메뉴 건너뛰기




Volumn 8, Issue 4, 2013, Pages

PPAR Agonist-Induced Reduction of Mcp1 in Atherosclerotic Plaques of Obese, Insulin-Resistant Mice Depends on Adiponectin-Induced Irak3 Expression

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FENOFIBRATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLACEBO; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE;

EID: 84876429730     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062253     Document Type: Article
Times cited : (34)

References (46)
  • 1
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS, (2006) Inflammation and metabolic disorders. Nature 444: 860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 2
    • 77951940786 scopus 로고    scopus 로고
    • The vicious circle between oxidative stress and inflammation in atherosclerosis
    • Hulsmans M, Holvoet P, (2010) The vicious circle between oxidative stress and inflammation in atherosclerosis. J.Cell Mol.Med. 14: 70-78.
    • (2010) J.Cell Mol.Med , vol.14 , pp. 70-78
    • Hulsmans, M.1    Holvoet, P.2
  • 3
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J.Clin.Invest 112: 1796-1808.
    • (2003) J.Clin.Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    McCann, D.2    Desai, M.3    Rosenbaum, M.4    Leibel, R.L.5
  • 4
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, et al. (2007) Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447: 1116-1120.
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth, M.H.3    Morel, C.R.4    Subramanian, V.5
  • 5
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, et al. (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J.Clin.Invest 116: 1784-1792.
    • (2006) J.Clin.Invest , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5
  • 6
    • 0034891684 scopus 로고    scopus 로고
    • Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin
    • Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, et al. (2001) Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J.Clin.Endocrinol.Metab 86: 3815-3819.
    • (2001) J.Clin.Endocrinol.Metab , vol.86 , pp. 3815-3819
    • Yang, W.S.1    Lee, W.J.2    Funahashi, T.3    Tanaka, S.4    Matsuzawa, Y.5
  • 7
    • 0033516561 scopus 로고    scopus 로고
    • IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
    • Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, et al. (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. Journal of Biological Chemistry 274: 19403-19410.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 19403-19410
    • Wesche, H.1    Gao, X.2    Li, X.3    Kirschning, C.J.4    Stark, G.R.5
  • 10
    • 84855853767 scopus 로고    scopus 로고
    • Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome
    • Hulsmans M, Geeraert B, De Keyzer D, Mertens A, Lannoo M, et al. (2012) Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome. PLoS.ONE. 7: e30414.
    • (2012) PLoS.ONE , vol.7
    • Hulsmans, M.1    Geeraert, B.2    De Keyzer, D.3    Mertens, A.4    Lannoo, M.5
  • 12
    • 0035146515 scopus 로고    scopus 로고
    • Once- and twice-daily dosing with rosiglitazone improves glycemic control in patients with type 2 diabetes
    • Phillips LS, Grunberger G, Miller E, Patwardhan R, Rappaport EB, et al. (2001) Once- and twice-daily dosing with rosiglitazone improves glycemic control in patients with type 2 diabetes. Diabetes Care 24: 308-315.
    • (2001) Diabetes Care , vol.24 , pp. 308-315
    • Phillips, L.S.1    Grunberger, G.2    Miller, E.3    Patwardhan, R.4    Rappaport, E.B.5
  • 13
    • 81055143970 scopus 로고    scopus 로고
    • PPAR{gamma} attenuates intimal hyperplasia through inhibiting TLR4-mediated inflammation in vascular smooth muscle cells
    • Zhang LL, Gao CY, Fang CQ, Wang YJ, Gao D, et al. (2011) PPAR{gamma} attenuates intimal hyperplasia through inhibiting TLR4-mediated inflammation in vascular smooth muscle cells. Cardiovascular Research 92: 484-493.
    • (2011) Cardiovascular Research , vol.92 , pp. 484-493
    • Zhang, L.L.1    Gao, C.Y.2    Fang, C.Q.3    Wang, Y.J.4    Gao, D.5
  • 14
    • 40049089939 scopus 로고    scopus 로고
    • Beneficial effects of rosiglitazone on novel cardiovascular risk factors in patients with Type 2 diabetes mellitus
    • Kadoglou NP, Iliadis F, Angelopoulou N, Perrea D, Liapis CD, et al. (2008) Beneficial effects of rosiglitazone on novel cardiovascular risk factors in patients with Type 2 diabetes mellitus. Diabetic Medicine 25: 333-340.
    • (2008) Diabetic Medicine , vol.25 , pp. 333-340
    • Kadoglou, N.P.1    Iliadis, F.2    Angelopoulou, N.3    Perrea, D.4    Liapis, C.D.5
  • 15
    • 0033520304 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
    • Delerive P, Martin-Nizard F, Chinetti G, Trottein F, Fruchart JC, et al. (1999) Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ.Res. 85: 394-402.
