메뉴 건너뛰기




Volumn 322, Issue 1-2, 2012, Pages 92-95

Chronic vascular risk factors (cholesterol, homocysteine, ethanol) impair spatial memory, decline cholinergic neurons and induce blood-brain barrier leakage in rats in vivo

Author keywords

Alzheimer's disease; Blood brain barrier leakage; Vascular dementia; Vascular risk factors

Indexed keywords

ALCOHOL; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CHOLESTEROL; HOMOCYSTEINE; TAU PROTEIN;

EID: 84867575586     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2012.07.002     Document Type: Article
Times cited : (49)

References (38)
  • 1
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • B.V. Zlokovic Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Nat Rev Neurosci 12 2011 723 738
    • (2011) Nat Rev Neurosci , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 2
    • 78649427539 scopus 로고    scopus 로고
    • Vascular basis for brain degeneration: Faltering controls and risk factors for dementia
    • R.N. Kalaria Vascular basis for brain degeneration: faltering controls and risk factors for dementia Nutr Rev 68 Suppl. 2 2010 74 87
    • (2010) Nutr Rev , vol.68 , Issue.SUPPL. 2 , pp. 74-87
    • Kalaria, R.N.1
  • 3
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 4
    • 81355164295 scopus 로고    scopus 로고
    • Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations
    • N.E. Shepardson, G.M. Shankar, and D.J. Selkoe Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations Arch Neurol 68 2011 1385 1392
    • (2011) Arch Neurol , vol.68 , pp. 1385-1392
    • Shepardson, N.E.1    Shankar, G.M.2    Selkoe, D.J.3
  • 5
    • 77954556007 scopus 로고    scopus 로고
    • Ethanol and cognition: Indirect effects, neurotoxicity and neuroprotection: A review
    • J.C. Brust Ethanol and cognition: indirect effects, neurotoxicity and neuroprotection: a review Int J Environ Res Public Health 7 2010 1540 1557
    • (2010) Int J Environ Res Public Health , vol.7 , pp. 1540-1557
    • Brust, J.C.1
  • 6
    • 80052024330 scopus 로고    scopus 로고
    • Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?
    • J.M. Zhuo, H. Wang, and D. Praticò Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol Sci 32 2011 562 571
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 562-571
    • Zhuo, J.M.1    Wang, H.2    Praticò, D.3
  • 8
    • 79952701977 scopus 로고    scopus 로고
    • Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?
    • C. Humpel Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease? Exp Gerontol 46 2011 225 232
    • (2011) Exp Gerontol , vol.46 , pp. 225-232
    • Humpel, C.1
  • 9
    • 0036218738 scopus 로고    scopus 로고
    • Alzheimer's disease as a vascular disorder
    • J.C. De la Torre Alzheimer's disease as a vascular disorder Stroke 33 2002 1152 1162
    • (2002) Stroke , vol.33 , pp. 1152-1162
    • De La Torre, J.C.1
  • 11
    • 84867575838 scopus 로고    scopus 로고
    • Vascular dementia
    • A.Y. Lee Vascular dementia Chonnam Med J 47 2011 66 71
    • (2011) Chonnam Med J , vol.47 , pp. 66-71
    • Lee, A.Y.1
  • 12
    • 0022371325 scopus 로고
    • Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: Kinetics of unidirectional influx, carrier specificity and effects of glucagon
    • G.E. Mann, B.V. Zlokovic, and D.L. Yudilevich Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon Biochim Biophys Acta 819 1985 241 248
    • (1985) Biochim Biophys Acta , vol.819 , pp. 241-248
    • Mann, G.E.1    Zlokovic, B.V.2    Yudilevich, D.L.3
  • 13
    • 0030933273 scopus 로고    scopus 로고
    • Cellular and molecular neurosurgery: Pathways from concept to reality - Part I: Target disorders and concept approaches to gene therapy of the central nervous system
    • B.V. Zlokovic, and M.L. Apuzzo Cellular and molecular neurosurgery: pathways from concept to reality - part I: target disorders and concept approaches to gene therapy of the central nervous system Neurosurgery 40 1997 789 803
    • (1997) Neurosurgery , vol.40 , pp. 789-803
    • Zlokovic, B.V.1    Apuzzo, M.L.2
  • 14
    • 0022377737 scopus 로고
    • Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone
