Low rates of Neospora caninum infection reactivation during gestation are observed in both chronically and congenitally infected mice

Parasitology

Volumn 140, Issue 2, 2013, Pages 220-228

  Jimenez Ruiz E ^a   Alvarez Garcia G ^a   Aguado Martinez A ^a   Ortega Mora, L M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

BALB c mice; high virulence isolates; low to moderate virulence isolates; Neospora caninum; pregnancy; reactivation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HUMORAL IMMUNITY; MALE; MORBIDITY; MORTALITY; MOUSE; NEOSPORA CANINUM; NEOSPOROSIS; NONHUMAN; PARASITE TRANSMISSION; PARASITE VIRULENCE; PREGNANCY; PRIORITY JOURNAL; SURVIVAL RATE; VERTICAL TRANSMISSION;

ANIMALS; COCCIDIOSIS; DISEASE MODELS, ANIMAL; FEMALE; IMMUNITY, HUMORAL; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MICE; MICE, INBRED BALB C; NEOSPORA; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; PREVALENCE;

EID: 84873381781     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182012001515     Document Type: Article

References (18)

1. Aguado-Martínez, A., Álvarez-García, G., Fernández-García, A., Risco-Castillo, V., Marugán- Hernández, V. and Ortega-Mora, L. M. (2009a). Failure of a vaccine using immunogenic recombinant proteins rNcSAG4 and rNcGRA7 against neosporosis in mice. Vaccine 27, 7331-7338. doi: 10.1016/j.vaccine.2009.09.050.
2. Aguado-Martínez, A., Ortega-Mora, L. M., Álvarez- García, G., Rodríguez-Marco, S., Risco-Castillo, V., Marugán-Hernández, V. and Fernández-García, A. (2009b). Stage-specific expression of Nc SAG4 as a marker of chronic Neospora caninum infection in a mouse model. Parasitology 136, 757-764. doi: 10.1017/S0031182009006076.
3. Aguado-Martínez, A., Álvarez-García, G., Fernández-García, A., Risco-Castillo, V., Arnaiz-Seco, I., Rebordosa-Trigueros, X., Navarro-Lozano, V. and Ortega-Mora, L. M. (2008). Usefulness of rNcGRA7- and rNcSAG4-based ELISA tests for distinguishing primoinfection, recrudescence, and chronic bovine neosporosis. Veterinary Parasitology 157, 182-195. doi: 10.1016/j.vetpar.2008.08.002.
4. Álvarez-García, G., Pereira-Bueno, J., Gómez- Bautista, M. and Ortega-Mora, L. M. (2002). Pattern of recognition of Neospora caninum tachyzoite antigens by naturally infected pregnant cattle and aborted foetuses. Veterinary Parasitology 107, 15-27.
5. Álvarez-García, G., Pitarch, A., Zaballos, A., Fernández-García, A., Gil, C., Gómez-Bautista, M., Aguado-Martínez, A. and Ortega-Mora, L. M. (2006). The NcGRA7 gene encodes the immunodominant 17 kDa antigen of Neospora caninum. Parasitology 134, 41-50. doi: 10.1017/S0031182006001284.
6. Appleby, P. and Catty, D. (1983). Transmission of immunoglobulin to foetal and neonatal mice. Journal of Reproductive Immunology 5, 203-213.
7. Bland, J. M. and Altman, D. G. (2004). The logrank test. BMJ (Clinical Research Edition) 328, 1073. doi: 10.1136/bmj.328.7447.1073.
8. Buxton, D. (1998). Protozoan infections (Toxoplasma gondii, Neospora caninum and Sarcocystis spp.) in sheep and goats: Recent advances. Veterinary Research 29, 289-310.
9. Caspe, S. G., Moore, D. P., Leunda, M. R., Cano, D. B., Lischinsky, L., Regidor-Cerrillo, J., Álvarez-García, G., Echaide, I. G., Bacigalupe, D., Ortega Mora, L. M., Odeon, A. C. and Campero, C. M. (2012). The Neospora caninum-Spain 7 isolate induces placental damage, fetal death and abortion in cattle when inoculated in early gestation. Veterinary Parasitology (in the Press). doi: 10.1016/j.vetpar. 2012.04.034.
10. Cole, R. A., Lindsay, D. S., Blagburn, B. L. and Dubey, J. P. (1995). Vertical transmission of Neospora caninum in mice. The Journal of Parasitology 81, 730-732.
11. Collantes-Fernández, E., Arrighi, R. B., Álvarez- García, G., Weidner, J. M., Regidor-Cerrillo, J., Boothroyd, J. C., Ortega-Mora, L. M. and Barragán, A. (2012). Infected dendritic cells facilitate systemic dissemination and transplacental passage of the obligate intracellular parasite Neospora caninum in mice. PloS One 7, e32123. doi: 10.1371/journal.pone.0032123.
12. Collantes-Fernández, E., López-Pérez, I., Álvarez-García, G. and Ortega-Mora, L. M. (2006). Temporal distribution and parasite load kinetics in blood and tissues during Neospora caninum infection in mice. Infection and Immunity 74, 2491-2494. doi: 10.1128/iai.74.4.2491- 2494.2006.
13. Dubey, J. P. and Schares, G. (2011). Neosporosis in animals-The last five years. Veterinary Parasitology 180, 90-108. doi: 10.1016/j.vetpar. 2011.05.031.
14. Dubey, J. P., Schares, G. and Ortega-Mora, L. M. (2007). Epidemiology and control of neosporosis and Neospora caninum. Clinical Microbiology Reviews 20, 323-367. doi: 10.1128/cmr.00031-06.
15. Entrican, G. (2002). Immune regulation during pregnancy and hostpathogen interactions in infectious abortion. Journal of Comparative Pathology 126, 79-94. doi: 10.1053/jcpa.2001.0539.
16. Fernández-García, A., Risco-Castillo, V., Zaballos, A., Álvarez- García, G. and Ortega-Mora, L. M. (2006). Identification and molecular cloning of the Neospora caninum SAG4 gene specifically expressed at bradyzoite stage. Molecular and Biochemical Parasitology 146, 89-97. doi: 10.1016/j.molbiopara.2005.08.019.
17. Innes, E. A., Wright, S., Bartley, P., Maley, S., Macaldowie, C., Esteban-Redondo, I. and Buxton, D. (2005). The host-parasite relationship in bovine neosporosis. Veterinary Immunology and Immunopathology 108, 29-36. doi: 10.1016/j.vetimm.2005.07.004.
18. Jiménez-Ruiz, E., Álvarez-García, G., Aguado-Martínez, A., Salman, H., Irache, J. M., Marugán- Hernández, V. and Ortega-Mora, L. M. (2012). Low efficacy of NcGRA7, NcSAG4, NcBSR4 and NcSRS9 formulated in poly-e-caprolactone against Neospora caninum infection in mice. Vaccine 30, 4983-4992. doi: 10.1016/j.vaccine.2012.