Pathophysiology of persistent pulmonary hypertension of the newborn: Impact of the perinatal environment

Archives of Cardiovascular Diseases

Volumn 106, Issue 3, 2013, Pages 169-177

  Storme, Laurent ^a,b   Aubry, Estelle ^a,b   Rakza, Thameur ^a,b   Houeijeh, Ali ^b   Debarge, Véronique ^a,b   Tourneux, Pierre ^c   Deruelle, Philippe ^a,b   Pennaforte, Thomas ^b  

^a UNIV LILLE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c AMIENS UNIVERSITY HOSPITAL   (France)

Author keywords

Hypoxaemia; Inhaled NO; Newborn; Pulmonary hypertension

Indexed keywords

CATECHOLAMINE; CORTICOSTEROID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NICOTINE; PHOSPHODIESTERASE V; REACTIVE OXYGEN METABOLITE; SEROTONIN UPTAKE INHIBITOR; SILDENAFIL; VASCULOTROPIN;

ARTIFICIAL VENTILATION; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR FUNCTION; CESAREAN SECTION; CONGENITAL DIAPHRAGM HERNIA; DIABETES MELLITUS; DISEASE ASSOCIATION; DUCTUS ARTERIOSUS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EPIGENETICS; FETUS CIRCULATION; GESTATIONAL AGE; HEART FORAMEN OVALE; HUMAN; HYPOXEMIA; LUNG BLOOD FLOW; LUNG CIRCULATION; LUNG VASCULAR RESISTANCE; LUNG VASOCONSTRICTION; MATERNAL NUTRITION; MATERNAL OBESITY; MECONIUM ASPIRATION; NEONATAL RESPIRATORY DISTRESS SYNDROME; NEWBORN DISEASE; NEWBORN SEPSIS; NONHUMAN; PERINATAL ASPHYXIA; PERINATAL DRUG EXPOSURE; PERSISTENT PULMONARY HYPERTENSION; RESPIRATORY DISTRESS; REVIEW;

ADAPTATION, PHYSIOLOGICAL; CARDIOVASCULAR AGENTS; CESAREAN SECTION; ENVIRONMENT; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HEMODYNAMICS; HUMANS; INFANT, NEWBORN; MATERNAL EXPOSURE; PAIN; PERSISTENT FETAL CIRCULATION SYNDROME; PREGNANCY; PULMONARY CIRCULATION; RESPIRATION, ARTIFICIAL; RISK FACTORS; STRESS, PHYSIOLOGICAL; TOBACCO SMOKE POLLUTION; TREATMENT OUTCOME;

EID: 84876282088     PISSN: 18752136     EISSN: 18752128     Source Type: Journal    
DOI: 10.1016/j.acvd.2012.12.005     Document Type: Review

References (65)

