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Volumn 43, Issue 4, 2013, Pages 1074-1084

Early divergence of Th1 and Th2 transcriptomes involves a small core response and sets of transiently expressed genes

Author keywords

Cellular activation; Gene regulation; Microarray; Th cells

Indexed keywords

MESSENGER RNA; TRANSCRIPTOME;

EID: 84876424586     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242979     Document Type: Article
Times cited : (9)

References (50)
  • 1
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta' reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B. et al., Transforming growth factor-beta' reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat. Immunol. 2008. 9: 1341-1346.
    • (2008) Nat. Immunol. , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    van Snick, J.3    Helmby, H.4    Westendorf, A.5    Buer, J.6    Martin, B.7
  • 2
    • 72849131815 scopus 로고    scopus 로고
    • Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    • Eyerich, S., Eyerich, K., Pennino, D., Carbone, T., Nasorri, F., Pallotta, S., Cianfarani, F. et al., Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J. Clin. Invest. 2009. 119: 3573-3585.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3573-3585
    • Eyerich, S.1    Eyerich, K.2    Pennino, D.3    Carbone, T.4    Nasorri, F.5    Pallotta, S.6    Cianfarani, F.7
  • 3
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations
    • Zhu, J., Yamane, H. and Paul, W. E., Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol. 2010. 28: 445-489.
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 4
    • 33646196946 scopus 로고    scopus 로고
    • Regulation of Th2 differentiation and Il4 locus accessibility
    • Ansel, K. M., Djuretic, I., Tanasa, B. and Rao, A., Regulation of Th2 differentiation and Il4 locus accessibility. Annu. Rev. Immunol. 2006. 24: 607-656.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 607-656
    • Ansel, K.M.1    Djuretic, I.2    Tanasa, B.3    Rao, A.4
  • 5
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
    • Heinzel, F. P., Sadick, M. D., Holaday, B. J., Coffman, R. L. and Locksley, R. M., Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 1989. 169: 59-72.
    • (1989) J. Exp. Med. , vol.169 , pp. 59-72
    • Heinzel, F.P.1    Sadick, M.D.2    Holaday, B.J.3    Coffman, R.L.4    Locksley, R.M.5
  • 6
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A. K., Murphy, K. M. and Sher, A., Functional diversity of helper T lymphocytes. Nature 1996. 383: 787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 7
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver, C. T., Hatton, R. D., Mangan, P. R. and Harrington, L. E., IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 2007. 25: 821-852.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 8
    • 84856226311 scopus 로고    scopus 로고
    • Expanding roles for CD4(+) T cells in immunity to viruses
    • Swain, S. L., McKinstry, K. K. and Strutt, T. M., Expanding roles for CD4(+) T cells in immunity to viruses. Nat. Rev. Immunol. 2012. 12: 136-148.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 136-148
    • Swain, S.L.1    McKinstry, K.K.2    Strutt, T.M.3
  • 12
    • 0029664574 scopus 로고    scopus 로고
    • Respiratory synctial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern
    • Waris, M. E., Tsou, C., Erdman, D. D., Zaki, S. R. and Anderson, L. J., Respiratory synctial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern. J. Virol. 1996. 70: 2852-2860.
    • (1996) J. Virol. , vol.70 , pp. 2852-2860
    • Waris, M.E.1    Tsou, C.2    Erdman, D.D.3    Zaki, S.R.4    Anderson, L.J.5
  • 13
    • 0036828165 scopus 로고    scopus 로고
    • Immunization of macaques with formalin-inactivated respiratory syncytial virus (RSV) induces interleukin-13-associated hypersensitivity to subsequent RSV infection
    • de Swart, R. L., Kuiken, T., Timmerman, H. H., van Amerongen, G., van den Hoogen, B. G., Vos, H. W., Neijens, H. J. et al., Immunization of macaques with formalin-inactivated respiratory syncytial virus (RSV) induces interleukin-13-associated hypersensitivity to subsequent RSV infection. J. Virol. 2002. 76: 11561-11569.
    • (2002) J. Virol. , vol.76 , pp. 11561-11569
    • de Swart, R.L.1    Kuiken, T.2    Timmerman, H.H.3    van Amerongen, G.4    van den Hoogen, B.G.5    Vos, H.W.6    Neijens, H.J.7
  • 14
    • 70350472844 scopus 로고    scopus 로고
