Ambulation and multiple sclerosis

Physical Medicine and Rehabilitation Clinics of North America

Volumn 24, Issue 2, 2013, Pages 325-336

  Motl, Robert W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Ambulation; Disability; Exercise; Multiple sclerosis; Quality of life; Walking

Indexed keywords

4 AMINOPYRIDINE; PLACEBO;

CAUSAL ATTRIBUTION; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL FEATURE; COGNITION; COMMUNITY LIVING; DAILY LIFE ACTIVITY; DISEASE ASSOCIATION; DRUG EFFICACY; FUNCTIONAL STATUS; GAIT; HUMAN; KINESIOTHERAPY; MOBILIZATION; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; OXYGEN CONSUMPTION; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; REHABILITATION CARE; REVIEW; TREADMILL EXERCISE; WALKING DIFFICULTY; WALKING SPEED;

DISABILITY EVALUATION; HUMANS; MULTIPLE SCLEROSIS; QUALITY OF LIFE; WALKING;

EID: 84876356092     PISSN: 10479651     EISSN: 15581381     Source Type: Journal    
DOI: 10.1016/j.pmr.2012.11.004     Document Type: Review

References (72)

1. National Multiple Sclerosis Society Multiple sclerosis information sourcebook 2005, Information Resource Center and Library of the National Multiple Sclerosis Society, New York.
2. Hemmer B., Nessler S., Zhou D., et al. Immunopathogenesis and immunotherapy of multiple sclerosis. Nat Clin Pract Neurol 2006, 2:201-211.
3. Trapp B.D., Nave K. Multiple sclerosis: an immune or neurodegenerative disorder?. Annu Rev Neurosci 2008, 31:247-269.
4. Lublin F.D. Clinical features and diagnosis of multiple sclerosis. Neurol Clin 2005, 23:1-15.
5. Larocca N.G. Impact of walking impairment in multiple sclerosis: perspectives of patients and care partners. Patient 2011, 4:189-201.
6. Murray T.J. Multiple sclerosis: the history of a disease 2005, Demos, New York.
7. Hobart J.C., Riazi A., Lamping D.L., et al. Measuring the impact of MS on walking ability: the 12-item MS Walking Scale (MSWS-12). Neurology 2003, 60:31-36.
8. Van Asch P. Impact of mobility impairment in multiple sclerosis 2 - Patients' perspectives. Eur Neurol Rev 2011, 6:115-120.
9. Pearson O.R., Busse M.E., Van Deursen R.W., et al. Quantification of walking mobility in neurological disorders. QJM 2004, 97:463-475.
10. Sosnoff J.J., Gappmaier E., Frame A., et al. Influence of spasticity on mobility and balance in persons with multiple sclerosis. J Neurol Phys Ther 2011, 35:129-132.
11. Huisinga J.M., Filipi M.L., Schmid K.K., et al. Is there a relationship between fatigue questionnaires and gait mechanisms in persons with multiple sclerosis?. Arch Phys Med Rehabil 2011, 92:1594-1601.
12. Motl R.W., Sandroff B.M., Suh Y., et al. Energy cost of walking and its association with gait parameters, daily activity, and fatigue in persons with mild multiple sclerosis. Neurorehabil Neural Repair 2012, 26:1015-1021.
13. Martin C.L., Phillips B.A., Kilpatrick T.J., et al. Gait and balance impairment in early multiple sclerosis in the absence of clinical disability. Mult Scler 2006, 12:620-628.
14. Saunders J.B., Inman V.T., Eberthart H.D. The major determinants in normal and pathological gait. J Bone Joint Surg Am 1953, 35:543-558.
15. Orendurff M.S., Segal A.D., Klute G.K., et al. The effect of walking speed on center of mass displacement. J Rehabil Res Dev 2004, 41:829-834.
16. Motl R.W., Sandroff B.M., Sosnoff J.J. Commercially available accelerometry as an ecologically valid measure of ambulation in persons with multiple sclerosis. Expert Rev Neurother 2012, 12:1079-1088.
17. Iezzoni L.I. When walking fails. Mobility problems of adults with chronic conditions 2003, University of California Press, Berkeley (CA).
18. Heesen C., Böhm J., Reich C., et al. Patient perception of bodily functions in multiple sclerosis: gait and visual function are the most valuable. Mult Scler 2008, 14:988-991.
19. Motl R.W., Snook E.M., McAuley E., et al. Demographic correlates of physical activity in individuals with multiple sclerosis. Disabil Rehabil 2007, 29:1301-1304.
20. Gijbels D., Alders G., Van Hoof E., et al. Predicting habitual walking performance in multiple sclerosis: relevance of capacity and self-report measures. Mult Scler 2010, 16:618-626.
