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Volumn 26, Issue 6, 2012, Pages 489-500

Dofetilide promotes repolarization abnormalities in perfused Guinea-pig Heart

Author keywords

Dofetilide; Electrical restitution; Proarrhythmia; Refractoriness; Repolarization

Indexed keywords

DOFETILIDE;

EID: 84876412086     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-012-6405-1     Document Type: Article
Times cited : (20)

References (49)
  • 1
    • 0028789950 scopus 로고
    • Electrophysiologic profile and efficacy of intravenous dofetilide (UK-68, 798) a new class III antiarrhythmic drug, in patients with sustained monomorphic ventricular tachycardia
    • Bashir Y, Thomsen PEB, Kingma JH, et al. Electrophysiologic profile and efficacy of intravenous dofetilide (UK-68,798) a new class III antiarrhythmic drug, in patients with sustained monomorphic ventricular tachycardia. Am J Cardiol. 1995;76:1040-4.
    • (1995) Am J Cardiol , vol.76 , pp. 1040-1044
    • Bashir, Y.1    Peb, T.2    Kingma, J.H.3
  • 2
    • 0001127258 scopus 로고
    • An analysis of the time-relations of electrocardiogram
    • Bazett HC. An analysis of the time-relations of electrocardiogram. Heart. 1920;7:353-70.
    • (1920) Heart , vol.7 , pp. 353-370
    • Bazett, H.C.1
  • 3
    • 0033931511 scopus 로고    scopus 로고
    • Comparison of intravenously administered dofetilide versus amiodarone in the acute termination of atrial fibrillation and flutter
    • Bianconi L, Castro A, Dinelli M, et al. Comparison of intravenously administered dofetilide versus amiodarone in the acute termination of atrial fibrillation and flutter. Eur Heart J. 2000;21:1265-73.
    • (2000) Eur Heart J , vol.21 , pp. 1265-1273
    • Bianconi, L.1    Castro, A.2    Dinelli, M.3
  • 4
    • 0019286312 scopus 로고
    • Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart
    • Boyett MR, Jewell BR. Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart. Prog Biophys Mol Biol. 1980;36:1-52.
    • (1980) Prog Biophys Mol Biol , vol.36 , pp. 1-52
    • Boyett, M.R.1    Jewell, B.R.2
  • 5
    • 0031007731 scopus 로고    scopus 로고
    • Regional localization of ERG, the channel protein responsible for the rapid component of the delayed rectifier, K+ current in the ferret heart
    • Brahmajothi MV, Morales MJ, Reimer KA, Strauss HC. Regional localization of ERG, the channel protein responsible for the rapid component of the delayed rectifier, K+ current in the ferret heart. Circ Res. 1997;81:128-35.
    • (1997) Circ Res , vol.81 , pp. 128-135
    • Brahmajothi, M.V.1    Morales, M.J.2    Reimer, K.A.3    Strauss, H.C.4
  • 6
    • 0032211575 scopus 로고    scopus 로고
    • Regional differences in the delayed rectifier current (IKr and IKs) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig
    • Bryant SM, Wan X, Shipsey SJ, Hart G. Regional differences in the delayed rectifier current (IKr and IKs) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig. Cardiovasc Res. 1998;40:322-31.
    • (1998) Cardiovasc Res , vol.40 , pp. 322-331
    • Bryant, S.M.1    Wan, X.2    Shipsey, S.J.3    Hart, G.4
  • 7
    • 0026640423 scopus 로고
    • Voltage-and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide
    • Carmeliet E. Voltage-and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide. J Pharmacol Exp Ther. 1992;262:809-17.
    • (1992) J Pharmacol Exp Ther , vol.262 , pp. 809-817
    • Carmeliet, E.1
  • 8
    • 0032999081 scopus 로고    scopus 로고
    • Heterogeneous distribution of the two components of delayed rectifier K + current: A potential mechanism of the proarrhythmic effects of methanesulfonanilide class III agents
    • Cheng J, Kamiya K, Liu W, Tsuji Y, Toyama J, Kodama I. Heterogeneous distribution of the two components of delayed rectifier K + current: a potential mechanism of the proarrhythmic effects of methanesulfonanilide class III agents. Cardiovasc Res. 1999;43:135-47.
