메뉴 건너뛰기




Volumn 43, Issue 5, 2013, Pages 491-500

Exploring the biology of cancer of unknown primary: Breakthroughs and drawbacks

Author keywords

Biology; Cancer of unknown primary; Metastases; Tumour regression

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELATINASE A; GELATINASE B; GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR; MICRORNA; NERVE CELL ADHESION MOLECULE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN P21; PROTEIN P53; SCATTER FACTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN;

EID: 84876480383     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/eci.12062     Document Type: Review
Times cited : (47)

References (53)
  • 2
    • 84859625307 scopus 로고    scopus 로고
    • Cancer of unknown primary site
    • Pavlidis N, Pentheroudakis G. Cancer of unknown primary site. Lancet 2012;9824:1428-35.
    • (2012) Lancet , vol.9824 , pp. 1428-1435
    • Pavlidis, N.1    Pentheroudakis, G.2
  • 3
    • 9244263076 scopus 로고    scopus 로고
    • Aneuploidy and cancer
    • Rajagopalan H, Lengauer C. Aneuploidy and cancer. Nature 2004;432:338-41.
    • (2004) Nature , vol.432 , pp. 338-341
    • Rajagopalan, H.1    Lengauer, C.2
  • 4
    • 0021927525 scopus 로고
    • Metastatic adenocarcinoma of unknown primary site: abnormalities of cellular DNA content and survival
    • Hedley DW, Leary JA, Kirsten F. Metastatic adenocarcinoma of unknown primary site: abnormalities of cellular DNA content and survival. Eur J Cancer Clin Oncol 1985;21:185-9.
    • (1985) Eur J Cancer Clin Oncol , vol.21 , pp. 185-189
    • Hedley, D.W.1    Leary, J.A.2    Kirsten, F.3
  • 6
    • 0028870392 scopus 로고
    • Molecular and cytogenetic studies in the diagnosis of patients with poorly differentiated carcinomas of unknown primary site
    • Motzer RJ, Rodriguez E, Reuter VE, Bosl GJ, Mazumdar M, Chaganti RS. Molecular and cytogenetic studies in the diagnosis of patients with poorly differentiated carcinomas of unknown primary site. J Clin Oncol 1995;13:274-82.
    • (1995) J Clin Oncol , vol.13 , pp. 274-282
    • Motzer, R.J.1    Rodriguez, E.2    Reuter, V.E.3    Bosl, G.J.4    Mazumdar, M.5    Chaganti, R.S.6
  • 7
    • 0032421515 scopus 로고    scopus 로고
    • Establishing germ cell origin of undifferentiated tumors by identifying gain of 12p material using comparative genomic hybridization analysis of paraffin-embedded samples
    • Summersgill B, Goker H, Osin P, Huddart R, Horwich A, Fisher C et al. Establishing germ cell origin of undifferentiated tumors by identifying gain of 12p material using comparative genomic hybridization analysis of paraffin-embedded samples. Diagn Mol Pathol 1998;7:260-6.
    • (1998) Diagn Mol Pathol , vol.7 , pp. 260-266
    • Summersgill, B.1    Goker, H.2    Osin, P.3    Huddart, R.4    Horwich, A.5    Fisher, C.6
  • 8
  • 9
    • 12244273951 scopus 로고    scopus 로고
    • Cytogenetic profile of unknown primary tumors: clues for their pathogenesis and clinical management
    • Pantou D, Tsarouha H, Papadopoulou A, Mahaira L, Kyriazoglou I, Apostolikas N et al. Cytogenetic profile of unknown primary tumors: clues for their pathogenesis and clinical management. Neoplasia 2003;5:23-31.
    • (2003) Neoplasia , vol.5 , pp. 23-31
    • Pantou, D.1    Tsarouha, H.2    Papadopoulou, A.3    Mahaira, L.4    Kyriazoglou, I.5    Apostolikas, N.6
  • 10
    • 49749110108 scopus 로고    scopus 로고
    • Molecular evidence for a clonal relationship between multiple lesions in patients with unknown primary adenocarcinoma
    • Speel EJ, van de Wouw AJ, Claessen SM, Haesevoets A, Hopman AH, van der Wurff AA et al. Molecular evidence for a clonal relationship between multiple lesions in patients with unknown primary adenocarcinoma. Int J Cancer 2008;123:1292-300.
