Endophytic fungi from medicinal plants: A treasure hunt for bioactive metabolites

Phytochemistry Reviews

Volumn 11, Issue 4, 2012, Pages 487-505

  Kaul, Sanjana ^a   Gupta, Suruchi ^a   Ahmed, Maroof ^a   Dhar, Manoj K ^a  

^a UNIVERSITY OF JAMMU   (India)

Author keywords

Bioactivities; Endophytes; Medicinal plants; New metabolites

Indexed keywords

3,11,12 TRIHYDROXYCADALENE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ANTITRYPANOSOMAL AGENT; ANTIVIRUS AGENT; CYTOSPORONE B; CYTOTOXIC AGENT; DICERANDROL A; HYDRACRYLIC ACID; IMMUNOMODULATING AGENT; MEVINIC ACID; OBLONGOLIDE Y; PHOMOARCHERIN A; PHOMOARCHERIN B; PHOMOARCHERIN C; PHOMODIONE; PHOMOL; PHOMOPSIN A; PHOMOPSIN B; PHOMOPSIN C; PHOMOXANTHONE A; PHOMOXANTHONE B; TENUAZONIC ACID; TERPENOID DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APIOSPORA MONTAGNEI; ASPERGILLUS; ASPERGILLUS NIGER; ASPERGILLUS PARASITICUS; AUREOBASIDIUM; BIOLOGICAL ACTIVITY; CEPHALOTHECA FAVEOLATA; CHAETOMIUM CHIVERSII; CYTOSPORA; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; EMERICELLA NIDULANS; ENDOPHYTE; ENDOPHYTIC FUNGUS; EUTYPELLA; FUNGUS; FUNGUS ISOLATION; GARCINIA; GUIGNARDIA; HALOROSELLINIA; HUMAN; HYPOXYLON TRUNCATUM; IMMUNOMODULATION; MEDICINAL PLANT; MYCELIA STERILIA; NONHUMAN; PERICONIA ATROPURPUREA; PHOMOPSIS; PLANT FUNGUS INTERACTION; PRIORITY JOURNAL; REVIEW; THIELAVIA SUBTHERMOPHILA; XYLARIA;

FUNGI;

EID: 84876280450     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1007/s11101-012-9260-6     Document Type: Review

References (122)

1. Aly AH, Edrada-Ebel R, Indriani ID, Wray V, Muller WEG, Totzke F, Zirrglebel U, Schachtele C, Kubbutat MHG, Lin WH, Proksch P, Ebel R (2008) Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. J Nat Prod 71(6):972-980
2. Bacon CW, White JF (2000) Microbial endophytes. Marcel Dekker, New York, pp 341-388
3. Balick MJ, Elisabetsky E, Laind SA (eds) (1996) Medicinal resources of the tropical forest: Biodiversity and its importance for human health. Columbia University Press, New York
4. Bentley R (2000) Mycophenolic acid: a one hundred year odyssey from antibiotic to immunosuppressant. Chem Rev 100(10):380-3826
5. Bibitha B, Jisha VK, Salitha CV, Mohan S, Valsa AK (2002) Antibacterial activity of different plant extracts. Ind J Microbiol 42:361-363
6. Borel JF, Kis ZL (1991) The discovery and development of cyclosporine. Transplant Proc 23:1867-1874
7. Brady SF, Singh MP, Janso JE, Clardy J (2000) Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. Org Lett 2(25):4047-4049
8. Brady SF, Bondi SM, Clardy J (2001) The Guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus. J Am Chem Soc 123:9900-9901
9. Budhiraja A, Nepali K, Sapra S, Gupta S, Kumar S, Dhar KL (2012) Bioactive metabolites from an endophytic fungus of Aspergillus species isolated from seeds of Gloriosa superba Linn. Med Chem Res. doi: 10.1007/s00044-012-0032- z
10. Bungihan ME, Tan MA, Kitajima M, Kogure N, Franzblau SG, Cruz TEE, Takayama H, Nonato MG (2011) Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius. J Nat Med 65:606-609
11. Bunyapaiboonsri T, Yoiprommarat S, Srikitikulchai P, Srichomthong K, Lumyong S (2010) Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789. J Nat Prod 73(1):55-59
12. Campos FF, Rosa LH, Cota BB, Caligiorne RB, Rabello ALT, Alves TMA, Rosa CA, Zani CL (2008) Leishmanicidal metabolites from Cochliobolus sp. an endophytic fungus isolated from Piptadenia adiantoides (Fabaceae). PLoS Negl Trop Dis 2(12):e348. doi: 10.1371/journal.pntd.0000348
