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Volumn 74, Issue 5, 2013, Pages 593-597

The HLA-G low expressor genotype is associated with protection against bipolar disorder

(19)  Debnath, Monojit a,b   Busson, Marc a,f   Jamain, Stéphane b,c,d,e   Etain, Bruno b,c,d,e   Hamdani, Nora b,c,d,e   Oliveira, José a,b   Boukouaci, Wahid a,f   Amokrane, Kahina a,f   Moins Teisserenc, Hélène a,e,f   Lajnef, Mohamed b,c,d,e   Bengoufa, Djaouida a   Malafosse, Alain g   Bellivier, Frank b,c,d,e   Henry, Chantal b,c,d,e   Kahn, Jean Pierre i   Krishnamoorthy, Rajagopal a,e,h   Charron, Dominique a,e,f   Leboyer, Marion b,c,d,e   Tamouza, Ryad a,e,f  


Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GENOMIC DNA; HLA G ANTIGEN;

EID: 84876331324     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2012.11.032     Document Type: Article
Times cited : (29)

References (58)
  • 2
    • 47749156793 scopus 로고    scopus 로고
    • The genetics of bipolar disorder: genome 'hot regions', genes, new potential candidates and future directions
    • Serretti A., Mandelli L. The genetics of bipolar disorder: genome 'hot regions', genes, new potential candidates and future directions. Mol Psychiatry 2008, 8:742-771.
    • (2008) Mol Psychiatry , vol.8 , pp. 742-771
    • Serretti, A.1    Mandelli, L.2
  • 3
    • 58149464318 scopus 로고    scopus 로고
    • Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    • Lichtenstein P., Yip B.H., Björk C., Pawitan Y., Cannon T.D., Sullivan P.F., et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009, 373:234-239.
    • (2009) Lancet , vol.373 , pp. 234-239
    • Lichtenstein, P.1    Yip, B.H.2    Björk, C.3    Pawitan, Y.4    Cannon, T.D.5    Sullivan, P.F.6
  • 5
    • 0036550299 scopus 로고    scopus 로고
    • Family, twin, and adoption studies of bipolar disease
    • Taylor L., Faraone S.V., Tsuang M.T. Family, twin, and adoption studies of bipolar disease. Curr Psychiatry Rep 2002, 4:130-133.
    • (2002) Curr Psychiatry Rep , vol.4 , pp. 130-133
    • Taylor, L.1    Faraone, S.V.2    Tsuang, M.T.3
  • 6
  • 7
    • 70349562518 scopus 로고    scopus 로고
    • Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature
    • Goldstein B.I., Kemp D.E., Soczynska J.K., McIntyre R.S. Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry 2009, 70:1078-1090.
    • (2009) J Clin Psychiatry , vol.70 , pp. 1078-1090
    • Goldstein, B.I.1    Kemp, D.E.2    Soczynska, J.K.3    McIntyre, R.S.4
  • 8
    • 84860844973 scopus 로고    scopus 로고
    • Immuno-inflammatory markers of bipolar disorder: a review of evidence
    • Hamdani N., Tamouza R., Leboyer M. Immuno-inflammatory markers of bipolar disorder: a review of evidence. Front Biosci (Elite Ed) 2012, 4:2170-2182.
    • (2012) Front Biosci (Elite Ed) , vol.4 , pp. 2170-2182
    • Hamdani, N.1    Tamouza, R.2    Leboyer, M.3
  • 9
    • 78651417057 scopus 로고    scopus 로고
    • Immune suppression and immune activation in depression
    • Blume J., Douglas S.D., Evans D.L. Immune suppression and immune activation in depression. Brain Behav Immun 2011, 25:221-229.
    • (2011) Brain Behav Immun , vol.25 , pp. 221-229
    • Blume, J.1    Douglas, S.D.2    Evans, D.L.3
  • 12
    • 4644250607 scopus 로고    scopus 로고
    • A high prevalence of organ-specific autoimmunity in patients with bipolar disorder
    • Padmos R.C., Bekris L., Knijff E.M., Tiemeier H., Kupka R.W., Cohen D., et al. A high prevalence of organ-specific autoimmunity in patients with bipolar disorder. Biol Psychiatry 2004, 56:476-482.