    • (2008) Int J Cancer , vol.123 , pp. 1292-1300
    • Speel, E.J.1    van de Wouw, A.J.2    Claessen, S.M.3    Haesevoets, A.4    Hopman, A.H.5    van der Wurff, A.A.6
  • 11
    • 0029549980 scopus 로고
    • Overexpression of C-myc, Ras and C-erbB-2 oncoproteins in carcinoma of unknown primary origin
    • Pavlidis N, Briassoulis E, Bai M, Fountzilas G, Agnantis N. Overexpression of C-myc, Ras and C-erbB-2 oncoproteins in carcinoma of unknown primary origin. Anticancer Res 1995;1:2563-67.
    • (1995) Anticancer Res , vol.1 , pp. 2563-2567
    • Pavlidis, N.1    Briassoulis, E.2    Bai, M.3    Fountzilas, G.4    Agnantis, N.5
  • 12
    • 0033966154 scopus 로고    scopus 로고
    • Overexpression of Her-2 in patients with poorly differentiated carcinoma or poorly differentiated adenocarcinoma of unknown primary site
    • Hainsworth JD, Lennington WJ, Greco FA. Overexpression of Her-2 in patients with poorly differentiated carcinoma or poorly differentiated adenocarcinoma of unknown primary site. J Clin Oncol 2000;1:632-5.
    • (2000) J Clin Oncol , vol.1 , pp. 632-635
    • Hainsworth, J.D.1    Lennington, W.J.2    Greco, F.A.3
  • 13
    • 1442350528 scopus 로고    scopus 로고
    • Clinical and immunohistochemical analysis of patients with unknown primary tumour. A search for prognostic factors in UPT
    • van de Wouw AJ, Jansen RLH, Griffioen AW, Hillen HFP. Clinical and immunohistochemical analysis of patients with unknown primary tumour. A search for prognostic factors in UPT. Anticancer Res 2004;24:297-302.
    • (2004) Anticancer Res , vol.24 , pp. 297-302
    • van de Wouw, A.J.1    Jansen, R.L.H.2    Griffioen, A.W.3    Hillen, H.F.P.4
  • 15
    • 34247611517 scopus 로고    scopus 로고
    • Global profiling of EGFR gene mutation, amplification, regulation and tissue protein expression in unknown primary carcinomas: to target or not to target?
    • Dova L, Pentheroudakis G, Georgiou I, Malamou-Mitsi V, Vartholomatos G, Fountzilas G et al. Global profiling of EGFR gene mutation, amplification, regulation and tissue protein expression in unknown primary carcinomas: to target or not to target? Clin Exp Metastasis 2007;24:79-86.
    • (2007) Clin Exp Metastasis , vol.24 , pp. 79-86
    • Dova, L.1    Pentheroudakis, G.2    Georgiou, I.3    Malamou-Mitsi, V.4    Vartholomatos, G.5    Fountzilas, G.6
  • 16
    • 34948816642 scopus 로고    scopus 로고
    • Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy?
    • Massard C, Voigt JJ, Laplanche A, Culine S, Lortholary A, Bugat R et al. Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy? Br J Cancer 2007;97:857-61.
    • (2007) Br J Cancer , vol.97 , pp. 857-861
    • Massard, C.1    Voigt, J.J.2    Laplanche, A.3    Culine, S.4    Lortholary, A.5    Bugat, R.6
  • 17
    • 80052334435 scopus 로고    scopus 로고
    • Hypoxia-related protein expression and its clinicopathologic implication in carcinoma of unknown primary
    • Koo JS, Kim H. Hypoxia-related protein expression and its clinicopathologic implication in carcinoma of unknown primary. Tumour Biol 2011;32:893-904.
    • (2011) Tumour Biol , vol.32 , pp. 893-904
    • Koo, J.S.1    Kim, H.2
  • 19
    • 30644462841 scopus 로고    scopus 로고
    • Targeted CML therapy: controlling drug resistance, seeking cure
    • O'Hare T, Corbin AS, Druker BJ. Targeted CML therapy: controlling drug resistance, seeking cure. Curr Opin Genet Dev 2006;16:92-9.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 92-99
    • O'Hare, T.1    Corbin, A.S.2    Druker, B.J.3
  • 21
    • 0031927260 scopus 로고    scopus 로고
    • Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: biological and clinical implications. A Hellenic Co-operative Oncology Group study
    • Briasoulis E, Tsokos M, Fountzilas G, Bafaloukos D, Kosmidis P, Samantas E et al. Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: biological and clinical implications. A Hellenic Co-operative Oncology Group study. Anticancer Res 1998;18:1907-14.