13. Chen Y, Guo H, Du Z, Liu XZ, Che Y, Ye X (2009) Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers. Cell Prolif 42(6):838-884
14. Cremasco MA, Hritzko BJ, Linda Wang NH (2009) Experimental purification of paclitaxel from a complex mixture of taxanes using a simulated moving bed. Braz J Chem Eng 26(1):207-218
15. Cui HB, Mei WL, Miao CD, Lin HP, Kui H, Dai HF (2008) Antibacterial constituents from the endophytic fungus Penicillium sp. 0935030 of a mangrove plant Acrostichum aureurm. Chin J Antibiot. doi: CNKI:SUN:ZKSS.0.2008-07-004
16. Daisy B, Strobel GA, Castillo U, Ezra D, Sears J, Weaver D, Runyon JB (2002a) Naphthalene, an insect repellent, is produced by Muscodor vitigenus, a novel endophytic fungus. Microbiol 148:3737-3741
17. Daisy B, Strobel GA, Ezra D, Castillo U, Baird G, Hess WM (2002b) Muscodor vitigenus anam. sp. nov., an endophyte from Paullinia paullinioides. Mycotaxon 84:39-50
18. Debbab A, Aly AH, Edrada-Ebel RA, Meuller WEG, Mosaddak M, Hakikj A, Ebel R, Proksch P (2009) Bioactive secondary metabolites from the endophytic fungus Chaetomium sp. isolated from Salvia officinalis growing in Morocco. Biotechnol Agron Soc Environ 13:229-234
19. Demain AL (2000) Microbial natural products: a past with a future. In: Wrigley SK, Hayes MA, Thomas R, Chrystal EJT, Nicholson N (eds) Biodiversity: new leads for pharmaceutical and agrochemical industries. The Royal Society of Chemistry, Cambridge, pp 3-16
20. Deshmukh SK, Mishra PD, Kulkarni-Almeida A, et al. (2009) Anti-inflammatory and anticancer activity of ergoflavin isolated from an endophytic fungus. Chem Biodiver 6(5):784-789
21. Ding G, Song YC, Chen JR, Xu C, Ge HM, Wang XT, Tan RX (2006) Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. J Nat Prod 69(2):302-304
22. Ding G, Liu S, Guo L, Zhou Y, Che Y (2007) Antifungal metabolites from the plant endophytic fungus Pestalotiopsis foedan. J Nat Prod 71(4):615-618
23. Ding G, Zheng Z, Liu L, Zhang H, Guo L, Che Y (2009) Photinides A-F, cytotoxic benzofuranone-derived γ-lactones from the plant endophytic fungus Pestalotiopsis photiniae. J Nat Prod 72(5):942-945
24. Eyberger L, Dondapati R, Porter JR (2006) Endophyte fungal isolates from Podophyllum peltatum produces podophyllotoxin. J Nat Prod 69:1121-1124
25. Fabio AP, Barros E, Rodrigues-Filho E (2005) Four spiroquinazoline alkaloids from Eupenicillium sp. isolated as an endophytic fungus from leaves of Murraya peniculata (Rutaceae). Biochem Sys Ecol 33:257-268
26. Findlay JA, Buthelezi S, Li G, Seveck M (1997) Insect toxins from an endophytic fungus from wintergreen. J Nat Prod 60:1214-1215
27. Ge HM, Yu ZG, Zhang J, Wu JH, Tan RX (2009) Bioactive alkaloids from endophytic Aspergillus fumigatus. J Nat Prod 72(4):753-755
28. Giridharan P, Verekar SA, Khanna A, Mishra PD, Deshmukh SK (2012) Anticancer activity of Sclerotiorin isolated from an endophytic fungus Cephalotheca faveoleta yaguchi, Nishim & Udagawa. Ind J Exp Biol 50:464-468
29. Gu W, Ge HM, Song YC, Ding H, Zhu HL, Zhao XA, Tan RX (2007) Cytotoxic Benzo[j]fluoranthene metabolites from Hypoxylon truncatum IFB-18, an endophyte of Artemisia annua. J Nat Prod 70:114-117
30. Guo B, Dai J, Ng S, Huang Y, Leong C, Ong W, Carte BK (2000) Cytonic acids A and B: novel tridepside inhibitors of hCMV protease from the endophytic fungus Cytonaema species. J Nat Prod 63:602-604
