HOXB8 expression in ovarian serous carcinoma effusions is associated with shorter survival

Gynecologic Oncology

Volumn 129, Issue 2, 2013, Pages 358-363

  Stavnes, Helene Tuft ^a   Holth, Arild ^a   Don, Trinh ^a   Kærn, Janne ^a   Vaksman, Olga ^b   Reich, Reuven ^b   Trope', Claes G ^a,c   Davidson, Ben ^a,c  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Chemotherapy; HOX transcription factors; Immunohistochemistry; Ovarian carcinoma; Serous effusions; Survival

Indexed keywords

HOX PROTEIN; HOXB5 PROTEIN; HOXB88 PROTEIN; PACLITAXEL; PLATINUM COMPLEX; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER SURVIVAL; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; METASTASIS; OVARIAN SEROUS CARCINOMA; OVARY CARCINOMA; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLOTTING, WESTERN; CHEMOTHERAPY, ADJUVANT; CYSTADENOCARCINOMA, SEROUS; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; OVARIAN NEOPLASMS; SURVIVAL ANALYSIS; TISSUE ARRAY ANALYSIS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84876285605     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2013.02.021     Document Type: Article

References (31)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2012 CA Cancer J Clin 62 2012 10 29
2. C.G. Tropé, M.B. Elstrand, B. Sandstad, B. Davidson, and H. Oksefjell Neoadjuvant chemotherapy, interval debulking surgery or primary surgery in stage IV ovarian cancer? Eur J Cancer 48 2012 2146 2154
3. B. Davidson, P. Firat, and C.W. Michael Serous effusions 2011 Springer London, UK
4. D.G. Grier, A. Thompson, A. Kwasniewska, G.J. McGonigle, H.L. Halliday, and T.R. Lappin The pathophysiology of HOX genes and their role in cancer J Pathol 205 2005 154 171
5. N. Shah, and S. Sukumar The Hox genes and their roles in oncogenesis Nat Rev Cancer 10 2010 361 371
6. Z.L. Kelly, A. Michael, S. Butler-Manuel, H.S. Pandha, and R.G. Morgan HOX genes in ovarian cancer J Ovarian Res 4 2011 16
7. H. Naora, F.J. Montz, C.Y. Chai, and R.B. Roden Aberrant expression of homeobox gene HOXA7 is associated with müllerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response Proc Natl Acad Sci U S A 98 2001 15209 15214
8. H. Naora, Y.Q. Yang, F.J. Montz, J.D. Seidman, R.J. Kurman, and R.B. Roden A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells Proc Natl Acad Sci U S A 98 2001 4060 4065
9. W. Cheng, J. Liu, H. Yoshida, D. Rosen, and H. Naora Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract Nat Med 11 2005 531 537
10. V. Andikyan, and H.S. Taylor WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type J Cell Mol Med 13 2009 4522 4531
11. C. Klausen, P.C. Leung, and N. Auersperg Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin Mol Cancer Res 7 2009 1425 1437
12. T. Ota, C. Klausen, M.C. Salamanca, H.L. Woo, P.C. Leung, and N. Auersperg Expression and function of HOXA genes in normal and neoplastic ovarian epithelial cells Differentiation 77 2009 162 171
13. B. Li, H. Jin, Y. Yu, C. Gu, X. Zhou, and N. Zhao HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival Int J Gynecol Cancer 19 2009 1347 1352
14. J. Miao, Z. Wang, H. Provencher, B. Muir, S. Dahiya, and E. Carney HOXB13 promotes ovarian cancer progression Proc Natl Acad Sci U S A 104 2007 17093 17098
15. T. Ota, C.B. Gilks, T. Longacre, P.C. Leung, and N. Auersperg HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features Reprod Sci 14 2007 605 614
16. H. Fiegl, G. Windbichler, E. Mueller-Holzner, G. Goebel, M. Lechner, and I.J. Jacobs HOXA11 DNA methylation - a novel prognostic biomarker in ovarian cancer Int J Cancer 123 2008 725 729
17. B. Davidson, H.T. Stavnes, A. Holth, X. Chen, Y. Yang, and IeM Shih Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions J Cell Mol Med 15 2011 535 544
18. R. Vang, Shih IeM, and R.J. Kurman Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems Adv Anat Pathol 16 2009 267 282
19. J.T. Thigpen, J.A. Blessing, H. Ball, S.J. Hummel, and R.J. Barrett Phase II trial of paclitaxel in patients with progressive ovarian carcinoma after platinum-based chemotherapy: a gynecologic oncology group study J Clin Oncol 12 1994 1748 1753
20. P. Therasse, S.G. Arbuck, E.A. Eisenhauer, J. Wanders, R.S. Kaplan, and L. Rubinstein New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 92 2000 205 216
21. A. Korshunov, K. Neben, G. Wrobel, B. Tews, A. Benner, and M. Hahn Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age Am J Pathol 163 2003 1721 1727
22. G.E. Lind, R.I. Skotheim, M.F. Fraga, V.M. Abeler, M. Esteller, and R.A. Lothe Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1) J Pathol 210 2006 441 449
23. M. di Pietro, P. Lao-Sirieix, S. Boyle, A. Cassidy, D. Castillo, and A. Saadi Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus Proc Natl Acad Sci U S A 109 2012 9077 9082
24. J. Luo, Q. Cai, W. Wang, H. Huang, H. Zeng, and W. He A microRNA-7 binding site polymorphism in HOXB5 leads to differential gene expression in bladder cancer PLoS One 7 2012 e40127
25. Q. Wu, R.A. Lothe, T. Ahlquist, I. Silins, C.G. Tropé, and F. Micci DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets Mol Cancer 6 2007 45
26. Y. Wu, M. Moser, V.L. Bautch, and C. Patterson HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells Mol Cell Biol 23 2003 5680 5691
27. B.Z. Vider, A. Zimber, D. Hirsch, D. Estlein, E. Chastre, and S. Prevot Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression Biochem Biophys Res Commun 232 1997 742 748
28. T. Fujino, Y. Yamazaki, D.A. Largaespada, N.A. Jenkins, N.G. Copeland, and K. Hirokawa Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes Exp Hematol 29 2001 856 863
29. R. Morgan, P.M. Pirard, L. Shears, J. Sohal, R. Pettengell, and H.S. Pandha Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma Cancer Res 67 2007 5806 5813
30. R. Morgan, A. Boxall, K.J. Harrington, G.R. Simpson, C. Gillett, and A. Michael Targeting the HOX/PBX dimer in breast cancer Breast Cancer Res Treat 136 2012 389 398
31. R. Morgan, L. Plowright, K.J. Harrington, A. Michael, and H.S. Pandha Targeting HOX and PBX transcription factors in ovarian cancer BMC Cancer 10 2010 89