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Volumn 97, Issue 2, 2013, Pages 183-192

Synergistic effect of pasireotide and teriflunomide in carcinoids in vitro

Author keywords

Carcinoid; Neuroendocrine; Pasireotide; Somatostatin analog; Synergy; Teriflunomide

Indexed keywords

BIOLOGICAL MARKER; CASPASE 3; CHROMOGRANIN A; MITOGEN ACTIVATED PROTEIN KINASE 3; PASIREOTIDE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); TERIFLUNOMIDE; TRANSCRIPTION FACTOR MASH1; MITOGEN ACTIVATED PROTEIN KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN MCL 1; RAF PROTEIN; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84876297619     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000341810     Document Type: Article
Times cited : (11)

References (49)
  • 1
    • 1842339356 scopus 로고    scopus 로고
    • An analysis of 8305 cases of carcinoid tumors
    • Modlin I, Sandor A: An analysis of 8305 cases of carcinoid tumors. Cancer 1997; 79: 813-829.
    • (1997) Cancer , vol.79 , pp. 813-829
    • Modlin, I.1    Sandor, A.2
  • 2
    • 0033087664 scopus 로고    scopus 로고
    • Review article: Current status of gastrointestinal carcinoids
    • Läuffer J, Zhang T, Modlin I: Review article: current status of gastrointestinal carcinoids. Aliment Pharmacol Ther 1999; 13: 271-287.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 271-287
    • Läuffer, J.1    Zhang, T.2    Modlin, I.3
  • 4
    • 58849090542 scopus 로고    scopus 로고
    • Genetics and molecular pathology of neuroendocrine gastrointestinal and pancreatic tumors (gastroenteropancreatic neuroendocrine tumors)
    • Oberg K: Genetics and molecular pathology of neuroendocrine gastrointestinal and pancreatic tumors (gastroenteropancreatic neuroendocrine tumors). Curr Opin Endocrinol Diabetes Obes 2009; 16: 72-78.
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , pp. 72-78
    • Oberg, K.1
  • 5
    • 70349860278 scopus 로고    scopus 로고
    • Carcinoid tumors
    • Pasieka J: Carcinoid tumors. Surg Clin North Am 2009; 89: 1123-1137.
    • (2009) Surg Clin North Am , vol.89 , pp. 1123-1137
    • Pasieka, J.1
  • 6
    • 76649101419 scopus 로고    scopus 로고
    • Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth
    • Cook M, Pinchot S, Jaskula-Sztul R, Luo J, Kunnimalaiyaan M, Chen H: Identification of a novel Raf-1 pathway activator that inhibits gastrointestinal carcinoid cell growth. Mol Cancer Ther 2010; 9: 429-437.
    • (2010) Mol Cancer Ther , vol.9 , pp. 429-437
    • Cook, M.1    Pinchot, S.2    Jaskula-Sztul, R.3    Luo, J.4    Kunnimalaiyaan, M.5    Chen, H.6
  • 8
    • 0035165659 scopus 로고    scopus 로고
    • Clinical significance of blood chromogranin A measurement in neuroendocrine tumours
    • Seregni E, Ferrari L, Bajetta E, Martinetti A, Bombardieri E: Clinical significance of blood chromogranin A measurement in neuroendocrine tumours. Ann Oncol 2001; 12(suppl 2):S69-S72.
    • (2001) Ann Oncol , vol.12 , Issue.SUPPL. 2
    • Seregni, E.1    Ferrari, L.2    Bajetta, E.3    Martinetti, A.4    Bombardieri, E.5
  • 10
    • 33646248388 scopus 로고    scopus 로고
    • The Raf-1 pathway: A molecular target for treatment of select neuroendocrine tumors?
    • Kunnimalaiyaan M, Chen H: The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? Anticancer Drugs 2006; 17: 139-142.
