Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear β-catenin in cerebral metastasis of lung adenocarcinomas

Clinical and Experimental Metastasis

Volumn 30, Issue 4, 2013, Pages 471-482

  Bleckmann, A ^a   Siam, L ^a   Klemm, F ^a   Rietkotter E ^a   Wegner, Chr ^a   Kramer, F ^a   Beissbarth, T ^a   Binder, C ^a   Stadelmann, Chr ^a   Pukrop, T ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

catenin; Brain metastases; Ki67; LEF1; Lung cancer; TCF4; TTF1

Indexed keywords

BETA CATENIN; CYCLIN D1; HERMES ANTIGEN; KI 67 ANTIGEN; LYMPHOID ENHANCER FACTOR 1; MESSENGER RNA; T CELL FACTOR PROTEIN; T CELL FACTOR PROTEIN 4; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BIOINFORMATICS; BRAIN METASTASIS; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL NUCLEUS; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG ADENOCARCINOMA; MALE; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIMARY TUMOR; PROTEIN EXPRESSION; TUMOR GROWTH; WNT SIGNALING PATHWAY;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BETA CATENIN; BRAIN NEOPLASMS; CELL NUCLEUS; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION PROFILING; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; LYMPHOID ENHANCER-BINDING FACTOR 1; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84876497593     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-012-9552-7     Document Type: Article