    • (1999) Cardiovasc Res , vol.43 , pp. 135-147
    • Cheng, J.1    Kamiya, K.2    Liu, W.3    Tsuji, Y.4    Toyama, J.5    Kodama, I.6
  • 9
    • 0032744871 scopus 로고    scopus 로고
    • Exaggerated QT prolongation after cardioversion of atrial fibrillation
    • Choy AMJ, Darbar D, Dell'Orto S, Roden DM. Exaggerated QT prolongation after cardioversion of atrial fibrillation. J Am Col Cardiol. 1999;34:396-401.
    • (1999) J Am Col Cardiol , vol.34 , pp. 396-401
    • Amj, C.1    Darbar, D.2    Dell'orto, S.3    Roden, D.M.4
  • 10
    • 34249046359 scopus 로고    scopus 로고
    • A rate-independent method of assessing QT-RR slope following conversion of atrial fibrillation
    • Darbar D, Hardin B, Harris P, Roden DM. A rate-independent method of assessing QT-RR slope following conversion of atrial fibrillation. J Cardiovasc Electrophysiol. 2007;18:636-41.
    • (2007) J Cardiovasc Electrophysiol , vol.18 , pp. 636-641
    • Darbar, D.1    Hardin, B.2    Harris, P.3    Roden, D.M.4
  • 11
    • 18844368814 scopus 로고    scopus 로고
    • Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease
    • Diaz A, Bourassa MG, Guertin MC, Tardif JC. Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. Eur Heart J. 2005; 26:967-74.
    • (2005) Eur Heart J , vol.26 , pp. 967-974
    • Diaz, A.1    Bourassa, M.G.2    Guertin, M.C.3    Tardif, J.C.4
  • 12
    • 80054772194 scopus 로고    scopus 로고
    • Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis
    • Du CY, El Harchi A, Zhang YH, Orchard CH, Hancox JC. Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis. J Cardiovasc Electrophysiol. 2011;22:1163-70.
    • (2011) J Cardiovasc Electrophysiol , vol.22 , pp. 1163-1170
    • Du, C.Y.1    El Harchi, A.2    Zhang, Y.H.3    Orchard, C.H.4    Hancox, J.C.5
  • 13
    • 0030614662 scopus 로고    scopus 로고
    • 3H Dofetilide binding to cardiac myocytes: Modulation by extracellular potassium
    • Duff HJ, Feng ZP, Fiset C, Wang L, Lees-Miller J, Sheldon RS. [3H]Dofetilide binding to cardiac myocytes: modulation by extracellular potassium. J Mol Cell Cardiol. 1997;29:183-91.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 183-191
    • Duff, H.J.1    Feng, Z.P.2    Fiset, C.3    Wang, L.4    Lees-Miller, J.5
  • 14
    • 0031029739 scopus 로고    scopus 로고
    • Intravenous dofetilide, a class III antiarrhythmic agent, for the termination of sustained atrial fibrillation or flutter
    • Falk RH, Pollak A, Singh SN, Friedrich T. Intravenous dofetilide, a class III antiarrhythmic agent, for the termination of sustained atrial fibrillation or flutter. J Am Col Cardiol. 1997;29:385-90.
