Mice congenitally infected with low-to-moderate virulence Neospora caninum isolates exhibited clinical reactivation during the mating period without transmission to the next generation

Experimental Parasitology

Volumn 134, Issue 2, 2013, Pages 244-248

  Jiménez Ruiz, Elena ^a   Álvarez García, Gema ^a   Aguado Martínez, Adriana ^a   Ortega Mora, Luis M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Congenital neosporosis; Endogenous transplacental transmission; Low to moderate virulence isolates; Mouse model; Neospora caninum; Reactivation

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEMALE; MATING; MOUSE; NEOSPOROSIS; NONHUMAN; PARASITE ISOLATION; PARASITE LOAD; PARASITE VIRULENCE; PLACENTAL TRANSFER; PRIORITY JOURNAL; REINFECTION; TACHYZOITE;

ANIMALS; ANTIBODIES, PROTOZOAN; COCCIDIOSIS; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOGLOBULIN G; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; MICE; NEOSPORA; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; VIRULENCE;

BOS; MUS; NEOSPORA CANINUM;

EID: 84876432325     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2013.03.002     Document Type: Article

References (27)

1. Aguado-Martínez A., Álvarez-García G., Fernández-García A., Risco-Castillo V., Arnaiz-Seco I., Rebordosa-Trigueros X., Navarro-Lozano V., Ortega-Mora L.M. Usefulness of rNcGRA7- and rNcSAG4-based ELISA tests for distinguishing primo-infection, recrudescence, and chronic bovine neosporosis. Vet. Parasitol. 2008, 157:182-195.
2. Aguado-Martínez A., Álvarez-García G., Fernández-García A., Risco-Castillo V., Marugán-Hernández V., Ortega-Mora L.M. Failure of a vaccine using immunogenic recombinant proteins rNcSAG4 and rNcGRA7 against neosporosis in mice. Vaccine 2009, 27(52):7331-7338.
3. Appleby P., Catty D. Transmission of immunoglobulin to foetal and neonatal mice. J. Reprod. Immunol. 1983, 5(4):203-213.
4. Buxton D. Protozoan infections (Toxoplasma gondii, Neospora caninum and Sarcocystis spp.) in sheep and goats: recent advances. Vet. Res. 1998, 29(3-4):289-310.
5. Charmandari E., Tsigos C., Chrousos G. Endocrinology of the stress response. Annu. Rev. Physiol. 2005, 67:259-284.
6. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med. 1995, 332(20):1351-1362.
7. Collantes-Fernández E., Álvarez-García G., Pérez-Pérez V., Pereira-Bueno J., Ortega-Mora L.M. Characterization of pathology and parasite load in outbred and inbred mouse models of chronic Neospora caninum infection. J. Parasitol. 2004, 90:579-583.
8. Collantes-Fernández E., López-Pérez I., Álvarez-García G., Ortega-Mora L.M. Temporal distribution and parasite load kinetics in blood and tissues during Neospora caninum infection in mice. Infect. Immun. 2006, 74(4):2491-2494.
9. Dubey J.P., Hattel A.L., Lindsay D.S., Topper M.J. Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission. J. Am. Vet. Med. Assoc. 1988, 193(10):1259-1263.
10. Dubey J.P., Schares G., Ortega-Mora L.M. Epidemiology and control of neosporosis and Neospora caninum. Clin. Microbiol. Rev. 2007, 20(2):323-367.
11. Entrican G. Immune regulation during pregnancy and host-pathogen interactions in infectious abortion. J. Comp. Pathol. 2002, 126(2-3):79-94.
12. Habib K.E., Gold P.W., Chrousos G.P. Neuroendocrinology of stress. Endocrinol. Metab. Clin. North Am. 2001, 30(3):695-728.
13. Innes E.A., Vermeulen A.N. Vaccination as a control strategy against the coccidial parasites Eimeria, Toxoplasma and Neospora. Parasitology 2006, 133(Suppl):S145-S168.
