Expression of genes involved in retinoic acid biosynthesis in human gastric cancer

Molecular Biology

Volumn 47, Issue 2, 2013, Pages 280-292

  Kropotova, E S ^a   Zinov'eva, O L ^a   Zyryanova, A F ^a   Choinzonov, E L ^b   Afanas'ev, S G ^b   Cherdyntseva, N V ^b   Beresten', S F ^a   Oparina, N Yu ^a   Mashkova, T D ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b CANCER RESEARCH INSTITUTE   (Russian Federation)

Author keywords

all trans retinoic acid; biosynthesis of retinoic acid; gastric cancer; gene expression; retinal(dehyde); retinol

Indexed keywords

EID: 84876425271     PISSN: 00268933     EISSN: 16083245     Source Type: Journal    
DOI: 10.1134/S0026893313020076     Document Type: Article

References (51)

1. Blomhoff R., Blomhoff H. K. 2006. Overview of retinoid metabolism and function. J. Neurobiol. 66, 606-630.
2. Harrison E. H. 2012. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Biochim. Biophys. Acta. 1821, 70-77.
3. Napoli J. L. 2012. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim. Biophys. Acta. 1821, 152-167.
4. Kumar S., Sandell L. L., Trainor P. A., Koentgen F., Duester G. 2012. Alcohol and aldehyde dehydrogenases: Retinoid metabolic effects in mouse knockout models. Biochim. Biophys. Acta. 1821, 198-205.
5. Duester G., Farrés J., Felder M. R., Holmes R. S., Höög J. O., Parés X., Plapp B. V., Yin S. J., Jörnvall H. 1999. Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family. Biochem. Pharmacol. 58, 389-395.
6. Estonius M., Svensson S., Höög J.-O. 1996. Alcohol dehydrogenase in human tissues: Localization of transcripts coding for five classes of the enzyme. FEBS Lett. 397, 338-342.
7. Molotkov A., Deltour L., Foglio M. H., Cuenca A. E., Duester G. 2002. Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice. J. Biol. Chem. 277, 13804-13811.
8. Molotkov A., Fan X., Deltour L., Foglio M. H., Martras S., Farrés J., Parés X., Duester G. 2002. Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3. Proc. Natl. Acad. Sci. U. S. A. 99, 5337-5342.
9. Gallego O., Belyaeva O. V., Porté S., Ruiz F. X., Stetsenko A. V., Shabrova E. V., Kostereva N. V., Farrés J., Parés X., Kedishvili N. Y. 2006. Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases, and aldo-keto reductases with retinoids. Biochem. J. 399, 101-109.
10. Parés X., Farrés J., Kedishvili N., Duester G. 2008. Medium- and short-chain dehydrogenase/reductase gene and protein families: Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism. Cell. Mol. Life Sci. 65, 3936-3949.
11. Lidén M., Eriksson U. 2006. Understanding retinol metabolism: Structure and function of retinol dehydrogenases. J. Biol. Chem. 281, 13001-13004.
12. Kallberg Y., Oppermann U., Persson B. 2010. Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models. FEBS J. 277, 2375-2386.
13. Belyaeva O. V., Johnson M. P., Kedishvili N. Y. 2008. Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase. J. Biol. Chem. 28, 20299-20308.
14. Belyaeva O. V., Korkina O. V., Stetsenko A. V., Kim T., Nelson P. S., Kedishvili N. Y. 2005. Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): Catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids. Biochemistry. 44, 7035-7047.
15. Crosas B., Hyndman D. J., Gallego O., Martras S., Parés X., Flynn T. G., Farrés J. 2003. Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: Consequences for retinoid metabolism. Biochem. J. 373, 973-979.
16. Ross A. C., Zolfaghari R. 2011. Cytochrome P450s in the regulation of cellular retinoic acid metabolism. Annu. Rev. Nutr. 31, 65-87.