1. K.N. Farrow, P. Fliman, and R.H. Steinhorn The diseases treated with ECMO: focus on PPHN Semin Perinatol 29 2005 8 14
2. J.P. Kinsella, and S.H. Abman Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn J Pediatr 126 1995 853 864
3. S.H. Abman New developments in the pathogenesis and treatment of neonatal pulmonary hypertension Pediatr Pulmonol Suppl 18 1999 201 204
4. P. Tourneux, T. Rakza, A. Bouissou, G. Krim, and L. Storme Pulmonary circulatory effects of norepinephrine in newborn infants with persistent pulmonary hypertension J Pediatr 153 2008 345 349
5. B. Weinberger, K. Weiss, D.E. Heck, D.L. Laskin, and J.D. Laskin Pharmacologic therapy of persistent pulmonary hypertension of the newborn Pharmacol Ther 89 2001 67 79
6. M.C. Walsh-Sukys, J.E. Tyson, and L.L. Wright Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes Pediatrics 105 2000 14 20
7. A.M. Rudolph, and M.A. Heymann Pulmonary circulation in fetal lambs Pediatr Res 6 1972 341 [abstract]
8. D.N. Cornfield, B.A. Chatfield, J.A. McQueston, I.F. McMurtry, and S.H. Abman Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus Am J Physiol 262 1992 H1474 H1481
9. D.D. Ivy, J.P. Kinsella, and S.H. Abman Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation J Clin Invest 93 1994 2141 2148
10. L. Storme, R.L. Rairigh, T.A. Parker, D.N. Cornfield, J.P. Kinsella, and S.H. Abman K+-channel blockade inhibits shear stress-induced pulmonary vasodilation in the ovine fetus Am J Physiol 276 1999 L220 L228
11. R.L. Rairigh, L. Storme, and T.A. Parker Inducible NO synthase inhibition attenuates shear stress-induced pulmonary vasodilation in the ovine fetus Am J Physiol 276 1999 L513 L521
12. J.P. Zenge, R.L. Rairigh, and T.R. Grover NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation Am J Physiol Lung Cell Mol Physiol 281 2001 L1157 L1163
13. R.L. Rairigh, L. Storme, and T.A. Parker Role of neuronal nitric oxide synthase in regulation of vascular and ductus arteriosus tone in the ovine fetus Am J Physiol Lung Cell Mol Physiol 278 2000 L105 L110
14. L. Storme, R.L. Rairigh, T.A. Parker, J.P. Kinsella, and S.H. Abman In vivo evidence for a myogenic response in the fetal pulmonary circulation Pediatr Res 45 1999 425 431
15. S.H. Abman, and F.J. Accurso Acute effects of partial compression of ductus arteriosus on fetal pulmonary circulation Am J Physiol 257 1989 H626 H634
16. P. Deruelle, T.R. Grover, L. Storme, and S.H. Abman Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus Am J Physiol Lung Cell Mol Physiol 288 2005 L727 L733
17. S. Jaillard, B. Larrue, and P. Deruelle Effects of phosphodiesterase 5 inhibitor on pulmonary vascular reactivity in the fetal lamb Ann Thorac Surg 81 2006 935 942
18. E. Villamor, T.D. Le Cras, M.P. Horan, A.C. Halbower, R.M. Tuder, and S.H. Abman Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus Am J Physiol 272 1997 L1013 L1020
19. L. Storme, R.L. Rairigh, T.A. Parker, J.P. Kinsella, and S.H. Abman Acute intrauterine pulmonary hypertension impairs endothelium-dependent vasodilation in the ovine fetus Pediatr Res 45 1999 575 581
20. L. Storme, T.A. Parker, J.P. Kinsella, R.L. Rairigh, and S.H. Abman Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lung Am J Physiol Lung Cell Mol Physiol 282 2002 L56 L66
21. K.A. Hanson, J.W. Ziegler, S.D. Rybalkin, J.W. Miller, S.H. Abman, and W.R. Clarke Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity Am J Physiol 275 1998 L931 L941
22. B. Larrue, S. Jaillard, and M. Lorthioir Pulmonary vascular effects of sildenafil on the development of chronic pulmonary hypertension in the ovine fetus Am J Physiol Lung Cell Mol Physiol 288 2005 L1193 L1200
