SmacN7 enhances the sensitivity of pancreatic cancer cells to tumor necrosis factor-related apoptosis-inducing ligand or gemcitabine

Oncology Letters

Volumn 5, Issue 6, 2013, Pages 1760-1764

  Zhou, Wuyuan ^a   Shi, Jun ^b   Niu, Zuoxing ^a   Luo, Hongmin ^c   Tian, He ^c   Gao, Jie ^c   Yu, Fachang ^c   Li, Sheng ^a  

^a SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

^b Shandong Blood Center   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Gemcitabine; Pancreatic cancer; Smac mimic polypeptide; Smac DIABLO; Tumor necrosis factor related apoptosis inducing ligand

Indexed keywords

CASPASE 3; CYTOCHROME C; GEMCITABINE; HYBRID PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE N7; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ARTICLE; CANCER CELL; CELL GROWTH; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PANCREAS CANCER; WESTERN BLOTTING;

EID: 84876459981     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1285     Document Type: Article

References (19)

1. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, et al: Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3: 673-682, 1995.
2. Jin Z, McDonald ER III, Dicker DT and El-Deiry WS: Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. J Biol Chem 279: 35829-35839, 2004.
3. Zhang L and Fang B: Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther 12: 228-237, 2005.
4. Platzbecker U, Kurre P, Guardiola P, Ward JL, Radich J P, Kiem HP and Deeg HJ: Fanconi anemia type C-deficient hematopoietic cells are resistant to TRAIL (TNF-related apoptosis-inducing ligand)-induced cleavage of pro-caspase-8. Exp Hematol 32: 815-821, 2004.
5. Poulaki V, Mitsiades CS, McMullan C, Fanourakis G, Negri J, Goudopoulou A, et al: Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspase-8 gene silencing. Invest Ophthalmol Vis Sci 46: 358-366, 2005.
6. Kim K, Fisher MJ, Xu SQ and El-Deiry WS: Molecular determinants of response to TRAIL in killing of normal and cancer cells. Clin Cancer Res 6: 335-346, 2000.
7. Ozören N, Fisher MJ, Kim K, Liu CX, Genin A, Shifman Y, et al: Homozygous deletion of the death receptor DR4 gene in a naso-pharyngeal cancer cell line is associated with TRAIL resistance. Int J Oncol 16: 917-925, 2000.
8. Kandasamy K, Srinivasula SM, Alnemri ES, Thompson CB, Korsmeyer SJ, Bryant JL and Srivastava RK: Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release. Cancer Res 63: 1712-1721, 2003.
9. Hasenjäger A, Gillissen B, Müller A, Normand G, Hemmati PG, Schuler M, et al: Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells. Oncogene 23: 4523-4535, 2004.
10. Thorén PE, Persson D, Karlsson M and Nordén B: The anten-napedia peptide penetratin translocates across lipid bilayers - the first direct observation. FEBS Lett 482: 265-268, 2000.
11. Suliman A, Lam A, Datta R and Srivastava RK: Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways. Oncogene 20: 2122-2133, 2001.
12. Saelens X, Festjens N, Vande Walle L, van Gurp M, van Loo G and Vandenabeele P: Toxic proteins released from mitochondria in cell death. Oncogene 23: 2861-2874, 2004.
13. Vaux DL and Silke J: Mammalian mitochondrial IAP binding proteins. Biochem Biophys Res Commun 304: 499-504, 2003.
14. Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE et al: Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102: 43-53, 2000.
15. Du C, Fang M, Li Y, Li L and Wang X: Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102: 33-42, 2000.
16. Guo F, Nimmanapalli R, Paranawithana S, Wittman S, Griffin D, Bali P, et al: Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis. Blood 99: 3419-3426, 2002.
17. Creagh EM, Murphy BM, Duriez PJ, Duckett CS and Martin SJ: Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins. J Biol Chem 279: 26906-26914, 2004.
18. Yoon K, Jang HD and Lee SY: Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. Biochem Biophys Res Commun 319: 649-654, 2004.
19. Ng CP and Bonavida B: X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-binding protein with low pl (Smac/DIABLO). Mol Cancer Ther 1: 1051-1058, 2002.