17. Jette C., Peterson P. W., Sandoval I. T., Manos E. J., Hadley E., Ireland C. M., Jones D. A. 2004. The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. J. Biol. Chem. 279, 34397-34405.
18. Pasquali D., Thaller C., Eichele G. 1996. Abnormal level of retinoic acid in prostate cancer tissues. J. Clin. Endocrinol. Metab. 81, 2186-2191.
19. Mira Y. L. R., Zheng W. L., Kuppumbatti Y. S., Rexer B., Jing Y., Ong D. E. 2000. Retinol conversion to retinoic acid is impaired in breast cancer cell lines relative to normal cells. J. Cell Physiol. 185, 302-309.
20. Williams S. J., Cvetkovic D., Hamilton T. C. 2009. Vitamin A metabolism is impaired in human ovarian cancer. Gynecol. Oncol. 112, 637-645.
21. Matsumoto M., Yokoyama H., Suzuki H., Shiraishi-Yokoyama H., Hibi T. 2005. Retinoic acid formation from retinol in the human gastric mucosa: Role of class IV alcohol dehydrogenase and its relevance to morphological changes. Am. J. Physiol. Gastrointest. Liver Physiol. 289, G429-433.
22. Jemal A., Bray F., Center M. M., Ferlay J., Ward E., Forman D. 2011. Global cancer statistics. CA Cancer J. Clin. 61, 69-90.
23. Davydov M. I., Aksel' E. M. 2011. Morbidity and mortality due to malignant neoplasms in Russia and CIS countries in 2009. Vestn. Ross. Onkol. Hauch. Tsentra im. N. N. Blokhina Ross. Akad. Med. Sci., 22, Suppl. 1, 54-123.
24. Yokoyama H., Matsumoto M., Shiraishi H., Miyagi M., Kato And S., Ishii H. 2001. Nicotinamide adenine dinucleotide-dependent retinoic acid formation from retinol in the human gastric mucosa: Inhibition by ethanol, acetaldehyde, and H2 blockers. Alcohol. Clin. Exp. Res. 25, 24S-28S.
25. Persson C., Sasazuki S., Inoue M., Kurahashi N., Iwasaki M., Miura T., Ye W., Tsugane S.; JPHC Study Group. 2008. Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: A nested case-control study. Carcinogenesis. 29, 1042-1048.
26. Larsson S. C., Bergkvist L., Näslund I., Rutegård J., Wolk A. 2007. Vitamin A, retinol, and carotenoids and the risk of gastric cancer: A prospective cohort study. Am. J. Clin. Nutr. 85, 497-503.
27. Rhodes D. R., Yu J., Shanker K., Deshpande N., Varambally R., Ghosh D., Barrette T., Pandey A., Chinnaiyan A. M. 2004. ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6, 1-6.
28. Manzeniuk O. Yu., Malakho S. G., Pekhov V. M., Kosorukova I. S., Poltaraus A. B. 2006. Characterization of the universal Russian reagent sets for real-time PCR and its application to molecular oncodiagnosis. Mol. Biol. (Moscow). 40, 305-311.
29. Zhang J. P., Chen X. Y., Li J. S. 2007. Effects of all-trans-retinoic on human gastric cancer cells BGC-823. J. Dig. Dis. 8, 29-34.
30. Fukumoto S., Yamauchi N., Moriguchi H., Hippo Y., Watanabe A., Shibahara J., Taniguchi H., Ishikawa S., Ito H., Yamamoto S., Iwanari H., Hironaka M., Ishikawa Y., Niki T., Sohara Y., Kodama T., Nishimura M., Fukayama M., Dosaka-Akita H., Aburatani H. 2005. Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas. Clin. Cancer Res. 11, 1776-1785.
31. Leclerc J., Courcot-Ngoubo Ngangue E., Cauffiez C., Allorge D., Pottier N., Lafitte J. J., Debaert M., Jaillard S., Broly F., Lo-Guidice J. M. 2011. Xenobiotic metabolism and disposition in human lung: Transcript profiling in non-tumoral and tumoral tissues. Biochimie. 93, 1012-1027.
32. Chiang C. P., Jao S. W., Lee S. P., Chen P. C., Chung C. C., Lee S. L., Nieh S., Yin S. J. 2012. Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: Association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer. Alcohol. 46, 37-49.
33. Zaitseva M., Vollenhoven B. J., Rogers P. A. 2007. Retinoic acid pathway genes show significantly altered expression in uterine fibroids when compared with normal myometrium. Mol. Hum. Reprod. 13, 577-585.