31. Harper JK, Arif AM, Ford EJ, Strobel GA, Porco JA, Tomer DP, Oneill KL, Heider EM, Grant DM (2003) Pestacin: a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotics activities. Tetrahedron 59:2471-2476
32. Hemtasin C, Kanokmedhakul S, Kanokmedhakul K, Hahnvajanawong C, Soytong K, Prabpai S, Kongsaeree P (2011) Cytotoxic Pentacyclic and tetracyclic aromatic sesquiterpenes from Phomopsis archeri. J Nat Prod 74(4):609-613
33. Hoffman AM, Mayer SG, Strobel GA, Hess WM, Sovocool GW, Grange AH, Harper JK, Arif AM, Grant DM, Kelley EG (2008) Purification, identification and activity of Phomodione, a furandione from an endophytic Phoma species. Phytochem 69(4):1049-1056
34. Huang WY, Cai YZ, Hyde KD, Corke H, Sun M (2007) Endophytic fungi from Nerium oleander L. (Apocynaceae): main constituents and antioxidant activity. World J Microbiol Biotechnol 23:1253-1263
35. Huang Z, Cai X, Shao C, She Z, Xia X, Chen Y, Yang J, Zhou S, Lin Y (2008) Chemistry and weak antimicrobial activities of Phomopsins produced by mangrove endophytic fungus Phomopsis sp. ZSU-H76. Phytochem 69(7):1604-1608
36. Huang YF, Zhao JL, Zhou LG, Wang MA, Wang JG, Li XL, Chen Q (2009a) Antimicrobial compounds from the endophytic fungus Fusarium sp. Ppf4 isolated from the medicinal plant Paris polyphylla var. yunnanensis. Nat Prod Comm 4:1455-1458
37. Huang Z, Guo Z, Yang R, Yin X, Li X, Luo W, She Z, Lin Y (2009b) Chemistry and cytotoxic activities of polyketides produced by the mangrove endophytic fungus Phomopsis sp. ZSU-H76. Chem Nat Comp 45(5):625-628
38. Huang XZ, Zhu Y, Guan XL, Tian K, Guo JM, Wang HB, Fu GM (2012) A novel antioxidant isobenzofuranone derivative from fungus Cephalosporium sp. AL031. Molecules 17:4219-4224
39. Isaka M, Jaturapat A, Rukseree K, Danwisetkanjana K, Tanticharoen M, Thebtaranonth Y (2001) Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. J Nat Prod 64(8):1015-1018
40. Isaka M, Berkaew P, Intereya K, Komwijit S, Sathitkunanon T (2007) Antiplasmodial and antiviral cyclohexadepsipeptides from the endophytic fungus Pullularia sp. BCC 8613. Tetrahedron 63(29):6855-6860
41. Isaka M, Palasarn S, Lapanun S, Chanthaket R, Boonyuen N, Lumyong S (2009) Lactones and ent-eudesmane sesquiterpenes from the endophytic fungus Eutypella sp. BCC 13199. J Nat Prod 72:1720-1722
42. Isaka M, Chinthanom P, Boonruangprapa T, Rungjindamai N, Pinruan U (2010) Eremophilanetype sesquiterpenes from the fungus Xylaria sp. BCC 21097. J Nat Prod 73:683-687
43. Kharwar RN, Verma VC, Kumar A, Gond SK, Harper JK, Hess WM, Lobkovosky E, Ma C, Ren Y, Strobel GA (2008) Javanicin, an antibacterial naphthaquinone from an endophytic fungus of neem, Chloridium sp. Current Microbiol 58:233-238
44. Kharwar RN, Mishra A, Gond SK, Stierle A, Stierle D (2011) Anticancer compounds derived from fungal endophytes: their importance and future challenges. Nat Prod Rep 28:1208-1228
45. Kjer J, Wray V, Edrada-Ebel R, Ebel R, Pretsch A, Lin W, Proksch P (2009) Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the mangrove plant Sonneratia alba. J Nat Prod 72(11):2053-2057
46. Klemke C, Kehraus S, Wright AD, Konig GM (2004) New secondary metabolites from the marine endophytic fungus Apiospora montagnei. J Nat Prod 67:1058-1063
47. Kobayashi H, Sunaga R, Furihata K, Morisaki N, Iwasaki S (1995) Isolation and structure of an antifungal antibiotic, fusarielin A, and related compounds produced by a Fusarium sp. J Antibiot 48:42-52