21. Goldman M.D., Motl R.W., Rudick R.A. Possible clinical outcome measures for clinical trials in patients with multiple sclerosis. Ther Adv Neurol Disord 2010, 3(4):229-239.
22. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983, 33(11):1444-1452.
23. Fischer J.S., Rudick R.A., Cutter G.R., et al. The Multiple Sclerosis Functional Composite measure (MFSC): an integrated approach to MS clinical outcome assessment. National MS Society Clinical Outcomes Assessment Task Force. Mult Scler 1999, 5:244-250.
24. Confavreux C., Vukusic S. Natural history of multiple sclerosis. Brain 2006, 129:606-616.
25. Confavreux C., Vukusic S., Adeline P. Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process. Brain 2003, 126:770-782.
26. Confavreux C., Vukusic S., Moreau T., et al. Relapses and progression of disability in multiple sclerosis. N Engl J Med 2000, 343:1430-1438.
27. Schwid S.R., Goodman A.D., McDermott M.P., et al. Quantitative functional measures in MS: what is reliable change?. Neurology 2002, 58:1294-1296.
28. Kieseier B.C., Pozzilli C. Assessing walking disability in multiple sclerosis. Mult Scler 2012, 18:914-924.
29. Phan-Ba R., Pace A., Calay P., et al. Comparison of the timed 25-foot and the 100-meter walk as performance measures in multiple sclerosis. Neurorehabil Neural Repair 2011, 25:672-679.
30. Goldman M.D., Marrie R.A., Cohen J.A. Evaluation of the six-minute walk in multiple sclerosis subjects and healthy controls. Mult Scler 2008, 14:383-390.
31. Heffernan K.S., Ranadive S., Weikert M., et al. Pulse pressure is associated with walking impairment in multiple sclerosis. J Neurol Sci 2011, 309:105-109.
32. Motl R.W., Suh Y., Balantrapu S., et al. Evidence for the different physiological significance of the 6- and 2-minute walk tests in multiple sclerosis. BMC Neurol 2012, 12:6.
33. Motl R.W., Weikert M., Suh Y., et al. Accuracy of the Actibelt(®) accelerometer for measuring walking speed in a controlled environment among persons with multiple sclerosis. Gait Posture 2012, 35:192-196.
34. Givon U., Zeilig G., Achiron A. Gait analysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system. Gait Posture 2009, 29:138-142.
35. Sosnoff J.J., Boes M.K., Sandroff B.M., et al. Walking and thinking in persons with multiple sclerosis who vary in disability. Arch Phys Med Rehabil 2011, 92:2028-2033.
36. Sosnoff J.J., Sandroff B., Motl R.W. Quantifying gait abnormalities in persons with multiple sclerosis with minimal disability. Gait Posture 2012, 36:154-156.
37. TM technology. Gait Posture 2011, 34:145-147.
38. Pilutti LA, Dlugonski D, Sandroff BM, et al. Further validation of Multiple Sclerosis Walking Scale-12 scores based on spatiotemporal gait parameters. Arch Phys Med Rehabil, in press.
39. Waters S., Mulroy S. The energy expenditure of normal and pathological gait. Gait Posture 1999, 9:207-231.
40. Motl R.W., Dlugonski D., Weikert M., et al. Multiple sclerosis walking scale-12 and oxygen cost of walking. Gait Posture 2010, 31:506-510.
41. Motl R.W., Snook E.M., Agiovlasitit S., et al. Calibration of accelerometer output for ambulatory adults with multiple sclerosis. Arch Phys Med Rehabil 2009, 90:1778-1784.
42. Motl R.W., Suh Y., Dlugonski D., et al. Oxygen cost of treadmill and over-ground walking in mildly disabled persons with multiple sclerosis. Neurol Sci 2011, 32:255-262.
43. Olgiati R., Jacquet J., Di Prampero P.E. Energy cost of walking and exertional dyspnea in multiple sclerosis. Am Rev Respir Dis 1986, 134:1005-1010.
44. Sandroff BM, Motl RW. Comparison of ActiGraph activity monitors in persons with multiple sclerosis and controls. Disabil Rehabil, in press.
45. Sosnoff J.J., Goldman M.S., Motl R.W. Real-life walking impairment in multiple sclerosis: preliminary comparison of four methods for processing accelerometry data. Mult Scler 2010, 16:868-877.
46. Weikert M., Suh Y., Lane A., et al. Accelerometry is associated with walking mobility, not physical activity, in persons with multiple sclerosis. Med Eng Phys 2012, 34:590-597.
47. Yogev-Seligmann G., Hausdorff J.M., Giladi N. The role of executive function and attention in gait. Mov Disord 2007, 23:329-342.
