol Biosyst , vol.7 , pp. 1603-1612
    • Ludyga, N.1    Anastasov, N.2    Gonzalez-Vasconcellos, I.3    Ram, M.4    Höfler, H.5    Aubele, M.6
  • 20
    • 17144412880 scopus 로고    scopus 로고
    • Simultaneous over-expression of the Her2/neu and PTK6 tyrosine kinases in archival invasive ductal breast carcinomas
    • DOI 10.1002/path.1720
    • Born M, Quintanilla-Fend L, Braselmann H, Reich U, Richter M, Hutzler P, et al. Simultaneous over-expression of the Her2/neu and PTK6 tyrosine kinases in archival invasive ductal breast carcinomas. J Pathol 2005;205:592-6. (Pubitemid 40514832)
    • (2005) Journal of Pathology , vol.205 , Issue.5 , pp. 592-596
    • Born, M.1    Quintanilla-Fend, L.2    Braselmann, H.3    Reich, U.4    Richter, M.5    Hutzler, P.6    Aubele, M.7
  • 22
    • 77955981271 scopus 로고    scopus 로고
    • In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues
    • Aubele M, Spears M, Ludyga N, Braselmann H, Feuchtinger A, Taylor KJ, et al. In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues. Br J Cancer 2010;103:663-7.
    • (2010) Br J Cancer , vol.103 , pp. 663-667
    • Aubele, M.1    Spears, M.2    Ludyga, N.3    Braselmann, H.4    Feuchtinger, A.5    Taylor, K.J.6
  • 24
    • 34447306848 scopus 로고    scopus 로고
    • Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
    • DOI 10.1093/annonc/mdl475
    • Valabrega G, Montemurro F, Aglietta M. Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol 2007;18:977-84. (Pubitemid 47050487)
    • (2007) Annals of Oncology , vol.18 , Issue.6 , pp. 977-984
    • Valabrega, G.1    Montemurro, F.2    Aglietta, M.3
  • 26
    • 79953725183 scopus 로고    scopus 로고
    • Inhibitor of Apoptosis (IAP) survivin is indispensable for survival of HER2 gene-amplified breast cancer cells with primary resistance to HER1/2-targeted therapies
    • Oliveras-Ferraros C, Vazquez-Martin A, Cufí S, Torres-Garcia VZ, Sauri-Nadal T, Barco SD, et al. Inhibitor of Apoptosis (IAP) survivin is indispensable for survival of HER2 gene-amplified breast cancer cells with primary resistance to HER1/2-targeted therapies. Biochem Bio-phys Res Commun 2011;407:412-9.
    • (2011) Biochem Bio-phys Res Commun , vol.407 , pp. 412-419
    • Oliveras-Ferraros, C.1    Vazquez-Martin, A.2    Cufí, S.3    Torres-Garcia, V.Z.4    Sauri-Nadal, T.5    Barco, S.D.6
  • 27
    • 77952300119 scopus 로고    scopus 로고
    • Efficient shRNA delivery into B and T lymphoma cells using lentiviral vector-mediated transfer
    • Anastasov N, Klier M, Koch I, Angermeier D, Höfler H, Fend F, et al. Efficient shRNA delivery into B and T lymphoma cells using lentiviral vector-mediated transfer. J Hematop 2009;2:9-19.
    • (2009) J Hematop , vol.2 , pp. 9-19
    • Anastasov, N.1    Klier, M.2    Koch, I.3    Angermeier, D.4    Höfler, H.5    Fend, F.6
  • 28
    • 34347218991 scopus 로고    scopus 로고
    • In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro
    • DOI 10.1038/nprot.2007.30, PII NPROT.2006.30
    • Liang CC, Park AY, Guan JL. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2007;2:329-33. (Pubitemid 47040047)
    • (2007) Nature Protocols , vol.2 , Issue.2 , pp. 329-333
    • Liang, C.-C.1    Park, A.Y.2    Guan, J.-L.3
  • 29
    • 67650504966 scopus 로고    scopus 로고
    • TScratch: A novel and simple software tool for automated analysis of monolayer wound healing assays
    • Geb̈ack T, Schulz MM, Koumoutsakos P, Detmar M. TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques 2009;46:265-74.