    • (1997) J Am Col Cardiol , vol.29 , pp. 385-390
    • Falk, R.H.1    Pollak, A.2    Singh, S.N.3    Friedrich, T.4
  • 15
    • 0034705040 scopus 로고    scopus 로고
    • Preventing ventricular fibrillation by flattening cardiac restitution
    • Garfinkel A, Kim YH, Voroshilovsky O, et al. Preventing ventricular fibrillation by flattening cardiac restitution. Proc Natl Acad Sci USA. 2000;97:6061-6.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6061-6066
    • Garfinkel, A.1    Kim, Y.H.2    Voroshilovsky, O.3
  • 16
    • 9344265214 scopus 로고    scopus 로고
    • Chronic betaadrenoreceptor activation increases cardiac cavity size through
    • chamber remodelling and not via modifications in myocardial material properties
    • Gibbs M, Veliotes DG, Anamourlis C, et al. Chronic betaadrenoreceptor activation increases cardiac cavity size through chamber remodelling and not via modifications in myocardial material properties. Am J Physiol Heart Circ Physiol. 2004;287: H2762-7.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Gibbs, M.1    Veliotes, D.G.2    Anamourlis, C.3
  • 17
    • 0029779365 scopus 로고    scopus 로고
    • Differential class III antiarrhythmic effects of ambasilide and dofetilide at different extracellular potassium and pacing frequencies
    • Gjini V, Korth M, Schreieck J, Weyerbrock S, Schomig A, Schmitt C. Differential class III antiarrhythmic effects of ambasilide and dofetilide at different extracellular potassium and pacing frequencies. J Cardiovasc Pharmacol. 1996;28:314-20.
    • (1996) J Cardiovasc Pharmacol , vol.28 , pp. 314-320
    • Gjini, V.1    Korth, M.2    Schreieck, J.3    Weyerbrock, S.4    Schomig, A.5    Schmitt, C.6
  • 18
    • 59849089650 scopus 로고    scopus 로고
    • Sympathetic and baroreflex cardiovascular control in hypertension-related left ventricular dysfunction
    • Grassi G, Seravalle G, Quarti-Trevano F, et al. Sympathetic and baroreflex cardiovascular control in hypertension-related left ventricular dysfunction. Hypertension. 2009;53:205-9.
    • (2009) Hypertension , vol.53 , pp. 205-209
    • Grassi, G.1    Seravalle, G.2    Quarti-Trevano, F.3
  • 19
    • 0035901578 scopus 로고    scopus 로고
    • Instability and triangulation of the action potential predict serious proarrhythmia, but APD prolongation is antiarrhythmic
    • Hondeghem L, Carlsson L, Duker G. Instability and triangulation of the action potential predict serious proarrhythmia, but APD prolongation is antiarrhythmic. Circulation. 2001;103:2004-13.
    • (2001) Circulation , vol.103 , pp. 2004-2013
    • Hondeghem, L.1    Carlsson, L.2    Duker, G.3
  • 20
    • 0027186122 scopus 로고
    • Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent
    • Jurkiewicz NK, Sanguinetti MC. Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Circ Res. 1993;72:75-83.
    • (1993) Circ Res , vol.72 , pp. 75-83
    • Jurkiewicz, N.K.1    Sanguinetti, M.C.2
  • 21
    • 0031785488 scopus 로고    scopus 로고
    • Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation
    • Koller ML, Riccio ML, Gilmour RF. Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation. Am J Physiol Heart Circ Physiol. 1998;275:H1635-42.
    • (1998) Am J Physiol Heart Circ Physiol , vol.275
    • Koller, M.L.1    Riccio, M.L.2    Gilmour, R.F.3
  • 23
    • 0032450779 scopus 로고    scopus 로고
    • Differential rate and potassium-dependent effects of the class III agents d-sotalol and dofetilide on guinea-pig papillary muscle
    • Marschang H, Beyer T, Karolyi L, Kubler W, Brachmann J. Differential rate and potassium-dependent effects of the class III agents d-sotalol and dofetilide on guinea-pig papillary muscle. Cardiovasc Drugs Ther. 1998;12:573-83.
    • (1998) Cardiovasc Drugs Ther , vol.12 , pp. 573-583
    • Marschang, H.1    Beyer, T.2    Karolyi, L.3    Kubler, W.4    Brachmann, J.5
  • 24
    • 0001392789 scopus 로고    scopus 로고
    • Potassium channel down-regulation in heart failure
    • Nabauer M, Kaab S. Potassium channel down-regulation in heart failure. Cardiovasc Res. 1998;37:324-34.
