Prediction of long-term (5 years) conversion to dementia using neuropsychological tests in a memory clinic setting

Journal of Alzheimer's Disease

Volumn 34, Issue 3, 2013, Pages 681-689

  Silva, Dina ^a   Guerreiro, Manuela ^a,b   Santana, Isabel ^c   Rodrigues, Ana ^c   Cardoso, Sandra ^a   Maroco, João ^d   De Mendonça, Alexandre ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^b HOSPITAL DE SANTA MARIA   (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d Superior Institute of Applied Psychology   (Portugal)

Author keywords

Alzheimer's disease; cognitive markers; cohort study; dementia; executive functions; long term follow up; neuropsychological tests; predictive value; verbal memory

Indexed keywords

AGED; ARTICLE; CONVERSION TO DEMENTIA; DEMENTIA; DISCRIMINANT ANALYSIS; DISEASE COURSE; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; OUTCOME ASSESSMENT; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY;

EID: 84876368687     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-122098     Document Type: Article

References (64)

1. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: Clinical characterization and outcome. Arch Neurol 56, 303-308. (Pubitemid 29120227)
2. Portet F, Ousset PJ, Visser PJ, Frisoni GB, Nobili F, Scheltens P, Vellas B, Touchon J; MCIWorking Group of the European Consortium on Alzheimer's Disease (EADC) (2006) Mild cognitive impairment (MCI) in medical practice: A critical review of the concept and new diagnostic procedure Report of the MCI Working Group of the European Consortium on Alzheimer's Disease. J Neurol Neurosurg Psychiatry 77, 714- 718. (Pubitemid 43837193)
3. Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, Thies B, Phelps CH (2011) Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 257-262.
4. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger- Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G,Meguro K, O'brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol 6, 734-746. (Pubitemid 47058377)
5. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH (2011) The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 270-279.
6. de MendonçaA(2012) Rethinking Alzheimer's disease.Front Neurol 3, 45.
7. Wilson RS, Leurgans SE, Boyle PA, Bennett DA (2011) Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment. Arch Neurol 68, 351-356.
8. Amieva H, LeGaff M, Millet X, Orgogozo JM, Péres K, Barberger-Gateau P, Jacqmin-Gadda H, Dartigues JF (2008) Prodromal Alzheimer's disease: Successive emergence of clinical symptoms. Ann Neurol 64, 492-498.
9. Johnson DK, Storandt M, Morris JC, Galvin JE (2009) Longitudinal study of the transition from healthy aging to Alzheimer disease. Arch Neurol 66, 1254-1259.
10. Grober E, Hall CB, Lipton RB, Zonderman AB, Resnick SM, Kawas C (2008) Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease. J Int Neuropsychol Soc 14, 266-278. (Pubitemid 351280005)
11. de Santi S, Pirraglia E, Barr W, Babb J, Williams S, Rogers K, Glodzik L, Brys M, Mosconi L, Reisberg B, Ferris S, de Leon MJ (2008) Robust and conventional neuropsychological norms: Diagnosis and prediction of age-related cognitive decline. Neuropsychology 22, 469-484. (Pubitemid 351992894)
12. Schink JA, Loewenstein DA, Raj A, Schoenberg MR, Banko JL, Potter H, Duara R (2010) Defining mild cognitive impairment: Impact of varying decision criteria on neuropsychological diagnostic frequencies and correlates. Am J Geriatr Psychiatry 18, 684-691.
13. Silva D, Guerreiro M, Maroco J, Santana I, Rodrigues A, Marques JB, de Mendonça A (2012) Comparison of four verbal memory tests for the diagnosis and predictive value of mild cognitive impairment. Dement Geriatr Cogn Disord Extra 2, 120-131.