    • (1999) Circ.Res , vol.85 , pp. 394-402
    • Delerive, P.1    Martin-Nizard, F.2    Chinetti, G.3    Trottein, F.4    Fruchart, J.C.5
  • 16
    • 0037380627 scopus 로고    scopus 로고
    • Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis
    • Mertens A, Verhamme P, Bielicki JK, Phillips MC, Quarck R, et al. (2003) Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis. Circulation 107: 1640-1646.
    • (2003) Circulation , vol.107 , pp. 1640-1646
    • Mertens, A.1    Verhamme, P.2    Bielicki, J.K.3    Phillips, M.C.4    Quarck, R.5
  • 17
    • 20844439184 scopus 로고    scopus 로고
    • Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice
    • Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, et al. (2004) Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice. Circulation 110: 3259-3269.
    • (2004) Circulation , vol.110 , pp. 3259-3269
    • Verreth, W.1    De Keyzer, D.2    Pelat, M.3    Verhamme, P.4    Ganame, J.5
  • 18
    • 36348998076 scopus 로고    scopus 로고
    • Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis
    • Taleb S, Herbin O, Ait-Oufella H, Verreth W, Gourdy P, et al. (2007) Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 27: 2691-2698.
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , pp. 2691-2698
    • Taleb, S.1    Herbin, O.2    Ait-Oufella, H.3    Verreth, W.4    Gourdy, P.5
  • 19
    • 34249697077 scopus 로고    scopus 로고
    • Rosuvastatin restores superoxide dismutase expression and inhibits accumulation of oxidized LDL in the aortic arch of obese dyslipidemic mice
    • Verreth W, De Keyzer D, Davey PC, Geeraert B, Mertens A, et al. (2007) Rosuvastatin restores superoxide dismutase expression and inhibits accumulation of oxidized LDL in the aortic arch of obese dyslipidemic mice. British Journal of Pharmacology 151: 347-355.
    • (2007) British Journal of Pharmacology , vol.151 , pp. 347-355
    • Verreth, W.1    De Keyzer, D.2    Davey, P.C.3    Geeraert, B.4    Mertens, A.5
  • 20
    • 77949541015 scopus 로고    scopus 로고
    • Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice
    • Geeraert B, Crombe F, Hulsmans M, Benhabiles N, Geuns JM, et al. (2010) Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice. Int.J.Obes.(Lond) 34: 569-577.
    • (2010) Int.J.Obes.(Lond) , vol.34 , pp. 569-577
    • Geeraert, B.1    Crombe, F.2    Hulsmans, M.3    Benhabiles, N.4    Geuns, J.M.5
  • 21
    • 0037372687 scopus 로고    scopus 로고
    • Nitric oxide partially controls Coxiella burnetii phase II infection in mouse primary macrophages
    • Zamboni DS, Rabinovitch M, (2003) Nitric oxide partially controls Coxiella burnetii phase II infection in mouse primary macrophages. Infect.Immun. 71: 1225-1233.
    • (2003) Infect.Immun , vol.71 , pp. 1225-1233
    • Zamboni, D.S.1    Rabinovitch, M.2
  • 22
    • 0029048270 scopus 로고
    • Granulocyte/macrophage colony-stimulating factor is expressed and secreted in cultures of murine L929 cells
    • Englen MD, Valdez YE, Lehnert NM, Lehnert BE, (1995) Granulocyte/macrophage colony-stimulating factor is expressed and secreted in cultures of murine L929 cells. J.Immunol.Methods 184: 281-283.
    • (1995) J.Immunol.Methods , vol.184 , pp. 281-283
    • Englen, M.D.1    Valdez, Y.E.2    Lehnert, N.M.3    Lehnert, B.E.4
  • 23
    • 34547492488 scopus 로고    scopus 로고
    • PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties
    • Bouhlel MA, Derudas B, Rigamonti E, Dievart R, Brozek J, et al. (2007) PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab 6: 137-143.
    • (2007) Cell Metab , vol.6 , pp. 137-143
    • Bouhlel, M.A.1    Derudas, B.2    Rigamonti, E.3    Dievart, R.4    Brozek, J.5
  • 24
    • 0036314839 scopus 로고    scopus 로고
    • Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size
    • Wayman NS, Hattori Y, McDonald MC, Mota-Filipe H, Cuzzocrea S, et al. (2002) Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB Journal 16: 1027-1040.
    • (2002) FASEB Journal , vol.16 , pp. 1027-1040
    • Wayman, N.S.1    Hattori, Y.2    McDonald, M.C.3    Mota-Filipe, H.4    Cuzzocrea, S.5
  • 26
    • 0037031267 scopus 로고    scopus 로고
    • Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus
    • Haffner SM, Greenberg AS, Weston WM, Chen H, Williams K, et al. (2002) Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 106: 679-684.
