Metabolic adaptive ALT isoenzyme response in livers of C57/BL6 mice treated with dexamethasone

Toxicologic Pathology

Volumn 40, Issue 8, 2012, Pages 1117-1127

  Reagan, William J ^a   Yang, Rong Ze ^b   Park, Soohyun ^b   Goldstein, Richard ^a   Brees, Dominique ^a   Gong, Da Wei ^b,c  

^a PFIZER INC   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

Author keywords

ALT; clinical pathology; hepatobiliary system; isoenzyme; mouse

Indexed keywords

ALANINE AMINOTRANSFERASE; ALANINE AMINOTRANSFERASE ISOENZYME 1; ALANINE AMINOTRANSFERASE ISOENZYME 2; DEXAMETHASONE; GLYCOGEN; ISOENZYME; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCONEOGENESIS; GLYCOGEN LIVER LEVEL; LIVER CELL; LIVER CELL DAMAGE; LIVER HISTOLOGY; LIVER NECROSIS; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

ADAPTATION, BIOLOGICAL; ALANINE TRANSAMINASE; ANIMALS; BLOTTING, WESTERN; DEXAMETHASONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOCORTICOIDS; GLYCOGEN; ISOENZYMES; LIVER; MICE; MICE, INBRED C57BL; RNA, MESSENGER;

MUS;

EID: 84870022996     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312447550     Document Type: Article

References (27)