14. Flicker C, Ferris SH, Reisberg B (1991) Mild cognitive impairment in the elderly: Predictors of dementia. Neurology 41, 1006-1009.
15. Tierney MC, Szalai JP, Snow WG, Fisher RH, Nores A, Nadon G, Dunn E, St George-Hyslop PH (1996) Prediction of probable Alzheimer's disease in memory-impaired patients:Aprospective longitudinal study. Neurology 46, 661- 665. (Pubitemid 26099629)
16. Devanand DP, Folz M, Gorlyn M, Moeller JR, Stern Y (1997) Questionable dementia: Clinical course and predictors of outcome. J Am Geriatr Soc 45, 321-328. (Pubitemid 27114305)
17. Kluger A, Ferris SH, Golomb J, Mittelman MS, Reisberg B (1999) Neuropsychological prediction of decline to dementia in nondemented elderly. J Geriatr Psychiatry Neurol 12, 168- 179. (Pubitemid 30072300)
18. de Jager CA, Milwain E, Budge M (2002) Early detection of isolated memory deficits in the elderly: The need for more sensitive neuropsychological tests. Psychol Med 32, 483-491. (Pubitemid 34308792)
19. Tian J, Bucks RS, Haworth J, Wilcock G (2003) Neuropsychological prediction of conversion to dementia from questionable dementia: Statistically significant but not yet clinically useful. J Neurol Neurosurg Psychiatry 74, 433-438. (Pubitemid 36379363)
20. Amieva H, Letenneur L, Dartigues JF, Rouch-Leroyer I, Sourgen C, D'Alchée-Birée F, Dib M, Barberger-Gateau P, Orgogozo JM, Fabrigoule C (2004) Annual rate and predictors of conversion to dementia in subjects presenting mild cognitive impairment criteria defined according to a population-based study. Dement Geriatr Cogn Disord 18, 87-93. (Pubitemid 38822744)
21. Atchison TB, BradshawM, Massman PJ (2004) Investigation of profile difference between Alzheimer's disease patients declining at different rates: Examination of baseline neuropsychological data. Arch Clin Neuropsychol 19, 1007- 1015. (Pubitemid 39472666)
22. Lehrner J, Gufler R, Guttmann G, Maly J, Gleiss A, Auff E, Dal-Bianco P (2005) Annual conversion to Alzheimer disease among patients with memory complaints attending an outpatient memory clinic: The influence of amnestic mild cognitive impairment and the predictive value of neuropsychological testing. Wien Klin Wochenschr 117, 629-635. (Pubitemid 41494965)
23. Blacker D, Lee H, Muzikansky A, Martin EC, Tanzi R, McArdle JJ, Moss M, Albert M (2007) Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Arch Neurol 64, 862-871. (Pubitemid 46919842)
24. Mickes L, Wixted JT, Fennema-Notestine C, Galasko D, Bondi MW, Thal LJ, Salmon DP (2007) Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease. Neuropsychology 21, 696- 705. (Pubitemid 350116513)
25. Carter SF, Caine D, Burns A, Herholz K, Lambon Ralph MA (2012) Staging of the cognitive decline in Alzheimer's disease: Insights from a detailed neuropsychological investigation of mild cognitive impairment and mild Alzheimer's disease. Int J Geriatr Psychiatry 27, 423-432.
26. Johnson JK, Gross AL, Pa J, McLaren DG, Park LQ, Manly JJ; Alzheimer's Disease Neuroimaging Initiative (2012) Longitudinal change in neuropsychological performance using latent growth models: A study of mild cognitive impairment. Brain Imaging Behav 6(4), 540-550.
27. Ewers M, Walsh C, Trojanowski JQ, Shaw LM, Petersen RC, Jack CR Jr, Feldman HH, Bokde AL, Alexander GE, Scheltens P, Vellas B, Dubois B, Weiner M, Hampel H; North American Alzheimer's Disease Neuroimaging Initiative (ADNI) (2012) Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance. Neurobiol Aging 33, 1203-1214.
28. Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C (2010) Dementia risk prediction in the population: Are screening models accurate? Nat Rev Neurol 6, 318-326.