    • The application of genomics to emerging zoonotic viral diseases
    • Haagmans, B. L., Andeweg, A. C. and Osterhaus, A. D. M. E., The application of genomics to emerging zoonotic viral diseases. PLoS Pathog. 2009. 5: 461-466.
    • (2009) PLoS Pathog. , vol.5 , pp. 461-466
    • Haagmans, B.L.1    Andeweg, A.C.2    Osterhaus, A.D.M.E.3
  • 15
    • 33947207887 scopus 로고    scopus 로고
    • Genome-wide identification of novel genes involved in early Th1 and Th2 cell differentiation
    • Lund, R. J., Löytömäki, M., Naumanen, T., Dixon, C., Chen, Z., Ahlfors, H., Tuomela, S. et al., Genome-wide identification of novel genes involved in early Th1 and Th2 cell differentiation. J. Immunol. 2007. 178: 3648-3660.
    • (2007) J. Immunol. , vol.178 , pp. 3648-3660
    • Lund, R.J.1    Löytömäki, M.2    Naumanen, T.3    Dixon, C.4    Chen, Z.5    Ahlfors, H.6    Tuomela, S.7
  • 16
    • 58149214356 scopus 로고    scopus 로고
    • Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    • Wei, G., Wei, L., Zhu, J., Zang, C., Hu-Li, J., Yao, Z., Cui, K. et al., Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 2009. 30: 155-167.
    • (2009) Immunity , vol.30 , pp. 155-167
    • Wei, G.1    Wei, L.2    Zhu, J.3    Zang, C.4    Hu-Li, J.5    Yao, Z.6    Cui, K.7
  • 17
    • 77953881949 scopus 로고    scopus 로고
    • Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
    • Elo, L. L., Järvenpää, H., Tuomela, S., Raghav, S., Ahlfors, H., Laurila, K., Gupta, B. et al., Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity 2010. 32: 852-862.
    • (2010) Immunity , vol.32 , pp. 852-862
    • Elo, L.L.1    Järvenpää, H.2    Tuomela, S.3    Raghav, S.4    Ahlfors, H.5    Laurila, K.6    Gupta, B.7
  • 18
    • 0344806280 scopus 로고    scopus 로고
    • Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression
    • Richter, A., Löhning, M. and Radbruch, A., Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression. J. Exp. Med. 1999. 190: 1439-1450.
    • (1999) J. Exp. Med. , vol.190 , pp. 1439-1450
    • Richter, A.1    Löhning, M.2    Radbruch, A.3
  • 19
    • 0032482996 scopus 로고    scopus 로고
    • Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation
    • Gett, A. V. and Hodgkin, P. D., Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation. Proc. Natl. Acad. Sci. USA 1998. 95: 9488-9493.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9488-9493
    • Gett, A.V.1    Hodgkin, P.D.2
  • 20
    • 0029617259 scopus 로고
    • Sequential production of Thl and Th2 cytokines in response to live bacillus
    • Sander, B., Hakansson, L. and Andersson, J., Sequential production of Thl and Th2 cytokines in response to live bacillus. Immunology 1995. 86: 512-518.
    • (1995) Immunology , vol.86 , pp. 512-518
    • Sander, B.1    Hakansson, L.2    Andersson, J.3
  • 21
    • 0029822291 scopus 로고    scopus 로고
    • Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches
    • Nakagawa, I., Takahashi, I., Kiyono, H., McGhee, J. R. and Hamada, S., Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches. J. Infect. Dis. 1996. 173: 1428-1436.
    • (1996) J. Infect. Dis. , vol.173 , pp. 1428-1436
    • Nakagawa, I.1    Takahashi, I.2    Kiyono, H.3    McGhee, J.R.4    Hamada, S.5
  • 22
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article3.
    • Smyth, G. K., Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 2004. 3: Article3.
    • (2004) Stat. Appl. Genet. Mol. Biol. , vol.3
    • Smyth, G.K.1
  • 23
    • 11244346557 scopus 로고    scopus 로고
    • Variance stabilization applied to microarray data calibration and to the quantification of differential expression
    • Huber, W., von Heydebreck, A., Sültmann, H., Poustka, A. and Vingron, M., Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 2002. 18(Suppl 1): S96-S104.
    • (2002) Bioinformatics , vol.18 , Issue.SUPPL. 1
    • Huber, W.1    von Heydebreck, A.2    Sültmann, H.3    Poustka, A.4    Vingron, M.5
  • 24
    • 77953917067 scopus 로고    scopus 로고
    • Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation
    • Wei, L., Vahedi, G., Sun, H. W., Watford, W. T., Takatori, H., Ramos, H. L., Takahashi, H. et al., Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity 2010. 32: 840-851.
    • (2010) Immunity , vol.32 , pp. 840-851
    • Wei, L.1    Vahedi, G.2    Sun, H.W.3    Watford, W.T.4    Takatori, H.5    Ramos, H.L.6    Takahashi, H.7
  • 25