    • (2004) Biol Psychiatry , vol.56 , pp. 476-482
    • Padmos, R.C.1    Bekris, L.2    Knijff, E.M.3    Tiemeier, H.4    Kupka, R.W.5    Cohen, D.6
  • 13
    • 34250716553 scopus 로고    scopus 로고
    • Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?
    • Vonk R., van der Schot A.C., Kahn R.S., Nolen W.A., Drexhage H.A. Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?. Biol Psychiatry 2007, 62:135-140.
    • (2007) Biol Psychiatry , vol.62 , pp. 135-140
    • Vonk, R.1    van der Schot, A.C.2    Kahn, R.S.3    Nolen, W.A.4    Drexhage, H.A.5
  • 14
  • 15
    • 0141644115 scopus 로고    scopus 로고
    • Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan
    • Terayama H., Nishino Y., Kishi M., Ikuta K., Itoh M., Iwahashi K. Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan. Psychiatry Res 2003, 120:201-206.
    • (2003) Psychiatry Res , vol.120 , pp. 201-206
    • Terayama, H.1    Nishino, Y.2    Kishi, M.3    Ikuta, K.4    Itoh, M.5    Iwahashi, K.6
  • 16
  • 17
    • 84860120334 scopus 로고    scopus 로고
    • Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder
    • Hornig M., Briese T., Licinio J., Khabbaz R.F., Altshuler L.L., Potkin S.G. Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder. Mol Psychiatry 2012, 17:486-493.
    • (2012) Mol Psychiatry , vol.17 , pp. 486-493
    • Hornig, M.1    Briese, T.2    Licinio, J.3    Khabbaz, R.F.4    Altshuler, L.L.5    Potkin, S.G.6
  • 18
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • International Schizophrenia Consortium
    • Purcell S.M., Wray N.R., Stone J.L., Visscher P.M., O'Donovan M.C., et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460:748-752. International Schizophrenia Consortium.
    • (2009) Nature , vol.460 , pp. 748-752
    • Purcell, S.M.1    Wray, N.R.2    Stone, J.L.3    Visscher, P.M.4    O'Donovan, M.C.5
  • 19
    • 84859704391 scopus 로고    scopus 로고
    • Reconsidering the association between the major histocompatibility complex and bipolar disorder
    • Figueiredo T.C., de Oliveira J.R. Reconsidering the association between the major histocompatibility complex and bipolar disorder. J Mol Neurosci 2011, 47:26-30.
    • (2011) J Mol Neurosci , vol.47 , pp. 26-30
    • Figueiredo, T.C.1    de Oliveira, J.R.2
  • 20
    • 0030612605 scopus 로고    scopus 로고
    • The alpha1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: is HLA-G the public ligand for natural killer cell inhibitory receptors?
    • Rouas-Freiss N., Marchal R.E., Kirszenbaum M., Dausset J., Carosella E.D. The alpha1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: is HLA-G the public ligand for natural killer cell inhibitory receptors?. Proc Natl Acad Sci USA 1997, 94:5249-5254.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5249-5254
    • Rouas-Freiss, N.1    Marchal, R.E.2    Kirszenbaum, M.3    Dausset, J.4    Carosella, E.D.5
  • 21
    • 0036569659 scopus 로고    scopus 로고
    • A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape
    • Wiendl H., Mitsdoerffer M., Hofmeister V., Wischhusen J., Bornemann A., Meyermann R., et al. A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape. J Immunol 2002, 168:4772-4780.
    • (2002) J Immunol , vol.168 , pp. 4772-4780
    • Wiendl, H.1    Mitsdoerffer, M.2    Hofmeister, V.3    Wischhusen, J.4    Bornemann, A.5    Meyermann, R.6
  • 22
    • 0033829539 scopus 로고    scopus 로고
    • HLA-G suppresses proliferation of CD4(+) T-lymphocytes
    • Bainbridge D.R., Ellis S.A., Sargent I.L. HLA-G suppresses proliferation of CD4(+) T-lymphocytes. J Reprod Immunol 2000, 48:17-26.
    • (2000) J Reprod Immunol , vol.48 , pp. 17-26
    • Bainbridge, D.R.1    Ellis, S.A.2    Sargent, I.L.3
  • 23
    • 0034516969 scopus 로고    scopus 로고
    • Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells
    • Paul P., Cabestre F.A., Ibrahim E.C., Lefebvre S., Khalil-Daher I., Vazeux G., et al. Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells. Hum Immunol 2000, 61:1138-1149.
