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Volumn 433, Issue 4, 2013, Pages 502-507

Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts

Author keywords

Fluorescence resonance energy transfer (FRET); MC3T3 E1; Mechanical loading; Mechanotransduction; Rho family GTPases; TCF LEF

Indexed keywords

BETA CATENIN; GREEN FLUORESCENT PROTEIN; MYOSIN; PROTEIN CDC42; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 84876491491     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.020     Document Type: Article
Times cited : (34)

References (36)
  • 1
    • 81255160693 scopus 로고    scopus 로고
    • Mechanical loading: bone remodeling and cartilage maintenance
    • Yokota H., Leong D.J., Sun H.B. Mechanical loading: bone remodeling and cartilage maintenance. Curr. Osteoporos. Rep. 2011, 9:237-242.
    • (2011) Curr. Osteoporos. Rep. , vol.9 , pp. 237-242
    • Yokota, H.1    Leong, D.J.2    Sun, H.B.3
  • 2
    • 77957851833 scopus 로고    scopus 로고
    • Mechanotransduction in bone repair and regeneration
    • Huang C., Ogawa R. Mechanotransduction in bone repair and regeneration. FASEB J. 2010, 24:3625-3632.
    • (2010) FASEB J. , vol.24 , pp. 3625-3632
    • Huang, C.1    Ogawa, R.2
  • 3
    • 0021322767 scopus 로고
    • Regulation of bone formation by applied dynamic loads
    • Rubin C.T., Lanyon L.E. Regulation of bone formation by applied dynamic loads. J. Bone Joint Surg. Am. 1984, 66:397-402.
    • (1984) J. Bone Joint Surg. Am. , vol.66 , pp. 397-402
    • Rubin, C.T.1    Lanyon, L.E.2
  • 4
    • 12344309568 scopus 로고    scopus 로고
    • Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight
    • Lang T., LeBlanc A., Evans H., Lu Y., Genant H., Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J. Bone Miner. Res. 2004, 19:1006-1012.
    • (2004) J. Bone Miner. Res. , vol.19 , pp. 1006-1012
    • Lang, T.1    LeBlanc, A.2    Evans, H.3    Lu, Y.4    Genant, H.5    Yu, A.6
  • 7
    • 77957755212 scopus 로고    scopus 로고
    • Activation of beta-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone
    • Kamel M.A., Picconi J.L., Lara-Castillo N., Johnson M.L. Activation of beta-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone. Bone 2010, 47:872-881.
    • (2010) Bone , vol.47 , pp. 872-881
    • Kamel, M.A.1    Picconi, J.L.2    Lara-Castillo, N.3    Johnson, M.L.4
  • 8
    • 57649237947 scopus 로고    scopus 로고
    • Beta-catenin levels influence rapid mechanical responses in osteoblasts
    • Case N., Ma M., Sen B., Xie Z., Gross T.S., Rubin J. Beta-catenin levels influence rapid mechanical responses in osteoblasts. J. Biol. Chem. 2008, 283:29196-29205.
    • (2008) J. Biol. Chem. , vol.283 , pp. 29196-29205
    • Case, N.1    Ma, M.2    Sen, B.3    Xie, Z.4    Gross, T.S.5    Rubin, J.6
  • 9
    • 0032729458 scopus 로고    scopus 로고
    • Signaling through beta-catenin and Lef/Tcf
    • Novak A., Dedhar S. Signaling through beta-catenin and Lef/Tcf. Cell. Mol. Life Sci. 1999, 56:523-537.
    • (1999) Cell. Mol. Life Sci. , vol.56 , pp. 523-537
    • Novak, A.1    Dedhar, S.2
  • 10
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature 2002, 420:629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 11
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes C.D., Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995, 81:53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 13
    • 70849098229 scopus 로고    scopus 로고
    • Rapid activation of Rac GTPase in living cells by force is independent of Src
    • Poh Y.C., Na S., Chowdhury F., Ouyang M., Wang Y., Wang N. Rapid activation of Rac GTPase in living cells by force is independent of Src. PLoS ONE 2009, 4:e7886.
    • (2009) PLoS ONE , vol.4
    • Poh, Y.C.1    Na, S.2    Chowdhury, F.3    Ouyang, M.4    Wang, Y.5    Wang, N.6
  • 14
    • 33644866797 scopus 로고    scopus 로고
    • Role of small GTPases in endothelial cytoskeletal dynamics and the shear stress response
    • Tzima E. Role of small GTPases in endothelial cytoskeletal dynamics and the shear stress response. Circ. Res. 2006, 98:176-185.
    • (2006) Circ. Res. , vol.98 , pp. 176-185
    • Tzima, E.1
  • 15
    • 64849094619 scopus 로고    scopus 로고
    • Mechanically induced osteogenic differentiation-the role of RhoA, ROCKII and cytoskeletal dynamics
    • Arnsdorf E.J., Tummala P., Kwon R.Y., Jacobs C.R. Mechanically induced osteogenic differentiation-the role of RhoA, ROCKII and cytoskeletal dynamics. J. Cell Sci. 2009, 122:546-553.
    • (2009) J. Cell Sci. , vol.122 , pp. 546-553
    • Arnsdorf, E.J.1    Tummala, P.2    Kwon, R.Y.3    Jacobs, C.R.4
  • 16
    • 0042707709 scopus 로고    scopus 로고
    • Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts
    • Chellaiah M.A., Biswas R.S., Rittling S.R., Denhardt D.T., Hruska K.A. Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts. J. Biol. Chem. 2003, 278:29086-29097.