    • (2009) Biotechniques , vol.46 , pp. 265-274
    • Geb̈ack, T.1    Schulz, M.M.2    Koumoutsakos, P.3    Detmar, M.4
  • 31
    • 33746897689 scopus 로고    scopus 로고
    • Identification of STAT3 as a specific substrate of breast tumor kinase
    • DOI 10.1038/sj.onc.1209501, PII 1209501
    • Liu L, Gao Y, Qiu H, Miller WT, Poli V, Reich NC. Identification of STAT3 as a specific substrate of breast tumor kinase. Oncogene 2006; 25:4904-12. (Pubitemid 44201181)
    • (2006) Oncogene , vol.25 , Issue.35 , pp. 4904-4912
    • Liu, L.1    Gao, Y.2    Qiu, H.3    Miller, W.T.4    Poli, V.5    Reich, N.C.6
  • 32
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • DOI 10.1128/MCB.20.14.5010-5018.2000
    • Vazquez F, Ramaswamy S, Nakamura N, Sellers WR. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 2000;20:5010-8. (Pubitemid 30431555)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.14 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3    Sellers, W.R.4
  • 33
    • 0002531429 scopus 로고    scopus 로고
    • The biochemical and cellular basis of cell proliferation assays that use tetrazolium salts
    • Berridge MV, Tan AS, McCoy KD, Wang R. The biochemical and cellular basis of cell proliferation assays that use tetrazolium salts. Biochemica 1996;4:15-9.
    • (1996) Biochemica , vol.4 , pp. 15-19
    • Berridge, M.V.1    Tan, A.S.2    McCoy, K.D.3    Wang, R.4
  • 34
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002;2:161-74. (Pubitemid 37328786)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.3 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 35
    • 35348905119 scopus 로고    scopus 로고
    • RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth
    • DOI 10.1002/ijc.22962
    • Kunigal S, Lakka SS, Gondi CS, Estes N, Rao JS. RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth. Int J Cancer 2007;121:2307-16. (Pubitemid 47585614)
    • (2007) International Journal of Cancer , vol.121 , Issue.10 , pp. 2307-2316
    • Kunigal, S.1    Lakka, S.S.2    Gondi, C.S.3    Estes, N.4    Rao, J.S.5
  • 36
    • 33744725239 scopus 로고    scopus 로고
    • SiRNA-medi-ated simultaneous downregulation of uPA and its receptor inhibits angiogenesis and invasiveness triggering apoptosis in breast cancer cells
    • Subramanian R, Gondi CS, Lakka SS, Jutla A, Rao JS. siRNA-medi-ated simultaneous downregulation of uPA and its receptor inhibits angiogenesis and invasiveness triggering apoptosis in breast cancer cells. Int J Oncol 2006;28:831-9.
    • (2006) Int J Oncol , vol.28 , pp. 831-839
    • Subramanian, R.1    Gondi, C.S.2    Lakka, S.S.3    Jutla, A.4    Rao, J.S.5
  • 37
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JE Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995;82:241-50.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell, Jr.J.E.3
  • 40
    • 64549083733 scopus 로고    scopus 로고
    • Therapeutic potential of siRNA-mediated targeting of urokinase plasminogen activator, its receptor, and matrix metallo-proteinases
    • Gondi CS, Rao JS. Therapeutic potential of siRNA-mediated targeting of urokinase plasminogen activator, its receptor, and matrix metallo-proteinases. Methods Mol Biol 2009;487:267-81
    • (2009) Methods Mol Biol , vol.487 , pp. 267-281
    • Gondi, C.S.1    Rao, J.S.2
  • 41
    • 35148859334 scopus 로고    scopus 로고
    • Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate
    • DOI 10.1158/0008-5472.CAN-07-1691
    • Eddy SF, Kane SE, Sonenshein GE. Trastuzumab-resistant HER2-driven breast cancer cells are sensitive to epigallocatechin-3 gallate. Cancer Res 2007;67:9018-23. (Pubitemid 47535884)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 9018-9023
    • Eddy, S.F.1    Kane, S.E.2    Sonenshein, G.E.3
  • 42
    • 0027333411 scopus 로고
    • Tumor cell interactions with the extracellular matrix during invasion and metastasis
    • Stetler-Stevenson WG, Aznavoorian S, Liotta LA. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 1993;9:541-73.
