HLA-G suppresses proliferation of CD4+ T-lymphocytes

Journal of Reproductive Immunology

Volumn 48, Issue 1, 2000, Pages 17-26

  Bainbridge, David R J ^a   Ellis, Shirley A ^b   Sargent, Ian L ^c  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

HLA G; MHC; Placenta; Pregnancy; T lymphocyte

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CELL DNA; HLA ANTIGEN CLASS 1; HLA G ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; THYMIDINE;

ALLOIMMUNITY; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSURVEILLANCE; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; MALE; MIXED LYMPHOCYTE REACTION; MONONUCLEAR CELL; PHAGOCYTE; PREGNANCY; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TROPHOBLAST;

CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELL LINE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HLA-A2 ANTIGEN; HUMAN; SUPPORT, NON-U.S. GOV'T; THYMIDINE;

EID: 0033829539     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0378(00)00070-X     Document Type: Article

References (17)

1. Allan D.S.J., Colonna M., Lanier L.L., et al. Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells. J. Exp. Med. 189:1999;1149-1155.
2. Bainbridge D.R.J., Ellis S.A., Sargent I.L. Little evidence of HLA-G mRNA polymorphism in Caucasian or Afro-Caribbean populations. J. Immunol. 163:1999;2023-2027.
3. Braud V.M., Allan D.S.J., O'Callaghan C.A., et al. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature. 391:1998;795-799.
4. Burt D., Johnston D., Rinke de Wit T., Van den Elsen P., Stern P.L. Cellular immune recognition of HLA-G-expressing choriocarcinoma cell line Jeg-3. Int. J. Cancer Suppl. 6:1991;117-122.
5. Crisa L., McMaster M.T., Ishii J.K., Fisher S.J., Salomon D.R. Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with foetal trophoblasts. J. Exp. Med. 186:1997;289-298.
6. Ellis S.A., Palmer M.S., McMichael A.J. Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA class I molecule. J. Immunol. 144:1990;731-735.
7. + T cells. Placenta. 20:1999;A25.
8. Fujii T., Ishitani A., Geraghty D.E. A soluble form of the HLA-G antigen is encoded by a messenger ribonucleic acid containing intron 4. J. Immunol. 153:1994;5516-5524.
9. Lampson L.A., Levy R. Two populations of IA-like molecules on a human B-cell line. J. Immunol. 125:1980;293-299.
10. Le Bouteiller P., Blaschitz A. The functionality of HLA-G is emerging. Immunol. Rev. 167:1999;233-244.
11. Lee N., Malacko A.K., Ishitani A., et al. The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association. Immunity. 3:1995;591-600.
12. Maejima M., Fujii T., Kozurna S., Okai T., Shibata Y., Taketani Y. Presence of HLA-G-expressing cells modulates the ability of peripheral blood mononuclear cells to release cytokines. Am. J. Reprod. Immunol. 38:1997;79-82.
13. McMaster M.Y., Librach C.L., Zhou Y., et al. Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. J. Immunol. 154:1995;3771-3778.
14. Pazmany L., Mandelboim O., Vales-Gomez M., David D.M., Reyburn H.T., Strominger J.L. Protection from natural killer cell-mediated lysis by HLA-G expression on target cells. Science. 274:1996;792-795.
15. Riteau B., Menier C., Khalil-Daher L., et al. HLA-G inhibits the allogeneic proliferative response. J. Reprod. Immunol. 43:1999;203-211.
16. Sanders S.K., Giblin P.A., Kavathas R. Cell-cell adhesion mediated by CD8 and human histocompatibility complex class I molecule on cytotrophoblasts. J. Exp. Med. 174:1991;737-740.
17. Sargent I.L. Maternal and foetal immune-responses during pregnancy. Exp. Clin. Immunogenet. 10:1993;85-102.