    • (2000) Hum Immunol , vol.61 , pp. 1138-1149
    • Paul, P.1    Cabestre, F.A.2    Ibrahim, E.C.3    Lefebvre, S.4    Khalil-Daher, I.5    Vazeux, G.6
  • 24
    • 70350712152 scopus 로고    scopus 로고
    • Human leukocyte antigen-G polymorphism in relation to expression, function, and disease
    • Larsen M.H., Hviid T.V. Human leukocyte antigen-G polymorphism in relation to expression, function, and disease. Hum Immunol 2009, 70:1026-1034.
    • (2009) Hum Immunol , vol.70 , pp. 1026-1034
    • Larsen, M.H.1    Hviid, T.V.2
  • 25
    • 51649107640 scopus 로고    scopus 로고
    • The 14 bp deletion polymorphisms in HLA-G gene play an important role in the expression of soluble HLA-G in plasma
    • Chen X.Y., Yan W.H., Lin A., Xu H.H., Zhang J.G., Wang X.X. The 14 bp deletion polymorphisms in HLA-G gene play an important role in the expression of soluble HLA-G in plasma. Tissue Antigens 2008, 72:335-341.
    • (2008) Tissue Antigens , vol.72 , pp. 335-341
    • Chen, X.Y.1    Yan, W.H.2    Lin, A.3    Xu, H.H.4    Zhang, J.G.5    Wang, X.X.6
  • 26
    • 43849108272 scopus 로고    scopus 로고
    • HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus
    • Rizzo R., Hviid T.V., Govoni M., Padovan M., Rubini M., Melchiorri L. HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus. Tissue Antigens 2008, 71:520-529.
    • (2008) Tissue Antigens , vol.71 , pp. 520-529
    • Rizzo, R.1    Hviid, T.V.2    Govoni, M.3    Padovan, M.4    Rubini, M.5    Melchiorri, L.6
  • 27
    • 84872122227 scopus 로고    scopus 로고
    • Association of HLA-G low expressor genotype with severeacute graft-versus-host disease after sibling bone marrow transplantation
    • Boukouaci W., Busson M., Fortier C., Amokrane K., Peffault de Latour R., Robin M. Association of HLA-G low expressor genotype with severeacute graft-versus-host disease after sibling bone marrow transplantation. Front Immunol 2011, 2:74-79.
    • (2011) Front Immunol , vol.2 , pp. 74-79
    • Boukouaci, W.1    Busson, M.2    Fortier, C.3    Amokrane, K.4    Peffault de Latour, R.5    Robin, M.6
  • 30
    • 0018425438 scopus 로고
    • A new depression scale designed to be sensitive to change
    • Montgomery S.A., Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979, 134:382-389.
    • (1979) Br J Psychiatry , vol.134 , pp. 382-389
    • Montgomery, S.A.1    Asberg, M.2
  • 31
    • 0017978095 scopus 로고
    • The mania rating scale: scale construction and interobserver agreement
    • Bech P., Rafaelsen O.J., Kramp P., Bolwig T.G. The mania rating scale: scale construction and interobserver agreement. Neuropharmacology 1978, 17:430-431.
    • (1978) Neuropharmacology , vol.17 , pp. 430-431
    • Bech, P.1    Rafaelsen, O.J.2    Kramp, P.3    Bolwig, T.G.4
  • 32
    • 84876338815 scopus 로고
    • Maxwell ME. Manual for the family interview for genetic studies. NIMH
    • Maxwell ME. Manual for the family interview for genetic studies. NIMH; 1992.
    • (1992)
  • 33
    • 10344233183 scopus 로고    scopus 로고
    • Role of 14-bp deletion in the HLA-G gene in the maintenance of pregnancy
    • Tripathi P., Abbas A., Naik S., Agrawal S. Role of 14-bp deletion in the HLA-G gene in the maintenance of pregnancy. Tissue Antigens 2004, 64:706-710.
