Efficacy of mesoporous silica nanoparticles in delivering BMP-2 plasmid DNA for in vitro osteogenic stimulation of mesenchymal stem cells

Journal of Biomedical Materials Research - Part A

Volumn 101 A, Issue 6, 2013, Pages 1651-1660

  Kim, Tae Hyun ^a,b   Kim, Meeju ^a,b   Eltohamy, Mohamed ^a,b,c   Yun, Ye Rang ^a,b   Jang, Jun Hyeog ^d   Kim, Hae Won ^a,b,e  

^a BK21 Plus NBM Global Research Center for Regenerative Medicine   (South Korea)

^b Dankook University   (South Korea)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d Inha University School of Medicine   (South Korea)

^e Dankook University   (South Korea)

Author keywords

bone morphogenetic protein; bone regeneration; gene delivery; mesenchymal stem cells; mesoporous silica nanoparticles

Indexed keywords

BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; GENE DELIVERY; MESENCHYMAL STEM CELL; MESOPOROUS SILICA NANOPARTICLES;

BIOMOLECULES; BONE; ENZYME ACTIVITY; FLOWCHARTING; GENE EXPRESSION; GENE TRANSFER; PROTEINS;

CELL CULTURE;

BONE MORPHOGENETIC PROTEIN 2; MESOPOROUS SILICA NANOPARTICLE; NANOPARTICLE; OSTEOCALCIN; OSTEOPONTIN; PLASMID DNA; SIALOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE REGENERATION; BONE TISSUE; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; IN VITRO STUDY; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; RAT;

ANIMALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; CELL COUNT; CELL DEATH; CELL LINE; CELL SURVIVAL; DNA; GENE EXPRESSION REGULATION; HUMANS; INTEGRIN-BINDING SIALOPROTEIN; INTRACELLULAR SPACE; MALE; MESENCHYMAL STROMAL CELLS; NANOPARTICLES; OSTEOCALCIN; OSTEOGENESIS; OSTEOPONTIN; PLASMIDS; POROSITY; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SILICON DIOXIDE; STATIC ELECTRICITY; TRANSFECTION;

EID: 84876294987     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34466     Document Type: Article

References (57)

