Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism

BioFactors

Volumn 39, Issue 2, 2013, Pages 209-220

  Pascual, Ana C ^a,b   Gaveglio, Virginia L ^a,b   Giusto, Norma M ^a,b   Pasquaré, Susana J ^a,b  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b Instituto de Investigaciones Bioquimicas Bahia Blanca   (Argentina)

Author keywords

2 arachidonoylglycerol; Cerebral cortex; Diacylglycerol; Lysophosphatidic acid; Monoacylglycerol; Synaptosomes

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ACYLGLYCEROL LIPASE; DIACYLGLYCEROL LIPASE ALPHA; LIPOPROTEIN LIPASE; LYSOPHOSPHATIDATE PHOSPHATASE; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; IMMUNOBLOTTING; MALE; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNAPTOSOME;

AGING; ANIMALS; ARACHIDONIC ACIDS; CEREBRAL CORTEX; DIGLYCERIDES; ENDOCANNABINOIDS; FATTY ACIDS; GLYCERIDES; IMMUNOBLOTTING; LIPOPROTEIN LIPASE; MALE; MONOACYLGLYCEROL LIPASES; MONOGLYCERIDES; RATS; RATS, WISTAR; SYNAPTOSOMES;

ANIMALIA; RATTUS;

EID: 84876421673     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1055     Document Type: Article

References (47)