    • (2006) Anticancer Drugs , vol.17 , pp. 139-142
    • Kunnimalaiyaan, M.1    Chen, H.2
  • 11
    • 0030908839 scopus 로고    scopus 로고
    • Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: Transcriptional regulation by dual inhibitory regions
    • Chen H, Biel M, Borges M, Thiagalingam A, Nelkin B, Baylin S, Ball D: Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions. Cell Growth Differ 1997; 8: 677-686.
    • (1997) Cell Growth Differ , vol.8 , pp. 677-686
    • Chen, H.1    Biel, M.2    Borges, M.3    Thiagalingam, A.4    Nelkin, B.5    Baylin, S.6    Ball, D.7
  • 14
    • 72949085528 scopus 로고    scopus 로고
    • Review article: Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours
    • Modlin I, Pavel M, Kidd M, Gustafsson B: Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours. Aliment Pharmacol Ther 2010; 31: 169-188.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 169-188
    • Modlin, I.1    Pavel, M.2    Kidd, M.3    Gustafsson, B.4
  • 19
    • 50249160709 scopus 로고    scopus 로고
    • Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines
    • Kidd M, Drozdov I, Joseph R, Pfragner R, Culler M, Modlin I: Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines. Cancer 2008; 113: 690-700.
    • (2008) Cancer , vol.113 , pp. 690-700
    • Kidd, M.1    Drozdov, I.2    Joseph, R.3    Pfragner, R.4    Culler, M.5    Modlin, I.6
  • 21
    • 36549070665 scopus 로고    scopus 로고
    • Pasireotide - A somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing's disease
    • Ben-Shlomo A, Melmed S: Pasireotide - a somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing's disease. IDrugs 2007; 10: 885-895.
    • (2007) IDrugs , vol.10 , pp. 885-895
    • Ben-Shlomo, A.1    Melmed, S.2
  • 22
    • 84876290127 scopus 로고    scopus 로고
    • Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: Results of a phase II study
    • The SOM230 Carcinoid Study Group: Atlanta, June
    • Kvols L, Oberg K, Glusman JE, O'dorisio TM, De Herder W, Gao B, Arnold R, Anthony L, The SOM230 Carcinoid Study Group: Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: results of a phase II study; in Am Soc Clin Oncol Annu Meet, Atlanta, June 2006.
    • (2006) Am Soc Clin Oncol Annu Meet
    • Kvols, L.1    Oberg, K.2    Glusman, J.E.3    O'Dorisio, T.M.4    De Herder, W.5    Gao, B.6    Arnold, R.7    Anthony, L.8
  • 24
    • 21344443715 scopus 로고    scopus 로고
    • ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells
    • Van Gompel J, Kunnimalaiyaan M, Holen K, Chen H: ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. Mol Cancer Ther 2005; 4: 910-917.
    • (2005) Mol Cancer Ther , vol.4 , pp. 910-917
    • Van Gompel, J.1    Kunnimalaiyaan, M.2    Holen, K.3    Chen, H.4
  • 25
    • 33646254621 scopus 로고    scopus 로고
    • ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells
    • Kappes A, Vaccaro A, Kunnimalaiyaan M, Chen H: ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells. J Surg Res 2006; 133: 42-45.
    • (2006) J Surg Res , vol.133 , pp. 42-45
    • Kappes, A.1    Vaccaro, A.2    Kunnimalaiyaan, M.3    Chen, H.4
  • 26
    • 0033728783 scopus 로고    scopus 로고
    • Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: Role of the phosphotyrosine phosphatase SHP-2
    • Florio T, Thellung S, Arena S, Corsaro A, Bajetto A, Schettini G, Stork P: Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2. J Physiol Paris 2000; 94: 239-250.
    • (2000) J Physiol Paris , vol.94 , pp. 239-250
    • Florio, T.1    Thellung, S.2    Arena, S.3    Corsaro, A.4    Bajetto, A.5    Schettini, G.6    Stork, P.7
  • 27
    • 0026793456 scopus 로고
    • Growth factor signaling by receptor tyrosine kinases
    • Schlessinger J, Ullrich A: Growth factor signaling by receptor tyrosine kinases. Neuron 1992; 9: 383-391.