14. Jiménez-Ruiz E., Álvarez-García G., Aguado-Martínez A., Salman H., Irache J.M., Marugán-Hernández V., Ortega-Mora L.M. Low efficacy of NcGRA7, NcSAG4, NcBSR4 and NcSRS9 formulated in poly-epsilon-caprolactone against Neospora caninum infection in mice. Vaccine 2012, 30(33):4983-4992.
15. Jiménez-Ruiz E., Álvarez-García G., Aguado-Martínez A., Ortega-Mora L.M. Low rates of Neospora caninum infection reactivation during gestation are observed in both chronically and congenitally infected mice. Parasitology 2013, 140(02):220-228.
16. López-Pérez I.C., Collantes-Fernández E., Aguado-Martínez A., Rodríguez-Bertos A., Ortega-Mora L.M. Influence of Neospora caninum infection in BALB/c mice during pregnancy in post-natal development. Vet. Parasitol. 2008, 155(3-4):175-183.
17. López-Pérez I.C., Risco-Castillo V., Collantes-Fernández E., Ortega-Mora L.M. Comparative effect of Neospora caninum infection in BALB/c mice at three different gestation periods. J. Parasitol. 2006, 92(6):1286-1291.
18. McCann C.M., McAllister M.M., Gondim L.F., Smith R.F., Cripps P.J., Kipar A., Williams D.J., Trees A.J. Neospora caninum in cattle: Experimental infection with oocysts can result in exogenous transplacental infection, but not endogenous transplacental infection in the subsequent pregnancy. Int. J. Parasitol. 2007, 37(14):1631-1639.
19. Moreno B., Collantes-Fernandez E., Villa A., Navarro A., Regidor-Cerrillo J., Ortega-Mora L.M. Occurrence of Neospora caninum and Toxoplasma gondii infections in ovine and caprine abortions. Vet. Parasitol. 2012, 187(1-2):312-318.
20. Nasir A., Ashraf M., Khan M.S., Javeed A., Yaqub T., Avais M., Reichel M.P. Prevalence of Neospora caninum antibodies in sheep and goats in Pakistan. J. Parasitol. 2012, 98(1):213-215.
21. Omata Y., Nidaira M., Kano R., Kobayashi Y., Koyama T., Furuoka H., Maeda R., Matsui T., Saito A. Vertical transmission of Neospora caninum in BALB/c mice in both acute and chronic infection. Vet. Parasitol. 2004, 121(3-4):323-328.
22. Pérez-Zaballos F.J., Ortega-Mora L.M., Álvarez-García G., Collantes-Fernández E., Navarro-Lozano V., García-Villada L., Costas E. Adaptation of Neospora caninum isolates to cell-culture changes: an argument in favor of its clonal population structure. J. Parasitol. 2005, 91(3):507-510.
23. Regidor-Cerrillo J., Gómez-Bautista M., Del Pozo I., Jiménez-Ruiz E., Aduriz G., Ortega-Mora L.M. Influence of Neospora caninum intra-specific variability in the outcome of infection in a pregnant BALB/c mouse model. Vet. Res. 2010, 41(4):52.
24. Reichel M.P., Ellis J.T. Neospora caninum-how close are we to development of an efficacious vaccine that prevents abortion in cattle?. Int. J. Parasitol. 2009, 39(11):1173-1187.
25. Rettigner C., De Meerschman F., Focant C., Vanderplasschen A., Losson B. The vertical transmission following the reactivation of a Neospora caninum chronic infection does not seem to be due to an alteration of the systemic immune response in pregnant CBA/Ca mice. Parasitology 2004, 128:149-160.
26. Trees A.J., Williams D.J.L. Endogenous and exogenous transplacental infection in Neospora caninum and Toxoplasma gondii. Trends Parasitol. 2005, 21(12):558-561.
27. Williams D.J., Guy C.S., McGarry J.W., Guy F., Tasker L., Smith R.F., MacEachern K., Cripps P.J., Kelly D.F., Trees A.J. Neospora caninum-associated abortion in cattle: the time of experimentally-induced parasitaemia during gestation determines foetal survival. Parasitology 2000, 121(4):347-358.