메뉴 건너뛰기




Volumn 119, Issue 12, 2012, Pages 1523-1528

Does structural neuroimaging reveal a disturbance of iron metabolism in Parkinson's disease? Implications from MRI and TCS studies

Author keywords

Magnetic resonance imaging; Parkinson's disease; Substantia nigra; Transcranial sonography

Indexed keywords

ARTICLE; ECHOGRAPHY; IRON METABOLISM; IRON METABOLISM DISORDER; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; SUBSTANTIA NIGRA; TRANSCRANIAL SONOGRAPHY;

EID: 84876250024     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0873-0     Document Type: Article
Times cited : (30)

References (52)
  • 2
    • 7244242355 scopus 로고    scopus 로고
    • T2-weighted MRI in Parkinson's disease; Substantia nigra pars compacta hypointensity correlates with the clinical scores
    • 15472421
    • Atasoy HT, Nuyan O, Tunc T, Yorubulut M, Unal AE, Inan LE (2004) T2-weighted MRI in Parkinson's disease; substantia nigra pars compacta hypointensity correlates with the clinical scores. Neurol India 52:332-337
    • (2004) Neurol India , vol.52 , pp. 332-337
    • Atasoy, H.T.1    Nuyan, O.2    Tunc, T.3    Yorubulut, M.4    Unal, A.E.5    Inan, L.E.6
  • 5
    • 67651161861 scopus 로고    scopus 로고
    • Hyperechogenicity of the substantia nigra in healthy controls is related to MRI changes and to neuronal loss as determined by F-Dopa PET
    • 19497378 10.1016/j.neuroimage.2009.05.072 1:STN:280: DC%2BD1MritlSrtg%3D%3D
    • Behnke S, Schroeder U, Dillmann U, Buchholz HG, Schreckenberger M, Fuss G, Reith W, Berg D, Krick CM (2009) Hyperechogenicity of the substantia nigra in healthy controls is related to MRI changes and to neuronal loss as determined by F-Dopa PET. Neuroimage 47:1237-1243
    • (2009) Neuroimage , vol.47 , pp. 1237-1243
    • Behnke, S.1    Schroeder, U.2    Dillmann, U.3    Buchholz, H.G.4    Schreckenberger, M.5    Fuss, G.6    Reith, W.7    Berg, D.8    Krick, C.M.9
  • 6
    • 34548760983 scopus 로고    scopus 로고
    • Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: Implications for idiopathic and monogenetic forms
    • 17468954 10.1007/s11064-007-9346-5 1:CAS:528:DC%2BD2sXhtVGmsL3M
    • Berg D (2007) Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: implications for idiopathic and monogenetic forms. Neurochem Res 32:1646-1654
    • (2007) Neurochem Res , vol.32 , pp. 1646-1654
    • Berg, D.1
  • 7
    • 80755173479 scopus 로고    scopus 로고
    • Substantia nigra hyperechogenicity is a risk marker of Parkinson's disease: Yes
    • 21207077 10.1007/s00702-010-0565-6
    • Berg D (2011) Substantia nigra hyperechogenicity is a risk marker of Parkinson's disease: yes. J Neural Transm 118:613-619
    • (2011) J Neural Transm , vol.118 , pp. 613-619
    • Berg, D.1
  • 9
    • 0032765888 scopus 로고    scopus 로고
    • Iron accumulation of the substantia nigra in rats visualized by ultrasound
    • 10461717 10.1016/S0301-5629(99)00046-0 1:STN:280:DyaK1MzptVyiug%3D%3D
    • Berg D, Grote C, Rausch WD, Mäurer M, Wesemann W, Riederer P, Becker G (1999b) Iron accumulation of the substantia nigra in rats visualized by ultrasound. Ultrasound Med Biol 25:901-904
    • (1999) Ultrasound Med Biol , vol.25 , pp. 901-904
    • Berg, D.1    Grote, C.2    Rausch, W.D.3    Mäurer, M.4    Wesemann, W.5    Riederer, P.6    Becker, G.7
  • 11
    • 18144397394 scopus 로고    scopus 로고
    • A five year follow-up study of hyperechogenicity of the substantia nigra in Parkinson′s disease
    • 15486999 10.1002/mds.20311