48. Benedict R.H., Holtzer R., Motl R.W., et al. Upper and lower extremity motor function and cognitive impairment in multiple sclerosis. J Int Neuropsychol Soc 2011, 13:1-11.
49. Hamilton F., Rochester L., Paul L., et al. Walking and talking: an investigation of cognitive-motor dual tasking in multiple sclerosis. Mult Scler 2009, 15:1215-1227.
50. Kalron A., Dvir Z., Achiron A. Walking while talking-difficulties incurred during the initial stages of multiple sclerosis disease process. Gait Posture 2010, 32:332-335.
51. Hersch C., Rae-Grant A. Extended-release dalfampridine in the management of multiple-sclerosis-related walking impairment. Ther Adv Neurol Disord 2012, 5:199-204.
52. Blight A.R. Treatment of walking impairment in multiple sclerosis with dalfampridine. Ther Adv Neurol Disord 2011, 4:99-109.
53. Goodman A.D., Brown T.R., Krupp L.B., et al. Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial. Lancet 2009, 373:732-738.
54. Goodman A.D., Brown T.R., Edwards K.R., et al. A phase 3 trial of extended release oral dalfampridine in multiple sclerosis. Ann Neurol 2010, 68:494-502.
55. Shakespeare D.T., Boggild M., Young C. Anti-spasticity agents for multiple sclerosis. Cochrane Database Syst Rev 2003, (4). CD001332.
56. Motl R.W. Physical activity and irreversible disability in multiple sclerosis. Exerc Sport Sci Rev 2010, 38:186-191.
57. Motl R.W., Goldman M.D., Benedict R.H. Walking impairment in patients with multiple sclerosis: exercise training as a treatment option?. Neuropsychiatr Dis Treat 2010, 6:767-774.
58. Motl R.W., Pilutti L.A. The benefits of exercise training in multiple sclerosis. Nat Rev Neurol 2012, 8:487-497.
59. Snook E.M., Motl R.W. Effect of exercise training on walking mobility in multiple sclerosis: a meta-analysis. Neurorehabil Neural Repair 2009, 23:108-116.
60. Motl R.W., Smith D.C., Elliott J., et al. Combined training improves walking mobility in persons with significant disability from multiple sclerosis: a pilot study. J Neurol Phys Ther 2012, 36:32-37.
61. Beer S., Aschbacher B., Manoglou D., et al. Robot-assisted gait training in multiple sclerosis: a pilot randomized trial. Mult Scler 2008, 14:231-236.
62. Geisser B., Beres-Jones J., Budovitch A., et al. Locomotor training using body weight support on a treadmill improves mobility in persons with multiple sclerosis: a pilot study. Mult Scler 2007, 13:224-231.
63. Lo A.C., Triche E.W. Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training. Neurorehabil Neural Repair 2008, 22:661-671.
64. Pilutti L.A., Lelli D.A., Paulseth J.E., et al. Effects of 12 weeks of supported treadmill training on functional ability and quality of life in progressive multiple sclerosis: a pilot study. Arch Phys Med Rehabil 2011, 92:31-36.
65. Kelleher K.J., Spence W., Solomonidis S., et al. Ambulatory rehabilitation in multiple sclerosis. Disabil Rehabil 2009, 31:1625-1632.
66. Wiles C.M. Physiotherapy and related activities in multiple sclerosis. Mult Scler 2008, 14:863-871.
67. Vaney C., Gattlen B., Lugon-Moulin V., et al. Robotic-assisted step training (Lokomat) not superior to equal intensity of over-ground rehabilitation in patients with multiple sclerosis. Neurorehabil Neural Repair 2012, 26(3):212-221.
68. Prakash R.S., Snook E.M., Erickson K.I., et al. Cardiorespiratory fitness: a predictor of cortical plasticity in multiple sclerosis. Neuroimage 2007, 34:1238-1244.
69. Prakash R.S., Snook E.M., Motl R.W., et al. Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis. Brain Res 2010, 1341:41-51.
70. Motl R.W., Sandroff B.M., Benedict R.H. Cognitive dysfunction and multiple sclerosis: developing a rationale for considering the efficacy of exercise training. Mult Scler 2011, 17:1034-1040.
71. Bartrés-Faz D., Arenaza-Urquijo E.M. Structural and functional imaging correlates of cognitive and brain reserve hypotheses in healthy and pathological aging. Brain Topogr 2011, 24:340-357.
72. Colcombe S.J., Kramer A.F., McAuley E., et al. Neurocognitive aging and cardiovascular fitness: recent findings and future directions. J Mol Neurosci 2004, 24:9-14.