34. Ashla A. A., Hoshikawa Y., Tsuchiya H., Hashiguchi K., Enjoji M., Nakamuta M., Taketomi A., Maehara Y., Shomori K., Kurimasa A., Hisatome I., Ito H., Shiota G. 2010. Genetic analysis of expression profile involved in retinoid metabolism in non-alcoholic fatty liver disease. Hepatol. Res. 40, 594-604.
35. O'Shaughnessy P. J., Abel M., Charlton H. M., Hu B., Johnston H., Baker P. J. 2007. Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology. 148, 2914-2924.
36. Collins M. D., Eckhoff C., Chahoud I., Bochert G., Nau H. 1992. 4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse. Arch. Toxicol. 66, 652-659.
37. Chetyrkin S. V., Belyaeva O. V., Gough W. H., Kedishvili N. Y. 2001. Characterization of a novel type of human microsomal 3α-hydroxysteroid dehydrogenase: Unique tissue distribution and catalytic properties. J. Biol. Chem. 276, 22278-22286.
38. Wang J., Chai X., Eriksson U., Napoli J. L. 1999. Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue. Biochem. J. 338, 23-27.
39. Chase J. R., Poolman M. G., Fell D. A. 2009. Contribution of NADH increases to ethanol's inhibition of retinol oxidation by human ADH isoforms. Alcohol. Clin. Exp. Res. 33, 571-580.
40. Yin S. J., Chou C. F., Lai C. L., Lee S. L., Han C. L. 2003. Human class IV alcohol dehydrogenase: Kinetic mechanism, functional roles and medical relevance. Chem. Biol. Interact. 143/144, 219-227.
41. Molotkov A., Duester G. 2003. Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid. J. Biol. Chem. 278, 36085-36090.
42. Mashkova T. D., Oparina N. Yu., Zinov'eva O. L., Kropotova E. S., Dubovaya V. I., Poltaraus A. B., Fridman M. V., Kopantsev E. P., Vinogradova T. V., Zinov'eva M. V., Laktionov K. K., Kasymova O. T., Zborovskaya I. B., Sverdlov E. D., Kisselev L. L. 2006. Transcription of TIMP3, DAPK1, and AKR1B10 in squamous-cell lung cancer. Mol. Biol. (Moscow). 40, 945-951.
43. Scuric Z., Stain S. C., Anderson W. F., Hwang J. J. 1998. New member of aldose reductase family proteins over-expressed in human hepatocellular carcinoma. Hepatology. 27, 943-950.
44. Kropotova E. S., Tychko R. A., Zinov'eva O. L., Zyryanova A. F., Khankin S. L., Cherkes V. L., Aliev V. A., Beresten S. F., Oparina N. Yu., Mashkova T. D. 2010. Downregulation of AKR1B10 expression in colorectal cancer. Mol. Biol. (Moscow). 44, 216-222.
45. Martin H. J., Maser E. 2009. Role of human aldoketoreductase AKR1B10 in the protection against toxic aldehydes. Chem. Biol. Interact. 178, 145-150.
46. Westerlund M., Belin A. C., Felder M. R., Olson L., Galter D. 2007. High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease. FEBS J. 274, 1212-1223.
47. Roberts E. S., Vaz A. D. N., Coon M. J. 1992. Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal. Mol. Pharmacol. 41, 427-433.
48. Tang X. H., Gudas L. J. 2011. Retinoids, retinoic acid receptors, and cancer. Annu. Rev. Pathol. 6, 345-364.
49. Li J., Ng E. K., Ng Y. P., Wong C. Y., Yu J., Jin H., Cheng V. Y., Go M. Y., Cheung P. K., Ebert M. P., Tong J., To K. F., Chan F. K., Sung J. J., Ip N. Y., Leung W. K. 2009. Identification of retinoic acid-regulated nuclear matrix-associated protein as a novel regulator of gastric cancer. Br. J. Cancer. 101, 691-698.
50. Hu K. W., Chen F. H., Ge J. F., Cao L. Y., Li H. 2012. Retinoid receptors in gastric cancer: Expression and influence on prognosis. Asian Pac. J. Cancer Prev. 13, 1809-1817.
51. Jiang S. Y., Shen S. R., Shyu R. Y., Yu J. C., Harn H. J., Yeh M. Y., Lee M. M., Chang Y. C. 1999. Expression of nuclear retinoid receptors in normal, premalignant and malignant gastric tissues determined by in situ hybridization. Br. J. Cancer. 80, 206-214.