    • Berg D, Merz B, Reiners K, Naumann M, Becker G (2005) A five year follow-up study of hyperechogenicity of the substantia nigra in Parkinson′s disease. Mov Disord 20:383-385
    • (2005) Mov Disord , vol.20 , pp. 383-385
    • Berg, D.1    Merz, B.2    Reiners, K.3    Naumann, M.4    Becker, G.5
  • 12
    • 53649086350 scopus 로고    scopus 로고
    • Transcranial sonography in movement disorders
    • 18940694 10.1016/S1474-4422(08)70239-4
    • Berg D, Godau J, Walter U (2008) Transcranial sonography in movement disorders. Lancet Neurol 7:1044-1055
    • (2008) Lancet Neurol , vol.7 , pp. 1044-1055
    • Berg, D.1    Godau, J.2    Walter, U.3
  • 15
    • 34147145066 scopus 로고    scopus 로고
    • Magnetic resonance imaging of iron deposition in neurological disorders
    • 17179895 10.1097/01.rmr.0000245459.82782.e4
    • Brass SD, Chen NK, Mulkern RV, Bakshi R (2006) Magnetic resonance imaging of iron deposition in neurological disorders. Top Magn Reson Imaging 17:31-40
    • (2006) Top Magn Reson Imaging , vol.17 , pp. 31-40
    • Brass, S.D.1    Chen, N.K.2    Mulkern, R.V.3    Bakshi, R.4
  • 16
    • 0028350924 scopus 로고
    • Isoforms of ferritin have a specific cellular distribution in the brain
    • 8021970 10.1002/jnr.490370405 1:CAS:528:DyaK2cXitFegsbY%3D
    • Connor JR, Boeshore KL, Benkovic SA, Menzies SL (1994) Isoforms of ferritin have a specific cellular distribution in the brain. J Neurosci Res 37:461-465
    • (1994) J Neurosci Res , vol.37 , pp. 461-465
    • Connor, J.R.1    Boeshore, K.L.2    Benkovic, S.A.3    Menzies, S.L.4
  • 18
    • 0027343942 scopus 로고
    • Implications of alterations in trace element levels in brain in Parkinson's disease and other neurological disorders affecting the basal ganglia
    • 8420143 1:CAS:528:DyaK3sXitlWmtbw%3D
    • Dexter DT, Sian J, Jenner P, Marsden CD (1993) Implications of alterations in trace element levels in brain in Parkinson's disease and other neurological disorders affecting the basal ganglia. Adv Neurol 60:273-281
    • (1993) Adv Neurol , vol.60 , pp. 273-281
    • Dexter, D.T.1    Sian, J.2    Jenner, P.3    Marsden, C.D.4
  • 19
    • 79961193718 scopus 로고    scopus 로고
    • Combined R2*and diffusion tensor imaging changes in the substantia nigra in Parkinson's disease
    • 21618607 10.1002/mds.23643
    • Du G, Lewis MM, Styner M, Shaffer ML, Sen S, Yang QX, Huang X (2011) Combined R2*and diffusion tensor imaging changes in the substantia nigra in Parkinson's disease. Mov Disord 26:1627-1632
    • (2011) Mov Disord , vol.26 , pp. 1627-1632
    • Du, G.1    Lewis, M.M.2    Styner, M.3    Shaffer, M.L.4    Sen, S.5    Yang, Q.X.6    Huang, X.7
  • 21
    • 0028000825 scopus 로고
    • Altered brain metabolism of iron as a cause of neurodegenerative diseases
    • 7519659 10.1046/j.1471-4159.1994.63030793.x 1:CAS:528:DyaK2cXlsFCgtLo%3D
    • Gerlach M, Ben-Shachar D, Riederer P, Youdim MB (1994) Altered brain metabolism of iron as a cause of neurodegenerative diseases. J Neurochem 63:793-807
    • (1994) J Neurochem , vol.63 , pp. 793-807
    • Gerlach, M.1    Ben-Shachar, D.2    Riederer, P.3    Youdim, M.B.4
  • 22
    • 0028998624 scopus 로고
    • Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease
    • 7783878 10.1212/WNL.45.6.1138 1:STN:280:DyaK2MzgtlaktA%3D%3D
    • Gorell JM, Ordidge RJ, Brown GG, Deniau JC, Buderer NM, Helpern JA (1995) Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology 45:1138-1143
    • (1995) Neurology , vol.45 , pp. 1138-1143
    • Gorell, J.M.1    Ordidge, R.J.2    Brown, G.G.3    Deniau, J.C.4    Buderer, N.M.5    Helpern, J.A.6