1. Khan Y, Yaszemski MJ, Mikos AG, Laurencin CT,. Tissue engineering of bone: Material and matrix considerations. J Bone Joint Surg Am 2008; 90: 36-42.
2. Arthur A, Zannettino A, Gronthos S,. The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair. J Cell Physiol 2009; 218: 237-245.
3. Riley EH, Lane JM, Urist MR, Lyons KM, Lieberman JR,. Bone morphogenetic protein-2: Biology and applications. Clin Orthop Relat Res 1996; 324: 39-46.
4. Poynton AR, Lane JM,. Safety profile for the clinical use of bone morphogenetic proteins in the spine. Spine 2002; 72: 40-48.
5. Shimer AL, Oner FC, Vaccaro AR,. Spinal reconstruction and bone morphogenetic proteins: Open questions. Injury 2009; 40: 32-38.
6. Southwood LL, Frisbie DD, Kawcak CE, McIlwraith CW,. Delivery of growth factors using gene therapy to enhance bone healing. Vet Surg 2004; 33: 565-578.
7. Dragoo JL, Choi JY, Lieberman JR, Huang J, Zuk PA, Zhang J, Hedrick MH, Benhaim P,. Bone induction by BMP-2 transduced stem cells derived from human fat. J Orthop Res 2003; 21: 622-629.
8. Tsuda H, Wada T, Ito Y, Uchida H, Dehari H, Nakamura K, Sasaki K, Kobune M, Yamashita T, Hamada H,. Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber mutant adenoviral vector. Mol Ther 2003; 7: 354-365.
9. Sugiyama O, An DS, Kung SP, Feeley BT, Gamradt S, Liu NQ, Chen IS, Lieberman JB,. Lentivirus mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo. Mol Ther 2005; 11: 390-398.
10. Yun YR, Jang JH, Jeon E, Kang W, Lee S, Won JE, Kim HW, Wall I,. Administration of growth factors for bone regeneration. Regen Med 2012; 7: 36-85.
11. Asahara T, Kalka C, Isner JM,. Stem cell therapy and gene transfer for regeneration. Gene Ther 2000; 7: 451-457.
12. Giannoudis PV, Tzioupis CC, Tsiridis E,. Gene therapy in orthopaedics. Injury 2006; 37: 30-40.
13. Luo D, Saltzman WM,. Synthetic DNA delivery systems. Nat Biotechnol 2000; 18: 33-37.
14. Louise C,. Nonviral vectors. Methods Mol Biol 2006; 333: 201-226.
15. Pietersz GA, Tang CK, Apostolopoulos V,. Structure and design of polycationic carriers for gene delivery. Mini Rev Med Chem 2006; 6: 1285-1298.
16. Aigner A,. Nonviral in vivo delivery of therapeutic small interfering RNAs. Curr Opin Mol Ther 2007; 9: 345-352.
17. Montier T, Benvegnu T, Jaffres PA, Yaouanc JJ, Lehn P,. Progress in cationic lipid mediated gene transfection: A series of bio-inspired lipids as an example. Curr Gene Ther 2008; 8: 296-312.
18. Midoux P, Pichon C, Yaouanc JJ, Jaffres PA,. Chemical vectors for gene delivery: A current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. Br J Pharmacol 2009; 157: 166-178.
19. Son SJ, Bai X, Lee SB,. Inorganic hollow nanoparticles and nanotubes in nanomedicine part 1. Drug/gene delivery applications, Drug Discov Today 2007; 12: 650-656.
20. Slowing II, Vivero-Escoto JL, Wu CW, Lin VS,. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Deliv Rev 2008; 60: 1278-1288.
21. Kim SY, Lee YM, Baik DJ, Kang JS,. Toxic characteristics of methoxy poly (ethylene glycol)/poly (epsilon-caprolactone) nanospheres; in vitro and in vivo studies in the normal mice. Biomaterials 2003; 24: 55-63.
22. Vallet-Regi M,. Ordered mesoporous materials in the context of drug delivery systems and bone tissue engineering. Chemistry 2006; 12: 5934-5943.
23. Chung TH, Wu SH, Yao M, Lu CW, Lin YS, Hung Y, Mou CY, Chen YC, Huang DM,. The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells. Biomaterials 2007; 28: 2959-2966.
24. Kneuer C, Sameti M, Bakowsky U, Schiestel T, Schirra H, Schmidt H, Lehr CM,. A non viral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjug Chem 2000; 11: 926-932.
25. Suwalski S, Dabboue H, Delalande A, Bensamoun SF, Canon F, Midoux PP, Saillant G, Klatzmann D, Salvetat JP, Pichon C,. Accelerated Achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles. Biomaterials 2010; 31: 5237-5245.
26. Eltohamy M, Shin US, Kim HW,. Silica nanoparticles with enlarged nanopore size for the loading and release of biological proteins. Mater Lett 2011; 65: 3570-3573.
27. Luo D, Saltzman WM,. Thinking of silica. Gene Ther 2006; 13: 585-586.
28. Hom C, Lu J, Liong M, Luo H, Li Z, Zink JI, Tamanoi F,. Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells. Small 2010; 6: 1185-1190.
29. Meng H, Liong M, Xia T, Li Z, Ji Z, Zink JJ, Nel AE,. Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano 2010; 4: 4539-4550.
30. Popat A, Hartono SB, Stahr F, Liu J, Qiao SZ, Qing Max Lu G,. Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers. Nanoscale 2011; 3: 2801-2818.
