Beclin-1 is required for chromosome congression and proper outer kinetochore assembly

EMBO Reports

Volumn 14, Issue 4, 2013, Pages 364-372

  Frémont, Stéphane ^a,b,c   Gérard, Annabelle ^a,b,c   Galloux, Marie ^a,b,c,d   Janvier, Katy ^a,b,c   Karess, Roger E ^b,c   Berlioz Torrent, Clarisse ^a,b,c  

^a INSTITUT COCHIN   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d INRA Institut National de la Recherche Agronomique   (France)

Author keywords

Beclin 1; chromosome congression; kinetochore assembly; mitosis; Zwint 1

Indexed keywords

BECLIN 1; CELL PROTEIN; CENTROMERE PROTEIN E; CENTROMERE PROTEIN F; UNCLASSIFIED DRUG; ZW10 PROTEIN;

ARTICLE; AUTOPHAGY; CENTROMERE; CHROMOSOME CONGRESSION; CHROMOSOMES AND CHROMOSOMAL PHENOMENA; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN INTERACTION;

APOPTOSIS REGULATORY PROTEINS; CHROMOSOME SEGREGATION; CHROMOSOMES, HUMAN; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETOCHORES; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MITOSIS; NUCLEAR PROTEINS; PROTEIN BINDING; RNA, SMALL INTERFERING; TIME-LAPSE IMAGING;

EID: 84876476422     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2013.23     Document Type: Article

References (24)

1. Yang Z, Klionsky DJ (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124-131
2. Thoresen SB, Pedersen NM, Liestol K, Stenmark H (2010) A phosphatidylinositol 3-kinase class III sub-complex containing VPS15 VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp Cell Res 316: 3368-3378
3. Sagona AP, Nezis IP, Pedersen NM, Liestol K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H (2010) PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol 12: 362-371
4. He C, Levine B (2010) The Beclin 1 interactome. Curr Opin Cell Biol 22: 140-149
5. Funderburk SF, Wang QJ, Yue Z (2010) The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond. Trends Cell Biol 20: 355-362
6. Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, Heintz N, Yue Z (2009) Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 11: 468-476
7. Matsunaga K et al (2009) Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Bio 11: 385-396
8. Abrahamsen H, Stenmark H, Platta HW (2012) Ubiquitination and phosphorylation of Beclin 1 and its binding partners: tuning class III phosphatidylinositol 3-kinase activity and tumor suppression. FEBS Lett 586: 1584-1591
9. Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E (2007) Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 21: 1367-1381 (Pubitemid 46871040)
10. Subramani S, Malhotra V (2013) Non-autophagic roles of autophagy-related proteins. EMBO Rep 14: 143-151
11. Nezi L, Musacchio A (2009) Sister chromatid tension and the spindle assembly checkpoint. Curr Opin Cell Biol 21: 785-795
12. Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR 3rd, Tagaya M, Cleveland DW (2005) ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol 169: 49-60 (Pubitemid 40562913)
13. Cheeseman IM, Desai A (2008) Molecular architecture of the kinetochore-microtubule interface. Nat Rev Mol Cell Biol 9: 33-46
14. Behrends C, Sowa ME, Gygi SP, Harper JW (2010) Network organization of the human autophagy system. Nature 466: 68-76
15. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (2004) A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat Cell Biol 6: 1135-1141 (Pubitemid 39468016)
16. Starr DA, Saffery R, Li Z, Simpson AE, Choo KH, Yen TJ, Goldberg ML (2000) HZwint-1, a novel human kinetochore component that interacts with HZW10. J Cell Sci 113(Pt 11): 1939-1950 (Pubitemid 30386498)
17. Lin YT, Chen Y, Wu G, Lee WH (2006) Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. Oncogene 25: 6901-6914 (Pubitemid 44684831)
18. Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR 3rd, Oegema K, Desai A (2004) A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev 18: 2255-2268 (Pubitemid 39209574)
19. Wang H et al (2004) Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J Biol Chem 279: 54590-54598 (Pubitemid 40053202)
20. Bomont P, Maddox P, Shah JV, Desai AB, Cleveland DW (2005) Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J 24: 3927-3939 (Pubitemid 41637999)
21. Zhu X, Mancini MA, Chang KH, Liu CY, Chen CF, Shan B, Jones D, Yang-Feng TL, Lee WH (1995) Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. Mol Cel Biol 15: 5017-5029
22. Furuya T et al (2010) Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell 38: 500-511
23. Joseph J, Liu ST, Jablonski SA, Yen TJ, Dasso M (2004) The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo. Curr Biol: CB 14: 611-617 (Pubitemid 38458952)
24. Salina D, Enarson P, Rattner JB, Burke B (2003) Nup358 integrates nuclear envelope breakdown with kinetochore assembly. J Cell Biol 162: 991-1001 (Pubitemid 37174183)