  • 23
    • 0033639207 scopus 로고    scopus 로고
    • Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence
    • 11099445 10.1093/brain/123.12.2423
    • Graham JM, Paley MN, Grünewald RA, Hoggard N, Griffiths PD (2000) Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence. Brain 123:2423-2431
    • (2000) Brain , vol.123 , pp. 2423-2431
    • Graham, J.M.1    Paley, M.N.2    Grünewald, R.A.3    Hoggard, N.4    Griffiths, P.D.5
  • 24
    • 78650009796 scopus 로고    scopus 로고
    • Utility of susceptibility-weighted MRI in differentiating Parkinson's disease and atypical parkinsonism
    • 20358367 10.1007/s00234-010-0677-6
    • Gupta D, Saini J, Kesavadas C, Sarma PS, Kishore A (2010) Utility of susceptibility-weighted MRI in differentiating Parkinson's disease and atypical parkinsonism. Neuroradiology 52:1087-1094
    • (2010) Neuroradiology , vol.52 , pp. 1087-1094
    • Gupta, D.1    Saini, J.2    Kesavadas, C.3    Sarma, P.S.4    Kishore, A.5
  • 26
    • 58249096160 scopus 로고    scopus 로고
    • Susceptibility-weighted imaging: Technical aspects and clinical applications, part 1
    • 19039041 10.3174/ajnr.A1400 1:STN:280:DC%2BD1M%2FmsFKitQ%3D%3D
    • Haacke EM, Mittal S, Wu Z, Neelavalli J, Cheng YC (2009) Susceptibility-weighted imaging: technical aspects and clinical applications, part 1. AJNR Am J Neuroradiol 30:19-30
    • (2009) AJNR Am J Neuroradiol , vol.30 , pp. 19-30
    • Haacke, E.M.1    Mittal, S.2    Wu, Z.3    Neelavalli, J.4    Cheng, Y.C.5
  • 27
    • 84871450023 scopus 로고    scopus 로고
    • Susceptibility-weighted imaging in detecting brain iron accumulation of Parkinson's disease
    • 21211325
    • Huang XM, Sun B, Xue YJ, Duan Q (2010) Susceptibility-weighted imaging in detecting brain iron accumulation of Parkinson's disease. Zhonghua Yi Xue Za Zhi 90:3054-3058
    • (2010) Zhonghua Yi Xue Za Zhi , vol.90 , pp. 3054-3058
    • Huang, X.M.1    Sun, B.2    Xue, Y.J.3    Duan, Q.4
  • 28
    • 77957970097 scopus 로고    scopus 로고
    • Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: A prospective study
    • Sleep Innsbruck Barcelona (SINBAR) group
    • Iranzo A, Lomeña F, Stockner H, Valldeoriola F, Vilaseca I, Salamero M, Molinuevo JL, Serradell M, Duch J, Pavía J, Gallego J, Seppi K, Högl B, Tolosa E, Poewe W, Santamaria J; Sleep Innsbruck Barcelona (SINBAR) group (2010) Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol 9:1070-1077
    • (2010) Lancet Neurol , vol.9 , pp. 1070-1077
    • Iranzo A, L.1
  • 29
    • 78650695967 scopus 로고    scopus 로고
    • Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease
    • 21109502 10.1093/brain/awq319
    • Jin L, Wang J, Zhao L, Jin H, Fei G, Zhang Y, Zeng M, Zhong C (2011) Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease. Brain 134:50-58
    • (2011) Brain , vol.134 , pp. 50-58
    • Jin, L.1    Wang, J.2    Zhao, L.3    Jin, H.4    Fei, G.5    Zhang, Y.6    Zeng, M.7    Zhong, C.8
  • 30
    • 31544442154 scopus 로고    scopus 로고
    • MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease
    • 15981079 10.1007/s00415-005-0914-9
    • Kosta P, Argyropoulou MI, Markoula S, Konitsiotis S (2006) MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease. J Neurol 253:26-32
    • (2006) J Neurol , vol.253 , pp. 26-32
    • Kosta, P.1    Argyropoulou, M.I.2    Markoula, S.3    Konitsiotis, S.4
  • 32
    • 42049123661 scopus 로고    scopus 로고
    • Midbrain iron content in early Parkinson disease: A potential biomarker of disease status
    • 18172063 10.1212/01.wnl.0000286384.31050.b5 1:CAS:528: DC%2BD1cXksFantr8%3D