    • (1992) Neuron , vol.9 , pp. 383-391
    • Schlessinger, J.1    Ullrich, A.2
  • 28
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 1990; 61: 203-212.
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 29
    • 0029011084 scopus 로고
    • G protein-coupled receptor systems involved in cell growth and oncogenesis
    • Dhanasekaran N, Heasley L, Johnson G: G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocr Rev 1995; 16: 259-270.
    • (1995) Endocr Rev , vol.16 , pp. 259-270
    • Dhanasekaran, N.1    Heasley, L.2    Johnson, G.3
  • 30
    • 34548463002 scopus 로고    scopus 로고
    • Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells
    • Greenblatt D, Vaccaro A, Jaskula-Sztul R, Ning L, Haymart M, Kunnimalaiyaan M, Chen H: Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells. Oncologist 2007; 12: 942-951.
    • (2007) Oncologist , vol.12 , pp. 942-951
    • Greenblatt, D.1    Vaccaro, A.2    Jaskula-Sztul, R.3    Ning, L.4    Haymart, M.5    Kunnimalaiyaan, M.6    Chen, H.7
  • 31
    • 9744254768 scopus 로고    scopus 로고
    • Evaluation of combination chemotherapy: Integration of nonlinear regression, curve shift, isobologram, and combination index analyses
    • Zhao L, Wientjes M, Au J: Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses. Clin Cancer Res 2004; 10: 7994-8004.
    • (2004) Clin Cancer Res , vol.10 , pp. 7994-8004
    • Zhao, L.1    Wientjes, M.2    Au, J.3
  • 32
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou T, Talalay P: Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984; 22: 27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.1    Talalay, P.2
  • 33
    • 73549093367 scopus 로고    scopus 로고
    • Agonist-biased signaling at the sst2A receptor: The multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways
    • Cescato R, Loesch K, Waser B, Mäcke H, Rivier J, Reubi J, Schonbrunn A: Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways. Mol Endocrinol 2010; 24: 240-249.
    • (2010) Mol Endocrinol , vol.24 , pp. 240-249
    • Cescato, R.1    Loesch, K.2    Waser, B.3    MäcKe, H.4    Rivier, J.5    Reubi, J.6    Schonbrunn, A.7
  • 34
    • 60849131483 scopus 로고    scopus 로고
    • Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells
    • Baumann P, Mandl-Weber S, Völkl A, Adam C, Bumeder I, Oduncu F, Schmidmaier R: Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells. Mol Cancer Ther 2009; 8: 366-375.
    • (2009) Mol Cancer Ther , vol.8 , pp. 366-375
    • Baumann, P.1    Mandl-Weber, S.2    Völkl, A.3    Adam, C.4    Bumeder, I.5    Oduncu, F.6    Schmidmaier, R.7
  • 35
    • 40749102909 scopus 로고    scopus 로고
    • The immunomodulatory drug Leflunomide inhibits cell cycle progression of B-CLL cells
    • Ringshausen I, Oelsner M, Bogner C, Peschel C, Decker T: The immunomodulatory drug Leflunomide inhibits cell cycle progression of B-CLL cells. Leukemia 2008; 22: 635-638.
    • (2008) Leukemia , vol.22 , pp. 635-638
    • Ringshausen, I.1    Oelsner, M.2    Bogner, C.3    Peschel, C.4    Decker, T.5
  • 36
    • 0031783131 scopus 로고    scopus 로고
    • Therapeutic alternatives in metastatic neuroendocrine tumors
    • Miller C, Ellison E: Therapeutic alternatives in metastatic neuroendocrine tumors. Surg Oncol Clin N Am 1998; 7: 863-879.
