Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro

International Journal of Antimicrobial Agents

Volumn 41, Issue 5, 2013, Pages 484-487

  Weiss, Johanna ^a   Haefeli, Walter Emil ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

CYP; Drug interaction; Drug transporter; PXR; Rilpivirine

Indexed keywords

8 FLUORESCEIN CYCLIC AMP; ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; CALCEIN; CYCLIC AMP DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 3A4; DIMETHYL SULFOXIDE; DRUG CARRIER; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A9; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1B1; ORGANIC ANION TRANSPORTER 1B3; PHEOPHORBIDE; PREGNANE X RECEPTOR; RIFAMPICIN; RILPIVIRINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; CELL LINE; CONTROLLED STUDY; DRUG INTERACTION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME SUBSTRATE; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MDCK CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-RETROVIRAL AGENTS; CELL LINE; ENZYME INHIBITORS; ENZYMES; GENE EXPRESSION REGULATION; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE TRANSPORT PROTEINS; NITRILES; PYRIMIDINES;

EID: 84876297950     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.01.004     Document Type: Article

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