    • 80051885764 scopus 로고    scopus 로고
    • Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types
    • Wei, G., Abraham, B. J., Yagi, R., Jothi, R., Cui, K., Sharma, S., Narlikar, L. et al., Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 2011. 35: 299-311.
    • (2011) Immunity , vol.35 , pp. 299-311
    • Wei, G.1    Abraham, B.J.2    Yagi, R.3    Jothi, R.4    Cui, K.5    Sharma, S.6    Narlikar, L.7
  • 26
    • 77956878307 scopus 로고    scopus 로고
    • Identification of helper T cell master regulator candidates using the polar score method
    • van den Ham, H. J., de Waal, L., Andeweg, A. C. and de Boer, R. J., Identification of helper T cell master regulator candidates using the polar score method. J. Immunol. Methods 2010. 361: 98-109.
    • (2010) J. Immunol. Methods , vol.361 , pp. 98-109
    • van den Ham, H.J.1    de Waal, L.2    Andeweg, A.C.3    de Boer, R.J.4
  • 27
    • 78650634605 scopus 로고    scopus 로고
    • Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C
    • DeKoter, R. P., Geadah, M., Khoosal, S., Xu, L. S., Thillainadesan, G., Torchia, J., Chin, S. S. et al., Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C. J. Immunol. 2010. 185: 7374-7384.
    • (2010) J. Immunol. , vol.185 , pp. 7374-7384
    • DeKoter, R.P.1    Geadah, M.2    Khoosal, S.3    Xu, L.S.4    Thillainadesan, G.5    Torchia, J.6    Chin, S.S.7
  • 28
    • 66049147305 scopus 로고    scopus 로고
    • Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor
    • Chuang, K. H., Altuwaijri, S., Li, G., Lai, J. J., Chu, C. Y., Lai, K. P., Lin, H. Y. et al., Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor. J. Exp. Med. 2009. 206: 1181-1199.
    • (2009) J. Exp. Med. , vol.206 , pp. 1181-1199
    • Chuang, K.H.1    Altuwaijri, S.2    Li, G.3    Lai, J.J.4    Chu, C.Y.5    Lai, K.P.6    Lin, H.Y.7
  • 30
    • 79956081339 scopus 로고    scopus 로고
    • The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
    • Ise, W., Kohyama, M., Schraml, B. U., Zhang, T., Schwer, B., Basu, U., Alt, F. W. et al., The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat. Immunol. 2011. 12: 536-543.
    • (2011) Nat. Immunol. , vol.12 , pp. 536-543
    • Ise, W.1    Kohyama, M.2    Schraml, B.U.3    Zhang, T.4    Schwer, B.5    Basu, U.6    Alt, F.W.7
  • 31
    • 60749112787 scopus 로고    scopus 로고
    • The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells
    • Lazarevic, V., Zullo, A. J., Schweitzer, M. N., Staton, T. L., Gallo, E. M., Crabtree, G. R. and Glimcher, L. H., The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells. Nat. Immunol. 2009. 10: 306-313.
    • (2009) Nat. Immunol. , vol.10 , pp. 306-313
    • Lazarevic, V.1    Zullo, A.J.2    Schweitzer, M.N.3    Staton, T.L.4    Gallo, E.M.5    Crabtree, G.R.6    Glimcher, L.H.7
  • 32
    • 78649816415 scopus 로고    scopus 로고
    • Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression
    • Chang, S. H., Chung, Y. and Dong, C., Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J. Biol. Chem. 2010. 285: 38751-38755.
    • (2010) J. Biol. Chem. , vol.285 , pp. 38751-38755
    • Chang, S.H.1    Chung, Y.2    Dong, C.3
  • 33
    • 78649542209 scopus 로고    scopus 로고
    • Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3
    • Potvin, E., Beuret, L., Cadrin-Girard, J. F., Carter, M., Roy, S., Tremblay, M. and Charron, J., Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. Mol. Cell. Biol. 2010. 30: 5348-5363.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 5348-5363
    • Potvin, E.1    Beuret, L.2    Cadrin-Girard, J.F.3    Carter, M.4    Roy, S.5    Tremblay, M.6    Charron, J.7
  • 34
    • 79952721606 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation
    • Pedroza-Gonzalez, A., Xu, K., Wu, T. C., Aspord, C., Tindle, S., Marches, F., Gallegos, M. et al., Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation. J. Exp. Med. 2011. 208: 479-490.
    • (2011) J. Exp. Med. , vol.208 , pp. 479-490
    • Pedroza-Gonzalez, A.1    Xu, K.2    Wu, T.C.3    Aspord, C.4    Tindle, S.5    Marches, F.6    Gallegos, M.7
  • 35
    • 29144535372 scopus 로고    scopus 로고
    • Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
    • Dai, M., Wang, P., Boyd, A. D., Kostov, G., Athey, B., Jones, E. G., Bunney, W. E. et al., Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res. 2005. 33: e175.
    • (2005) Nucleic Acids Res. , vol.33
