Colonoscopy and μPET/CT are valid techniques to monitor inflammation in the adoptive transfer colitis model in mice

Inflammatory Bowel Diseases

Volumn 19, Issue 5, 2013, Pages 967-976

  Heylen, Marthe ^a   Deleye, Steven ^b   De Man, Joris G ^a   Ruyssers, Nathalie E ^a   Vermeulen, Wim ^a   Stroobants, Sigrid ^b,c   Pelckmans, Paul A ^a,c   Moreels, Tom G ^a,c   Staelens, Steven ^b   De Winter, Benedicte Y ^a  

^a Laboratory of Experimental Medicine and Pediatrics   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

PET CT; Adoptive transfer model; Colitis; Colonoscopy

Indexed keywords

MYELOPEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CD4+ CD25+ T LYMPHOCYTE; COLITIS; COLONOSCOPY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; IMMUNE DEFICIENCY; INFLAMMATION; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; COLITIS; COLONOSCOPY; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMATION; MICE; MICE, INBRED BALB C; MICE, SCID; PEROXIDASE; POSITRON-EMISSION TOMOGRAPHY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84876380837     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e3182802c7c     Document Type: Article

References (31)

1. Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142:46-54 e42.
2. Neurath MF, Vehling D, Schunk K, et al. Noninvasive assessment of Crohn's disease activity: a comparison of 18F-fluorodeoxyglucose positron emission tomography, hydromagnetic resonance imaging, and granulocyte scintigraphy with labeled antibodies. Am J Gastroenterol. 2002;97:1978-1985.
3. Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002;347: 417-429.
4. Choquet P, Calon A, Breton E, et al. Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice. C R Biol. 2007;330:821-827.
5. Elson CO, Cong Y, McCracken VJ, et al. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev. 2005;206:260-276.
6. Wirtz S, Neurath MF. Mouse models of inflammatory bowel disease. Adv Drug Deliver Rev. 2007;59:1073-1083.
7. Eri R, McGuckin MA, Wadley R. T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation. Methods Mol Biol. 2012;844:261-275.
8. Morrissey PJ, Charrier K, Braddy S, et al. CD4+ T-cells that express highlevels of CD45rb induce wasting disease when transferred into congenic severe combined immunodeficient mice-disease development is prevented by cotransfer of purified CD4+ T-cells. J Exp Med. 1993;178: 237-244.
9. Powrie F, Leach MW, Mauze S, et al. Phenotypically distinct subsets of CD4(+) T-cells induce or protect from chronic intestinal inflammation in C.B-17 scid mice. Int Immunol. 1993;5:1461-1471.
10. Powrie F, Leach MW, Mauze S, et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity. 1994;1:553-562.
11. Mudter J, Wirtz S, Galle PR, et al. A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+CD4+T cells: insights into the regulatory role of interleukin-6 on apoptosis. Pathobiology. 2002;70: 170-176.
12. Ostanin DV, Bao J, Koboziev I, et al. T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. Am J Physiol Gastrointest Liver Physiol. 2009;296:G135-G146.
13. Ogino H, Nakamura K, Ihara E, et al. CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model. Dig Dis Sci. 2011;56:376-386.
14. Huang EH, Carter JJ, Whelan RL, et al. Colonoscopy in mice. Surg Endosc. 2002;16:22-24.
15. Vermeulen W, De Man JG, Nullens S, et al. The use of colonoscopy to follow the inflammatory time course of TNBS colitis in rats. Acta Gastroenterol Belg. 2011;74:304-311.
16. Fredin MF, Hultin L, Hyberg G, et al. Predicting and monitoring colitis development in mice by micro-computed tomography. Inflamm Bowel Dis. 2008;14:491-499.
17. Herschman HR. Micro-PET imaging and small animal models of disease. Curr Opin Immunol. 2003;15:378-384.
18. Brewer S, McPherson M, Fujiwara D, et al. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography. Gastroenterology. 2008;135:744-755.
19. Brewer S, Nair-Gill E, Wei B, et al. Epithelial uptake of [18F]1-(2'- deoxy-2'-arabinofuranosyl) cytosine indicates intestinal inflammation in mice. Gastroenterology. 2010;138:1266-1275.
20. Hindryckx P, Staelens S, Devisscher L, et al. Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using muPET/CT. Inflamm Bowel Dis. 2011;17:2058-2064.
21. Ruyssers NE, De Winter BY, De Man JG, et al. Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice. Inflamm Bowel Dis. 2009;15:491-500.
22. Neurath MF, Weigmann B, Finotto S, et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med. 2002;195:1129-1143.
23. Becker C, Fantini MC, Wirtz S, et al. In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy. Gut. 2005;54:950-954.
24. Becker C, Fantini MC, Neurath MF. High resolution colonoscopy in live mice. Nat Protoc. 2006;1:2900-2904.
25. Haney CR, Parasca AD, Ichikawa K, et al. Reduction of image artifacts in mice by bladder flushing with a novel double-lumen urethral catheter. Mol Imaging. 2006;5:175-179.
26. Ostanin DV, Pavlick KP, Bharwani S, et al. T cell-induced inflammation of the small and large intestine in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol. 2006;290:G109-G119.
27. Moreels TG, De Man JG, Bogers JJ, et al. Effect of Schistosoma mansoniinduced granulomatous inflammation on murine gastrointestinal motility. Am J Physiol Gastrointest Liver Physiol. 2001;280:G1030-G1042.
28. Zhuang H, Yu JQ, Alavi A. Applications of fluorodeoxyglucose-PET imaging in the detection of infection and inflammation and other benign disorders. Radiol Clin North Am. 2005;43:121-134.
29. Spier BJ, Perlman SB, Reichelderfer M. FDG-PET in inflammatory bowel disease. Q J Nucl Med Mol Imaging. 2009;53:64-71.
30. Spier BJ, Perlman SB, Jaskowiak CJ, et al. PET/CT in the evaluation of inflammatory bowel disease: studies in patients before and after treatment. Mol Imaging Biol. 2010;12:85-88.
31. Groshar D, Bernstine H, Stern D, et al. PET/CT enterography in Crohn disease: correlation of disease activity on CT enterography with 18F-FDG uptake. J Nucl Med. 2010;51:1009-1014.