48. Kour AS, Shawl S, Rehman S, Sultan P, Qazi PH, Suden P, Khajuria RK, Verma V (2008) Isolation and identification of an endophytic strain of Fusarium oxysporum producing podophyllotoxin from Juniperus recurva. World J Microbiol Biotech 24:1115-1121
49. Kralj A, Kehraus S, Krick A, Eguereva E, Kelter G, Maurer M, Wortmann A, Fiebig HH, Konig GM (2006) Arugosins G and H: prenylated polyketides from the marine-derived fungus Emericella nidulans var. acristata. J Nat Prod 69(7):995-1000
50. Kusari S, Lamshoft M, Spiteller M (2009a) Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro-drug deoxypodophyllotoxin. J Appl Microbiol 107(3):1019-1030
51. Kusari S, Zuhlke S, Spiteller M (2009b) An endophytic fungus from Camptotheca acuminata that produces camptothecin and analogues. J Nat Prod 72(1):2-7
52. Kusari S, Zuhlke S, Kosuth J, Cellarova E, Spiteller M (2009c) Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. J Nat Prod 72(10):1825-1835
53. Larsen TO, Smedsgaard J, Nielsen KF, Hansen ME, Frisvad JC (2005) Phenotypic taxonomy and metabolite profiling in microbial drug discovery. Nat Prod Rep 22(6):672-695
54. Lee J, Lobkovsky E, Pliam NB, Strobel GA, Clardy J (1995) Subglutinols A and B: immunosuppressive compounds from the endophytic fungus Fusarium subglutinans. J Org Chem 60:7076-7077
55. Lee JC, Strobel GA, Lobkovsky E, Clardy J (1996) Torreyanic acid: a selectively cytotoxic quinone dimer from the endophytic fungus Pestalotiopsis microspora. J Org Chem 61(10):3232-3233
56. Li JY, Strobel GA (2000) Jesterone and hydroxy-jesterone antioomycete cyclohexenone epoxides from the endophytic fungus Pestalotiopsis jester. Phytochemistry 57:261-265
57. Li E, Jiang L, Guo L, Zhang H, Che Y (2008a) Pestalachlorides A-C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta. Bioorg Med Chem 16:7849-7899
58. Li E, Tian R, Liu S, Chen X, Guo L, Che Y (2008b) Pestalotheols A-D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae. J Nat Prod 71(4):664-668
59. Li XJ, Zhang Q, Zhang AL, Gao JM (2012) Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities. J Agric Food Chem 60:3424-3431
60. Liu JY, Song YC, Zhang Z, Wang L, Guo ZJ, Zou WX, Tan RX (2004) Aspergillus fumigatus CY018, an endophytic fungus in Cynodon dactylon as a versatile producer of new and bioactive metabolites. J Biotechnol 114:279-287
61. Liu X, Dong M, Chen X, Jiang M, Lv X, Yan G (2007) Antioxidant activity and phenolics of an endophytic Xylaria sp. from Ginkgo biloba. Food Chem 105:554-584
62. Liu X, Dong M, Chen X, Jiang M, Lv X, Zhou J (2008) Antimicrobial activity of an endophytic Xylaria sp. YX-28 and identification of its antimicrobial compound 7-amino-4-methylcoumarin. Appl Microbiol Biotechnol 78:241-247
63. Liu L, Liu S, Chen X, Guo L, Che Y (2009) Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici. Bioorg Med Chem 17:606-613
64. Macias-Rubalcava ML, Hernandez-Bautista BE, Jimenez-Estrada M, Gonzalez MC, Glenn AE, Hanlin RT, Hernandez-ortega S, Saucedo-Garcia A, Muria-Gonzalez JM, Anaya AL (2008) Napthaquinone spiroketal with allelochemical activity from the newly discovered endophytic fungus Edenia gomezpompe. Phytochemistry 69:1185-1196
65. Maghrani M, Zeggwagh N, Michel J, Eddouks M (2005) Antihypertensive effect of Lepidium sativum L. in spontaneously hypertensive rats. J Ethnopharm 100(102):193-197
66. Marinho AMR, Rodrigues Filho E, Moitinho MDLR, Santos LS (2005) Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach. J Braz Chem Soc 16:280-283
