Pulmonary vascular effects of sildenafil on the development of chronic pulmonary hypertension in the ovine fetus

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 288, Issue 6 32-6, 2005, Pages

  Larrue, B ^a   Jaillard, S ^a   Lorthioir, M ^a   Roubliova, X ^b   Butrous, G ^c   Rakza, T ^a   Warembourg, H ^a   Storme, L ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b Center for Surgical Technologies Leuven   (Belgium)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Nitric oxide; Phosphodiesterase; Pulmonary hypertension; Shear stress; Vascular reactivity

Indexed keywords

PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL OXYGEN TENSION; ARTERY COMPRESSION; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; DRUG EFFECT; DUCTUS ARTERIOSUS; ENZYME ACTIVITY; FETUS; HEART RIGHT VENTRICLE; LAMB; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG VASCULAR RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PULMONARY HYPERTENSION; SHEAR STRESS;

EID: 18844431309     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00405.2004     Document Type: Article

References (39)

1. Abman SH, Shanley PF, and Accurso FJ. Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs. J Clin Invest 83: 1849-1859, 1989.
2. Abman SH and Accurso FJ. Acute effects of partial compression of ductus arteriosus on fetal pulmonary circulation. Am J Physiol Heart Circ Physiol 257: H626-H634, 1989.
3. Abman SH, Chatfield BA, Hall SL, and McMurtry IF. Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol Heart Circ Physiol 259: H1921-H1927, 1990.
4. Anderson DF, Bissonette JM, Farber JJ, and Thornburg KL. Central shunt flows and pressures in the mature fetal lamb. Am J Physiol Heart Circ Physiol 241: H60-H66, 1981.
5. Belik J and Light RB. Effect of increased afterload on right ventricular function in the newborn pig. J Appl Physiol 66: 868-869, 1989.
6. Belik J, Baron K, and Light RB. Central hemodynamic and regional blood flow changes in the newborn with right ventricular hypertension. Pediatr Res 26: 548-553, 1989.
7. Cassin S. Role of prostaglandins, thromboxanes, and leucotrienes in the control of the pulmonary circulation in the fetus and newborn. Semin Perinatol 11:53-63, 1987.
8. Cohen AH, Hanson K, Morris K, Fouty B, McMurtry IF, Clarke W, and Rodman DM. Inhibition of cyclic 3′-5′-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats. J Clin Invest 97: 172-179, 1996.
9. Cornfield DN, Chatfield BA, McQueston JA, McMurtry IF, and Abman SH. Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus. Am J Physiol Heart Circ Physiol 262: H1474-H1481, 1992.
10. Dukarm RC, Russell JA, Morin FC III, Perry BJ, and Steinhorn RH. The cGMF-specific phosphodiesterase inhibitor E4021 dilates the pulmonary circulation. Am J Respir Crit Care Med 160: 858-865, 1999.
11. Eerkes A, Addison T, and Naidong W. Simultaneous assay of sildenafil and desmethylsildenafil in human plasma using liquid chromatographytandem mass spectrometry on silica column with aqueous-organic mobile phase. J Chromatogr B Analyt Technol Biomed Life Sci 768: 277-284, 2002.
12. Hanson KA, Burns F, Rybalkin SD, Miller JW, Beavo J, and Clarke WR. Developmental changes in lung cGMP phosphodiesterase-5 activity, protein, and message. Am J Respir Crit Care Med 158: 279-288, 1998.
13. Hanson KA, Ziegler JW, Rybalkin SD, Miller JW, Abman SH, and Clarke WR. Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity. Am J Physiol Lung Cell Mol Physiol 275: L931-L941, 1998.
14. Kolpakov V, Rekhter MD, Gordon D, Wang WH, and Kulik TJ. Effect of mechanical forces on growth and matrix protein synthesis in the in vitro pulmonary artery. Analysis of the role of individual cell types. Circ Res 77: 823-31, 1995.
15. Levin DL, Heyman MA, Kitterman JA, Gregory GA, Phibbs RH, and Rudolph AM. Persistent pulmonary hypertension of the newborn. J Pediatr 89: 626-630, 1976.
16. Levin DL, Hyman AI, Heymann MA, and Rudolph AM. Fetal hypertension and the development of increased pulmonary vascular smooth muscle: a possible mechanism for persistent pulmonary hypertension of the newborn infant. J Pediatr 92: 265-269, 1978.
