Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes

Experimental Hematology

Volumn 29, Issue 7, 2001, Pages 856-863

  Fujino, Takashi ^a,b   Yamazaki, Yukari ^a   Largaespada, David A ^b   Jenkins, Nancy A ^c   Copeland, Neal G ^c   Hirokawa, Katsuiku ^b   Nakamura, Takuro ^a  

^a CANCER INSTITUTE   (Japan)

^b Aging and Developmental Sciences ^*  (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; BONE MARROW CULTURE; CELL DIFFERENTIATION; CELL LINE; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; GENE ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HOMEOBOX; IN VITRO STUDY; NONHUMAN; ONCOGENE; PRIORITY JOURNAL;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; LEUKOPOIESIS; MICE;

EID: 0034954065     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(01)00655-5     Document Type: Conference Paper

References (31)

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4. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
5. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
6. NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia
7. NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15)
8. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity
9. + subpopulations of human bone marrow cells
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12. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
13. Extra specificity from extradenticle; the partnership between HOX and PBX/EXD homeodomain proteins
14. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins
15. AbdB-Like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins
16. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins
17. Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein
18. Control of the nuclear localization of Extradenticle by competing nuclear import and export signals
19. The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH
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26. Identification of a new family of Pbx-related homeobox genes
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28. Cross-regulation in the mouse HoxB complex; the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1
29. The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity
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