    • (1998) Surg Oncol Clin N Am , vol.7 , pp. 863-879
    • Miller, C.1    Ellison, E.2
  • 37
    • 0031867308 scopus 로고    scopus 로고
    • Isolated liver metastases from neuroendocrine tumors: Does resection prolong survival?
    • discussion 92-93
    • Chen H, Hardacre J, Uzar A, Cameron J, Choti M: Isolated liver metastases from neuroendocrine tumors: does resection prolong survival? J Am Coll Surg 1998; 187: 88-92, discussion 92-93.
    • (1998) J Am Coll Surg , vol.187 , pp. 88-92
    • Chen, H.1    Hardacre, J.2    Uzar, A.3    Cameron, J.4    Choti, M.5
  • 38
    • 43549111835 scopus 로고    scopus 로고
    • Pasireotide (SOM230): Development, mechanism of action and potential applications
    • Schmid H: Pasireotide (SOM230): development, mechanism of action and potential applications. Mol Cell Endocrinol 2008; 286: 69-74.
    • (2008) Mol Cell Endocrinol , vol.286 , pp. 69-74
    • Schmid, H.1
  • 40
    • 0033113378 scopus 로고    scopus 로고
    • Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human smallcell lung cancer cells
    • Ravi R, Thiagalingam A, Weber E, Mc- Mahon M, Nelkin B, Mabry M: Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human smallcell lung cancer cells. Am J Respir Cell Mol Biol 1999; 20: 543-549.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 543-549
    • Ravi, R.1    Thiagalingam, A.2    Weber, E.3    Mc-Mahon, M.4    Nelkin, B.5    Mabry, M.6
  • 41
    • 33746565515 scopus 로고    scopus 로고
    • Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway
    • Gollob J, Wilhelm S, Carter C, Kelley S: Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol 2006; 33: 392-406.
    • (2006) Semin Oncol , vol.33 , pp. 392-406
    • Gollob, J.1    Wilhelm, S.2    Carter, C.3    Kelley, S.4
  • 43
    • 33748132208 scopus 로고    scopus 로고
    • In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer
    • Vaccaro A, Chen H, Kunnimalaiyaan M: In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer. Anticancer Drugs 2006; 17: 849-853.
    • (2006) Anticancer Drugs , vol.17 , pp. 849-853
    • Vaccaro, A.1    Chen, H.2    Kunnimalaiyaan, M.3
  • 44
    • 22244454759 scopus 로고    scopus 로고
    • Medullary thyroid cancer: The functions of raf-1 and human achaete-scute homologue- 1
    • Chen H, Kunnimalaiyaan M, Van Gompel J: Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue- 1. Thyroid 2005; 15: 511-521.
    • (2005) Thyroid , vol.15 , pp. 511-521
    • Chen, H.1    Kunnimalaiyaan, M.2    Van Gompel, J.3
  • 45
    • 0346887056 scopus 로고    scopus 로고
    • The role of human achaete-scute homolog-1 in medullary thyroid cancer cells
    • discussion 871-873
    • Sippel R, Carpenter J, Kunnimalaiyaan M, Chen H: The role of human achaete-scute homolog-1 in medullary thyroid cancer cells. Surgery 2003; 134: 866-871; discussion 871-873.
    • (2003) Surgery , vol.134 , pp. 866-871
    • Sippel, R.1    Carpenter, J.2    Kunnimalaiyaan, M.3    Chen, H.4
  • 46
    • 60549091925 scopus 로고    scopus 로고
    • Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway
    • Pinchot S, Adler J, Luo Y, Ju J, Li W, Shen B, Kunnimalaiyaan M, Chen H: Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. Am J Surg 2009; 197: 313-319.
    • (2009) Am J Surg , vol.197 , pp. 313-319
    • Pinchot, S.1    Adler, J.2    Luo, Y.3    Ju, J.4    Li, W.5    Shen, B.6    Kunnimalaiyaan, M.7    Chen, H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.