67. Martinez-Luis S, Cherigo L, Spadafora C, Gerwick WH, Billa-Rios LC (2009) Additional anti-leishmanial constituents of the Panamanian endophytic fungus Edenia sp. Revista Latinoamericana de Química 37(2):104-114
68. Martinez-Luis S, Cheirgo L, Arnold E, Spadafora C, Gerwick WH, Cubilla-Rios L (2012) Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544. Nat Prod Comm 7(2):165-168
69. Moreno E, Varughese T, Spadafora C, Arnold AE, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L (2011) Chemical Constituents of the new endophytic fungus Mycosphaerella sp. nov. and their antiparasitic activity. Nat Prod Comm 6(6):835-840
70. Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461-477
71. Nithya K, Muthumary J (2010) Secondary metabolite from Phomopsis sp. isolated from Plumeria acutifolia Poiret. Recent Res Sci Tech 2(4):99-103
72. Olalde Rangel JA (2005) The systemic theory of living systems and relevance to CAM. Part I: the theory. Evid Based Comp Alt Med 2:13-18
73. Owen NL, Hundley N (2004) Endophytes - the chemical synthesizers inside plants. Sci Prog 87(2):79-99
74. Puri SC, Verma V, Amna T, Qazi GN, Spiteller M (2005) An endophytic fungus from Nothapodytes foetida that produces camptothecin. J Nat Prod 68:1717-1719
75. Puri SC, Nazir A, Chawla R (2006) The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans. J Biotech 122(4):494-510
76. Qin JC, Zhang YM, Gao JM, Bai MS, Yang SX, Laatsch H, Zhang AL (2009) Bioactive metabolites produced by Chaetomium globosum an endophyte isolated from Ginkgo biloba. Bioorg Med Chem Lett 19:1572-1574
77. Ren Y, Strobel GA, Graff JC, Jutila M, Park SG, Gosh S, Teplow D, Condron M, Pang E, Hess WM, Moore E (2008) Colutellin A, an immunosuppressive peptide from Colletotrichum dematium. Microbiology 154:1973-1979
78. Robert A, Benoit-Vical F, Dechy-Cabaret O, Meunier B (2001) From classical antimalarial drugs to new compounds based on the mechanism of action of artemisinin. Pure Appl Chem 73:1173-1188
79. Rukachaisirikul V, Sommart U, Phongpaichit S, Sakayaroj J, Kirtikara K (2008) Metabolites from the endophytic fungus Phomopsis sp. PSU-D15. Phytochemistry 69:783-787
80. Saikkonen K, Wali P, Helander M, Faeth SH (2004) Evolution of endophyte-plant symbiosis. Trends Plant Sci 9:275-280
81. Santiago C, Fitchett C, Murno MHG, Jalil J, Santhanam J (2012) Cytotoxic and antifungal activities of 5-Hydroxyramulosin, a compound produced by an endophytic fungus isolated from Cinnamomum mollisimum. Evid Based Complement Alternat Med. doi: 10.1155/2012/689310
82. Sappapan R, Sommit D, Ngamrojanavanich N, Pengpreecha S, Wiyakrutta S, Sriubolmas N, Pudhom K (2008) 11-Hyroxymonocerin from the plant endophytic fungus Exserohilum rostratum. J Nat Prod 71(9):1657-1659
83. Schulz B, Boyle C, Draeger S, Rommert AK, Krohn K (2002) Endophytic fungi:a source of novel biologically active secondary metabolites. Mycol Res 106:996-1004
84. Schwarz M, Kopcke B, Weber RWS, Sterner O, Anke H (2004) 3-Hydroxypropionic acid as a nematicidal principle in endophytic fungi. Phytochemistry 65:2239-2245
85. Silva GH, Teles HL, Zanardi LM, Young MCM, Eberlin MN, Haddad RP, Fenning LH, Costa-Neta C, Castro-Gamboa I, Bolzani VS, Araujo AR (2006) Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis (Leguminosae). Phytochemistry 67:1964-1969
86. Silva GH, Oliveira CM, Teles HL, Pauletti PM, Gamboa IC, Silva HS, Bolzani VS, Young MCM, Casto-neta CM, Pfenning LH, Berlinck GS, Araujo AR (2010) Sesquiterpenes from Xylaria sp. an endophytic fungus associated with Piper aduncum (Piperaceae). Phytochem Lett 3:164-167