    • (2004) Tissue Antigens , vol.64 , pp. 706-710
    • Tripathi, P.1    Abbas, A.2    Naik, S.3    Agrawal, S.4
  • 35
    • 79951550728 scopus 로고    scopus 로고
    • Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association
    • Donadi E.A., Castelli E.C., Arnaiz-Villena A., Roger M., Rey D., Moreau P. Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association. Cell Mol Life Sci 2011, 68:369-395.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 369-395
    • Donadi, E.A.1    Castelli, E.C.2    Arnaiz-Villena, A.3    Roger, M.4    Rey, D.5    Moreau, P.6
  • 36
    • 0035197109 scopus 로고    scopus 로고
    • Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease
    • O'Brien M., McCarthy T., Jenkins D., Paul P., Dausset J., Carosella E.D., et al. Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease. Cell Mol Life Sci 2001, 58:1943-1949.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 1943-1949
    • O'Brien, M.1    McCarthy, T.2    Jenkins, D.3    Paul, P.4    Dausset, J.5    Carosella, E.D.6
  • 37
    • 0242609928 scopus 로고    scopus 로고
    • The 14 bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability
    • Rousseau P., Le Discorde M., Mouillot G., Marcou C., Carosella E.D., Moreau P. The 14 bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability. Hum Immunol 2003, 64:1005-1010.
    • (2003) Hum Immunol , vol.64 , pp. 1005-1010
    • Rousseau, P.1    Le Discorde, M.2    Mouillot, G.3    Marcou, C.4    Carosella, E.D.5    Moreau, P.6
  • 38
    • 0037793279 scopus 로고    scopus 로고
    • HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels
    • Hviid T.V., Hylenius S., Rørbye C., Nielsen L.G. HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels. Immunogenetics 2003, 55:63-79.
    • (2003) Immunogenetics , vol.55 , pp. 63-79
    • Hviid, T.V.1    Hylenius, S.2    Rørbye, C.3    Nielsen, L.G.4
  • 39
    • 59649114764 scopus 로고    scopus 로고
    • Tolerance versus immune response - microRNAs as important elements in the regulation of the HLA-G gene expression
    • Veit T.D., Chies J.A. Tolerance versus immune response - microRNAs as important elements in the regulation of the HLA-G gene expression. Transpl Immunol 2009, 20:229-231.
    • (2009) Transpl Immunol , vol.20 , pp. 229-231
    • Veit, T.D.1    Chies, J.A.2
  • 42
    • 57649152984 scopus 로고    scopus 로고
    • A single base-pair mutation in the 3'-untranslated region of HLA-G mRNA is associated with pre-eclampsia
    • Yie S.M., Li L.H., Xiao R., Librach C.L. A single base-pair mutation in the 3'-untranslated region of HLA-G mRNA is associated with pre-eclampsia. Mol Hum Reprod 2008, 14:649-653.
    • (2008) Mol Hum Reprod , vol.14 , pp. 649-653
    • Yie, S.M.1    Li, L.H.2    Xiao, R.3    Librach, C.L.4
  • 43
    • 76249091273 scopus 로고    scopus 로고
    • The 3'-untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited
    • Larsen M.H., Hylenius S., Andersen A.M., Hviid T.V. The 3'-untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited. Tissue Antigens 2010, 75:253-261.
    • (2010) Tissue Antigens , vol.75 , pp. 253-261
    • Larsen, M.H.1    Hylenius, S.2    Andersen, A.M.3    Hviid, T.V.4
  • 44
    • 0034659769 scopus 로고    scopus 로고
    • Modulation of HLA-G antigens expression by human cytomegalovirus: specific induction in activated macrophages harboring human cytomegalovirus infection
    • Onno M., Pangault C., Le Friec G., Guilloux V., Andre P., Fauchet R. Modulation of HLA-G antigens expression by human cytomegalovirus: specific induction in activated macrophages harboring human cytomegalovirus infection. J Immunol 2000, 164:6426-6434.
    • (2000) J Immunol , vol.164 , pp. 6426-6434
    • Onno, M.1    Pangault, C.2    Le Friec, G.3    Guilloux, V.4    Andre, P.5    Fauchet, R.6
  • 47
  • 49
    • 79551688322 scopus 로고    scopus 로고
    • CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population
    • Liu J., Li J., Li T., Wang T., Li Y., Zeng Z., et al. CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population. Brain Behav Immun 2011, 25:429-433.
    • (2011) Brain Behav Immun , vol.25 , pp. 429-433
    • Liu, J.1    Li, J.2    Li, T.3    Wang, T.4    Li, Y.5    Zeng, Z.6
  • 50
    • 79953021083 scopus 로고    scopus 로고
    • HLA-G expression in cancers: potential role in diagnosis, prognosis and therapy
    • Yan W.H. HLA-G expression in cancers: potential role in diagnosis, prognosis and therapy. Endocr Metab Immune Disord Drug Targets 2011, 11:76-89.