    • B.V. Zlokovic, M.B. Segal, D.J. Begley, H. Davson, and L. Rakić Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone Brain Res 358 1985 191 199
    • (1985) Brain Res , vol.358 , pp. 191-199
    • Zlokovic, B.V.1    Segal, M.B.2    Begley, D.J.3    Davson, H.4    Rakić, L.5
  • 15
    • 0022257648 scopus 로고
    • Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine)
    • B.V. Zlokovic, D.J. Begley, and D.G. Chain-Eliash Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine) Brain Res 336 1985 125 132
    • (1985) Brain Res , vol.336 , pp. 125-132
    • Zlokovic, B.V.1    Begley, D.J.2    Chain-Eliash, D.G.3
  • 16
    • 0024435745 scopus 로고
    • Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain
    • B.V. Zlokovic, J.B. Mackic, B. Djuricic, and H. Davson Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain J Neurochem 53 1989 1333 1340
    • (1989) J Neurochem , vol.53 , pp. 1333-1340
    • Zlokovic, B.V.1    MacKic, J.B.2    Djuricic, B.3    Davson, H.4
  • 18
    • 84861418194 scopus 로고    scopus 로고
    • Apolipoprotein e controls cerebrovascular integrity via cyclophilin A
    • R.D. Bell, E.A. Winkler, I. Singh, A.P. Sagare, R. Deane, and Z. Wu Apolipoprotein E controls cerebrovascular integrity via cyclophilin A Nature 485 2012 512 516
    • (2012) Nature , vol.485 , pp. 512-516
    • Bell, R.D.1    Winkler, E.A.2    Singh, I.3    Sagare, A.P.4    Deane, R.5    Wu, Z.6
  • 19
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • R.D. Bell, E.A. Winkler, A.P. Sagare, I. Singh, B. LaRue, and R. Deane Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Neuron 68 2010 409 427
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3    Singh, I.4    Larue, B.5    Deane, R.6
  • 20
    • 77957959900 scopus 로고    scopus 로고
    • Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits
    • C. Ullrich, M. Pirchl, and C. Humpel Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits Mol Cell Neurosci 45 2010 408 417
    • (2010) Mol Cell Neurosci , vol.45 , pp. 408-417
    • Ullrich, C.1    Pirchl, M.2    Humpel, C.3
  • 21
    • 78149262357 scopus 로고    scopus 로고
    • Differential effects of short- and long-term hyperhomocysteinemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats
    • M. Pirchl, C. Ullrich, and C. Humpel Differential effects of short- and long-term hyperhomocysteinemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats Eur J Neurosci 32 2010 1516 1527
    • (2010) Eur J Neurosci , vol.32 , pp. 1516-1527
    • Pirchl, M.1    Ullrich, C.2    Humpel, C.3
  • 22
    • 84858009243 scopus 로고    scopus 로고
    • Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation and vascular impairment in rats
    • Ehrlich Daniela, Pirchl Michael, and Christian Humpel Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation and vascular impairment in rats Neuroscience 205 2012 154 166
    • (2012) Neuroscience , vol.205 , pp. 154-166
    • Daniela, E.1    Michael, P.2    Humpel, C.3
  • 23
    • 0021687512 scopus 로고
    • On the role of hippocampal connections in the performance of place and cue tasks: Comparisons with damage to hippocampus
    • L.E. Jarrard, H. Okaichi, O. Steward, and R.B. Goldschmidt On the role of hippocampal connections in the performance of place and cue tasks: comparisons with damage to hippocampus Behav Neurosci 98 1984 946 954
    • (1984) Behav Neurosci , vol.98 , pp. 946-954
    • Jarrard, L.E.1    Okaichi, H.2    Steward, O.3    Goldschmidt, R.B.4
  • 24
    • 55849111494 scopus 로고    scopus 로고
    • Cholinergic system during the progression of Alzheimer's disease: Therapeutic implications
    • E.J. Mufson, S.E. Counts, S.E. Perez, and S.D. Ginsberg Cholinergic system during the progression of Alzheimer's disease: therapeutic implications Expert Rev Neuroether 8 2008 1703 1718
    • (2008) Expert Rev Neuroether , vol.8 , pp. 1703-1718
    • Mufson, E.J.1    Counts, S.E.2    Perez, S.E.3    Ginsberg, S.D.4
  • 25
    • 84856754551 scopus 로고    scopus 로고
    • Role of interleukin 6 and alpha-globulins in differentiating Alzheimer and vascular dementias
    • [Epub ahead of print]
    • A.A. Helmy, M.M. Abdel Naseer, S. El Shafie, and M.A. Nada Role of interleukin 6 and alpha-globulins in differentiating Alzheimer and vascular dementias Neurodegener Dis 9 2 2012 81 86 [Epub ahead of print]