31. Kneuer C, Sameti M, Bakowsky U, Schiestel T, Schirra H, Schmidt H, Lehr CM,. A nonviral DNA delivery system based on surface modified silica nanoparticles can efficiently transfect cells in vitro. Bioconjuate Chem 2000; 11: 926-932.
32. Peng J, He X, Wang K, Tan W, Li H, Xing X, Yang Y,. An antisense oligonucleotide carrier based on amino silica nanoparticles for antisense inhibition of cancer cells. Nanomed Nanotech Biol Med 2006; 2: 113-120.
33. He X, Wang K, Tan W, Liu B, Lin X, Huang S, Li D, He C, Li J,. A novel gene carrier based on amino-modified silica nanoparticles. Chin Sci Bull 2003; 48: 223-228.
34. Lu X, Qian J, Zhou H, Gan Q, Tnag W, Lu J, Yuan Y, Liu C,. In vitro cytotoxicity and induction of apoptosis by silica nanoparticles in human HepG2 hepatoma cells. Int J Nanomed 2011; 6: 1889-1901.
35. Sayes CM, Reed KL, Warheit DB,. Assessing toxicity of fine and nanoparticles: Comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol Sci 2007; 97: 163-180.
36. Lin W, Huang YW, Zhou XD, Ma Y,. In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol 2006; 217: 252-259.
37. Kaewamatawong T, Shimada A, Okajima M, Inoue H, Morita T, Inoue K, Takano H,. Acute and subacute pulmonary toxicity of low dose of ultrafine colloidal silica particles in mice after intratracheal instillation. Toxicol Pathol 2006; 34: 958-965.
38. Chang JS, Chang KL, Hwang DF, Kong ZL,. In vitro cytotoxicitiy of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environ Sci Technol 2007; 41: 2064-2068.
39. Jin Y, Kannan S, Wu M, Zhao JX,. Toxicity of luminescent silica nanoparticles to living cells. Chem Res Toxicol 2007; 20: 1126-1133.
40. Kortesuo P, Ahola M, Karlsson S, Kangasniemi I, Yli-Urpo A, Kiesvaara J,. Silica xerogel as an implantable carrier for controlled drug delivery-evaluation of drug distribution and tissue effects after implantation. Biomaterials 1999; 21: 193-198.
41. Gamradt SC, Lieberman JR,. Genetic modification of stem cells to enhance bone repair. Ann Biomed Eng 2004; 32: 136-147.
42. Yun YR, Jang JH, Jeon E, Kang W, Won JE, Kim HW, Wall I,. Administration of growth factors for bone regeneration. Regen Med 2012; 7: 369-385.
43. Yun YR, Won JE, Jeon E, Lee J, Kang W, Jo H, Jang JH, Kim HW,. Fibroblast growth factors: biology, function, and application for tissue regeneration. J Tissue Eng 7; 2010: 218142.
44. Phillips JE, Gersbach CA, Garcia AJ,. Virus-based gene therapy strategies for bone regeneration. Biomaterials 2007; 28: 211-229.
45. Bleiziffer O, Eriksson E, Yao F, Horch RE, Kneser U,. Gene transfer strategies in tissue engineering. J Cell Mol Med 2007; 11: 206-223.
46. Kim DH, Rossi JJ,. Strategies for silencing human disease using RNA interference. Nat Rev Genet 2007; 8: 173-184.
47. Mornet S, Lambert O, Duguet E, Brisson A,. The formation of supported lipid bilayers on silica nanoparticles revealed by cryoelectron microscopy. Nano Lett 2005; 5: 281-285.
48. Huang DM, Hung Y, Ko BS, Hsu SC, Chen WH, Chien CL, Tsai CP, Kuo CT, Kang JC, Yang CS, Mou CY, Chen YC,. Highly efficient cellular labeling of mesoporous nanoparticles in human mesenchymal stem cells: implication for stem cell tracking. FASEB J 2005; 19: 2014-2016.
49. Lopotko DO, Lukianova-Hleb EY, Oraevsky AO,. Clusterization of nanoparticles during their interaction with living cells. Nanomedicine 2007; 2: 241-253.
50. Kofron MD, Laurencin CT,. Bone tissue engineering by gene delivery. Adv Drug Deliv Rev 2006; 58: 555-576.
51. Zhang X, Zhang C, Tang T, Qu Z, Lou J, Dai K,. Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and BMP2. J Orthop Res 2008; 26: 314-321.
52. Tsuda H, Wada T, Yamashita T, Hamada H,. Enhanced osteoinduction by mesenchymal stem cells transfected with a fiber mutant adenoviral BMP2 gene. J Gene Med 2005; 7: 1322-1334.
53. Kim MH, Na HK, Kim YK, Ryoo SR, Cho HS, Lee KE, Jeon H, Ryoo R, Min DH,. Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery. ACS Nano 2011; 5: 3568-3576.
54. Liu J, Stace-Naughton A, Brinker J,. Silica nanoparticle supported lipid bilayers for gene delivery. Chem Commum (Camb) 2009; 34: 5100-5102.
55. Xia T, Kovochich M, Liong M, Meng H, Kabehie S, Geroge S, Zink JI, Nel AE,. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano 2009; 3: 3273-3286.
56. Gao Y, Zhang Z, Chen L, Gu W, Li Y,. Chitosan N-betainates/DNA self-assembly nanoparticles for gene delivery: In vitro uptake andtransfection efficiency. Int J Pharm 2009; 371: 156-162.
57. Javed A, Chen H, Ghori FY,. Genetic and transcriptional control of bone formation. Oral Maxillofac Surg Clin North Am 2010; 22: 283-293.