    • (2002) Circulation , vol.106 , pp. 679-684
    • Haffner, S.M.1    Greenberg, A.S.2    Weston, W.M.3    Chen, H.4    Williams, K.5
  • 27
    • 0036517747 scopus 로고    scopus 로고
    • Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes
    • Chu NV, Kong AP, Kim DD, Armstrong D, Baxi S, et al. (2002) Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes. Diabetes Care 25: 542-549.
    • (2002) Diabetes Care , vol.25 , pp. 542-549
    • Chu, N.V.1    Kong, A.P.2    Kim, D.D.3    Armstrong, D.4    Baxi, S.5
  • 28
    • 33646690228 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha,gamma-agonist improves insulin sensitivity and prevents loss of left ventricular function in obese dyslipidemic mice
    • Verreth W, Ganame J, Mertens A, Bernar H, Herregods MC, et al. (2006) Peroxisome proliferator-activated receptor-alpha,gamma-agonist improves insulin sensitivity and prevents loss of left ventricular function in obese dyslipidemic mice. Arteriosclerosis, Thrombosis, and Vascular Biology 26: 922-928.
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , pp. 922-928
    • Verreth, W.1    Ganame, J.2    Mertens, A.3    Bernar, H.4    Herregods, M.C.5
  • 29
    • 4243645912 scopus 로고    scopus 로고
    • Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization
    • Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, et al. (2002) Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 143: 998-1007.
    • (2002) Endocrinology , vol.143 , pp. 998-1007
    • Combs, T.P.1    Wagner, J.A.2    Berger, J.3    Doebber, T.4    Wang, W.J.5
  • 30
    • 0037677767 scopus 로고    scopus 로고
    • Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors
    • Iwaki M, Matsuda M, Maeda N, Funahashi T, Matsuzawa Y, et al. (2003) Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52: 1655-1663.
    • (2003) Diabetes , vol.52 , pp. 1655-1663
    • Iwaki, M.1    Matsuda, M.2    Maeda, N.3    Funahashi, T.4    Matsuzawa, Y.5
  • 31
    • 84876453239 scopus 로고    scopus 로고
    • Role of Adiponectin in the metabolic syndrome: current perspectives on its modulation as a treatment strategy
    • doi:CPD-EPUB-20130220-9
    • Padmalayam I, Suto M (2013) Role of Adiponectin in the metabolic syndrome: current perspectives on its modulation as a treatment strategy. Curr.Pharm.Des doi:CPD-EPUB-20130220-9.
    • (2013) Curr.Pharm.Des
    • Padmalayam, I.1    Suto, M.2
  • 32
    • 84873738842 scopus 로고    scopus 로고
    • Adiponectin Regulates Vascular Endothelial Growth Factor-C Expression in Macrophages via Syk-ERK Pathway
    • Hu D, Fukuhara A, Miyata Y, Yokoyama C, Otsuki M, et al. (2013) Adiponectin Regulates Vascular Endothelial Growth Factor-C Expression in Macrophages via Syk-ERK Pathway. PLoS.ONE. 8: e56071.
    • (2013) PLoS.ONE , vol.8
    • Hu, D.1    Fukuhara, A.2    Miyata, Y.3    Yokoyama, C.4    Otsuki, M.5
  • 33
    • 76349098660 scopus 로고    scopus 로고
    • Adiponectin: an indispensable molecule in rosiglitazone cardioprotection following myocardial infarction
    • Tao L, Wang Y, Gao E, Zhang H, Yuan Y, et al. (2010) Adiponectin: an indispensable molecule in rosiglitazone cardioprotection following myocardial infarction. Circulation Research 106: 409-417.
    • (2010) Circulation Research , vol.106 , pp. 409-417
    • Tao, L.1    Wang, Y.2    Gao, E.3    Zhang, H.4    Yuan, Y.5
  • 34
    • 79960018147 scopus 로고    scopus 로고
    • Adiponectin is required for PPARgamma-mediated improvement of endothelial function in diabetic mice
    • Wong WT, Tian XY, Xu A, Yu J, Lau CW, et al. (2011) Adiponectin is required for PPARgamma-mediated improvement of endothelial function in diabetic mice. Cell Metab 14: 104-115.
    • (2011) Cell Metab , vol.14 , pp. 104-115
    • Wong, W.T.1    Tian, X.Y.2    Xu, A.3    Yu, J.4    Lau, C.W.5
  • 35
    • 34248571041 scopus 로고    scopus 로고
    • Adiponectin is associated with improvement of endothelial function after rosiglitazone treatment in non-diabetic individuals with metabolic syndrome
    • Bahia L, Aguiar LG, Villela N, Bottino D, Godoy-Matos AF, et al. (2007) Adiponectin is associated with improvement of endothelial function after rosiglitazone treatment in non-diabetic individuals with metabolic syndrome. Atherosclerosis 195: 138-146.