    • (2003) J. Biol. Chem. , vol.278 , pp. 29086-29097
    • Chellaiah, M.A.1    Biswas, R.S.2    Rittling, S.R.3    Denhardt, D.T.4    Hruska, K.A.5
  • 17
    • 77953181212 scopus 로고    scopus 로고
    • Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization
    • Ito Y., Teitelbaum S.L., Zou W., Zheng Y., Johnson J.F., Chappel J., Ross F.P., Zhao H. Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. J. Clin. Invest. 2010, 120:1981-1993.
    • (2010) J. Clin. Invest. , vol.120 , pp. 1981-1993
    • Ito, Y.1    Teitelbaum, S.L.2    Zou, W.3    Zheng, Y.4    Johnson, J.F.5    Chappel, J.6    Ross, F.P.7    Zhao, H.8
  • 18
    • 0032938495 scopus 로고    scopus 로고
    • Rac-GTPase, osteoclast cytoskeleton and bone resorption
    • Razzouk S., Lieberherr M., Cournot G. Rac-GTPase, osteoclast cytoskeleton and bone resorption. Eur. J. Cell Biol. 1999, 78:249-255.
    • (1999) Eur. J. Cell Biol. , vol.78 , pp. 249-255
    • Razzouk, S.1    Lieberherr, M.2    Cournot, G.3
  • 19
    • 0033081753 scopus 로고    scopus 로고
    • Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
    • Ren X.D., Kiosses W.B., Schwartz M.A. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 1999, 18:578-585.
    • (1999) EMBO J. , vol.18 , pp. 578-585
    • Ren, X.D.1    Kiosses, W.B.2    Schwartz, M.A.3
  • 21
    • 0036724188 scopus 로고    scopus 로고
    • Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells
    • Itoh R.E., Kurokawa K., Ohba Y., Yoshizaki H., Mochizuki N., Matsuda M. Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. Mol. Cell. Biol. 2002, 22:6582-6591.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6582-6591
    • Itoh, R.E.1    Kurokawa, K.2    Ohba, Y.3    Yoshizaki, H.4    Mochizuki, N.5    Matsuda, M.6
  • 22
    • 0033560932 scopus 로고    scopus 로고
    • Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress
    • Li S., Chen B.P., Azuma N., Hu Y.L., Wu S.Z., Sumpio B.E., Shyy J.Y., Chien S. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. J. Clin. Invest. 1999, 103:1141-1150.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1141-1150
    • Li, S.1    Chen, B.P.2    Azuma, N.3    Hu, Y.L.4    Wu, S.Z.5    Sumpio, B.E.6    Shyy, J.Y.7    Chien, S.8
  • 23
    • 0033594123 scopus 로고    scopus 로고
    • Rho GTPases control polarity, protrusion, and adhesion during cell movement
    • Nobes C.D., Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 1999, 144:1235-1244.
    • (1999) J. Cell Biol. , vol.144 , pp. 1235-1244
    • Nobes, C.D.1    Hall, A.2
  • 25
    • 0037014456 scopus 로고    scopus 로고
    • Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function
    • Murase S., Mosser E., Schuman E.M. Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function. Neuron 2002, 35:91-105.
    • (2002) Neuron , vol.35 , pp. 91-105
    • Murase, S.1    Mosser, E.2    Schuman, E.M.3
  • 26
    • 0028386524 scopus 로고
    • A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
    • Weinbaum S., Cowin S.C., Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J. Biomech. 1994, 27:339-360.
    • (1994) J. Biomech. , vol.27 , pp. 339-360
    • Weinbaum, S.1    Cowin, S.C.2    Zeng, Y.3
  • 28
    • 2442664118 scopus 로고    scopus 로고
    • Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    • Gao Y., Dickerson J.B., Guo F., Zheng J., Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc. Nat. Acad. Sci. USA 2004, 101:7618-7623.
    • (2004) Proc. Nat. Acad. Sci. USA , vol.101 , pp. 7618-7623
    • Gao, Y.1    Dickerson, J.B.2    Guo, F.3    Zheng, J.4    Zheng, Y.5
  • 30
    • 41949105179 scopus 로고    scopus 로고
    • Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling
    • Wu X., Tu X., Joeng K.S., Hilton M.J., Williams D.A., Long F. Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 2008, 133:340-353.
    • (2008) Cell , vol.133 , pp. 340-353
    • Wu, X.1    Tu, X.2    Joeng, K.S.3    Hilton, M.J.4    Williams, D.A.5    Long, F.6
  • 32
    • 0034256024 scopus 로고    scopus 로고
    • Signaling networks linking integrins and rho family GTPases
    • Schwartz M.A., Shattil S.J. Signaling networks linking integrins and rho family GTPases. Trends Biochem. Sci. 2000, 25:388-391.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 388-391
    • Schwartz, M.A.1    Shattil, S.J.2
  • 35
    • 34250823973 scopus 로고    scopus 로고
    • Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton
    • Baron R., Rawadi G. Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology 2007, 148:2635-2643.
    • (2007) Endocrinology , vol.148 , pp. 2635-2643
    • Baron, R.1    Rawadi, G.2
  • 36
    • 8844264528 scopus 로고    scopus 로고
    • Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation
    • Esufali S., Bapat B. Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. Oncogene 2004, 23:8260-8271.
    • (2004) Oncogene , vol.23 , pp. 8260-8271
    • Esufali, S.1    Bapat, B.2


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