1. Baque S., Roca A., Guinovart J. J., Gomez-Foix A. M.. Direct activating effects of dexamethasone on glycogen metabolizing enzymes in primary cultured rat hepatocytes. Eur J Biochem. 1996 ; 236: 772-77
2. Boone L., Meyer D., Cusick P., Ennulat D., Bolliger A. P., Everds N., Meador V., Elliott G., Honor D., Bounous D., Jordan H.. Selection and interpretation of clinical pathology indicators of hepatic injury in preclinical studies. Vet Clin Path. 2005 ; 34: 182-88
3. Boyd J. W.. The mechanisms relating to increases in plasma enzymes and isoenzymes in diseases of animals. Vet Clin Pathol. 1983 ; 12: 9-24
4. De Rosa G., Burk T. L., Swick R. W.. Isolation and characterization of mitochondrial alanine aminotransferase from porcine tissue. Biochim Biophys Acta. 1979 ; 567: 116-24
5. Diaz-Juarez J., Rivera-Valerdi L., Bernal-Cerrillo D. E., Hernandez-Munoz R.. Predominance of released mitochondrial enzymes by partial hepatectomy-induced rat regenerating liver is controlled by hemodynamic changes and not related to mitochondrial damage. Scand J Gastroenterol. 2006 ; 41: 223-33
6. Edgar A. D., Tomkiewicz C., Costet P., Legendre C., Aggerbeck M., Bouguet J., Staels B., Guyomard C., Pineau T., Barouki R.. Fenofibrate modifies transaminase gene expression via a peroxisome proliferator activated receptor alpha-dependent pathway. Toxicol Lett. 1998 ; 98: 13-23
7. Giffen P. S., Pick C. R., Price M. A., Williams A., York M. J.. Alpha-glutathione S -transferase in the assessment of hepatotoxicity-Its diagnostic utility in comparison with other recognized markers in the wistar han rat. Toxicol Pathol. 2002 ; 30: 365-72
8. Gores G. J., Herman B., Lemasters J. J.. Plasma membrane bleb formation and rupture: A common feature of hepatocellular injury. Hepatology. 1990 ; 11: 690-98
9. Gounarides J. S., Korach-Andre M., Killary K., Argentieri G., Turner O., Laurent D.. Effect of dexamethasone on glucose tolerance and fat metabolism in a diet-induced obesity mouse model. Endocrinology. 2008 ; 149: 758-66
10. Hagopian K., Ramsey J. J., Weindruch R.. Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver. Exp Gerontol. 2003 ; 38: 267-78
11. Iacobellis G., Moschetta A., Buzzetti R., Ribaudo M. C., Baroni M. G., Leonetti F.. Aminotransferase activity in morbid and uncomplicated obesity: Predictive role of fasting insulin. Nutr Metab Cardiovasc Dis. 2007 ; 17: 442-47
12. Jackson E. R., Kilroy C., Joslin D. L., Schomaker S. J., Pruimboom-Brees I., Amacher D. E.. The early effects of short-term dexamethasone administration on hepatic and serum alanine aminotransferase in the rat. Drug Chem Toxicol. 2008 ; 31: 427-45
13. Jadhao S. B., Yang R. Z., Lin Q., Hu H., Anania F. A., Shuldiner A. R., Gong D. W.. Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver [erratum appears in Hepatology 2004 Jul;40(1),269 Note: Jadaho Sanjay B [corrected to Jadhao Sanjay B]]. Hepatology. 2004 ; 39: 1297-302
14. Kafer E., Pollak J. K.. Amino acid metabolism of growing tissues. II. Alanine-glutamic acid transaminase activity of embryonic rat liver. Exp Cell Res. 1961 ; 22: 120-36
15. Katunuma N., Mikumo K., Matsuda M., Okada M.. Differences between the transaminases in mitochondria and soluble fraction. I. Glutamic-pyruvic transaminase. J Vitaminol (Kyoto). 1962 ; 8: 68-73
16. La Loux M., Stalmans W., Hers H.. On the mechanism by which glucocorticoids cause the activation of glycogen synthase in mouse and rat livers. European Journal of Biochemistry. 1983 ; 136: 175-81
17. Liu R., Pan X., Whitington P. F.. Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. Liver Int. 2009 ; 29: 337-43
18. O'Brien P. J., Slaughter M. R., Polley S. R., Kramer K.. Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats. Lab Anim. 2002 ; 36: 313-21
19. Olson H., Betton G., Robinson D., Thomas K., Monro A., Kolaja G., Lilly P., Sanders J., Sipes G., Bracken W., Dorato M., Van Deun K., Smith P., Berger B., Heller A.. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul Toxicol Pharmacol. 2000 ; 32: 56-67
20. Passonneau J. V., Lauderdale V. R.. A comparison of three methods of glycogen measurement in tissues. Anal Biochem. 1974 ; 60: 405-12
21. Rosen F., Roberts N. R., Nichol C. A.. Glucocorticosteroids and transaminase activity. I. Increased activity of glutamic pyruvic transaminase in four conditions associated with gluconeogenesis. J Biol Chem. 1959 ; 234: 476-80
22. Sohocki M. M., Sullivan L. S., Harrison W. R., Sodergren E. J., Elder F. F., Weinstock G., Tanase S., Daiger S. P.. Human glutamate pyruvate transaminase (GPT): Localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites. Genomics. 1997 ; 40: 247-52
23. Swick R. W., Barnstein P. L., Stange J. L.. The metabolism of mitochondrial proteins. I. Distribution and characterization of the isozymes of alanine aminotransferase in rat liver. J Biol Chem. 1965 ; 240: 3334-40
24. Thulin P., Rafter I., Stockling K., Tomkiewicz C., Norjavaara E., Aggerbeck M., Hellmold H., Ehrenborg E., Andersson U., Cotgreave I., Glinghammar B.. PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes. Toxicol Appl Pharmacol. 2008 ; 231: 1-9
25. Vanstapel F., Bollena M., Wulfa H., Willy Stalmansa W.. Induction of hepatic glycogen synthesis by glucocorticoids is not mediated by insulin. Mol Cell Endocrinol. 1982 ; 27: 107-114
26. Yang R. Z., Blaileanu G., Hansen B. C., Shuldiner A. R., Gong D. W.. cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase. Genomics. 2002 ; 79: 445-50
27. Yang R. Z., Park S., Reagan W. J., Goldstein R., Zhong S., Lawton M., Rajamohan F., Qian K., Liu L., Gong D. W.. Alanine aminotransferase isoenzymes: Molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Hepatology. 2009 ; 49: 598-607