    • (2007) Atherosclerosis , vol.195 , pp. 138-146
    • Bahia, L.1    Aguiar, L.G.2    Villela, N.3    Bottino, D.4    Godoy-Matos, A.F.5
  • 36
    • 79957627922 scopus 로고    scopus 로고
    • TGF-beta-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth
    • Standiford TJ, Kuick R, Bhan U, Chen J, Newstead M, et al. (2011) TGF-beta-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth. Oncogene 30: 2475-2484.
    • (2011) Oncogene , vol.30 , pp. 2475-2484
    • Standiford, T.J.1    Kuick, R.2    Bhan, U.3    Chen, J.4    Newstead, M.5
  • 37
    • 84871914561 scopus 로고    scopus 로고
    • Endogenous IRAK-M Attenuates Postinfarction Remodeling Through Effects on Macrophages and Fibroblasts
    • Chen W, Saxena A, Li N, Sun J, Gupta A, et al. (2012) Endogenous IRAK-M Attenuates Postinfarction Remodeling Through Effects on Macrophages and Fibroblasts. Arteriosclerosis, Thrombosis, and Vascular Biology 32: 2598-2608.
    • (2012) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.32 , pp. 2598-2608
    • Chen, W.1    Saxena, A.2    Li, N.3    Sun, J.4    Gupta, A.5
  • 38
    • 77955486597 scopus 로고    scopus 로고
    • Rosiglitazone inhibits monocyte/macrophage adhesion through de novo adiponectin production in human monocytes
    • Tsai JS, Chen CY, Chen YL, Chuang LM, (2010) Rosiglitazone inhibits monocyte/macrophage adhesion through de novo adiponectin production in human monocytes. J.Cell Biochem. 110: 1410-1419.
    • (2010) J.Cell Biochem , vol.110 , pp. 1410-1419
    • Tsai, J.S.1    Chen, C.Y.2    Chen, Y.L.3    Chuang, L.M.4
  • 39
    • 84867890016 scopus 로고    scopus 로고
    • Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers
    • Burgos-Ramos E, Sackmann-Sala L, Baquedano E, Cruz-Topete D, Barrios V, et al. (2012) Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers. Metabolism 61: 1646-1657.
    • (2012) Metabolism , vol.61 , pp. 1646-1657
    • Burgos-Ramos, E.1    Sackmann-Sala, L.2    Baquedano, E.3    Cruz-Topete, D.4    Barrios, V.5
  • 41
    • 13744249406 scopus 로고    scopus 로고
    • PPARgamma-mediated insulin sensitization: the importance of fat versus muscle
    • Kintscher U, Law RE, (2005) PPARgamma-mediated insulin sensitization: the importance of fat versus muscle. Am.J.Physiol Endocrinol.Metab 288: E287-E291.
    • (2005) Am.J.Physiol Endocrinol.Metab , vol.288
    • Kintscher, U.1    Law, R.E.2
  • 42
    • 0031813989 scopus 로고    scopus 로고
    • Effects of fenofibrate on plasma cytokine concentrations in patients with atherosclerosis and hyperlipoproteinemia IIb
    • Madej A, Okopien B, Kowalski J, Zielinski M, Wysocki J, et al. (1998) Effects of fenofibrate on plasma cytokine concentrations in patients with atherosclerosis and hyperlipoproteinemia IIb. Int.J Clin.Pharmacol.Ther. 36: 345-349.
    • (1998) Int.J Clin.Pharmacol.Ther , vol.36 , pp. 345-349
    • Madej, A.1    Okopien, B.2    Kowalski, J.3    Zielinski, M.4    Wysocki, J.5
  • 45
    • 78650824245 scopus 로고    scopus 로고
    • Evaluation of anti-atherosclerotic activities of PPAR-alpha, PPAR-gamma, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters
    • Srivastava RA, (2011) Evaluation of anti-atherosclerotic activities of PPAR-alpha, PPAR-gamma, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters. Atherosclerosis 214: 86-93.
    • (2011) Atherosclerosis , vol.214 , pp. 86-93
    • Srivastava, R.A.1
  • 46
    • 2242436246 scopus 로고    scopus 로고
    • Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice
    • Duez H, Chao YS, Hernandez M, Torpier G, Poulain P, et al. (2002) Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice. Journal of Biological Chemistry 277: 48051-48057.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 48051-48057
    • Duez, H.1    Chao, Y.S.2    Hernandez, M.3    Torpier, G.4    Poulain, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.