Establishing germ cell origin of undifferentiated tumors by identifying gain of 12p material using comparative genomic hybridization analysis of paraffin-embedded samples

Diagnostic Molecular Pathology

Volumn 7, Issue 5, 1998, Pages 260-266

  Summersgill, Brenda ^a   Goker, Hakan ^a   Osin, Pinchas ^a   Huddart, Robert ^a   Horwich, Alan ^a   Fisher, Cyril ^b   Shipley, Janet ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

12p gain; Comparative genomic hybridization; Formalin fixed; Germ cell tumors; Paraffin embedded

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CARBOPLATIN; CISPLATIN; DNA; ETOPOSIDE; FORMALDEHYDE; IFOSFAMIDE; PARAFFIN; VINCRISTINE;

ADULT; ARTICLE; CHROMOSOME 12P; CLINICAL ARTICLE; CONTROLLED STUDY; EMBEDDING; FLUORESCENCE IN SITU HYBRIDIZATION; GENOME; GERM CELL TUMOR; HISTOGENESIS; HUMAN; HUMAN CELL; IMAGE ANALYSIS; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TESTIS TUMOR; TISSUE FIXATION; TUMOR DIAGNOSIS;

EID: 0032421515     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-199810000-00005     Document Type: Article

References (28)

1. Atkin N, Fox M, Baker M, Jackson Z. Chromosome 12-containing markers, including two dicentrics, in three i(12p)-negative testicular germ cell tumors. Genes Chrom Cancer 1993;6:218-21.
2. Blough R, Smolaarek T, Ulbright T, Heerema N. Bicolor fluorescence in situ hybridization on nuclei from formalin-fixed, paraffin embedded testicular germ cell tumors: comparison with standard metaphase analysis. Cancer Genet Cytogenet 1997;94:79-84.
3. Chaganti R, Rodriguez E, Mathew S. Origin of adult male mediastinal germ-cell tumors. Lancet 1994;343:1130-2.
4. Greco F, Vaughn W, Hainsworth J. Advanced poorly differentiated carcinoma of unknown primary site: recognition of a treatable syndrome. Ann Intern Med 1986;104:547-53.
5. Hainsworth J, Greco F. Extragonadal germ cell tumors and unrecognized germ cell tumors. Semin Oncol 1992;19:119-27.
6. Hermsen M, Meijer G, Baak J, Joenje H, Walboomers J. Comparative genomic hybridization: a new tool in cancer pathology. Human Pathol 1996;27:342-49.
7. Hogan B, Fellous M, Avner P, Jacob F. Isolation of a human teratoma cell line which expresses F9 antigen. Nature 1977;270: 515-8.
8. Houri T, Hashimoto N, Ibayashi N, et al. Chromosomal translocation, t(1;11)(q12;p15), in an extragonadal immature teratoma. Cancer Genet Cytogenet 1997;97:79-80.
9. Korn W, Olde Weghuis D, Suijkerbuijk R, et al. Detection of chromosomal DNA gains and losses in testicular germ cell tumors by comparative genomic hybridization. Genes Chrom Cancer 1996;17:78-87.
10. Lakhani SR, Collins N, Sloane JP, Stratton M. Loss of heterozygosity in lobular carcinoma in situ of the breast. J Clin Pathol 1995;48:74-8.
11. Lindemaeman G, Tattersall M. Chapter 12. In: Peckham M, Piuedo HM, Verovesi U, eds. Oxford textbook of oncology. Oxford, UK: Oxford Medical Publications, 1995:2155-65.
12. Malek N, Casper J, Looijenga L, et al. Quantification of additional short arms of chromosome 12 in germ cell tumors using the polymerase chain reaction. Eur J Cancer 1997;33:1488-94.
13. Mitelman F, Catalog of chromosome aberrations in cancer. 5th ed. New York: Wiley-Liss, 1994.
14. Mostert M, van de Pol M, Olde Weghuis D, et al. Comparative genomic hybridization of germ cell tumors of the adult testis: confirmation of karyotypic findings and identification of a 12p amplicon. Cancer Genet Cytogenet 1996a;89:146-52.
15. Mostert M, van de Pol M, van Echten J, et al. Fluorescence in situ hybridization-based approaches for detection of 12p overrepresentation, in particular i(12p), in cell lines of human testicular germ cell tumors of adults. Cancer Genet Cytogenet 1996b;87:95-102.
16. Motzer R, Amsterdam A, Prieto V, et al. Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. J Urol 1998;159:133-8.
17. Motzer R, Rodriguez E, Reuter V, et al. Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies. J Natl Cancer Instit 1991;83:341-6.
18. Motzer R, Rodriguez E, Reuter V, et al. Molecular and cytogenetic studies in the diagnosis of patients with poorly differentiated carcinomas of unknown primary site. J Clin Oncol 1995;13:274-82.
19. Mukherjee A, Murty V, Rodriguez E, et al. Detection and analysis of origin of i(12p), a diagnostic marker of human male germ cell tumors, by fluorescence in situ hybridization. Genes Chrom Cancer 1991;3:300-7.
20. Oosterhuis J, Van den Berg E, de Jong B, et al. Mediastinal germ cell tumor with secondary nongermcell malignancy, and extensive hematopoietic activity. Cancer Genet Cytogent 1991;54:183-95.
21. Rodriguez E, Houldsworth J, Reuter VE, et al. Molecular cytogenetic analysis of i(12p) negative human male germ cell tumors. Genes Chrom Cancer 1993;8:230-6.
22. Rooney D, Michael H, Foster R, Miller K, Einhorn L. Germ cell tumor associated peripheral neuroectodermal tumors [abstract]. Proceedings of ASCO 1997;16:323a.
23. Shipley J, Fisher C. Chromosome translocations in sarcomas and the analysis of paraffin-embedded material. J Pathol 1998;184: 1-3.
24. Suijkerbuijk R, Sinke R, Meloni A, et al. Overrepresentation of chromosome 12p sequences and karyotypic evolution in i(12p)-negative testicular germ cell tumors revealed by fluorescence in situ hybridization. Cancer Genet Cytogenet 1993;70:85-93.
25. Suijkerbuijk R, Sinke R, Olde Weghuis D, et al. Amplification of chromosome subregion 12p11.2-p12.1 in a metastasis of an i(12p)-negative seminoma: relationship to tumor progression? Cancer Genet Cytogenet 1994;78:145-52.
26. Summersgill B, Goker H, Weber-Hall S, et al. Molecular cytogenetic analysis of adult testicular germ cell tumors and identification of regions of consensus copy number change. Br J Cancer 1998; 77:305-13.
27. Telenius H, Carter N, Bebb CE, et al. Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer. Genomics 1992;13:718-25.
28. van Ecten J, de Jong B, Sinke R, et al. Definition of a new entity of malignant extragonadal germ cell tumors. Genes Chrom Cancer 1995b;12:8-15.