메뉴 건너뛰기




Volumn 57, Issue 5, 2013, Pages 886-895

Invadopodia-associated proteins blockade as a novel mechanism for 6-shogaol and pterostilbene to reduce breast cancer cell motility and invasion

Author keywords

6 Shogaol; Breast cancer; Invadopodia; Metastasis; Pterostilbene

Indexed keywords

ACTIN; CATECHOL DERIVATIVE; CORTACTIN; CSK TYROSINE PROTEIN KINASE; CSK TYROSINE-PROTEIN KINASE; CTTN PROTEIN, HUMAN; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MMP14 PROTEIN, HUMAN; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; NUCLEAR PROTEIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN TYROSINE KINASE; PTEROSTILBENE; SHOGAOL; STILBENE DERIVATIVE; TRANSCRIPTION FACTOR TWIST; TWIST1 PROTEIN, HUMAN;

EID: 84876431098     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200715     Document Type: Article
Times cited : (31)

References (43)
  • 1
    • 84867984352 scopus 로고    scopus 로고
    • The role of FOXP3 in the development and metastatic spread of breast cancer
    • Douglass, S., Ali, S., Meeson, A. P., Browell, D., Kirby, J. A., The role of FOXP3 in the development and metastatic spread of breast cancer. Cancer Metast. Rev. 2012, 31, 843-854.
    • (2012) Cancer Metast. Rev , vol.31 , pp. 843-854
    • Douglass, S.1    Ali, S.2    Meeson, A.P.3    Browell, D.4    Kirby, J.A.5
  • 2
    • 0035908479 scopus 로고    scopus 로고
    • Angiogenic heterogeneity: regulation of neoplastic angiogenesis by the organ microenvironment
    • Fidler, I. J., Angiogenic heterogeneity: regulation of neoplastic angiogenesis by the organ microenvironment. J. Natl. Cancer Inst. 2001, 93, 1040-1041.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1040-1041
    • Fidler, I.J.1
  • 3
    • 84861880572 scopus 로고    scopus 로고
    • Strategies for the discovery and development of therapies for metastatic breast cancer
    • Eckhardt, B. L., Francis, P. A., Parker, B. S., Anderson, R. L., Strategies for the discovery and development of therapies for metastatic breast cancer. Nat. Rev. Drug Discov. 2012, 11, 479-497.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 479-497
    • Eckhardt, B.L.1    Francis, P.A.2    Parker, B.S.3    Anderson, R.L.4
  • 4
    • 79960898998 scopus 로고    scopus 로고
    • Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions
    • Huang, Y., Simms, A. E., Mazur, A., Wang, S. et al., Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions. Clin. Exp. Metastas. 2011, 28, 567-579.
    • (2011) Clin. Exp. Metastas. , vol.28 , pp. 567-579
    • Huang, Y.1    Simms, A.E.2    Mazur, A.3    Wang, S.4
  • 5
    • 0033999308 scopus 로고    scopus 로고
    • Matrix metalloproteinases: biologic activity and clinical implications
    • Nelson, A. R., Fingleton, B., Rothenberg, M. L., Matrisian, L. M., Matrix metalloproteinases: biologic activity and clinical implications. J. Clin. Oncol. 2000, 18, 1135-1149.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1135-1149
    • Nelson, A.R.1    Fingleton, B.2    Rothenberg, M.L.3    Matrisian, L.M.4
  • 6
    • 0028115933 scopus 로고
    • Invadopodia promote proteolysis of a wide variety of extracellular matrix proteins
    • Kelly, T., Mueller, S. C., Yeh, Y., Chen, W. T, Invadopodia promote proteolysis of a wide variety of extracellular matrix proteins. J. Cell Physiol. 1994, 158, 299-308.
