Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Feng, Bin ^a,c   Jiao, Ping ^c   Nie, Yaohui ^c   Kim, Thomas ^c   Jun, Dale ^c   van Rooijen, Nico ^b   Yang, Zaiqing ^a   Xu, Haiyan ^c  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLODRONIC ACID; GLYCOPROTEIN P 15095; INSULIN; LIPOSOME; TRIACYLGLYCEROL; ADIPOCYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEPLETION; DRUG EFFICACY; DRUG MECHANISM; FATTY LIVER; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTRAABDOMINAL FAT; MACROPHAGE ACTIVATION; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OBESITY; TISSUE LEVEL; ADIPOCYTE; ADIPOSE TISSUE; ANIMAL; BLOOD; BODY WEIGHT; C57BL MOUSE; CELL STRAIN 3T3; CHEMISTRY; COCULTURE; DIET; DRUG EFFECT; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HUMAN; LIVER; MACROPHAGE; METABOLISM; METABOLOME; MOUSE MUTANT; ORGAN SIZE; PATHOLOGY; STROMA CELL; VISCERA;

ANIMALIA; MUS;

3T3-L1 CELLS; ADIPOCYTES; ADIPOKINES; ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CLODRONIC ACID; COCULTURE TECHNIQUES; DIET; FATTY LIVER; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; LIPOSOMES; LIVER; MACROPHAGES; MALE; METABOLOME; MICE; MICE, INBRED C57BL; MICE, OBESE; ORGAN SIZE; STROMAL CELLS; TRIGLYCERIDES; VISCERA;

EID: 80052635573     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024358     Document Type: Article

References (44)

1. Festa A, D'Agostino R Jr, Howard G, Mykkanen L, Tracy RP, et al. (2000) Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102: 42-7.
2. Pickup JC, Mattock MB, Chusney GD, Burt D, (1997) NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40: 1286-92.
3. Festa A, D'Agostino R Jr, Tracy RP, Haffner SM, (2002) Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 51: 1131-7.
4. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM, (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. Jama 286: 327-34.
5. Vozarova B, Weyer C, Lindsay RS, Pratley RE, Bogardus C, et al. (2002) High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51: 455-61.
6. Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-30.
7. Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, et al. (2004) Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 110: 1564-71.
8. Hotamisligil GS, Erbay E, (2008) Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 8: 923-34.
9. Schenk S, Saberi M, Olefsky JM, (2008) Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118: 2992-3002.
10. Guilherme A, Virbasius JV, Puri V, Czech MP, (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9: 367-77.
11. Shoelson SE, Lee J, Goldfine AB, (2006) Inflammation and insulin resistance. J Clin Invest 116: 1793-801.
12. Liu J, Divoux A, Sun J, Zhang J, Clement K, et al. (2009) Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 15: 940-5.
13. Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, et al. (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15: 914-20.
14. Winer S, Chan Y, Paltser G, Truong D, Tsui H, et al. (2009) Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 15: 921-9.
15. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, et al. (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15: 930-9.
16. Elgazar-Carmon V, Rudich A, Hadad N, Levy R, (2008) Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res 49: 1894-903.
17. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-808.
18. Lumeng CN, Bodzin JL, Saltiel AR, (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-84.
19. Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, et al. (2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116: 115-124.
20. Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, et al. (2007) Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest 117: 2877-88.
21. Nara N, Nakayama Y, Okamoto S, Tamura H, Kiyono M, et al. (2007) Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance. J Biol Chem 282: 30794-803.
22. Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, et al. (2008) Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 8: 301-9.
23. Hirasaka K, Kohno S, Goto J, Furochi H, Mawatari K, et al. (2007) Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Diabetes 56: 2511-22.
24. Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, et al. (2006) Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 281: 26602-14.
25. Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa KI, et al. (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116: 1494-1505.
26. Bennett CL, Clausen BE, (2007) DC ablation in mice: promises, pitfalls, and challenges. Trends Immunol 28: 525-31.
27. van Rooijen N, Sanders A, (1996) Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid. Hepatology 23: 1239-43.
28. Su D, van Rooijen N, (1989) The role of macrophages in the immunoadjuvant action of liposomes: effects of elimination of splenic macrophages on the immune response against intravenously injected liposome-associated albumin antigen. Immunology 66: 466-70.
29. Lanthier N, Molendi-Coste O, Horsmans Y, van Rooijen N, Cani PD, et al. (2010) Kupffer cell activation is a causal factor for hepatic insulin resistance. Am J Physiol Gastrointest Liver Physiol 298: G107-16.
30. Clementi AH, Gaudy AM, van Rooijen N, Pierce RH, Mooney RA, (2009) Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta 1792: 1062-72.
31. Stienstra R, Saudale F, Duval C, Keshtkar S, Groener JE, et al. (2010) Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology 51: 511-22.
32. van Rooijen N, van Kesteren-Hendrikx E, (2003) "In vivo" depletion of macrophages by liposome-mediated "suicide". Methods Enzymol 373: 3-16.
33. Kosteli A, Sugaru E, Haemmerle G, Martin JF, Lei J, et al. (2010) Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest 120: 3466-79.
34. Stofkova A, (2009) Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. Endocr Regul 43: 157-68.
35. Asano T, Watanabe K, Kubota N, Gunji T, Omata M, et al. (2009) Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis. J Gastroenterol Hepatol 24: 1669-76.
36. Wang Y, Zhou M, Lam KS, Xu A, (2009) Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications. Arq Bras Endocrinol Metabol 53: 201-12.
37. Polyzos SA, Kountouras J, Zavos C, Tsiaousi E, (2010) The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease. Diabetes Obes Metab 12: 365-83.
38. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, et al. (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8: 1288-95.
39. Shen Z, Liang X, Rogers CQ, Rideout D, You M, (2010) Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 298: G364-74.
40. Hajri T, Tao H, Wattacheril J, Marks-Shulman P, Abumrad NN, (2011) Regulation of adiponectin production by insulin: interactions with tumor necrosis factor-alpha and interleukin-6. Am J Physiol Endocrinol Metab 300: E350-60.
41. Zhang H, Park Y, Zhang C, (2010) Coronary and aortic endothelial function affected by feedback between adiponectin and tumor necrosis factor alpha in type 2 diabetic mice. Arterioscler Thromb Vasc Biol 30: 2156-63.
42. Komai N, Morita Y, Sakuta T, Kuwabara A, Kashihara N, (2007) Anti-tumor necrosis factor therapy increases serum adiponectin levels with the improvement of endothelial dysfunction in patients with rheumatoid arthritis. Mod Rheumatol 17: 385-90.
43. Kim KY, Kim JK, Jeon JH, Yoon SR, Choi I, et al. (2005) c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes. Biochem Biophys Res Commun 327: 460-7.
44. Lim JY, Kim WH, Park SI, (2008) GO6976 prevents TNF-alpha-induced suppression of adiponectin expression in 3T3-L1 adipocytes: putative involvement of protein kinase C. FEBS Lett 582: 3473-8.