References (40)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69-90
2. Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK (2011) The biology of brain metastases-translation to new therapies. Nat Rev Clin Oncol 8:344-356
3. Steeg PS, Camphausen KA, Smith QR (2011) Brain metastases as preventive and therapeutic targets. Nat Rev Cancer 11:352-363
4. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D (2011) International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 6:244-285
5. Anagnostou VK, Syrigos KN, Bepler G, Homer RJ, Rimm DL (2009) Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma. J Clin Oncol 27:271-278
6. Barletta JA, Perner S, Iafrate AJ, Yeap BY, Weir BA, Johnson LA, Johnson BE, Meyerson M, Rubin MA, Travis WD, Loda M, Chirieac LR (2009) Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma. J Cell Mol Med 13:1977-1986
7. Perner S, Wagner PL, Soltermann A, LaFargue C, Tischler V, Weir BA, Weder W, Meyerson M, Giordano TJ, Moch H, Rubin MA (2009) TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival. J Pathol 217:65-72
8. Oka S, Uramoto H, Shimokawa H, Iwanami T, Tanaka F (2011) The expression of Ki-67, but not proliferating cell nuclear antigen, predicts poor disease free survival in patients with adenocarcinoma of the lung. Anticancer Res 31:4277-4282
9. Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massague J (2009) WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 138:51-62
10. Arce L, Yokoyama NN, Waterman ML (2006) Diversity of LEF/TCF action in development and disease. Oncogene 25:7492-7504
11. Wend P, Holland JD, Ziebold U, Birchmeier W (2010) Wnt signaling in stem and cancer stem cells. Semin Cell Dev Biol 21:855-863
12. Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, Joshi MB, Harpole D, Lancaster JM, Berchuck A, Olson JA Jr, Marks JR, Dressman HK, West M, Nevins JR (2006) Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 439:353-357
13. Smid M, Wang Y, Zhang Y, Sieuwerts AM, Yu J, Klijn JG, Foekens JA, Martens JW (2008) Subtypes of breast cancer show preferential site of relapse. Cancer Res 68:3108-3114
14. Klemm F, Bleckmann A, Siam L, Chuang HN, Rietkotter E, Behme D, Schulz M, Schaffrinski M, Schindler S, Trumper L, Kramer F, Beissbarth T, Stadelmann C, Binder C, Pukrop T (2011) β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis. Carcinogenesis 32:434-442
15. Pukrop T, Dehghani F, Chuang HN, Lohaus R, Bayanga K, Heermann S, Regen T, Van RD, Klemm F, Schulz M, Siam L, Hoffmann A, Trumper L, Stadelmann C, Bechmann I, Hanisch UK, Binder C (2010) Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. Glia 58:1477-1489
16. Barrett T, Edgar R (2006) Mining microarray data at NCBI's Gene Expression Omnibus (GEO). Methods Mol Biol 338:175-190
17. Cox DR (1972) Regression models and life-tables. J Roy Stat Soc 34:187-220
18. Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Mol Biol 2004;3
19. Kanehisa M (2002) The KEGG database. Novartis Found Symp 247:91-101
20. Beissbarth T (2006) Interpreting experimental results using gene ontologies. Methods Enzymol 411:340-352
21. Hsu DS, Acharya CR, Balakumaran BS, Riedel RF, Kim MK, Stevenson M, Tuchman S, Mukherjee S, Barry W, Dressman HK, Nevins JR, Powers S, Mu D, Potti A (2009) Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. Proc Natl Acad Sci USA 106:5312-5317
22. van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111:241-250
23. Huang CL, Liu D, Nakano J, Ishikawa S, Kontani K, Yokomise H, Ueno M (2005) Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor-an expression in non-small-cell lung cancer. J Clin Oncol 23:8765-8773
24. Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K (2003) The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol 23:131-139
25. Kuhl M, Geis K, Sheldahl LC, Pukrop T, Moon RT, Wedlich D (2001) Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+signaling. Mech Dev 106:61-76
26. Nakashima T, Liu D, Nakano J, Ishikawa S, Yokomise H, Ueno M, Kadota K, Huang CL (2008) Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients. Oncol Rep 19:203-209
27. Duan D, Yue Y, Zhou W, Labed B, Ritchie TC, Grosschedl R, Engelhardt JF (1999) Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1). Development 126:4441-4453
28. Mucenski ML, Wert SE, Nation JM, Loudy DE, Huelsken J, Birchmeier W, Morrisey EE, Whitsett JA (2003) beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem 278:40231-40238
29. Pacheco-Pinedo EC, Durham AC, Stewart KM, Goss AM, Lu MM, Demayo FJ, Morrisey EE (2011) Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J Clin Invest 121:1935-1945
30. Lucero OM, Dawson DW, Moon RT, Chien AJ (2010) A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep 12:314-318
31. Murakami T, Toda S, Fujimoto M, Ohtsuki M, Byers HR, Etoh T, Nakagawa H (2001) Constitutive activation of Wnt/beta-catenin signaling pathway in migration-active melanoma cells: role of LEF-1 in melanoma with increased metastatic potential. Biochem Biophys Res Commun 288:8-15
32. Kriegl L, Horst D, Reiche JA, Engel J, Kirchner T, Jung A (2010) LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer. J Transl Med 8:123
33. Elzagheid A, Buhmeida A, Korkeila E, Collan Y, Syrjanen K, Pyrhonen S (2008) Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma. World J Gastroenterol 14:3866-3871
34. Giese K, Grosschedl R (1993) LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites. EMBO J 12:4667-4676
35. Giese K, Pagel J, Grosschedl R (1997) Functional analysis of DNA bending and unwinding by the high mobility group domain of LEF-1. Proc Natl Acad Sci USA 94:12845-12850
36. Love JJ, Li X, Case DA, Giese K, Grosschedl R, Wright PE (1995) Structural basis for DNA bending by the architectural transcription factor LEF-1. Nature 376:791-795
37. Mallory MJ, Jackson J, Weber B, Chi A, Heyd F, Lynch KW: Signal- and developmental-dependent alternative splicing of LEF1 in T cells is controlled by CELF2. Mol Cell Biol 2011
38. Prieve MG, Guttridge KL, Munguia JE, Waterman ML (1996) The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins. J Biol Chem 271:7654-7658
39. Prieve MG, Guttridge KL, Munguia J, Waterman ML (1998) Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1. Mol Cell Biol 18:4819-4832
40. Nawshad A, Medici D, Liu CC, Hay ED (2007) TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex. J Cell Sci 120:1646-1653