A-mangostin suppresses lipopolysaccharide-induced invasion by inhibiting matrix metalloproteinase-2/9 and increasing E-cadherin expression through extracellular signal-regulated kinase signaling in pancreatic cancer cells

Oncology Letters

Volumn 5, Issue 6, 2013, Pages 1958-1964

  Yuan, Jiangao ^a   Wu, Yaolu ^a   Lu, Guiang ^b  

^a YAN'AN UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

mangostin; E cadherin; Invasion; MMP 2; MMP 9; Pancreatic cancer

Indexed keywords

ALPHA MANGOSTIN; ANTINEOPLASTIC AGENT; GELATINASE A; GELATINASE B; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CANCER INHIBITION; CANCER INVASION; CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; PANCREAS ISLET CELL CARCINOMA; PANCREAS METASTASIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECTROPHOTOMETRY; WESTERN BLOTTING; WOUND HEALING;

EID: 84876497922     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1290     Document Type: Article

References (20)

1. Bosetti C, Bertuccio P, Negri E, La Vecchia C, Zeegers MP and Boffetta P: Pancreatic cancer: overview of descriptive epidemiology. Mol Carcinog 51: 3-13, 2012.
2. Ksiazkiewicz M, Markiewicz A and Zaczek AJ: Epithelial-mesenchymal transition: a hallmark in metastasis formation linking circulating tumor cells and cancer stem cells. Pathobiology 79: 195-208, 2012.
3. Brunner T: Gemcitabine in the chemoradiotherapy for locally advanced pancreatic cancer: a meta-analysis. Strahlenther Onkol 188: 366-367, 2012 (In German).
4. Ngawhirunpat T, Opanasopi P, Sukma M, et al: Antioxidant, free radical-scavenging activity and cytotoxicity of different solvent extracts and their phenolic constituents from the fruit hull of mangosteen (Garcinia mangostana). Pharm Biol 48: 55-62, 2010.
5. Martínez-Abundis E, García N, Correa F, Hernández-Reséndiz S, Pedraza-Chaverri J and Zazueta C: Effects of alpha-mangostin on mitochondrial energetic metabolism. Mitochondrion 10: 151-157, 2010.
6. Bumrungpert A, Kalpravidh RW, Chuang CC, et al: Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. J Nutr 140: 842-847, 2010.
7. Sánchez-Pérez Y, Morales-Bárcenas R, García-Cuellar CM, et al: The alpha-mangostin prevention on cisplatin-induced apoptotic death in LLC-PK1 cells is associated to an inhibition of ROS production and p53 induction. Chem Biol Interact 188: 144-150, 2010.
8. Lee YB, Ko KC, Shi MD, et al: Alpha-Mangostin, a novel dietary xanthone, suppresses TPA-Mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells. J Food Sci 75: H13-H23, 2010.
9. Hung SH, Shen KH, Wu CH, Liu CL and Shih YW: Alpha-Mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling 10. pathway. J Agric Food Chem 57: 1291-1298, 2009.
10. Matsumoto K, Akao Y, Ohguchi K, et al: Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells. Bioorg Med Chem 13: 6064-6069, 2005
11. Lu X and Kang Y: Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 16: 5928-5935, 2010.
12. Higgins DF, Kimura K, Bernhardt WM, et al: Hypoxia promotes fbrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesen-chymal transition. J Clin Invest 117: 3810-3820, 2007
13. Shih YW, Chien ST, Chen PS, Lee JH, Wu SH and Yin LT: Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells. Cell Biochem Biophys 58: 31-44, 2010.
14. Patel P and Chen EI: Cancer stem cells, tumor dormancy, and metastasis. Front Endocrinol (Lausanne) 3: 125, 2012.
15. Nakayama K, Nakayama N, Katagiri H and Miyazaki K: Mechanisms of ovarian cancer metastasis: biochemical pathways. Int J Mol Sci 13: 11705-11717, 2012.
16. Wilmanns C, Steinhauer S, Großmann J, Schmitt-Gräff A and Ruf G: Cooperate concept of metastasis: site-specific requirement of activated differentiation and dynamic deterioration. Cancer Metastasis Rev 31: 269-276, 2012.
17. Buda A and Pignatelli M: E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis. Cell Commun Adhes 18: 133-143, 2011.
18. Kowluru RA, Zhong Q and Santos JM: Matrix metallopro-teinases in diabetic retinopathy: potential role of MMP-9. Expert Opin Investig Drugs 21: 797-805, 2012.
19. Romi F, Helgeland G and Gilhus NE: Serum levels of matrix metalloproteinases: implications in clinical neurology. Eur Neurol 67: 121-128, 2012.
20. Han L, Zhang H W, Zhou WP, Chen GM and Guo KJ: The effects of genistein on transforming growth factor-β1-induced invasion and metastasis in human pancreatic cancer cell line Panc-1 in vitro. Chin Med J (Engl) 125: 2032-2040, 2012.