1. Cravatt, B. F. and Lichtman, A. H. ( 2004) The endogenous cannabinoid system and its role in nociceptive behavior. J. Neurobiol. 61, 149-160.
2. Di Marzo V., De, P. L., and Bisogno, T. ( 2005) The biosynthesis, fate and pharmacological properties of endocannabinoids. Handb. Exp. Pharmacol. 168: 147-185.
3. Viveros, M. P., Marco, E. M., and File, S. E. ( 2005) Endocannabinoid system and stress and anxiety responses. Pharmacol. Biochem. Behav. 81, 331-342.
4. Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., et al. ( 1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949.
5. Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., et al. ( 1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50, 83-90.
6. Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., et al. ( 1995) 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res. Commun. 215, 89-97.
7. Sugiura, T., Kishimoto, S., Oka, S., and Gokoh, M. ( 2006) Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog. Lipid Res. 45, 405-446.
8. Nakane, S., Oka, S., Arai, S., Waku, K., Ishima, Y., et al. ( 2002) 2-Arachidonoyl-sn-glycero-3-phosphate, an arachidonic acid-containing lysophosphatidic acid: occurrence and rapid enzymatic conversion to 2-arachidonoyl-sn-glycerol, a cannabinoid receptor ligand, in rat brain. Arch. Biochem. Biophys. 402, 51-58.
9. Vandevoorde, S. and Lambert, D. M. ( 2007) The multiple pathways of endocannabinoid metabolism: a zoom out. Chem. Biodivers. 4, 1858-1881.
10. Blankman, J. L., Simon, G. M., and Cravatt, B. F. ( 2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem. Biol. 14, 1347-1356.
11. Muccioli, G. G., Xu, C., Odah, E., Cudaback, E., Cisneros, J. A., et al. ( 2007) Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells. J. Neurosci. 27, 2883-2889.
12. Saario, S. M., Savinainen, J. R., Laitinen, J. T., Jarvinen, T., and Niemi, R. ( 2004) Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes. Biochem. Pharmacol. 67, 1381-1387.
13. Kreitzer, A. C. and Regehr, W. G. ( 2002) Retrograde signaling by endocannabinoids. Curr. Opin. Neurobiol. 12, 324-330.
14. Ohno-Shosaku, T., Maejima, T., and Kano, M. ( 2001) Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. Neuron 29, 729-738.
15. Wilson, R. I. and Nicoll, R. A. ( 2002) Endocannabinoid signaling in the brain. Science 296, 678-682.
16. van der Stelt, M. and Di Marzo, V. ( 2005) Cannabinoid receptors and their role in neuroprotection. Neuromolecular. Med. 7, 37-50.
17. Cotman, C. W. ( 1974) Isolation of synaptosomal and synaptic plasma membrane fractions. Methods Enzymol. 31, 445-452.
18. Pasquare de Garcia, S. J. and Giusto, N. M. ( 1986) Phosphatidate phosphatase activity in isolated rod outer segment from bovine retina. Biochim. Biophys. Acta 875, 195-202.
19. Parkes, J. G. and Thompson, W. ( 1973) Synthesis in vivo of phospholipids of liver mitochondria and endoplasmic reticulum from glycerol and fatty acids. Biochim. Biophys. Acta 306, 403-411.
20. Giusto, N. M. and Bazan, N. G. ( 1979) Phospholipids and acylglycerols biosynthesis and 14CO2 production from [14C]glycerol in the bovine retina: the effects of incubation time, oxygen and glucose. Exp. Eye Res. 29, 155-168.
21. Folch, J., Lees, M., and Sloane Stanley, G. H. ( 1957) A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226, 497-509.
22. Brockerhoff, H. ( 1969) Esters of phenols as substrates for pancreatic lipase. Biochim. Biophys. Acta 191, 181-183.
23. Morrison, W. R. and Smith, L. M. ( 1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 5, 600-608.
24. Fleming, I. N. and Yeaman, S. J. ( 1995) Subcellular distribution of N-ethylmaleimide-sensitive and -insensitive phosphatidic acid phosphohydrolase in rat brain. Biochim. Biophys. Acta 1254, 161-168.
25. Laemmli, U. K. ( 1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
26. Bradford, M. M. ( 1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
27. Rouser, G., Fkeischer, S., and Yamamoto, A. ( 1970) Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 5, 494-496.
28. King, A. R., Duranti, A., Tontini, A., Rivara, S., Rosengarth, A., et al. ( 2007) URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chem. Biol. 14, 1357-1365.
29. Chang, J. W., Niphakis, M. J., Lum, K. M., Cognetta, A. B., III, Wang, C., et al. ( 2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem. Biol. 19, 579-588.
30. Mor, M., Rivara, S., Lodola, A., Plazzi, P. V., Tarzia, G., et al. ( 2004) Cyclohexylcarbamic acid 3′- or 4′-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies. J. Med. Chem. 47, 4998-5008.
31. Prescott, S. M. and Majerus, P. W. ( 1983) Characterization of 1, 2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J. Biol. Chem. 258, 764-769.
32. Ahn, K., McKinney, M. K., and Cravatt, B. F. ( 2008) Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem. Rev. 108, 1687-1707.
33. Bisogno, T., Howell, F., Williams, G., Minassi, A., Cascio, M. G., et al. ( 2003) Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J. Cell Biol. 163, 463-468.
34. Tanimura, A., Yamazaki, M., Hashimotodani, Y., Uchigashima, M., Kawata, S., et al. ( 2010) The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron 65, 320-327.
35. Gao, Y., Vasilyev, D. V., Goncalves, M. B., Howell, F. V., Hobbs, C., et al. ( 2010) Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J. Neurosci. 30, 2017-2024.
36. Savinainen, J. R., Saario, S. M., and Laitinen, J. T. ( 2012) The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors. Acta Physiol. (Oxf) 204, 267-276.
37. Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., et al. ( 2010) Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat. Neurosci. 13, 1113-1119.
38. Nomura, D. K., Long, J. Z., Niessen, S., Hoover, H. S., Ng, S. W., et al. ( 2010) Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 140, 49-61.
39. Fegley, D., Gaetani, S., Duranti, A., Tontini, A., Mor, M., et al. ( 2005) Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3′-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J. Pharmacol. Exp. Ther. 313, 352-358.
40. Viso, A., Cisneros, J. A., and Ortega-Gutierrez, S. ( 2008) The medicinal chemistry of agents targeting monoacylglycerol lipase. Curr. Top. Med. Chem. 8, 231-246.
41. Marrs, W. R., Blankman, J. L., Horne, E. A., Thomazeau, A., Lin, Y. H., et al. ( 2010) The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat. Neurosci. 13, 951-957.
42. Cheer, J. F., Wassum, K. M., Heien, M. L., Phillips, P. E., and Wightman, R. M. ( 2004) Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats. J. Neurosci. 24, 4393-4400.
43. Gessa, G. L., Mascia, M. S., Casu, M. A., and Carta, G. ( 1997) Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A. Eur. J. Pharmacol. 327, R1-R2.
44. Gifford, A. N. and Ashby, C. R., Jr. ( 1996) Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A. J. Pharmacol. Exp. Ther. 277, 1431-1436.
45. Basavarajappa, B. S., Nixon, R. A., and Arancio, O. ( 2009) Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini. Rev. Med. Chem. 9, 448-462.
46. Mulder, J., Zilberter, M., Pasquare, S. J., Alpar, A., Schulte, G., et al. ( 2011) Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. Brain 134, 1041-1060.
47. Zuccato, C. and Cattaneo, E. ( 2009) Brain-derived neurotrophic factor in neurodegenerative diseases. Nat. Rev. Neurol. 5, 311-322.