    • (1998) Cardiovasc Res , vol.37 , pp. 324-334
    • Nabauer, M.1    Kaab, S.2
  • 25
    • 33644828353 scopus 로고    scopus 로고
    • Whole heart action potential duration restitution properties in cardiac patients: A combined clinical and modelling study
    • Nash MP, Bradley CP, Sutton PM, et al. Whole heart action potential duration restitution properties in cardiac patients: a combined clinical and modelling study. Exp Physiol. 2006; 91:339-54.
    • (2006) Exp Physiol , vol.91 , pp. 339-354
    • Nash, M.P.1    Bradley, C.P.2    Sutton, P.M.3
  • 26
    • 34047112435 scopus 로고    scopus 로고
    • Rat strainrelated differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and function
    • Osadchii O, Norton G, Deftereos D, Woodiwiss A. Rat strainrelated differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and function. Pharmacol Res. 2007;55:287-94.
    • (2007) Pharmacol Res , vol.55 , pp. 287-294
    • Osadchii, O.1    Norton, G.2    Deftereos, D.3    Woodiwiss, A.4
  • 27
    • 27744536658 scopus 로고    scopus 로고
    • Mechanisms of preserved baseline cardiac systolic function in rats with adrenergic inotropic downregulation
    • Osadchii O, Woodiwiss A, Alves N, Norton G. Mechanisms of preserved baseline cardiac systolic function in rats with adrenergic inotropic downregulation. Life Sci. 2005;78:366-75.
    • (2005) Life Sci , vol.78 , pp. 366-375
    • Osadchii, O.1    Woodiwiss, A.2    Alves, N.3    Norton, G.4
  • 28
    • 77956975963 scopus 로고    scopus 로고
    • Mechanisms of hypokalemia-induced ventricular arrhythmogenicity
    • Osadchii OE. Mechanisms of hypokalemia-induced ventricular arrhythmogenicity. Fund Clin Pharmacol. 2010;24:547-59.
    • (2010) Fund Clin Pharmacol , vol.24 , pp. 547-559
    • Osadchii, O.E.1
  • 29
    • 73549103079 scopus 로고    scopus 로고
    • Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity
    • Osadchii OE, Larsen AP, Olesen SP. Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity. Am J Physiol Heart Circ Physiol. 2010;298:H210-20.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Osadchii, O.E.1    Larsen, A.P.2    Olesen, S.P.3
  • 30
    • 70350761979 scopus 로고    scopus 로고
    • Electrophysiological determinants of hypokalemia-induced arrhythmogenicity in the guinea-pig heart
    • Osadchii OE, Olesen SP. Electrophysiological determinants of hypokalemia-induced arrhythmogenicity in the guinea-pig heart. Acta Physiol (Oxf). 2009;197:273-87.
    • (2009) Acta Physiol (Oxf , vol.197 , pp. 273-287
    • Osadchii, O.E.1    Olesen, S.P.2
  • 31
    • 84863817383 scopus 로고    scopus 로고
    • Effects of ventricular pacing protocol on electrical restitution assessments in guinea-pig heart
    • Osadchii OE. Effects of ventricular pacing protocol on electrical restitution assessments in guinea-pig heart. Exp Physiol. 2012; 97:807-21.
    • (2012) Exp Physiol , vol.97 , pp. 807-821
    • Osadchii, O.E.1
  • 32
    • 10944220512 scopus 로고    scopus 로고
    • Spatial dispersion of action potential duration restitution kinetics is associated with induction of ventricular tachycardia/fibrillation in humans
    • Pak HN, Hong SJ, Hwang GS, et al. Spatial dispersion of action potential duration restitution kinetics is associated with induction of ventricular tachycardia/fibrillation in humans. J Cardiovasc Electrophysiol. 2004;15:1357-63.
    • (2004) J Cardiovasc Electrophysiol , vol.15 , pp. 1357-1363
    • Pak, H.N.1    Hong, S.J.2    Hwang, G.S.3
  • 33
    • 0033617107 scopus 로고    scopus 로고
    • Electrical restitution and spatiotemporal organization during ventricular fibrillation
    • Riccio ML, Koller ML, Gilmour RF. Electrical restitution and spatiotemporal organization during ventricular fibrillation. Circ Res. 1999;84:955-63.
