Development of a new model to investigate the fetal nociceptive pathways: Experimental study in the ovine fetus

Fetal Diagnosis and Therapy

Volumn 20, Issue 5, 2005, Pages 415-419

  Debarge, Véronique Houfflin ^a,b   Bresson, Sophie ^a,b   Jaillard, Sophie ^a,b   Elbaz, Frédéric ^a   Riou, Yvon ^b   Dalmas, Serge ^a   Deruelle, Philippe ^a,b   Ducloy, Anne Sophie ^a   Puech, Francis ^a   Storme, Laurent ^a,b  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b EA 1049   (France)

Author keywords

Fetal analgesia; Fetal pain; Nociceptive flexion reflex; Ovine fetus

Indexed keywords

CATECHOLAMINE; SUFENTANIL;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; BRADYCARDIA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRIC CURRENT; ELECTROMYOGRAPHY; ELECTROSTIMULATION; EXPERIMENTAL MODEL; FEMALE; FETUS; FLEXOR REFLEX; HAMSTRING; INFUSION; LAMB; MUSCLE REFLEX; NERVE STIMULATION; NERVE TRACT; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RECORDING; SURAL NERVE;

EID: 23944510646     PISSN: 10153837     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086823     Document Type: Article

References (20)

1. Smith RP, Gitau R, Glover V, Fisk NM: Pain and stress in the human fetus. Eur J Obstet Gynecol Reprod Biol 2000;92:161-165.
2. Anand KJ, Hickey PR: Pain and its effects in the human neonate and fetus. N Engl J Med 1987;317:1321-1329.
3. Glover V, Fisk NM: Fetal pain: implications for research and practice. Br J Obstet Gynaecol 1999;106:881-886.
4. Fisk NM, Gitau R, Teixeira JM, Giannakoulopoulos X, Cameron AD, Glover VA: Effect of direct fetal opioid analgesia on fetal hormonal and hemodynamic stress response to intrauterine needling. Anesthesiology 2001;95:828-835.
5. Uno H, Lohmiller L, Thieme C, Kemnitz JW, Engle MJ, Roecker EB, et al: Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus. Brain Res Dev Brain Res 1990;53:157-167.
6. Clarke AS, Wittwer DJ, Abbott DH, Schneider ML: Long-term effects of prenatal stress on HPA axis activity in juvenile rhesus monkeys. Dev Psychobiol 1994;27:257-269.
7. Maccari S, Darnaudery M, Morley-Fletcher S, Zuena AR, Cinque C, Van Reeth O: Prenatal stress and long-term consequences: Implications of glucocorticoid hormones. Neurosci Biobehav Rev 2003;27:119-127.
8. Barbazanges A, Piazza PV, Le Moal M, Maccari S: Maternal glucocorticoid secretion mediates long-term effects of prenatal stress. J Neurosci 1996;16:3943-3949.
9. Schneider ML, Roughton EC, Koehler AJ, Lubach GR: Growth and development following prenatal stress exposure in primates: An examination of ontogenetic vulnerability. Child Dev 1999;70:263-274.
10. Taylor A, Fisk NM, Glover V: Mode of delivery and subsequent stress response. Lancet 2000;355:120.
11. Taddio A, Katz J, Ilersich AL, Koren G: Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet 1997;349:599-603.
12. Alreja M, Mutalik P, Nayar U, Manchanda SK: The formalin test: a tonic pain model in the primate. Pain 1984;20:97-105.
13. Falinower S, Wilier JC, Junien JL, Le Bars D: A C-fiber reflex modulated by heterotopic noxious somatic stimuli in the rat. J Neurophysiol 1994;72:194-213.
14. You HJ, Morch CD, Chen J, Arendt-Nielsen L: Role of central NMDA versus non-NMDA receptor in spinal withdrawal reflex in spinal anesthetized rats under normal and hyperexcitable conditions. Brain Res 2003;981:12-22.
15. Le Bars D, Gozariu M, Cadden SW: Animal models of nociception. Pharmacol Rev 2001;53:597-652.
16. Willer JC: Comparative study of perceived pain and nociceptive flexion reflex in man. Pain 1977;3:69-80.
17. Strimbu-Gozariu M, Guirimand F, Willer JC, Le Bars D: A sensitive test for studying the effects of opioids on a C-fibre reflex elicited by a wide range of stimulus intensities in the rat. Eur J Pharmacol 1993;237:197-205.
18. Fitzgerald M, Shaw A, MacIntosh N: Postnatal development of the cutaneous flexor reflex: Comparative study of preterm infants and newborn rat pups. Dev Med Child Neurol 1988;30.520-526.
19. Willer JC: Studies on pain: Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man. Brain Res 1985;331:105-114.
20. Bossard AE, Guirimand F, Fletcher D, Gaude-Joindreau V, Chauvin M, Bouhassira D: Interaction of a combination of morphine and ketamine on the nociceptive flexion reflex in human volunteers. Pain 2002;98:47-57.