    • Dai, M.1    Wang, P.2    Boyd, A.D.3    Kostov, G.4    Athey, B.5    Jones, E.G.6    Bunney, W.E.7
  • 36
    • 84862514267 scopus 로고    scopus 로고
    • Identification of early gene expression changes during human Th17 cell differentiation
    • Tuomela, S., Salo, V., Tripathi, S. K., Chen, Z., Laurila, K., Gupta, B., Aijö, T. et al., Identification of early gene expression changes during human Th17 cell differentiation. Blood 2012. 119: 151-160.
    • (2012) Blood , vol.119 , pp. 151-160
    • Tuomela, S.1    Salo, V.2    Tripathi, S.K.3    Chen, Z.4    Laurila, K.5    Gupta, B.6    Aijö, T.7
  • 37
    • 77953293952 scopus 로고    scopus 로고
    • Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
    • Durant, L., Watford, W. T., Ramos, H. L., Laurence, A., Vahedi, G., Wei, L., Takahashi, H. et al., Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 2010. 32: 605-615.
    • (2010) Immunity , vol.32 , pp. 605-615
    • Durant, L.1    Watford, W.T.2    Ramos, H.L.3    Laurence, A.4    Vahedi, G.5    Wei, L.6    Takahashi, H.7
  • 39
    • 70449571945 scopus 로고    scopus 로고
    • The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
    • Jenner, R. G., Townsend, M. J., Jackson, I., Sun, K., Bouwman, R. D., Young, R. A., Glimcher, L. H. et al., The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc. Natl. Acad. Sci. USA 2009. 106: 17876-17881.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 17876-17881
    • Jenner, R.G.1    Townsend, M.J.2    Jackson, I.3    Sun, K.4    Bouwman, R.D.5    Young, R.A.6    Glimcher, L.H.7
  • 40
    • 18144408736 scopus 로고    scopus 로고
    • Cell fates as high-dimensional attractor states of a complex gene regulatory network
    • Huang, S., Eichler, G., Bar-Yam, Y. and Ingber, D. E., Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys. Rev. Lett. 2005. 94: 1-4.
    • (2005) Phys. Rev. Lett. , vol.94 , pp. 1-4
    • Huang, S.1    Eichler, G.2    Bar-Yam, Y.3    Ingber, D.E.4
  • 41
    • 74549148040 scopus 로고    scopus 로고
    • Decomposition of gene expression state space trajectories
    • Mar, J. C. and Quackenbush, J., Decomposition of gene expression state space trajectories. PLoS Comput. Biol. 2009. 5: e1000626.
    • (2009) PLoS Comput. Biol. , vol.5
    • Mar, J.C.1    Quackenbush, J.2
  • 42
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jäger, A., Dardalhon, V., Sobel, R. A., Bettelli, E. and Kuchroo, V. K., Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 2009. 183: 7169-7177.
    • (2009) J. Immunol. , vol.183 , pp. 7169-7177
    • Jäger, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 43
    • 84867740388 scopus 로고    scopus 로고
    • Cell division curtails helper phenotype plasticity and expedites helper T-cell differentiation
    • van den Ham, H. J. and de Boer, R. J., Cell division curtails helper phenotype plasticity and expedites helper T-cell differentiation. Immunol. Cell Biol. 2012. 9: 860-868.
    • (2012) Immunol. Cell Biol. , vol.9 , pp. 860-868
    • van den Ham, H.J.1    de Boer, R.J.2
  • 44
    • 0025697469 scopus 로고
    • Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
    • Murphy, K., Heimberger, A. and Loh, D., Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 1990. 250: 1720-1723.
    • (1990) Science , vol.250 , pp. 1720-1723
    • Murphy, K.1    Heimberger, A.2    Loh, D.3
  • 45
    • 79961135005 scopus 로고    scopus 로고
    • R Development Core Team, R Foundation for Statistical Computing, Vienna, Austria
    • R Development Core Team, R: A language and environment for statistical computing, R Foundation for Statistical Computing, Vienna, Austria, 2011.
    • (2011) R: A language and environment for statistical computing
  • 47
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: kyoto encyclopedia of genes and genomes
    • Kanehisa, M. and Goto, S., KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000. 28: 27-30.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 49
    • 0345832338 scopus 로고    scopus 로고
    • A global test for groups of genes: testing association with a clinical outcome
    • Goeman, J. J., van de Geer, S. A., de Kort, F. and van Houwelingen, H. C., A global test for groups of genes: testing association with a clinical outcome. Bioinformatics 2003. 20: 93-99.
    • (2003) Bioinformatics , vol.20 , pp. 93-99
    • Goeman, J.J.1    van de Geer, S.A.2    de Kort, F.3    van Houwelingen, H.C.4


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