    • (1994) J. Cell Physiol. , vol.158 , pp. 299-308
    • Kelly, T.1    Mueller, S.C.2    Yeh, Y.3    Chen, W.T.4
  • 7
    • 78649864017 scopus 로고    scopus 로고
    • c-Src differentially regulates the functions of microtentacles and invadopodia
    • Balzer, E. M., Whipple, R. A., Thompson, K., Boggs, A. E. et al., c-Src differentially regulates the functions of microtentacles and invadopodia. Oncogene 2010, 29, 6402-6408.
    • (2010) Oncogene , vol.29 , pp. 6402-6408
    • Balzer, E.M.1    Whipple, R.A.2    Thompson, K.3    Boggs, A.E.4
  • 8
    • 69449096397 scopus 로고    scopus 로고
    • Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
    • Oser, M., Yamaguchi, H., Mader, C. C., Bravo-Cordero, J. J. et al., Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J. Cell Biol. 2009, 186, 571-587.
    • (2009) J. Cell Biol. , vol.186 , pp. 571-587
    • Oser, M.1    Yamaguchi, H.2    Mader, C.C.3    Bravo-Cordero, J.J.4
  • 9
    • 13844264301 scopus 로고    scopus 로고
    • The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells
    • Seals, D. F., Azucena, E. F. Jr., Pass, I., Tesfay, L. et al., The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell 2005, 7, 155-165.
    • (2005) Cancer Cell , vol.7 , pp. 155-165
    • Seals, D.F.1    Azucena Jr, E.F.2    Pass, I.3    Tesfay, L.4
  • 10
    • 33748979745 scopus 로고    scopus 로고
    • Invadopodia: specialized cell structures for cancer invasion
    • Weaver, A. M., Invadopodia: specialized cell structures for cancer invasion. Clin. Exp. Metastas. 2006, 23, 97-105.
    • (2006) Clin. Exp. Metastas. , vol.23 , pp. 97-105
    • Weaver, A.M.1
  • 11
    • 0042839756 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas
    • Munaut, C., Noël, A., Hougrand, O., Foidart, J. M. et al., Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas. Int. J. Cancer 2003, 106, 848-855.
    • (2003) Int. J. Cancer , vol.106 , pp. 848-855
    • Munaut, C.1    Noël, A.2    Hougrand, O.3    Foidart, J.M.4
  • 12
    • 0029999333 scopus 로고    scopus 로고
    • Proteases associated with invadopodia, and their role in degradation of extracellular matrix
    • Chen, W. T., Proteases associated with invadopodia, and their role in degradation of extracellular matrix. Enzyme Protein 1996, 49, 59-71.
    • (1996) Enzyme Protein , vol.49 , pp. 59-71
    • Chen, W.T.1
  • 13
    • 84891482887 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang, J., Mani, S. A., Donaher, J. L, Ramaswamy, S. et al., Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004, 11, 7927-7939.
    • (2004) Cell , vol.11 , pp. 7927-7939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3    Ramaswamy, S.4
  • 14
    • 79952499030 scopus 로고    scopus 로고
    • Twist1-induced invadopodia formation promotes tumor metastasis
    • Eckert, M. A., Lwin, T. M., Chang, A. T., Kim, J. et al., Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 2011, 19, 372-386.
    • (2011) Cancer Cell , vol.19 , pp. 372-386
    • Eckert, M.A.1    Lwin, T.M.2    Chang, A.T.3    Kim, J.4
  • 15
    • 78449234396 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion
    • Bourguignon, L. Y., Wong, G., Earle, C., Krueger, K., Spevak, C. C., Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion. J. Biol. Chem. 2010, 285, 36721-36735.
    • (2010) J. Biol. Chem. , vol.285 , pp. 36721-36735
    • Bourguignon, L.Y.1    Wong, G.2    Earle, C.3    Krueger, K.4    Spevak, C.C.5
  • 16
    • 33645507413 scopus 로고    scopus 로고
    • Dynamic interactions of cortactin and membrane type 1 metalloproteinase at invadopodia: defining the stages of invadopodia formation and function
    • Artym, V. V., Zhang, Y., Seillier-Moiseiwitsch, F., Yamada, K. M., Mueller, S. C., Dynamic interactions of cortactin and membrane type 1 metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res. 2006, 66, 3034-3043.