    • (2012) Neurodegener Dis , vol.9 , Issue.2 , pp. 81-86
    • Helmy, A.A.1    Abdel Naseer, M.M.2    El Shafie, S.3    Nada, M.A.4
  • 26
    • 0037421206 scopus 로고    scopus 로고
    • Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
    • R. Ehehalt, P. Keller, C. Haass, C. Thiele, and K. Simons Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts J Cell Biol 160 2003 113 123
    • (2003) J Cell Biol , vol.160 , pp. 113-123
    • Ehehalt, R.1    Keller, P.2    Haass, C.3    Thiele, C.4    Simons, K.5
  • 27
    • 68149148938 scopus 로고    scopus 로고
    • Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidativestress in aged APP mice
    • X.K. Tong, N. Nicolakakis, P. Fernandes, B. Ongali, J. Brouillette, and R. Quirion Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidativestress in aged APP mice Neurobiol Dis 35 2009 406 414
    • (2009) Neurobiol Dis , vol.35 , pp. 406-414
    • Tong, X.K.1    Nicolakakis, N.2    Fernandes, P.3    Ongali, B.4    Brouillette, J.5    Quirion, R.6
  • 28
    • 77953282057 scopus 로고    scopus 로고
    • Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?
    • A.J. Beel, M. Sakakura, P.J. Barrett, and C.R. Sanders Direct binding of cholesterol to the amyloid precursor protein: an important interaction in lipid-Alzheimer's disease relationships? Biochim Biophys Acta 1801 2010 975 982
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 975-982
    • Beel, A.J.1    Sakakura, M.2    Barrett, P.J.3    Sanders, C.R.4
  • 29
  • 31
    • 34848891770 scopus 로고    scopus 로고
    • Hypermethioninemia increases cerebral acetylcholinesterase activity and impairs memory in rats
    • F.M. Stefanello, S.C. Monteiro, C. Matte', E.B. Scherer, C.A. Netto, and A.T. Wyse Hypermethioninemia increases cerebral acetylcholinesterase activity and impairs memory in rats Neurochem Res 32 2007 1868 1874
    • (2007) Neurochem Res , vol.32 , pp. 1868-1874
    • Stefanello, F.M.1    Monteiro, S.C.2    Mattec3    Scherer, E.B.4    Netto, C.A.5    Wyse, A.T.6
  • 33
    • 0028170860 scopus 로고
    • Impairment in memory function and neurodegenerative changes in the cholinergic basal forebrain system induced by chronic intake of ethanol
    • T. Arendt Impairment in memory function and neurodegenerative changes in the cholinergic basal forebrain system induced by chronic intake of ethanol J Neural Transm Suppl 44 1994 173 187
    • (1994) J Neural Transm Suppl , vol.44 , pp. 173-187
    • Arendt, T.1
  • 34
    • 0028953736 scopus 로고
    • Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury - II. Reactive expression of the nerve growth factor gene in astrocytes
    • T. Arendt, M.K. Brückner, T. Krell, S. Pagliusi, L. Kruska, and R. Heumann Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury - II. Reactive expression of the nerve growth factor gene in astrocytes Neuroscience 65 1995 647 659
    • (1995) Neuroscience , vol.65 , pp. 647-659
    • Arendt, T.1    Brückner, M.K.2    Krell, T.3    Pagliusi, S.4    Kruska, L.5    Heumann, R.6
  • 35
    • 68049115742 scopus 로고    scopus 로고
    • Alcohol consumption as a risk factor for dementia and cognitive decline: Meta-analysis of prospective studies
    • K.J. Anstey, H.A. Mack, and N. Cherubin Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies Am J Geriatr Psychiatry 17 2009 542 555
    • (2009) Am J Geriatr Psychiatry , vol.17 , pp. 542-555
    • Anstey, K.J.1    MacK, H.A.2    Cherubin, N.3
  • 36
    • 0035912198 scopus 로고    scopus 로고
    • Pathways to neuronal injury and apoptosis in HIV-associated dementia
    • M. Kaul, G.A. Garden, and S.A. Lipoton Pathways to neuronal injury and apoptosis in HIV-associated dementia Nature 410 2001 988 994
    • (2001) Nature , vol.410 , pp. 988-994
    • Kaul, M.1    Garden, G.A.2    Lipoton, S.A.3
  • 37
    • 0034054259 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of alcohol absorption
    • T.R. Gentry Effect of food on the pharmacokinetics of alcohol absorption Alcohol Clin Exp Res 24 2000 403 404
    • (2000) Alcohol Clin Exp Res , vol.24 , pp. 403-404
    • Gentry, T.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.