23. T.R. Grover, T.A. Parker, J.P. Zenge, N.E. Markham, J.P. Kinsella, and S.H. Abman Intrauterine hypertension decreases lung VEGF expression and VEGF inhibition causes pulmonary hypertension in the ovine fetus Am J Physiol Lung Cell Mol Physiol 284 2003 L508 L517
24. J. Gien, G.J. Seedorf, V. Balasubramaniam, N. Markham, and S.H. Abman Intrauterine pulmonary hypertension impairs angiogenesis in vitro: role of vascular endothelial growth factor nitric oxide signaling Am J Respir Crit Care Med 176 2007 1146 1153
25. X.F. Xu, X.L. Ma, Z. Shen, X.L. Wu, F. Cheng, and L.Z. Du Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat J Hypertens 28 2010 2227 2235
26. G.H. Kim, J.J. Ryan, G. Marsboom, and S.L. Archer Epigenetic mechanisms of pulmonary hypertension Pulm Circ 1 2011 347 356
27. C. Bearer, R.K. Emerson, M.A. O'Riordan, E. Roitman, and C. Shackleton Maternal tobacco smoke exposure and persistent pulmonary hypertension of the newborn Environ Health Perspect 105 1997 202 206
28. J.K. Muraskas, L.J. Juretschke, M.G. Weiss, M. Bhola, and R.E. Besinger Neonatal-perinatal risk factors for the development of persistent pulmonary hypertension of the newborn in preterm newborns Am J Perinatol 18 2001 87 91
29. J.L. Wright, and A. Churg Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: analysis using guinea pig precision cut lung slices J Appl Physiol 104 2008 1462 1469
30. V. Houfflin-Debarge, E. Sabbah-Briffaut, E. Aubry, P. Deruelle, C. Alexandre, and L. Storme Effects of environmental tobacco smoke on the pulmonary circulation in the ovine fetus Am J Obstet Gynecol 204 2011 450 [e8-50 e14]
31. S. Jaillard, V. Houfflin-Debarge, and Y. Riou Effects of catecholamines on the pulmonary circulation in the ovine fetus Am J Physiol Regul Integr Comp Physiol 281 2001 R607 R614
32. E. Magnenant, S. Jaillard, and P. Deruelle Role of the alpha2-adrenoceptors on the pulmonary circulation in the ovine fetus Pediatr Res 54 2003 44 51
33. S. Jaillard, F. Elbaz, and S. Bresson-Just Pulmonary vasodilator effects of norepinephrine during the development of chronic pulmonary hypertension in neonatal lambs Br J Anaesth 93 2004 818 824
34. V. Houfflin-Debarge, P. Deruelle, and S. Jaillard Effects of antenatal glucocorticoids on circulatory adaptation at birth in the ovine fetus Biol Neonate 88 2005 73 78
35. P. Deruelle, V. Houfflin-Debarge, and E. Magnenant Effects of antenatal glucocorticoids on pulmonary vascular reactivity in the ovine fetus Am J Obstet Gynecol 189 2003 208 215
36. E.M. Levine, V. Ghai, J.J. Barton, and C.M. Strom Mode of delivery and risk of respiratory diseases in newborns Obstet Gynecol 97 2001 439 442
37. S. Jaillard, V. Houfflin-Debarge, and L. Storme Higher risk of persistent pulmonary hypertension of the newborn after cesarean J Perinat Med 31 2003 538 539
38. M.L. Pokela Pain relief can reduce hypoxemia in distressed neonates during routine treatment procedures Pediatrics 93 1994 379 383
39. V. Houfflin-Debarge, A. Delelis, and S. Jaillard Effects of nociceptive stimuli on the pulmonary circulation in the ovine fetus Am J Physiol Regul Integr Comp Physiol 288 2005 R547 R553
40. V. Houfflin-Debarge, S. Bresson, and S. Jaillard Development of a new model to investigate the fetal nociceptive pathways Fetal Diagn Ther 20 2005 415 419
41. V. Houfflin-Debarge, B. Sicot, and S. Jaillard The mechanisms of pain-induced pulmonary vasoconstriction: an experimental study in fetal lambs Anesth Analg 104 2007 799 806
42. M.A. Alano, E. Ngougmna, E.M. Ostrea Jr., and G.G. Konduri Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn Pediatrics 107 2001 519 523
43. V. Gournay, C. Savagner, G. Thiriez, A. Kuster, and J.C. Roze Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants Lancet 359 2002 1486 1488