    • (2006) Cancer Res , vol.66 , pp. 3034-3043
    • Artym, V.V.1    Zhang, Y.2    Seillier-Moiseiwitsch, F.3    Yamada, K.M.4    Mueller, S.C.5
  • 18
    • 33750036084 scopus 로고    scopus 로고
    • 6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant
    • Levy, A. S., Simon, O., Shelly, J., Gardener, M., 6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant. BMC Pharmacol. 2006, 6, 12-20.
    • (2006) BMC Pharmacol. , vol.6 , pp. 12-20
    • Levy, A.S.1    Simon, O.2    Shelly, J.3    Gardener, M.4
  • 19
    • 0032547010 scopus 로고    scopus 로고
    • Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice
    • Park, K. K., Chun, K. S., Lee, J. M., Lee, S. S., Surh, Y. J., Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett. 1998, 129, 139-144.
    • (1998) Cancer Lett , vol.129 , pp. 139-144
    • Park, K.K.1    Chun, K.S.2    Lee, J.M.3    Lee, S.S.4    Surh, Y.J.5
  • 20
    • 33846394444 scopus 로고    scopus 로고
    • The effect of extracts from ginger rhizome on inflammatory mediator production
    • Lantz, R. C., Chen, G. J., Sarihan, M., Solyom, A. M. et al., The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine 2007, 14, 123-128.
    • (2007) Phytomedicine , vol.14 , pp. 123-128
    • Lantz, R.C.1    Chen, G.J.2    Sarihan, M.3    Solyom, A.M.4
  • 21
    • 48649093632 scopus 로고    scopus 로고
    • 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression
    • Pan, M. H., Hsieh, M. C., Kuo, J. M., Lai, C. S. et al., 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. Mol. Nutr. Food Res. 2008, 52, 527-537.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 527-537
    • Pan, M.H.1    Hsieh, M.C.2    Kuo, J.M.3    Lai, C.S.4
  • 22
    • 78349245958 scopus 로고    scopus 로고
    • Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells
    • Weng, C. J., Wu, C. F., Huang, H. W., Ho, C. T., Yen, G. C., Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. Mol. Nutr. Food Res. 2010, 54, 1618-1627.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 1618-1627
    • Weng, C.J.1    Wu, C.F.2    Huang, H.W.3    Ho, C.T.4    Yen, G.C.5
  • 23
    • 0030963473 scopus 로고    scopus 로고
    • Resveratrol: a molecule whose time has come? and gone?
    • Soleas, G. J., Diamandis, E. P., Goldberg, D. M., Resveratrol: a molecule whose time has come? and gone? Clin. Biochem. 1997, 30, 91-113.
    • (1997) Clin. Biochem. , vol.30 , pp. 91-113
    • Soleas, G.J.1    Diamandis, E.P.2    Goldberg, D.M.3
  • 24
    • 19944410516 scopus 로고    scopus 로고
    • Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters
    • Rimando, A. M., Nagmani, R., Feller, D. R., Yokoyama, W., Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J. Agric. Food Chem. 2005, 53, 3403-3407.
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 3403-3407
    • Rimando, A.M.1    Nagmani, R.2    Feller, D.R.3    Yokoyama, W.4
  • 25
    • 79953269714 scopus 로고    scopus 로고
    • Suppression of Heregulin-{beta}1/HER2-modulated invasive and aggressive phenotype of breast carcinoma by pterostilbene via inhibition of matrix metalloproteinase-9, p38 kinase Cascade and Akt activation
    • Pan, M. H., Lin, Y. T., Lin, C. L., Wei, C. S. et al., Suppression of Heregulin-{beta}1/HER2-modulated invasive and aggressive phenotype of breast carcinoma by pterostilbene via inhibition of matrix metalloproteinase-9, p38 kinase Cascade and Akt activation. Evid. Based Complement Alternat. Med. 2011, 1-12.