    • Martin WR, Wieler M, Gee M (2008) Midbrain iron content in early Parkinson disease: a potential biomarker of disease status. Neurology 70:1411-1417
    • (2008) Neurology , vol.70 , pp. 1411-1417
    • Martin, W.R.1    Wieler, M.2    Gee, M.3
  • 33
    • 34147107527 scopus 로고    scopus 로고
    • Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts
    • 17149719 10.1002/mds.21227
    • Michaeli S, Oz G, Sorce DJ, Garwood M, Ugurbil K, Majestic S, Tuite P (2007) Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts. Mov Disord 22:334-340
    • (2007) Mov Disord , vol.22 , pp. 334-340
    • Michaeli, S.1    Oz, G.2    Sorce, D.J.3    Garwood, M.4    Ugurbil, K.5    Majestic, S.6    Tuite, P.7
  • 34
    • 0036757032 scopus 로고    scopus 로고
    • Magnetic resonance relaxometry in Parkinson's disease
    • 12548357 10.1007/s100720200083
    • Mondino F, Filippi P, Magliola U, Duca S (2002) Magnetic resonance relaxometry in Parkinson's disease. Neurol Sci 23:S87-S88
    • (2002) Neurol Sci , vol.23
    • Mondino, F.1    Filippi, P.2    Magliola, U.3    Duca, S.4
  • 36
    • 0028142827 scopus 로고
    • Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla
    • 7984066 10.1002/mrm.1910320309 1:CAS:528:DyaK2cXmslGrtro%3D
    • Ordidge RJ, Gorell JM, Deniau JC, Knight RA, Helpern JA (1994) Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla. Magn Reson Med 32:335-341
    • (1994) Magn Reson Med , vol.32 , pp. 335-341
    • Ordidge, R.J.1    Gorell, J.M.2    Deniau, J.C.3    Knight, R.A.4    Helpern, J.A.5
  • 40
    • 0027348686 scopus 로고
    • Magnetic resonance imaging in parkinsonisms
    • 8420184 1:STN:280:DyaK3s7ivVSrtg%3D%3D
    • Rutledge JN, Schallert T, Hall S (1993) Magnetic resonance imaging in parkinsonisms. Adv Neurol 60:529-534
    • (1993) Adv Neurol , vol.60 , pp. 529-534
    • Rutledge, J.N.1    Schallert, T.2    Hall, S.3
  • 41
    • 0029054075 scopus 로고
    • Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease
    • 7763206 10.1001/archneur.1995.00540300057013 1:STN:280: DyaK2M3otlCrtQ%3D%3D
    • Ryvlin P, Broussolle E, Piollet H, Viallet F, Khalfallah Y, Chazot G (1995) Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease. Arch Neurol 52:583-588
    • (1995) Arch Neurol , vol.52 , pp. 583-588
    • Ryvlin, P.1    Broussolle, E.2    Piollet, H.3    Viallet, F.4    Khalfallah, Y.5    Chazot, G.6
  • 42
    • 0028183613 scopus 로고
    • Magnetic resonance imaging in progressive supranuclear palsy and other parkinsonian disorders
    • 7964700 10.1007/978-3-7091-6641-3-8 1:STN:280:DyaK2M%2Fltl2qsg%3D%3D
    • Savoiardo M, Girotti F, Strada L, Ciceri E (1994) Magnetic resonance imaging in progressive supranuclear palsy and other parkinsonian disorders. J Neural Transm Suppl 42:93-110
    • (1994) J Neural Transm Suppl , vol.42 , pp. 93-110
    • Savoiardo, M.1    Girotti, F.2    Strada, L.3    Ciceri, E.4
  • 43
    • 72849128179 scopus 로고    scopus 로고
    • Potential role of high-field MRI for studies in Parkinson's disease
    • 19877239 10.1002/mds.22647
    • Schuff N (2009) Potential role of high-field MRI for studies in Parkinson's disease. Mov Disord 24:S684-S690
    • (2009) Mov Disord , vol.24
    • Schuff, N.1
  • 44
    • 0023804321 scopus 로고
    • Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
    • 3210014 10.1007/BF01244786 1:STN:280:DyaL1M%2FpsVegsQ%3D%3D
    • Sofic E, Riederer P, Heinsen H, Beckmann H, Reynolds GP, Hebenstreit G, Youdim MB (1988) Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J Neural Transm 74:199-205