    • (1998) Anticancer Res , vol.18 , pp. 1907-1914
    • Briasoulis, E.1    Tsokos, M.2    Fountzilas, G.3    Bafaloukos, D.4    Kosmidis, P.5    Samantas, E.6
  • 22
    • 30144433850 scopus 로고    scopus 로고
    • Locus-specific mutation databases: pitfalls and good practice based on the p53 experience
    • Soussi T, Ishioka C, Claustres M, Béroud C. Locus-specific mutation databases: pitfalls and good practice based on the p53 experience. Nat Rev Cancer 2006;6:83-90.
    • (2006) Nat Rev Cancer , vol.6 , pp. 83-90
    • Soussi, T.1    Ishioka, C.2    Claustres, M.3    Béroud, C.4
  • 23
    • 0027331870 scopus 로고
    • p53 gene mutation spectrum in human unknown primary tumors
    • Bar-Eli M, Abbruzzese JL, Lee-Jackson D et al. p53 gene mutation spectrum in human unknown primary tumors. Anticancer Res 1993;13:1619-23.
    • (1993) Anticancer Res , vol.13 , pp. 1619-1623
    • Bar-Eli, M.1    Abbruzzese, J.L.2    Lee-Jackson, D.3
  • 24
    • 0033899551 scopus 로고    scopus 로고
    • Analysis of the p53 gene status of lymph node metastasis in the head and neck region in occult primary cancer
    • Gottschlich S, Schuhmacher O, Gorogh T, Hoffmann M, Maune S. Analysis of the p53 gene status of lymph node metastasis in the head and neck region in occult primary cancer. Laryngorhinootologie 2000;79:434-7.
    • (2000) Laryngorhinootologie , vol.79 , pp. 434-437
    • Gottschlich, S.1    Schuhmacher, O.2    Gorogh, T.3    Hoffmann, M.4    Maune, S.5
  • 27
    • 58549103114 scopus 로고    scopus 로고
    • Systemic dissemination in cancer of unknown primary is independent of mutational inactivation of the KiSS-1 metastasis-suppressor gene
    • Dova L, Golfinopoulos V, Pentheroudakis G, Georgiou I, Pavlidis N. Systemic dissemination in cancer of unknown primary is independent of mutational inactivation of the KiSS-1 metastasis-suppressor gene. Pathol Oncol Res 2008;14:239-41.
    • (2008) Pathol Oncol Res , vol.14 , pp. 239-241
    • Dova, L.1    Golfinopoulos, V.2    Pentheroudakis, G.3    Georgiou, I.4    Pavlidis, N.5
  • 28
  • 31
    • 80051879881 scopus 로고    scopus 로고
    • Angiogenic ability of metastatic squamous carcinoma in the cervical lymph nodes from unknown primary tumours
    • Agarwal B, Das P, Naresh KN, Borges AM. Angiogenic ability of metastatic squamous carcinoma in the cervical lymph nodes from unknown primary tumours. J Clin Pathol 2011;64:765-70.
    • (2011) J Clin Pathol , vol.64 , pp. 765-770
    • Agarwal, B.1    Das, P.2    Naresh, K.N.3    Borges, A.M.4
  • 32
    • 75449086584 scopus 로고    scopus 로고
    • Paclitaxel/carboplatin plus bevacizumab/erlotinib in the first-line treatment of patients with carcinoma of unknown primary site
    • Hainsworth JD, Spigel DR, Thompson DS, Murphy PB, Lane CM, Waterhouse DM et al. Paclitaxel/carboplatin plus bevacizumab/erlotinib in the first-line treatment of patients with carcinoma of unknown primary site. Oncologist 2009;14:1189-97.
    • (2009) Oncologist , vol.14 , pp. 1189-1197
    • Hainsworth, J.D.1    Spigel, D.R.2    Thompson, D.S.3    Murphy, P.B.4    Lane, C.M.5    Waterhouse, D.M.6
  • 33
    • 34248995210 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and erlotinib in carcinomas of unknown primary site: the Minnie pearl cancer research network
    • Hainsworth JD, Spigel DR, Farley C, Thompson DS, Shipley DL, Greco FA. Phase II trial of bevacizumab and erlotinib in carcinomas of unknown primary site: the Minnie pearl cancer research network. J Clin Oncol 2007;25:1747-52.