87. Singh SB, Ondeyka JG, Tsipouras N, Ruby C, Sardana V, Schulman M, Sanchez M, Pelaez F, Stahlhut MW, Munshi S, Olsen DB, Lingham RB (2004) Hinnuliquinone, a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Biochem Biophys Res Comm 324:108-113
88. Sonaimuthu V, Parihar S, Thakur JP, Luqman S, Saikia D, Chanotiya CS, Jhonpaul M, Negi AS (2011) Tenuazonic acid: a promising antitubercular principle from Alternaria alternate. Microbiol Res 2(2):63-65
89. Song YC, Li H, Ye YH, Shan CY, Yang YM, Tan RX (2004) Endophytic naphthopyrone metabolites are co-inhibitors of xanthine oxidase, SW1116 cell and some microbial growths. FEMS Microbiol Lett 241(1):67-72
90. Song YC, Huang WY, Sun C, Wang FW, Tan RX (2005) Characterization of Graphislactone A as the antioxidant and free radical-scavenging substance from the culture of Cephalosporium sp. IFB-E001, an endophytic fungus in Trachelospermum jasminoides. Biol Pharm Bull 28(3):506-509
91. Stierle G, Strobel Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260(5105):214-216
92. Stierle AA, Stierle DB, Bugni T (1999) Sequoiatones A and B: novel antitumor metabolites isolated from a redwood endophyte. J Org Chem 64(15):5479-5484
93. Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbial Mol Biol Rev 67(4):491-502
94. Strobel GA, Miller RV, Martinez-Miller C, Condron MM, Teplow DB, Hess WM (1999) Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Microbiology 145:1919-1926
95. Strobel G, Ford E, Worapong J, Harper JK, Arif AM, Grant DM, Fung PCW, Chau RMW (2002) Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities. Phytochemistry 60:179-183
96. Strobel GA, Daisy B, Castillo U, Harper J (2004) Natural products from endophytic microorganisms. J Nat Prod 67(2):257-268
97. Tan RX, Zou WX (2001) Endophytes: a rich source of functional metabolites. Nat Prod Rep 18:448-459
98. Tansuwan S, Pornpakakul S, Roengsumran S, Peston A, Muangsin N, Sihanonta P, Chaichit N (2007) Antimalarial benzoquinones from an endophytic fungus, Xylaria sp. J Nat Prod 70:1620-1623
99. Tayung K, Barik BP, Jha DK, Deka DC (2011) Identification and characterization of antimicrobial metabolite from an endophytic fungus, Fusarium solani isolated from bark of Himalayan yew. Mycosphere 2(3):203-213
100. Tejesvi MV, Nalini MS, Mahesh B, Parkash SH, Kinni RK, Shetty HS, Subbiah V (2007) New hopes from endophytic fungal secondary metabolite. Bol Soc Quim Mex 1:19-26
101. Teles HL, Sordi R, Silva GH, Castro-Gamboa I, da Silva BV, Pfenning LH, de Abreu LM, Costa-Neto CM, Young MCM, Araujo AR (2006) Aromatic compounds produced by Periconia atropurpurea, an endophytic fungus associated with Xylopia aromatica. Phytochemistry 67(24):2686-2690
102. Turbyville TJ, Kithsiri Wijeratne EM, Liu MX, Burns AM, Seliga CJ, Luevano LA, David CL, Faeth SH, Whitesell L, Gunatilaka AAL (2006) Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of Radicicol and Monocillin I from two plant-associated fungi of the Sonoran desert. J Nat Prod 69:178-184
103. Uma SR, Ramesha BT, Ravikanth G, Rajesh PG, Vasudeva R, Ganeshaiah KN (2008) Chemical profiling of Nothapodytes nimmoniana for camptothecin, an important anticancer alkaloid: towards the development of a sustainable production system in bioactive molecules and medicinal plants. In: Ramawat KG, Merillon JM (eds) Bioactive molecules and medicinal plants. Springer, Berlin, pp 197-213