    • (2011) Endocr Metab Immune Disord Drug Targets , vol.11 , pp. 76-89
    • Yan, W.H.1
  • 51
    • 0031558802 scopus 로고    scopus 로고
    • Seasonality of births in schizophrenia and bipolar disorder: a review of the literature
    • Torrey E.F., Miller J., Rawlings R., Yolken R.H. Seasonality of births in schizophrenia and bipolar disorder: a review of the literature. Schizophr Res 1997, 28:1-38.
    • (1997) Schizophr Res , vol.28 , pp. 1-38
    • Torrey, E.F.1    Miller, J.2    Rawlings, R.3    Yolken, R.H.4
  • 52
    • 0042009757 scopus 로고    scopus 로고
    • Risk factors in relation to an emergence of bipolar disorder: a systematic review
    • Tsuchiya K.J., Byrne M., Mortensen P.B. Risk factors in relation to an emergence of bipolar disorder: a systematic review. Bipolar Disord 2003, 5:231-242.
    • (2003) Bipolar Disord , vol.5 , pp. 231-242
    • Tsuchiya, K.J.1    Byrne, M.2    Mortensen, P.B.3
  • 54
    • 23844464762 scopus 로고    scopus 로고
    • Human endogenous retrovirus expression profiles in samples from brains of patients with schizophrenia and bipolar disorder
    • Frank O., Giehl M., Zheng C., Hehlmann R., Leib-Mosch C., Seifarth W. Human endogenous retrovirus expression profiles in samples from brains of patients with schizophrenia and bipolar disorder. J Virol 2005, 79:890-901.
    • (2005) J Virol , vol.79 , pp. 890-901
    • Frank, O.1    Giehl, M.2    Zheng, C.3    Hehlmann, R.4    Leib-Mosch, C.5    Seifarth, W.6
  • 55
    • 34247542075 scopus 로고    scopus 로고
    • Reduced expression of human endogenous retrovirus (HERV)-W GAG protein in the cingulate gyrus and hippocampus in schizophrenia, bipolar disorder, and depression
    • Weis S., Llenos I.C., Sabunciyan S., Dulay J.R., Isler L., Yolken R. Reduced expression of human endogenous retrovirus (HERV)-W GAG protein in the cingulate gyrus and hippocampus in schizophrenia, bipolar disorder, and depression. J Neural Transm 2007, 114:645-655.
    • (2007) J Neural Transm , vol.114 , pp. 645-655
    • Weis, S.1    Llenos, I.C.2    Sabunciyan, S.3    Dulay, J.R.4    Isler, L.5    Yolken, R.6
  • 56
    • 0034917315 scopus 로고    scopus 로고
    • Griffiths DJ. Endogenous retroviruses in the human genome sequence. Genome Biol; 2: REVIEWS1017
    • Griffiths DJ. Endogenous retroviruses in the human genome sequence. Genome Biol 2001; 2: REVIEWS1017.
    • (2001)
  • 57
    • 34247550995 scopus 로고    scopus 로고
    • Transactivation of elements in the human endogenous retrovirus W family by viral infection
    • Retrovirology
    • Nellaker C, Yao Y, Jones-Brando L, Mallet F, Yolken RH, Karlsson H. Transactivation of elements in the human endogenous retrovirus W family by viral infection. Retrovirology 2006; 3: 44.
    • (2006) , vol.3 , pp. 44
    • Nellaker, C.1    Yao, Y.2    Jones-Brando, L.3    Mallet, F.4    Yolken, R.H.5    Karlsson, H.6
  • 58
    • 0027439483 scopus 로고
    • Herpes simplex virus ICP0 and ICP4 immediate early proteins strongly enhance expression of a retrovirus harboured by a leptomeningeal cell line from a patient with multiple sclerosis
    • Perron H., Suh M., Lalande B., Gratacap B., Laurent A., Stoebner P. Herpes simplex virus ICP0 and ICP4 immediate early proteins strongly enhance expression of a retrovirus harboured by a leptomeningeal cell line from a patient with multiple sclerosis. J Gen Virol 1993, 74:65-72.
    • (1993) J Gen Virol , vol.74 , pp. 65-72
    • Perron, H.1    Suh, M.2    Lalande, B.3    Gratacap, B.4    Laurent, A.5    Stoebner, P.6


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