    • (2007) J Clin Oncol , vol.25 , pp. 1747-1752
    • Hainsworth, J.D.1    Spigel, D.R.2    Farley, C.3    Thompson, D.S.4    Shipley, D.L.5    Greco, F.A.6
  • 34
    • 78650373860 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors: master regulators of metastasis
    • Lu X, Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 2010;16:5928-35.
    • (2010) Clin Cancer Res , vol.16 , pp. 5928-5935
    • Lu, X.1    Kang, Y.2
  • 35
    • 75649151387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer development and its clinical significance
    • Iwatsuki M, Mimori K, Yokobori T, Ishi H, Beppu T, Nakamori S et al. Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci 2010;101:293-9.
    • (2010) Cancer Sci , vol.101 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3    Ishi, H.4    Beppu, T.5    Nakamori, S.6
  • 37
    • 84860006878 scopus 로고    scopus 로고
    • Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility
    • Stoyianni A, Goussia A, Pentheroudakis G, Siozopoulou V, Ioachim E, Krikelis D et al. Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility. Anticancer Res 2012;32:1273-81.
    • (2012) Anticancer Res , vol.32 , pp. 1273-1281
    • Stoyianni, A.1    Goussia, A.2    Pentheroudakis, G.3    Siozopoulou, V.4    Ioachim, E.5    Krikelis, D.6
  • 38
    • 84861194295 scopus 로고    scopus 로고
    • Cancer stem cells and metastasis
    • Sampieri K, Fodde R. Cancer stem cells and metastasis. Semin Cancer Biol 2012;22(3):187-93.
    • (2012) Semin Cancer Biol , vol.22 , Issue.3 , pp. 187-193
    • Sampieri, K.1    Fodde, R.2
  • 39
    • 84863637373 scopus 로고    scopus 로고
    • Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary
    • Krikelis D, Pentheroudakis G, Goussia A, Siozopoulou V, Bobos M, Petrakis D et al. Profiling immunohistochemical expression of NOTCH1-3, JAGGED1, cMET, and phospho-MAPK in 100 carcinomas of unknown primary. Clin Exp Metastasis 2012;29:603-14.
    • (2012) Clin Exp Metastasis , vol.29 , pp. 603-614
    • Krikelis, D.1    Pentheroudakis, G.2    Goussia, A.3    Siozopoulou, V.4    Bobos, M.5    Petrakis, D.6
  • 41
    • 84861733799 scopus 로고    scopus 로고
    • MET: a promising anticancer therapeutic target
    • Peters S, Adjei AA. MET: a promising anticancer therapeutic target. Nat Rev Clin Oncol 2012;9:314-26.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 314-326
    • Peters, S.1    Adjei, A.A.2
  • 42
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 43
    • 84867130245 scopus 로고    scopus 로고
    • Intracellular signalling via the AKT axis and downstream effectors is active and prognostically significant in cancer of unknown primary (CUP): a study of 100 CUP cases
    • Golfinopoulos V, Pentheroudakis G, Goussia A, Siozopoulou V, Bobos M, Krikelis D et al. Intracellular signalling via the AKT axis and downstream effectors is active and prognostically significant in cancer of unknown primary (CUP): a study of 100 CUP cases. Ann Oncol 2012;23:2725-30.
    • (2012) Ann Oncol , vol.23 , pp. 2725-2730
    • Golfinopoulos, V.1    Pentheroudakis, G.2    Goussia, A.3    Siozopoulou, V.4    Bobos, M.5    Krikelis, D.6
  • 45
    • 84875579895 scopus 로고    scopus 로고
    • Circulating tumor cells: liquid biopsy of cancer
    • Epub ahead of print].
    • Alix-Panabières C, Pantel K. Circulating tumor cells: liquid biopsy of cancer. Clin Chem 2012. [Epub ahead of print].