104. Van der Sar SA, Blunt JW, Munro MHG (2006) spiro-Mamakone A: a unique relative of the spirobisnaphthalene class of compounds. Org Lett 8(10):2059-2061
105. Verza M, Arakawa NS, Lopes NP, Kato MJ, Pupo MT, Said S, Carvalho I (2009) Biotransformation of a tetra hydrofuran lignan by the endophytic fungus Phomopsis sp. J Braz Chem Soc 20(1):195-200
106. Wagenaar MM, Clardy J (2001) Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint. J Nat Prod 64(8):1006-1009
107. Wagenaar MM, Corwin J, Strobel G, Clardy J (2000) Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. J Nat Prod 63(12):1692-1695
108. Wang S, Li XM, Teuscher F, Li DL, Diesel A, Ebel R, Proksch P, Wang BG (2006) Chaetopyranin, a benzaldehyde derivative and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphonia urceolata. J Nat Prod 69:1622-1625
109. Wang LW, Xu BG, Wang JY, Su ZZ, Lin FC, Zhang CL, Kubicek CP (2012) Bioactive metabolites from Phoma species, an endophytic fungus from the Chinese medicinal plant Arisaema erubescens. Appl Microbiol Biotechnol 93:1231-1239
110. Weber D, Sterner O, Anke T, Gorzalczancy S, Martin V, Acevedo C (2004) Phomol, a new antinflammatory metabolite from an endophyte of the medicinal plant Erythrina cristagalli. J Antibiot 57:559-563
111. Wicklow DT, Roth S, Deyrup ST, Gloer JB (2005) A protective endophyte of maize: Acremonium zeae antibiotics inhibitory to Aspergillus flavus and Fusarium verticillioides. Mycol Res 109(5):610-618
112. Wijeratne EMK, Paranagama PA, Marron MT, Gunatilaka MK, Arnold AE, Gunatilaka AAL (2008) Sesquiterpene quinines and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert. J Nat Prod 71(2):218-222
113. Yang X, Zhang L, Guo B, Guo S (2004) Preliminary study of vincristine-producing endophytic fungus isolated from leaves of Catharanthus roseus. China Trade Herb Drugs 35:79-81
114. Zhan J, Burns AM, Liu MX, Faeth SH, Gunatilaka AAL (2007) Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum. J Nat Prod 70:227-232
115. Zhang HW, Song YC, Tan RX (2006) Biology and chemistry of endophytes. Nat Prod Rep 23:753-771
116. Zhang JY, Tao LY, Liang YJ, et al. (2009) Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G1 with involvement of GSK-3β/β-catenin/c-Myc pathway. Cell Cycle 8(15):2444-2450
117. Zhang X, Shi Y, Wang X, Zhang W, Lou K (2010a) Isolation, identification and insecticidal activity of endophyte from Achnatherum inebrians. Wei Sheng Wu Xue Bao 50(4):530-536
118. Zhang JY, Tao LY, Liang YJ, Chen LM, Mi YJ, Zheng LS, Wang F, She ZG, Lin YC, To KKW, Fu LW (2010b) Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi. Drugs 8(4):1469-1481
119. Zhao J, Mou Y, Shan T, Li Y, Zhou L, Wang M, Wang J (2010) Antimicrobial metabolites from the endophytic fungus Pichia guilliermondii isolated from Paris Polyphylla var. Yunnanensis. Molecules 15:7961-7970
120. Zhao JT, Fu YJ, Luo M, Zu YG, Wang W, Zhao CJ, Gu CB (2012a) Endophytic fungi from pigeon pea [Cajanus cajan(L.) Mill sp.] produce antioxidant Cajaninstilbene Acid. J Agric Food Chem 60:4314-4319
121. Zhao J, Sun W, Shan T, Mou Y, Lou J, Li Y, Wang M, Zhou L (2012b) Antimicrobial metabolites from the endophytic fungus Gliomastix murorum Ppf8 associated with the medicinal plant Paris polyphylla var. yunnanensis. J Med Plant Res 6(11):2100-2104
122. Zou WX, Meng JC, Lu H, Chen GX, Shi GX, Zhang TY, Tan RX (2000) Metabolites of Colletrotrichum gloeosporioides, an endophytic fungus in Artemisia mongolica. J Nat Prod 63:1529-1530