29. Maroco J, Silva D, Rodrigues A, Guerreiro M, Santana I, de MendonçaA(2011) Data mining methods in the prediction of Dementia: A real-data comparison of the accuracy, sensitivity and specificity of linear discriminant analysis, logistic regression, neural networks, support vector machines, classification trees and random forests. BMC Res Notes 4, 299.
30. American Psychiatric Association (2000) DSM-IV-TR. APA, 4th edition, text revision, Washington, DC.
31. Barreto J, Leuschner A, Santos F, Sobral M (2008) Geriatric Depression Scale (GDS). In Escalas e Testes na Demência, de Mendonça A, Guerreiro M, eds. Grupo de Estudos de Envelhecimento Cerebral e Demência, 3rd edition, Lisboa, pp. 71-72.
32. Ribeiro F, de Mendonça A, GuerreiroM(2006) Mild cognitive impairment: Deficits in cognitive domains other than memory. Dement Geriatr Cogn Disord 21, 284-290. (Pubitemid 43735671)
33. Garcia C (1984) Doeņca de Alzheimer, problemas do diagnóstico clínico. Tese de Doutoramento, Faculdade de Medicina de Lisboa.
34. Guerreiro M (1998) Contributo da Neuropsicologia para o Estudo das Demências. Disserta̧c ao de Doutoramento em Ciências Biomédicas, Faculdade de Medicina de Lisboa, pp. 37-61.
35. Blessed G, Tomlinson B, RothM(1968) Association between quantitative measures of dementing and senile change in cerebral grey matter of elderly subjects. Br J Psychiatry 114, 797-811.
36. Garcia C (2008) Blessed Dementia Rating Scale (BDRS). In Escalas e Testes na Demência, de Mendonça A, Guerreiro M, eds. Grupo de Estudos de Envelhecimento Cerebral e Demência, 3rd edition, Lisboa, pp. 105-106.
37. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, AdeyM, Leirer VO (1983) Development and validation of a geriatric depression screening scale: A preliminary report. J Psychiatr Res 17, 37-49. (Pubitemid 13123113)
38. Sheikh JI, Yesavage JA (1986) Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. In Clinical Gerontology: A Guide to Assessment and Intervention, TL Brink, ed. The Haworth Press Inc, NY, pp. 165-173. (Pubitemid 17221439)
39. Kawas C, Segal J, Stewart WF, Corrada M, Thal LJ (1994) A validation study of the Dementia Questionnaire. Arch Neurol 51, 901-906. (Pubitemid 24286045)
40. van Uffelen JG, Chin A, Paw MJ, Klein M, van Mechelen W, Hopman-Rock M(2007) Detection of memory impairment in the general population: Screening by questionnaire and telephone compared to subsequent face-to-face assessment. Int J Geriatr Psychiatry 22, 203-210. (Pubitemid 46436694)
41. Wechsler D (1945/1997) Wechsler Memory Scale (WMS-III), 3rd edition. Harcourt Assessment, San Antonio.
42. Reed BR, Mungas DM, Kramer JH, Ellis W, Vinters HV, Zarow C, Jagust WJ, Chui HC(2007) Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease. Brain 130, 731-739. (Pubitemid 46410743)
43. Devanand DP, Bansal R, Liu J, Hao X, Pradhaban G, Peterson BS (2012) MRI hippocampal and entorhinal cortex mapping in predicting conversion to Alzheimer's disease. Neuroimage 60, 1622-1629.
44. Tabert MH,Manly JJ, Liu X, Pelton GH, Rosenblum S, Jacobs M, Zamora D, Goodkind M, Bell K, Stern Y, Devanand DP (2006) Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Arch Gen Psychiatry 63, 916-924. (Pubitemid 44188484)
45. Sarazin M, Berr C, De Rotrou J, Fabrigoule C, Pasquier F, Legrain S, Michel B, Puel M, Volteau M, Touchon J, Verny M, Dubois B (2007) Amnestic syndrome of the medial temporal type identifies prodromal AD: A longitudinal study. Neurology 69, 1859-1867. (Pubitemid 350071147)
46. Grober E, Sanders AE, Hall C, Lipton RB (2010) Free and cued selective reminding identifies very mild dementia in primary care. Alzheimer Dis Assoc Disord 24, 284-290.