    • (1988) J Neural Transm , vol.74 , pp. 199-205
    • Sofic, E.1    Riederer, P.2    Heinsen, H.3    Beckmann, H.4    Reynolds, G.P.5    Hebenstreit, G.6    Youdim, M.B.7
  • 45
    • 36149008265 scopus 로고
    • Relaxation processes in a system of two spins
    • 10.1103/PhysRev.99.559 1:CAS:528:DyaG2MXotFOruw%3D%3D
    • Solomon I (1955) Relaxation processes in a system of two spins. Phys Rev 99:559-565
    • (1955) Phys Rev , vol.99 , pp. 559-565
    • Solomon, I.1
  • 47
    • 0033045138 scopus 로고    scopus 로고
    • T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: Relation to iron content
    • 10228533 1:STN:280:DyaK1M3ksFaitQ%3D%3D
    • Vymazal J, Righini A, Brooks RA, Canesi M, Mariani C, Leonardi M, Pezzoli G (1999) T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: relation to iron content. Radiology 211:489-495
    • (1999) Radiology , vol.211 , pp. 489-495
    • Vymazal, J.1    Righini, A.2    Brooks, R.A.3    Canesi, M.4    Mariani, C.5    Leonardi, M.6    Pezzoli, G.7
  • 49
    • 84863146124 scopus 로고    scopus 로고
    • Different iron-deposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility-weighted imaging
    • 22051807 10.3174/ajnr.A2765 1:STN:280:DC%2BC383islansQ%3D%3D
    • Wang Y, Butros SR, Shuai X, Dai Y, Chen C, Liu M, Haacke EM, Hu J, Xu H (2012) Different iron-deposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility-weighted imaging. AJNR Am J Neuroradiol 33:266-273
    • (2012) AJNR Am J Neuroradiol , vol.33 , pp. 266-273
    • Wang, Y.1    Butros, S.R.2    Shuai, X.3    Dai, Y.4    Chen, C.5    Liu, M.6    Haacke, E.M.7    Hu, J.8    Xu, H.9
  • 50
    • 27844547163 scopus 로고    scopus 로고
    • In vivo detection of iron and neuromelanin by transcranial sonography a new approach for early detection of substantia nigra damage
    • 15986424 10.1002/mds.20550
    • Zecca L, Berg D, Arzberger T, Ruprecht P, Rausch WD, Musico M, Tampellini T, Riederer P, Gerlach M, Becker G (2005) In vivo detection of iron and neuromelanin by transcranial sonography a new approach for early detection of substantia nigra damage. Mov Disord 20:1278-1285
    • (2005) Mov Disord , vol.20 , pp. 1278-1285
    • Zecca, L.1    Berg, D.2    Arzberger, T.3    Ruprecht, P.4    Rausch, W.D.5    Musico, M.6    Tampellini, T.7    Riederer, P.8    Gerlach, M.9    Becker, G.10
  • 51
    • 72349088723 scopus 로고    scopus 로고
    • Determination of brain iron content in patients with Parkinson's disease using magnetic susceptibility imaging
    • 19927171 10.1007/s12264-009-0225-8 1:CAS:528:DC%2BD1MXhtFSlt73K
    • Zhang W, Sun SG, Jiang YH, Qiao X, Sun X, Wu Y (2009) Determination of brain iron content in patients with Parkinson's disease using magnetic susceptibility imaging. Neurosci Bull 25:353-360
    • (2009) Neurosci Bull , vol.25 , pp. 353-360
    • Zhang, W.1    Sun, S.G.2    Jiang, Y.H.3    Qiao, X.4    Sun, X.5    Wu, Y.6
  • 52
    • 77955905072 scopus 로고    scopus 로고
    • Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: An in vivo MR study
    • 20303339 10.1016/j.brainres.2010.03.036 1:CAS:528:DC%2BC3cXltF2jtLg%3D
    • Zhang J, Zhang Y, Wang J, Cai P, Luo C, Qian Z, Dai Y, Feng H (2010) Characterizing iron deposition in Parkinson's disease using susceptibility- weighted imaging: an in vivo MR study. Brain Res 1330:124-130
    • (2010) Brain Res , vol.1330 , pp. 124-130
    • Zhang, J.1    Zhang, Y.2    Wang, J.3    Cai, P.4    Luo, C.5    Qian, Z.6    Dai, Y.7    Feng, H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.