메뉴 건너뛰기




Volumn 35, Issue 1, 2013, Pages 59-66

Hyperhomocysteinemic mice show cognitive impairment without features of alzheimer's disease phenotype

Author keywords

Alzheimer's disease; blood brain barrier; cognitive impairment; dementia; Homocysteine; microvascular permeability; microvessels

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; LRP1 PROTEIN; PGP PROTEIN; PROTEIN; RAGE PROTEIN; UNCLASSIFIED DRUG;

EID: 84876360474     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-122347     Document Type: Article
Times cited : (9)

References (33)
  • 1
    • 0036250657 scopus 로고    scopus 로고
    • The public health impact of Alzheimer's disease, 2000-2050: Potential implication of treatment advances
    • DOI 10.1146/annurev.publhealth.23.100901.140525
    • Sloane PD, Zimmerman S, Suchindran C, Reed P, Wang L, Boustani M, Sudha S (2002) The public health impact of Alzheimer's disease, 2000-2050: Potential implication of treatment advances. Annu Rev Public Health 23, 213-231. (Pubitemid 34508073)
    • (2002) Annual Review of Public Health , vol.23 , pp. 213-231
    • Sloane, P.D.1    Zimmerman, S.2    Suchindran, C.3    Reed, P.4    Wang, L.5    Boustani, M.6    Sudha, S.7
  • 5
    • 77951078680 scopus 로고    scopus 로고
    • Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease
    • Hartz AM, Miller DS, Bauer B (2010) Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Mol Pharmacol 77, 715-723.
    • (2010) Mol Pharmacol , vol.77 , pp. 715-723
    • Hartz, A.M.1    Miller, D.S.2    Bauer, B.3
  • 10
    • 80052024330 scopus 로고    scopus 로고
    • Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?
    • Zhuo JM, Wang H, Pratico D (2011) Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol Sci 32, 562-571.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 562-571
    • Zhuo, J.M.1    Wang, H.2    Pratico, D.3
  • 11
    • 65349162724 scopus 로고    scopus 로고
    • Hyperhomocysteinemia increases betaamyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain
    • Zhang CE, Wei W, Liu YH, Peng JH, Tian Q, Liu GP, Zhang Y, Wang JZ (2009) Hyperhomocysteinemia increases betaamyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. Am J Pathol 174, 1481-1491.
    • (2009) Am J Pathol , vol.174 , pp. 1481-1491
    • Zhang, C.E.1    Wei, W.2    Liu, Y.H.3    Peng, J.H.4    Tian, Q.5    Liu, G.P.6    Zhang, Y.7    Wang, J.Z.8
  • 13
    • 3242676904 scopus 로고    scopus 로고
    • Chronic hyperhomocysteinemia provokes a memory deficit in rats in the Morris water maze task
    • DOI 10.1016/j.bbr.2003.12.013, PII S0166432803004820
    • Streck EL, Bavaresco CS, Netto CA,WyseAT (2004) Chronic hyperhomocysteinemia provokes a memory deficit in rats in the Morris water maze task. Behav Brain Res 153, 377-381. (Pubitemid 38953111)
    • (2004) Behavioural Brain Research , vol.153 , Issue.2 , pp. 377-381
    • Streck, E.L.1    Bavaresco, C.S.2    Netto, C.A.3    Wyse, A.T.D.S.4
  • 14
    • 80051891527 scopus 로고    scopus 로고
    • Hyperhomocysteinemia increases permeability of the blood-brain barrier by NMDA receptor-dependent regulation of adherens and tight junctions
    • Beard RS Jr,Reynolds JJ, Bearden SE (2011) Hyperhomocysteinemia increases permeability of the blood-brain barrier by NMDA receptor-dependent regulation of adherens and tight junctions. Blood 118, 2007-2014.
    • (2011) Blood , vol.118 , pp. 2007-2014
    • Beard Jr., R.S.1    Reynolds, J.J.2    Bearden, S.E.3
  • 16
    • 78049386757 scopus 로고    scopus 로고
    • Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Abeta accumulation in AD brain
    • Owen JB, Sultana R, Aluise CD, Erickson MA, Price TO, Bu G, Banks WA, Butterfield DA (2010) Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Abeta accumulation in AD brain. Free Radic Biol Med 49, 1798-1803.
    • (2010) Free Radic Biol Med , vol.49 , pp. 1798-1803
    • Owen, J.B.1    Sultana, R.2    Aluise, C.D.3    Erickson, M.A.4    Price, T.O.5    Bu, G.6    Banks, W.A.7    Butterfield, D.A.8
  • 17
    • 27244455440 scopus 로고    scopus 로고
    • High homocysteine and low B vitamins predict cognitive decline in aging men: The Veterans Affairs Normative Aging Study
    • Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A, 3rd (2005) High homocysteine and low B vitamins predict cognitive decline in aging men: The Veterans Affairs Normative Aging Study. Am J Clin Nutr 82, 627-635.
    • (2005) Am J Clin Nutr , vol.82 , pp. 627-635
    • Tucker, K.L.1    Qiao, N.2    Scott, T.3    Rosenberg, I.4    Spiro III, A.5
  • 20
    • 0029865065 scopus 로고    scopus 로고
    • Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study
    • Riggs KM, Spiro A, 3rd, Tucker K, Rush D (1996) Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 63, 306-314. (Pubitemid 26074688)
    • (1996) American Journal of Clinical Nutrition , vol.63 , Issue.3 , pp. 306-314
    • Riggs, K.M.1    Spiro III, A.2    Tucker, K.3    Rush, D.4
  • 23
    • 79953282242 scopus 로고    scopus 로고
    • Impairments in brain-to-blood transport of amyloid-beta and reabsorption of cerebrospinal fluid in an animal model of Alzheimer's disease are reversed by antisense directed against amyloid-beta protein precursor
    • Banks WA, Kumar VB, Farr SA, Nakaoke R, Robinson SM, Morley JE (2011) Impairments in brain-to-blood transport of amyloid-beta and reabsorption of cerebrospinal fluid in an animal model of Alzheimer's disease are reversed by antisense directed against amyloid-beta protein precursor. J Alzheimers Dis 23, 599-605.
    • (2011) J Alzheimers Dis , vol.23 , pp. 599-605
    • Banks, W.A.1    Kumar, V.B.2    Farr, S.A.3    Nakaoke, R.4    Robinson, S.M.5    Morley, J.E.6
  • 25
    • 84867575586 scopus 로고    scopus 로고
    • Chronic vascular risk factors (cholesterol, homocysteine, ethanol) impair spatial memory, decline cholinergic neurons and induce blood-brain barrier leakage in rats in vivo
    • Ehrlich D, Humpel C (2012) Chronic vascular risk factors (cholesterol, homocysteine, ethanol) impair spatial memory, decline cholinergic neurons and induce blood-brain barrier leakage in rats in vivo. J Neurol Sci.
    • (2012) J Neurol Sci
    • Ehrlich, D.1    Humpel, C.2
  • 26
    • 30744450012 scopus 로고    scopus 로고
    • Elevated levels of homocysteine compromise blood-brain barrier integrity in mice
    • DOI 10.1182/blood-2005-06-2506
    • Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, Wagner DD (2006) Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood 107, 591-593. (Pubitemid 43090794)
    • (2006) Blood , vol.107 , Issue.2 , pp. 591-593
    • Kamath, A.F.1    Chauhan, A.K.2    Kisucka, J.3    Dole, V.S.4    Loscalzo, J.5    Handy, D.E.6    Wagner, D.D.7
  • 28
    • 77949675424 scopus 로고    scopus 로고
    • Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease
    • Zhuo JM, Portugal GS, Kruger WD, Wang H, Gould TJ, Pratico D (2010) Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. Curr Alzheimer Res 7, 140-149.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 140-149
    • Zhuo, J.M.1    Portugal, G.S.2    Kruger, W.D.3    Wang, H.4    Gould, T.J.5    Pratico, D.6
  • 29
    • 77957848546 scopus 로고    scopus 로고
    • Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease
    • Zhuo JM, Pratico D (2010) Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease. FASEB J 24, 3895-3902.
    • (2010) FASEB J , vol.24 , pp. 3895-3902
    • Zhuo, J.M.1    Pratico, D.2
  • 30
    • 76749128435 scopus 로고    scopus 로고
    • Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet
    • Zhuo JM, Pratico D (2010) Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet. Exp Gerontol 45, 195-201.
    • (2010) Exp Gerontol , vol.45 , pp. 195-201
    • Zhuo, J.M.1    Pratico, D.2
  • 32
    • 77954981559 scopus 로고    scopus 로고
    • Severe in vivo hyperhomocysteinemia is not associatedwith elevation of amyloidbeta peptides in the Tg2576 mice
    • Zhuo JM, Pratico D (2010) Severe In vivo hyperhomocysteinemia is not associatedwith elevation of amyloidbeta peptides in the Tg2576 mice. J Alzheimers Dis 21, 133-140.
    • (2010) J Alzheimers Dis , vol.21 , pp. 133-140
    • Zhuo, J.M.1    Pratico, D.2
  • 33
    • 78149262357 scopus 로고    scopus 로고
    • Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats
    • Pirchl M, Ullrich C, Humpel C (2010) Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats. Eur J Neurosci 32, 1516-1527.
    • (2010) Eur J Neurosci , vol.32 , pp. 1516-1527
    • Pirchl, M.1    Ullrich, C.2    Humpel, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.