    • (2011) Evid. Based Complement Alternat. Med. , pp. 1-12
    • Pan, M.H.1    Lin, Y.T.2    Lin, C.L.3    Wei, C.S.4
  • 26
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 27
    • 77952625527 scopus 로고    scopus 로고
    • Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling
    • Yeh, C. T., Wu, C. H., Yen, G. C., Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. Mol. Nutr. Food Res. 2010, 54, 1285-1295.
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 1285-1295
    • Yeh, C.T.1    Wu, C.H.2    Yen, G.C.3
  • 28
    • 77949367262 scopus 로고    scopus 로고
    • Evaluation of anti-invasion effect of resveratrol and related methoxy analogues on human hepatocarcinoma cells
    • Weng, C. J., Wu, C. F., Huang, H. W., Wu, C. H. et al., Evaluation of anti-invasion effect of resveratrol and related methoxy analogues on human hepatocarcinoma cells. J. Agric. Food Chem. 2010, 58, 2886-2894.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 2886-2894
    • Weng, C.J.1    Wu, C.F.2    Huang, H.W.3    Wu, C.H.4
  • 29
    • 38849178686 scopus 로고    scopus 로고
    • Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1
    • Weng, C. J., Chau, C. F., Hsieh, Y. S., Yang, S. F., Yen, G. C., Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1. Carcinogenesis 2008, 29, 147-156.
    • (2008) Carcinogenesis , vol.29 , pp. 147-156
    • Weng, C.J.1    Chau, C.F.2    Hsieh, Y.S.3    Yang, S.F.4    Yen, G.C.5
  • 30
    • 78649411147 scopus 로고    scopus 로고
    • 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation
    • Ling, H., Yang, H., Tan, S. H., Chui, W. K., Chew, E. H., 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Br. J. Pharmacol. 2010, 161, 1763-1777.
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 1763-1777
    • Ling, H.1    Yang, H.2    Tan, S.H.3    Chui, W.K.4    Chew, E.H.5
  • 31
    • 78149299411 scopus 로고    scopus 로고
    • Pterostilbene and tamoxifen show an additive effect against breast cancer in vitro
    • Mannal, P., McDonald, D., McFadden, D., Pterostilbene and tamoxifen show an additive effect against breast cancer in vitro. Am. J. Surg. 2010, 200, 577-580.
    • (2010) Am. J. Surg. , vol.200 , pp. 577-580
    • Mannal, P.1    McDonald, D.2    McFadden, D.3
  • 32
    • 77951938665 scopus 로고    scopus 로고
    • Pterostilbene inhibits breast cancer in vitro through mitochondrial depolarization and induction of caspase-dependent apoptosis
    • Alosi, J. A., McDonald, D. E., Schneider, J. S., Privette, A. R., McFadden, D. W., Pterostilbene inhibits breast cancer in vitro through mitochondrial depolarization and induction of caspase-dependent apoptosis. J. Surg. Res. 2010, 161, 195-201.
    • (2010) J. Surg. Res , vol.161 , pp. 195-201
    • Alosi, J.A.1    McDonald, D.E.2    Schneider, J.S.3    Privette, A.R.4    McFadden, D.W.5
  • 33
    • 77953531884 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231
    • Sen, T., Dutta, A., Chatterjee, A., Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231. Anticancer Drugs 2010, 21, 632-644.
    • (2010) Anticancer Drugs , vol.21 , pp. 632-644
    • Sen, T.1    Dutta, A.2    Chatterjee, A.3
  • 34
    • 0036323896 scopus 로고    scopus 로고
    • Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator inhibitor type 1, and tissue metalloproteinase inhibitor type 1 gene expressions in primary breast cancer
    • Castelló, R., Estellés, A., Vázquez, C., Falcó, C. et al., Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator inhibitor type 1, and tissue metalloproteinase inhibitor type 1 gene expressions in primary breast cancer. Clin. Chem. 2002, 48, 1288-1295.