44. C. Delaney, J. Gien, T.R. Grover, G. Roe, and S.H. Abman Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus Am J Physiol Lung Cell Mol Physiol 301 2011 L937 L944
45. E. Fornaro, D. Li, J. Pan, and J. Belik Prenatal exposure to fluoxetine induces fetal pulmonary hypertension in the rat Am J Respir Crit Care Med 176 2007 1035 1040
46. C.D. Chambers, S. Hernandez-Diaz, and L.J. Van Marter Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn N Engl J Med 354 2006 579 587
47. I. Seri Circulatory support of the sick preterm infant Semin Neonatol 6 2001 85 95
48. A. Bouissou, T. Rakza, S. Klosowski, P. Tourneux, M. Vanderborght, and L. Storme Hypotension in preterm infants with significant patent ductus arteriosus: effects of dopamine J Pediatr 153 2008 790 794
49. E.A. Nohr, E. Villamor, M. Vaeth, J. Olsen, and S. Cnattingius Mortality in infants of obese mothers: is risk modified by mode of delivery? Acta Obstet Gynecol Scand 91 2012 363 371
50. R.J. Vosatka, S. Kashyap, and R.R. Trifiletti Arginine deficiency accompanies persistent pulmonary hypertension of the newborn Biol Neonate 66 1994 65 70
51. A. Houeijeh, E. Aubry, and H. Coridon Effects of n-3 polyunsaturated fatty acids in the fetal pulmonary circulation Crit Care Med 39 2011 1431 1438
52. S. Wedgwood, and S.M. Black Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide Am J Physiol Lung Cell Mol Physiol 288 2005 L480 L487
53. J.P. Kinsella, T.A. Parker, J.M. Davis, and S.H. Abman Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambs Am J Respir Crit Care Med 172 2005 745 749
54. P. Bagolan, G. Casaccia, F. Crescenzi, A. Nahom, A. Trucchi, and C. Giorlandino Impact of a current treatment protocol on outcome of high-risk congenital diaphragmatic hernia J Pediatr Surg 39 2004 313 318 [discussion 13-8]
55. Finer NN, Barrington KJ. Nitric oxide for respiratory failure in infants born at or near term. Cochrane Database Syst Rev 2006:CD000399.
56. J.P. Kinsella, S.R. Neish, D.D. Ivy, E. Shaffer, and S.H. Abman Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide J Pediatr 123 1993 103 108
57. The Neonatal Inhaled Nitric Oxide Study Group (NINOS) Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia Pediatrics 99 1997 838 845
58. S. Noori, P. Friedlich, P. Wong, A. Garingo, and I. Seri Cardiovascular effects of sildenafil in neonates and infants with congenital diaphragmatic hernia and pulmonary hypertension Neonatology 91 2007 92 100
59. R.L. Keller, P. Moore, D. Teitel, S. Hawgood, J. McQuitty, and J.R. Fineman Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy Pediatr Crit Care Med 7 2006 589 594
60. R.H. Steinhorn, J.P. Kinsella, and C. Pierce Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertension J Pediatr 155 2009 841 847 [e1]
61. Shah PS, Ohlsson A. Sildenafil for pulmonary hypertension in neonates. Cochrane Database Syst Rev 2011:CD005494.
62. P. Betremieux, T. Gaillot, and A. de la Pintiere Congenital diaphragmatic hernia: prenatal diagnosis permits immediate intensive care with high survival rate in isolated cases. A population-based study Prenat Diagn 24 2004 487 493
63. M. Levy, D.S. Celermajer, E. Bourges-Petit, M.J. Del Cerro, F. Bajolle, and D. Bonnet Add-on therapy with subcutaneous treprostinil for refractory pediatric pulmonary hypertension J Pediatr 158 2011 584 588
64. D.D. Ivy, T.A. Parker, and J.W. Ziegler Prolonged endothelin A receptor blockade attenuates chronic pulmonary hypertension in the ovine fetus J Clin Invest 99 1997 1179 1186
65. C. Goissen, L. Ghyselen, and P. Tourneux Persistent pulmonary hypertension of the newborn with transposition of the great arteries: successful treatment with bosentan Eur J Pediatr 167 2008 437 440