17. Maclean MR, Johnston ED, Mcculloch KM, Pooley L, Houslay MD, and Sweeney G. Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension. J Pharmacol Exp Ther 283: 619-624, 1997.
18. McQueston JA, Kinsella JP, Ivy DD, McMurtry IF, and Abman SH. Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation. Am J Physiol Heart Circ Physiol 268: H288-H294, 1995.
19. Michelakis ED, Tymchak W, Noga M, Webster L, Wu XC, Lien D, Wang SH, Modry D, and Archer SL. Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation 108: 2066-2069, 2003.
20. Morin FC. Ligating the DA before birth causes persistent pulmonary hypertension in the newborn lamb. Pediatr Res 25: 245-250, 1989.
21. Rabe KF, Tenor H, Dent G, Schudt C, Nakashima M, and Magnussen H. Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors. Am J Physiol Lung Cell Mol Physiol 266: L536-L543, 1994.
22. Rudolph A. Distribution, and regulation of blood flow in the fetal and neonatal lamb. Circ Res 57: 811-819, 1985.
23. Schermuly RT, Kreisselmeier KP, Ghofrani HA, Yilmaz H, Butrous G, Ermert L, Ermert M, Weissmann N, Rose F, Guenther A, Walmrath D, Seeger W, and Grimminger F. Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats. Am J Respir Crit Care Med 169: 39-45, 2004.
24. Sebkhi A, Strange JW, Phillips SC, Wharton J, and Wilkins MR. Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension. Circulation 107: 3230-3235, 2003.
25. Shaul PW and Wells LB. Oxygen modulates nitric oxide production selectively in fetal pulmonary endothelial cells. Am J Respir Cell Mol Biol 11: 432-438, 1994.
26. Shaul PW, Yuhanna IS, German Z, Chen Z, Steinhorn RN, and Morin FC. Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 272: L1005-L1012, 1997.
27. Shekerdemian LS, Ravn HB, and Penny DJ. Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension. Am J Respir Crit Care Med 165: 1098-1102, 2002.
28. Storme L, Rairigh RL, Parker TA, Kinsella JP, and Abman SH. In vivo evidence for a myogenic response in the fetal pulmonary circulation. Pediatr Res 45: 425-431, 1999.
29. Storme L, Parker TA, Kinsella JP, Rairigh RL, and Abman SH. Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lung. Am J Physiol Lung Cell Mol Physiol 282: L56-L66, 2002.
30. +-channel blockade inhibits shear stress-induced pulmonary vasodilation in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 276: L220-L228, 1999.
31. Teitel DF, Iwamoto HS, and Rudolph AM. Effects of birth-related events on central blood flow patterns. Pediatr Res 22: 557-566, 1987.
32. Thusu KG, Morin FC, Russel JA, and Steinhorn RH. The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide. Am J Respir Crit Care Med 152: 1605-1610, 1995.
33. Villamor E, Le Cras TD, Horan M, Halbower AC, Tuder RM, and Abman SH. Chronic hypertension impairs endothelial NO synthase in the ovine fetus. Am J Physiol 16: L1013-L1020, 1997.
34. Wallis RM, Corbin JD, Francis SH, and Ellis P. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol 83: 3C-12C, 1999.
35. Walther FJ, Benders MJ, and Leigtilon JO. Persistent pulmonary hypertension in premature neonates with severe respiratory distress syndrome. Pediatrics 90: 899-904, 1992.
36. Weiser MC, Majack RA, Tucker A, and Orton EC. Static tension is associated with increased smooth muscle cell DNA synthesis in rat pulmonary arteries. Am J Physiol Heart Circ Physiol 268: H1 133-H1138, 1995.
37. Zenge JP, Rairigh RL, Grover TR, Storme L, Parker TA, Kinsella JP, and Abman SH. NO and prostaglandin interactions during hemodynamic stress in the fetal ovine pulmonary circulation. Am J Physiol Lung Cell Mol Physiol 281: L1157-L1163, 2001.
38. Zhao L, Mason NA, Morrell NW, Kojonazarov B, Sadykov A, Maripov A, Mirrakhimov MM, Aldashev A, and Wilkins MR. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 104: 424-428, 2001.
39. Ziegler JW, Ivy DD, Fox JJ, Kinsella JP, Clarcke WR, and Abman SH. Dipyridamole potentiates pulmonary vasodilation induced by acetylcholine and nitric oxide in the ovine fetus. Am J Respir Crit Care Med 157: 1104-1110, 1998.