    • (1999) Circ Res , vol.84 , pp. 955-963
    • Riccio, M.L.1    Koller, M.L.2    Gilmour, R.F.3
  • 34
    • 34047130207 scopus 로고    scopus 로고
    • The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts
    • Sabir IN, Fraser JA, Killeen MJ, Grace AA, Huang CL. The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts. Pflugers Arch. 2007;454:209-22.
    • (2007) Pflugers Arch , vol.454 , pp. 209-222
    • Sabir, I.N.1    Fraser, J.A.2    Killeen, M.J.3    Grace, A.A.4    Huang, C.L.5
  • 35
    • 0026814904 scopus 로고
    • Role of external Ca2+ and K+ in gating of cardiac delayed rectifier K+ currents
    • Sanguinetti MC, Jurkiewicz NK. Role of external Ca2+ and K+ in gating of cardiac delayed rectifier K+ currents. Pflugers Arch. 1992;420:180-6.
    • (1992) Pflugers Arch , vol.420 , pp. 180-186
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2
  • 36
    • 18144451374 scopus 로고
    • Delayed K+ current and external K+ in single cardiac Purkinje cells
    • Scamps F, Carmeliet E. Delayed K+ current and external K+ in single cardiac Purkinje cells. Am J Physiol Cell Physiol. 1989;257: C1086-92.
    • (1989) Am J Physiol Cell Physiol , vol.257
    • Scamps, F.1    Carmeliet, E.2
  • 37
    • 0026498376 scopus 로고
    • Effects of the class III antiarrhythmic drug dofetilide on ventricular monophasic action potential duration and QT interval dispersion in stable angina pectoris
    • Sedgwick ML, Rasmussen HS, Cobbe SM. Effects of the class III antiarrhythmic drug dofetilide on ventricular monophasic action potential duration and QT interval dispersion in stable angina pectoris. Am J Cardiol. 1992;70:1432-7.
    • (1992) Am J Cardiol , vol.70 , pp. 1432-1437
    • Sedgwick, M.L.1    Rasmussen, H.S.2    Cobbe, S.M.3
  • 38
    • 0026608567 scopus 로고
    • Clinical and electrophysiologic effects of intravenous dofetilide (UK-68, 798), a new class III antiarrhythmic drug, in patients with angina pectoris
    • Sedgwick ML, Rasmussen HS, Cobbe SM. Clinical and electrophysiologic effects of intravenous dofetilide (UK-68,798), a new class III antiarrhythmic drug, in patients with angina pectoris. Am J Cardiol. 1992;69:513-7.
    • (1992) Am J Cardiol , vol.69 , pp. 513-517
    • Sedgwick, M.L.1    Rasmussen, H.S.2    Cobbe, S.M.3
  • 39
    • 21344463329 scopus 로고    scopus 로고
    • Refining detection of drug-induced proarrhythmia: QT interval and TRIaD
    • Shah RR, Hondeghem LM. Refining detection of drug-induced proarrhythmia: QT interval and TRIaD. Hear Rhythm. 2005; 2:758-72.
    • (2005) Hear Rhythm , vol.2 , pp. 758-772
    • Shah, R.R.1    Hondeghem, L.M.2
  • 40
    • 0034619437 scopus 로고    scopus 로고
    • Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter
    • Singh S, Zoble RG, Yellen L, et al. Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter. Circulation. 2000; 102:2385-90.
    • (2000) Circulation , vol.102 , pp. 2385-2390
    • Singh, S.1    Zoble, R.G.2    Yellen, L.3
  • 41
    • 79959378055 scopus 로고    scopus 로고
    • Myocardial structural, contractile and electrophysiological changes in the guinea-pig heart failure model induced by chronic sympathetic activation
    • Soltysinska E, Olesen SP, Osadchii OE. Myocardial structural, contractile and electrophysiological changes in the guinea-pig heart failure model induced by chronic sympathetic activation. Exp Physiol. 2011;96:647-63.