    • (2012) Clin Chem
    • Alix-Panabières, C.1    Pantel, K.2
  • 46
    • 84876489084 scopus 로고    scopus 로고
    • Circulating tumour cells in cancer of unknown primary site:correlation with clinico pathologic characteristics and prognosis
    • Abstr 865:
    • Pentheroudakis G, Apostolaki S, Stoyianni A, Karaxalios D, Patramani S, Goussia A et al. Circulating tumour cells in cancer of unknown primary site:correlation with clinico pathologic characteristics and prognosis. Ann Oncol 2010; 21:Abstr 865: viii269.
    • (2010) Ann Oncol , vol.21 , pp. 8269
    • Pentheroudakis, G.1    Apostolaki, S.2    Stoyianni, A.3    Karaxalios, D.4    Patramani, S.5    Goussia, A.6
  • 47
    • 34247869752 scopus 로고    scopus 로고
    • Cancer of unknown primary site: missing primary or missing biology?
    • Pentheroudakis G, Briasoulis E, Pavlidis N. Cancer of unknown primary site: missing primary or missing biology? Oncologist 2007;12:418-25.
    • (2007) Oncologist , vol.12 , pp. 418-425
    • Pentheroudakis, G.1    Briasoulis, E.2    Pavlidis, N.3
  • 48
    • 34548497417 scopus 로고    scopus 로고
    • Switching benchmarks in cancer of unknown primary: from autopsy to microarray
    • Pentheroudakis G, Golfinopoulos V, Pavlidis N. Switching benchmarks in cancer of unknown primary: from autopsy to microarray. Eur J Cancer 2007;43:2026-36.
    • (2007) Eur J Cancer , vol.43 , pp. 2026-2036
    • Pentheroudakis, G.1    Golfinopoulos, V.2    Pavlidis, N.3
  • 49
    • 76449096120 scopus 로고    scopus 로고
    • Diagnosis of metastatic neoplasms: molecular approaches for identification of tissue of origin
    • Monzon FA, Koen TJ. Diagnosis of metastatic neoplasms: molecular approaches for identification of tissue of origin. Arch Pathol Lab Med 2010;134:216-24.
    • (2010) Arch Pathol Lab Med , vol.134 , pp. 216-224
    • Monzon, F.A.1    Koen, T.J.2
  • 50
    • 84872567958 scopus 로고    scopus 로고
    • Molecular gene expression profiling to predict the tissue of origin and direct site-specific therapy in patients with carcinoma of unknown primary site: a prospective trial of the sarah cannon research institute
    • Hainsworth JD, Rubin MS, Spigel DR, Boccia RV, Raby S, Quinn R et al. Molecular gene expression profiling to predict the tissue of origin and direct site-specific therapy in patients with carcinoma of unknown primary site: a prospective trial of the sarah cannon research institute. J Clin Oncol 2013;31(2):217-23.
    • (2013) J Clin Oncol , vol.31 , Issue.2 , pp. 217-223
    • Hainsworth, J.D.1    Rubin, M.S.2    Spigel, D.R.3    Boccia, R.V.4    Raby, S.5    Quinn, R.6
  • 51
    • 64049104974 scopus 로고    scopus 로고
    • Molecular assignment of tissue of origin in cancer of unknown primary may not predict response to therapy or outcome: a systematic literature review
    • Pentheroudakis G, Greco FA, Pavlidis N. Molecular assignment of tissue of origin in cancer of unknown primary may not predict response to therapy or outcome: a systematic literature review. Cancer Treat Rev 2009;35:221-7.
    • (2009) Cancer Treat Rev , vol.35 , pp. 221-227
    • Pentheroudakis, G.1    Greco, F.A.2    Pavlidis, N.3
  • 52
    • 84876473020 scopus 로고    scopus 로고
    • Global microRNA profiling in favorable prognosis subgroups of cancer of unknown primary (CUP) demonstrates no significant expression differences with metastases of matched known primary tumors
    • Epub ahead of print
    • Pentheroudakis G, Spector Y, Krikelis D, Kotoula V, Meiri E, Malamou-Mitsi V et al. Global microRNA profiling in favorable prognosis subgroups of cancer of unknown primary (CUP) demonstrates no significant expression differences with metastases of matched known primary tumors. Clin Exp Metastasis 2012. [Epub ahead of print].
    • (2012) Clin Exp Metastasis
    • Pentheroudakis, G.1    Spector, Y.2    Krikelis, D.3    Kotoula, V.4    Meiri, E.5    Malamou-Mitsi, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.