    • (2002) Clin. Chem. , vol.48 , pp. 1288-1295
    • Castelló, R.1    Estellés, A.2    Vázquez, C.3    Falcó, C.4
  • 35
    • 84862833208 scopus 로고    scopus 로고
    • Targeting invadopodia to block breast cancer metastasis
    • Eckert, M. A., Yang, J., Targeting invadopodia to block breast cancer metastasis. Oncotarget 2011, 2, 562-568.
    • (2011) Oncotarget , vol.2 , pp. 562-568
    • Eckert, M.A.1    Yang, J.2
  • 36
    • 19344366798 scopus 로고    scopus 로고
    • Gelatinase-mediated migration and invasion of cancer cells
    • Björklund, M., Koivunen, E., Gelatinase-mediated migration and invasion of cancer cells. Biochim. Biophys. Acta 2005, 1755, 37-69.
    • (2005) Biochim. Biophys. Acta , vol.1755 , pp. 37-69
    • Björklund, M.1    Koivunen, E.2
  • 37
    • 41849124923 scopus 로고    scopus 로고
    • 6-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells
    • Lee, H. S., Seo, E. Y., Kang, N. E., Kim, W. K., 6-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J. Nutr. Biochem. 2008, 19, 313-319.
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 313-319
    • Lee, H.S.1    Seo, E.Y.2    Kang, N.E.3    Kim, W.K.4
  • 38
    • 54049152086 scopus 로고    scopus 로고
    • Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects
    • Zick, S. M., Djuric, Z., Ruffin, M. T., Litzinger, A. J. et al., Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidem Biomar 2008, 17, 1930-1936.
    • (2008) Cancer Epidem Biomar , vol.17 , pp. 1930-1936
    • Zick, S.M.1    Djuric, Z.2    Ruffin, M.T.3    Litzinger, A.J.4
  • 39
    • 70449103478 scopus 로고    scopus 로고
    • Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry
    • Tao, Y., Li, W., Liang, W., Van Breemen, R. B., Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry. J. Agric. Food Chem. 2009, 57, 10014-10021.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 10014-10021
    • Tao, Y.1    Li, W.2    Liang, W.3    Van Breemen, R.B.4
  • 40
    • 80054014686 scopus 로고    scopus 로고
    • Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats
    • Kapetanovic, I. M., Muzzio, M., Huang, Z., Thompson, T. N., McCormick, D. L., Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemother. Pharmacol. 2011, 68, 593-601.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , pp. 593-601
    • Kapetanovic, I.M.1    Muzzio, M.2    Huang, Z.3    Thompson, T.N.4    McCormick, D.L.5
  • 41
    • 80052594368 scopus 로고    scopus 로고
    • Examination of the pharmacokinetics of active ingredients of ginger in humans
    • Yu, Y., Zick, S., Li, X., Zou, P. et al., Examination of the pharmacokinetics of active ingredients of ginger in humans. AAPS J. 2011, 13, 417-426.
    • (2011) AAPS J. , vol.13 , pp. 417-426
    • Yu, Y.1    Zick, S.2    Li, X.3    Zou, P.4
  • 42
    • 59849106109 scopus 로고    scopus 로고
    • Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats
    • Jiang, S. Z., Wang, N. S., Mi, S. Q., Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats. Biopharm. Drug Dispos. 2008, 29, 529-537.
    • (2008) Biopharm. Drug Dispos. , vol.29 , pp. 529-537
    • Jiang, S.Z.1    Wang, N.S.2    Mi, S.Q.3
  • 43
    • 84863385553 scopus 로고    scopus 로고
    • Metabolism of [6]-shogaol in mice and in cancer cells
    • Chen, H., Lv, L., Soroka, D., Warin, R. F. et al., Metabolism of [6]-shogaol in mice and in cancer cells. Drug Metab. Dispos. 2012, 40, 742-753.
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 742-753
    • Chen, H.1    Lv, L.2    Soroka, D.3    Warin, R.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.