47. Delis DC, Kramer JH, Kaplan E, Ober BA (1987) The California Verbal Learning Test: Research Edition Adult Version, The Psychological Corporation, San Antonio.
48. Grober E, Buschke H (1987) Genuine memory deficit in dementia. Dev Neuropsychol 3, 13-36.
49. Fabrigoule C, Rouch I, Taberly A, Letenneur L, Commenges D, Mazaux JM, Orgogozo JM, Dartigues JF (1998) Cognitive process in preclinical phase of dementia. Brain 121, 135-141. (Pubitemid 28045512)
50. Jungwirth S, Zehetmayer S, Bauer P,Weissgram S, Tragl KH, Fischer P (2009) Prediction of Alzheimer dementia with short neuropsychological instruments. J Neural Transm 116, 1513- 1521.
51. Manly JJ, Tang MX, Schupf N, Stern Y, Vonsattel JP, Mayeux R (2008) Frequency and course of mild cognitive impairment in a multiethnic community. Ann Neurol 63, 494-506. (Pubitemid 351614715)
52. Gagnon LG, Belleville S (2011) Working memory in mild cognitive impairment and Alzheimer's disease: Contribution of forgetting and predictive value of complex span tasks. Neuropsychology 25, 226-236.
53. Baddeley A, Logie R, Bressi S, Della Salla S, Spinnler H (1986) Dementia and working memory. Q J Exp Psychol A 38, 603-618.
54. Lafleche G, Albert MS (1995) Executive function deficits in mild Alzheimer's disease. Neuropsychology 9, 313-320.
55. Traykov L, Raoux N, Latour F, Gallo L, Hanon O, Baudic S, Bayle C, Wenisch E, Remy P, Rigaud AS (2007) Executive functions deficit in mild cognitive impairment. Cogn Behav Neurol 20, 219-224. (Pubitemid 350307878)
56. Thillainadesan S, Wen W, Zhuang L, Crawford J, Kochan N, Reppermund S, Slavin M, Trollor J, Brodaty H, Sachdev P (2012) Changes in mild cognitive impairment and its subtypes as seen on diffusion tensor imaging. Int Psychogeriatr 27, 1-11.
57. Nutter-Upham KE, Saykin AJ, Rabin LA, Roth RM,Wishart HA, Pare N, FlashmanLA(2008)Verbal fluency performance in amnestic MCI and older adults with cognitive complaints. Arch Clin Neuropsychol 23, 229-241.
58. Corbett F, Jefferies E, Burns A, Ralph MA (2012) Unpicking the semantic impairment in Alzheimer's disease: Qualitative changes with disease severity. Behav Neurol 25, 23-34.
59. Rabin LA, Paré N, Saykin AJ, Brown MJ, Wishart HA, Flashman LA, Santulli RB (2009) Differential memory test sensitivity for diagnosing amnestic mild cognitive impairment and predicting conversion to Alzheimer's disease. Neuropsychol DevCogn B Aging Neuropsychol Cogn 16, 357- 376.
60. Gallagher D, Mhaolain AN, Coen R, Walsh C, Kilroy D, Belinski K, Bruce I, Coakley D, Walsh JB, Cunningham C, Lawlor BA (2010) Detecting prodromal Alzheimer's disease in mild cognitive impairment: Utility of the CAMCOG and other neuropsychological predictors. Int J Geriatr Psychiatry 25, 1280-1287.
61. Landau SM, Harvey D, Madison CM, Reiman EM, Foster NL, Aisen PS, Petersen RC, Shaw LM, Trojanowski JQ, Jack CR Jr,Weiner MW, Jagust WJ; Alzheimer's Disease Neuroimaging Initiative (2010) Comparing predictors of conversion and decline in mild cognitive impairment. Neurology 75, 230-238.
62. Aretouli E, Okonkwo OC, Samek J, Brandt J (2011) The fate of the 0.5 s: Predictors of 2-year outcome in mild cognitive impairment. J Int Neuropsychol Soc 17, 277-288.
63. The Ronald Nancy Reagan Research Institute of the Alzheimer's Association and National Institute on Aging Working Group [No authors listed] (1998) Consensus report of theWorking Group on: "Molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on AgingWorking Group. Neurobiol Aging 19, 109-116.
64. Nunes T, Fragata I, Ribeiro F, Palma T, Maroco J, Cannas J, Secca M, Menezes C, Carmo I, Cunha G, Castelo Branco M, Guerreiro M, de Mendonça A (2010) The outcome of elderly patients with cognitive complaints but normal neuropsychological tests. J Alzheimers Dis 19, 137-145.