Expected and observed mortality in critically ill patients receiving initial antibiotic therapy

Wiener Klinische Wochenschrift

Volumn 124, Issue 21-22, 2012, Pages 775-781

  Janisch, Thorsten ^a   Wendt, Johannes ^a   Hoffmann, Rainer ^a   Ortlepp, Jan R ^a,b  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b Asklepios Hospital Seesen   (Germany)

Author keywords

Antibiotic; Critically ill; Mortality; SAPSII expanded; Sepsis

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; CEFAZOLIN; CEFTRIAXONE; CEFUROXIME; CIPROFLOXACIN; CLINDAMYCIN; COTRIMOXAZOLE; FOSFOMYCIN; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; MEROPENEM; METRONIDAZOLE; MEZLOCILLIN; MOXIFLOXACIN; SULTAMICILLIN; VANCOMYCIN;

ACUTE HEART INFARCTION; ACUTE KIDNEY FAILURE; AGED; ANTIBIOTIC THERAPY; AORTA DISSECTION; ARTICLE; CENTRAL VENOUS CATHETER; CHRONIC KIDNEY FAILURE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CRITICALLY ILL PATIENT; FEMALE; HUMAN; KIDNEY FAILURE; LENGTH OF STAY; LEUKOCYTE COUNT; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; PRACTICE GUIDELINE; RESPIRATORY FAILURE; SHOCK;

AGED; ANTI-BACTERIAL AGENTS; AUSTRIA; CRITICAL ILLNESS; FEMALE; HOSPITAL MORTALITY; HUMANS; LENGTH OF STAY; MALE; PREVALENCE; RETROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; SURVIVAL ANALYSIS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84876471930     PISSN: 00435325     EISSN: 16137671     Source Type: Journal    
DOI: 10.1007/s00508-012-0276-0     Document Type: Article

References (20)

1. Lever A, Mackenzie I. Sepsis: definition, epidemiology and diagnosis. BMJ. 2007 Oct 27;335(7625):879-83. (Pubitemid 350069465)
2. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock. Crit Care Med. 2008;36(1):296-32.
3. Rubulotta FM, Ramsay G, Parker MM, Dellinger RP, Levy MM, Poeze M. An international survey: public and perception of sepsis. Crit Care Med. 2009;37(1):167-70.
4. Poeze M, Ramsay G, Gerlach H, Rubulotta F, Levy M. An international sepsis survey: a study of doctors' knowledge and perception about sepsis. Crit Care. 2004;8(6):R409-13.
5. Brunkhorst FM, Engel C, Ragaller M, Welte T, Rossaint R, Gerlach H, et al. German sepsis competence network (SepNet). Practice and perception-a nationwide survey of therapy habits in sepsis. Crit Care Med. 2008;36(10):2719-25.
6. Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999;115(2):462-74. (Pubitemid 29083057)
7. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000;118(1):146-55. (Pubitemid 30485502)
8. Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit Care Med. 2003;31(12):2742-51. (Pubitemid 38010630)
9. Garnacho-Montero J, Ortiz-Leyba C, Herrera-Melero I, Aldabó- Pallás T, Cayuela-Dominguez A, Marquez-Vacaro JA, et al. Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study. J Antimicrob Chemother. 2008;61(2):436-41.
10. Fraser A, Paul M, Almanasreh N, Tacconelli E, Frank U, Cauda R, et al. Benefit of appropriate empirical antibiotic treatment: thirty-day mortality and duration of hospital stay. Am J Med. 2006;119(11):970-6. (Pubitemid 44634308)
11. Stone S, Gonzales R, Maselli J, Lowenstein SR. Antibiotic prescribing for patients with colds, upper respiratory tract infections, and bronchitis: a national study of hospital-based emergency departments. Ann Emerg Med. 2000;36(4):320-7.
12. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II] based on a European/North American multicenter study. JAMA. 1993;270:2957-63 (Erratum: JAMA 1994;271:1321). (Pubitemid 24000804)
13. Le Gall JR, Neumann A, Hemery F, Bleriot JP, Fulgencio JP, Garrigues B, et al. Mortality prediction using SAPS II: an update for French intensive care units. Crit Care. 2005;9:R645-52.
14. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, et al. Surviving sepsis campaign management guidelines committee. Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32(3):858-73. (Pubitemid 38344143)
15. Umgelter A, Reindl W, Miedaner M, Schmid RM, Huber W. Failure of current antibiotic first-line regimens and mortality in hospitalized patients with spontaneous bacterial peritonitis. Infection. 2009;37:2-8.
16. Edelsberg J, Berger A, Weber DJ, Mallick R, Kuznik A, Oster G. Clinical and economic consequences of failure of initial antibiotic therapy for hospitalized patients with complicated skin and skin-structure infections. Infect Control Hosp Epidemiol. 2008;29:160-9. (Pubitemid 351269212)
17. Ramritu P, Halton K, Cook D, Whitby M, Graves N. Catheter-related bloodstream infections in intensive care units: a systematic review with meta-analysis. J Adv Nurs. 2008;62:3-21.
18. Wunder C, Eichelbrönner O, Roewer N. Are IL-6, IL-10 and PCT plasma concentrations reliable for outcome prediction in severe sepsis? A comparison with APACHE III and SAPS II. Inflamm Res. 2004;53:158-63. (Pubitemid 38526599)
19. Nguyen HB, Banta JE, Cho TW, Van Ginkel C, Burroughs K, Wittlake WA, et al. Mortality predictions using current physiologic scoring systems in patients meeting criteria for early goal-directed therapy and the severe sepsis resuscitation bundle. Shock. 2008;30(1):23-8.
20. Arabi Y, Al Shirawi N, Memish Z, Venkatesh S, Al-Shimemeri A. Assessment of six mortality prediction models in patients admitted with severe sepsis and septic shock to the intensive care unit: a prospective cohort study. Crit Care. 2003;7(5):R116-22.