    • (2011) Exp Physiol , vol.96 , pp. 647-663
    • Soltysinska, E.1    Olesen, S.P.2    Osadchii, O.E.3
  • 42
    • 0032979720 scopus 로고    scopus 로고
    • Electrophysiological remodelling in hypertrophy and heart failure
    • Tomaselli GF, Marban E. Electrophysiological remodelling in hypertrophy and heart failure. Cardiovasc Res. 1999;42:270-83.
    • (1999) Cardiovasc Res , vol.42 , pp. 270-283
    • Tomaselli, G.F.1    Marban, E.2
  • 43
    • 0033575989 scopus 로고    scopus 로고
    • Dofetilide in patients with congestive heart failure and left ventricular dysfunction
    • Torp-Pedersen C, Moller M, Bloch-Thomsen PE, et al. Dofetilide in patients with congestive heart failure and left ventricular dysfunction. New Engl J Med. 1999;341:857-65.
    • (1999) New Engl J Med , vol.341 , pp. 857-865
    • Torp-Pedersen, C.1    Moller, M.2    Bloch-Thomsen, P.E.3
  • 44
    • 0034077362 scopus 로고    scopus 로고
    • Progress in the understanding of cardiac early afterdepolarizations and torsade de pointes: Time to revise current concepts
    • Volders PGA, Vos MA, Szabo B, et al. Progress in the understanding of cardiac early afterdepolarizations and torsade de pointes: time to revise current concepts. Cardiovasc Res. 2000;46:376-92.
    • (2000) Cardiovasc Res , vol.46 , pp. 376-392
    • Pga, V.1    Vos, M.A.2    Szabo, B.3
  • 45
    • 0033151558 scopus 로고    scopus 로고
    • Chaos and the transition to ventricular fibrillation. A new approach to antiarrhythmic drug evaluation
    • Weiss JN, Garfinkel A, Karaguezian HS, Qu Z, Chen PS. Chaos and the transition to ventricular fibrillation. A new approach to antiarrhythmic drug evaluation. Circulation. 1999; 99:2819-26.
    • (1999) Circulation , vol.99 , pp. 2819-2826
    • Weiss, J.N.1    Garfinkel, A.2    Karaguezian, H.S.3    Qu, Z.4    Chen, P.S.5
  • 46
    • 0032480801 scopus 로고    scopus 로고
    • Cellular basis for the normal T wave and the electrocardiographic manifestations of the long QT syndrome
    • Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long QT syndrome. Circulation. 1998;98:1928-36.
    • (1998) Circulation , vol.98 , pp. 1928-1936
    • Yan, G.X.1    Antzelevitch, C.2
  • 47
    • 0026757742 scopus 로고
    • Effects of altered extracellular potassium and pacing cycle length on the class III antiarrhythmic actions of dofetilide (UK-68, 798) in guinea-pig papillary muscle
    • Yang T, Tande PM, Lathrop DA, Refsum H. Effects of altered extracellular potassium and pacing cycle length on the class III antiarrhythmic actions of dofetilide (UK-68,798) in guinea-pig papillary muscle. Cardiovasc Drugs Ther. 1992;6:429-36.
    • (1992) Cardiovasc Drugs Ther , vol.6 , pp. 429-436
    • Yang, T.1    Tande, P.M.2    Lathrop, D.A.3    Refsum, H.4
  • 48
    • 0030022457 scopus 로고    scopus 로고
    • Extracellular potassium modulation of drug block of IKr
    • Yang T, Roden DM. Extracellular potassium modulation of drug block of IKr. Circulation. 1996;93:407-11.
    • (1996) Circulation , vol.93 , pp. 407-411
    • Yang, T.1    Roden, D.M.2
  • 49
    • 0029024749 scopus 로고
    • Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea-pig type. Theoretical formulation and their role in repolarization
    • Zeng J, Laurita KR, Rosenbaum DS, Rudy Y. Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea-pig type. Theoretical formulation and their role in repolarization. Circ Res. 1995;77:140-52.
    • (1995) Circ Res , vol.77 , pp. 140-152
    • Zeng, J.1    Laurita, K.R.2    Rosenbaum, D.S.3    Rudy, Y.4


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