Determination of withaferin A and withanolide A in mice plasma using high-performance liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics after oral administration of Withania somnifera aqueous extract

Journal of Pharmaceutical and Biomedical Analysis

Volumn 80, Issue , 2013, Pages 203-212

  Patil, Dada ^a   Gautam, Manish ^b   Mishra, Sanjay ^a   Karupothula, Suresh ^b   Gairola, Sunil ^b   Jadhav, Suresh ^b   Pawar, Shrikrishna ^c   Patwardhan, Bhushan ^d  

^a Serum Institute   (India)

^b Serum Institute   (India)

^c Kharadi Mundhwa Bypass   (India)

^d UNIVERSITY OF PUNE   (India)

Author keywords

HPLC ESI MS MS; Pharmacokinetic study; Tandem mass spectrometry; Withaferin A; Withania somnifera; Withanolide A

Indexed keywords

AMMONIUM ACETATE; CLONAZEPAM; METHANOL; TIANEPTINE; UNCLASSIFIED DRUG; WITHAFERIN A; WITHANIA SOMNIFERA EXTRACT; WITHANOLIDE; WITHANOLIDE A;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION (PARAMETERS); DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; ELECTROSPRAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION PAIR CHROMATOGRAPHY; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MOUSE; NONHUMAN; PLANT ROOT; PLASMA; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VALIDATION STUDY; WITHANIA SOMNIFERA;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; LIMIT OF DETECTION; MEDICINE, AYURVEDIC; MICE; PLANT EXTRACTS; PLANT ROOTS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; WITHANIA; WITHANOLIDES;

EID: 84876313798     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.03.001     Document Type: Article

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