    • (1993) Annu Rev Cell Biol , vol.9 , pp. 541-573
    • Stetler-Stevenson, W.G.1    Aznavoorian, S.2    Liotta, L.A.3
  • 43
    • 0344825125 scopus 로고    scopus 로고
    • Small interfering RNA (siRNA) inhibits the expression of the Her2/Neu gene, upregulates HLA class I and induces apoptosis of Her2/Neu positive tumor cell lines
    • DOI 10.1002/ijc.11497
    • Choudhury A, Charo J, Parapuram SK, Hunt RC, Hunt DM, Seliger B, et al. Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines. Int J Cancer 2004;108:71-7. (Pubitemid 37444446)
    • (2004) International Journal of Cancer , vol.108 , Issue.1 , pp. 71-77
    • Choudhury, A.1    Charo, J.2    Parapuram, S.K.3    Hunt, R.C.4    Hunt, D.M.5    Seliger, B.6    Kiessling, R.7
  • 44
    • 54249162412 scopus 로고    scopus 로고
    • Breast tumor kinase phosphorylatesp190RhoGAP to regulaterho andrasand promote breast carcinoma growth, migration, and invasion
    • Shen CH, Chen HY, Lin MS, Li FY, Chang CC, Kuo ML, et al. Breast tumor kinase phosphorylatesp190RhoGAP to regulaterho andrasand promote breast carcinoma growth, migration, and invasion. Cancer Res 2008;68:7779-87.
    • (2008) Cancer Res , vol.68 , pp. 7779-7787
    • Shen, C.H.1    Chen, H.Y.2    Lin, M.S.3    Li, F.Y.4    Chang, C.C.5    Kuo, M.L.6
  • 45
    • 80052856012 scopus 로고    scopus 로고
    • Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK
    • Lofgren KA, Ostrander JH, Housa D, Hubbard GK, Locatelli A, Bliss RL, et al. Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK. Breast Cancer Res 2011;13:R89.
    • (2011) Breast Cancer Res , vol.13
    • Lofgren, K.A.1    Ostrander, J.H.2    Housa, D.3    Hubbard, G.K.4    Locatelli, A.5    Bliss, R.L.6
  • 46
    • 33745208666 scopus 로고    scopus 로고
    • Stable RNA interference of ErbB-2 gene synergistic with epirubicin suppresses breast cancer growth in vitro and in vivo
    • Hu X, Su F, Qin L, Jia W, Gong C, Yu F, et al. Stable RNA interference of ErbB-2 gene synergistic with epirubicin suppresses breast cancer growth in vitro and in vivo. Biochem Biophys Res Commun 2006;346:778-85.
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 778-785
    • Hu, X.1    Su, F.2    Qin, L.3    Jia, W.4    Gong, C.5    Yu, F.6
  • 47
    • 33745437746 scopus 로고    scopus 로고
    • Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine
    • DOI 10.1128/MCB.01901-05
    • Haegebarth A, Bie W, Yang R, Crawford SE, Vasioukhin V, Fuchs E, et al. Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. Mol Cell Biol 2006;26:4949-57. (Pubitemid 43955811)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.13 , pp. 4949-4957
    • Haegebarth, A.1    Bie, W.2    Yang, R.3    Crawford, S.E.4    Vasioukhin, V.5    Fuchs, E.6    Tyner, A.L.7
  • 48
    • 73849110288 scopus 로고    scopus 로고
    • Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6
    • Palka-Hamblin HL, Gierut JJ, Bie W, Brauer PM, Zheng Y, Asara JM, et al. Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. J Cell Sci 2010;123:236-45.
    • (2010) J Cell Sci , vol.123 , pp. 236-245
    • Palka-Hamblin, H.L.1    Gierut, J.J.2    Bie, W.3    Brauer, P.M.4    Zheng, Y.5    Asara, J.M.6


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