Benefit of Appropriate Empirical Antibiotic Treatment: Thirty-day Mortality and Duration of Hospital Stay

American Journal of Medicine

Volumn 119, Issue 11, 2006, Pages 970-976

  Fraser, Abigail ^a   Paul, Mical ^a,b   Almanasreh, Nadja ^c   Tacconelli, Evelina ^d   Frank, Uwe ^c   Cauda, Roberto ^d   Borok, Sara ^a   Cohen, Michal ^a   Andreassen, Steen ^e   Nielsen, Anders D ^e   Leibovici, Leonard ^a,b  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c UNIVERSITY OF FREIBURG   (Germany)

^d CATHOLIC UNIVERSITY   (Italy)

^e AALBORG UNIVERSITY   (Denmark)

Author keywords

Appropriate antibiotic treatment; Duration of hospitalization; Mortality

Indexed keywords

ANTIBIOTIC AGENT;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA ANALYSIS; DISEASE DURATION; EMPIRICISM; EVALUATION; FEMALE; GERMANY; HOSPITALIZATION; HUMAN; ISRAEL; ITALY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SURVIVAL; TREATMENT OUTCOME;

ADULT; AGED; ANTI-BACTERIAL AGENTS; FEMALE; GERMANY; HUMANS; INFECTION; ISRAEL; ITALY; LENGTH OF STAY; LINEAR MODELS; LOGISTIC MODELS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; ODDS RATIO; PROSPECTIVE STUDIES;

EID: 33750330729     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2006.03.034     Document Type: Article

References (19)

1. Leibovici L., Shraga I., and Andreassen S. How do you choose antibiotic treatment?. BMJ 318 (1999) 1614-1618
2. Hanon F.X., Monnet D.L., Sorensen T.L., et al. Survival of patients with bacteraemia in relation to initial empirical antimicrobial treatment. Scand J Infect Dis 34 (2002) 520-528
3. Harbath S., Garbino J., Pugin J., et al. Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis. Am J Med 115 (2003) 529-535
4. Ibrahim E.H., Sherman G., Ward S., et al. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 118 (2000) 146-155
5. Kang C.I., Kim S.H., Park W.B., et al. Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother 49 (2005) 760-766
6. Kollef M.H., Sherman G., Ward S., and Fraser V.J. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 115 (1999) 462-474
7. Leibovici L., Shraga I., Drucker M., et al. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 244 (1998) 379-386
8. Zaidi M., Sifuentes-Osornio J., Rolon A.L., et al. Inadequate therapy and antibiotic resistance. Risk factors for mortality in the intensive care unit. Arch Med Res 33 (2002) 290-294
9. Valles J., Rello J., Ochagavia A., et al. Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival. Chest 123 (2003) 1615-1624
10. Zaragoza R., Artero A., Camarena J.J., et al. The influence of inadequate empirical antimicrobial treatment on patients with bloodstream infections in an intensive care unit. Clin Microbiol Infect 9 5 (2003) 412-418
11. Kim S.H., Park W.B., Lee K.D., et al. Outcome of inappropriate initial antimicrobial treatment in patients with methicillin-resistant Staphylococcus aureus bacteraemia. J Antimicrob Chemother 54 (2004) 489-497
12. Dupont H., Montravers P., Gauzit R., et al. Outcome of postoperative pneumonia in the EOLE study. Intensive Care Med 29 (2003) 179-188
13. Tacconelli E., Paul M., Cataldo M.A., et al. TREAT: a system for balancing antibiotic treatment against development of drug resistance (2004), American Society for Microbiology, Washington, D.C 44th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2004
14. Tacconelli E. Computerised decision support for management of bacterial infections. Effective and appropriate treatment at less cost (2005), European Society of Clinical Microbiology and Infectious Diseases, Copenhagen, Denmark 15th European Congress of Clinical Microbiology and Infectious Diseases, 2-5 April 2005
15. Bone R.C., Balk R.A., Cerra F.B., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101 (1992) 1644-1655
16. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20 (1992) 864-874
17. Baker G.R., Norton P.G., Flintoft V., et al. The Canadian Adverse Events Study: the incidence of adverse events among hospital patients in Canada. CMAJ 170 (2004) 1678-1686
18. Slam T.G., Amin A., Brunton S.A., et al. A clinician's guide to the appropriate and accurate use of antibiotics: the Council for Appropriate and Rational Antibiotic Therapy (CARAT) criteria. Am J Med 118 (2005) 1S-6S
19. Garg A.X., Adhikari N.K., McDonald H., et al. Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review. JAMA 293 (2005) 1223-1238